Xenobiotica, Volume 52, Issue 6 (2022)

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Xenobiotica, Volume 52, Issue 6 (2022)

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Clinical Pharmacokinetics and Metabolism

Article
The impact of ibuprofen on valproic acid plasma concentration in pediatric patients
Peng Gao, Junyan Wang, Liwen Zhang, Huijuan Wang, Yan Hu, Yinghua Ni, Lingfei Huang, Zhengyi Zhu & Luo Fang
Pages: 535-540
Published online: 29 Aug 2022
AbstractforThe impact of ibuprofen on valproic acid plasma concentration in pediatric patients | Full Text | References | PDF (950.8 KB) | EPUB
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Article
Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects
Peter Gorycki, Mindy Magee, Peter Ackerman, Xiusheng Miao & Katy Moore
Pages: 541-554
Published online: 21 Sep 2022
AbstractforPharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 277 Views
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Article
A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1)
Lu Zhang, Bill Poland, Michelle Green, Shekman Wong & J. Greg Slatter
Pages: 555-566
Published online: 03 Oct 2022
AbstractforA population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1) | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 951 Views
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Open Access
Article
Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chinese volunteers
Xianjing Li, Haitao Yu, Wenjing Guo, Minlu Cheng, Qinxin Song & Li Ding
Pages: 567-574
Published online: 27 Sep 2022
AbstractforDevelopment and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chinese volunteers | Full Text | References | PDF (1.4 MB) | EPUB
  • 89 Views
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics of levonorgestrel and etonogestrel in rat or minipig following intravenous, subcutaneous, or intradermal administration
Paul J. Ko, Mark A. Milad, Louis L. Radulovic & Don M. Gibson
Pages: 575-582
Published online: 31 Aug 2022
AbstractforPharmacokinetics of levonorgestrel and etonogestrel in rat or minipig following intravenous, subcutaneous, or intradermal administration | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 1752 Views
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Open Access
Article
Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis
Shinji Kobuchi, Naoya Kanda, Taichi Okumi, Yuma Kano, Himawari Tachi, Yukako Ito & Toshiyuki Sakaeda
Pages: 583-590
Published online: 08 Sep 2022
AbstractforComparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis | Full Text | References | PDF (1 MB) | EPUB
  • 140 Views
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Article
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
Kristine Langthaler, Christopher R. Jones, Rasmus B. Christensen, Elin Eneberg, Birger Brodin & Christoffer Bundgaard
Pages: 591-607
Published online: 01 Sep 2022
AbstractforCharacterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2257 Views
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Open Access
Article
In vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin
Ai Hasegawa, Yoshie Tsujiya, Ayaka Ueda, Motohiro Yamamori & Noboru Okamura
Pages: 608-612
Published online: 01 Sep 2022
AbstractforIn vivo evaluation of pharmacokinetic drug–drug interactions between fluorinated pyrimidine anticancer drugs, 5-fluorouracil and capecitabin, and an anticoagulant, warfarin | Full Text | References | PDF (655.7 KB) | EPUB
  • 158 Views
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Article
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Naoki Cho, Hiroshi Ikeda, Satoshi Maeda, Kensuke Kagiyama, Atsunori Miyata, Hiroshi Suemizu & Kazumasa Fukasawa
Pages: 613-624
Published online: 05 Oct 2022
AbstractforSelection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets | Full Text | References | PDF (2 MB) | EPUB
  • 987 Views
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Open Access

Molecular Toxicology

Article
Cadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta
Xiaojie Zhang, Kai Chen, Zhu Meng, Ru Jia, Feifei Lian & Feng Lin
Pages: 625-632
Published online: 21 Sep 2022
AbstractforCadmium-induced preeclampsia-like phenotype in the rat is related to decreased progesterone synthesis in the placenta | Full Text | References | PDF (1.3 MB) | EPUB
  • 167 Views
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Article
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity
Li Zhang, Fugui Zhang, Yifei Xiao, Jianhao Du, Xingwang Zhang, Min Chen & Baojian Wu
Pages: 633-643
Published online: 05 Oct 2022
AbstractforThe nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 163 Views
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Xenobiotic Transporters

Article
Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters
Lisa Chedik, Dominique Mias-Lucquin, Olivier Fardel, Olivier Delalande & Arnaud Bruyere
Pages: 644-652
Published online: 05 Oct 2022
AbstractforInteractions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 129 Views
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