Xenobiotica, Volume 54, Issue 2 (2024)

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Xenobiotica, Volume 54, Issue 2 (2024)

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General Xenobiochemistry

Article
High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry
Yu Yumoto, Takuro Endo, Hiroshi Harada, Kaoru Kobayashi, Takeshi Nakabayashi & Yoshikazu Abe
Pages: 45-56
Published online: 01 Feb 2024
AbstractforHigh-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes
Rui Wang, Kai Zheng, Yunjiao Liu, Shuxia Ji, Yaxin Tang, Jie Wang & Rong Jiang
Pages: 57-63
Published online: 12 Jan 2024
AbstractforEffect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human
Laurent Salphati, Jodie Pang, Bruno Alicke, Emile G. Plise, Jonathan Cheong, Allan Jaochico, Alan G. Olivero, Deepak Sampath, Susan Wong & Xiaolin Zhang
Pages: 64-74
Published online: 15 Jan 2024
AbstractforPreclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics
Yan Liu, Jiahui Sun, Chunjuan Yang, Mengnan Qin, Shiwei Xu, Yue Zhao & Gaofeng Liu
Pages: 75-82
Published online: 13 Mar 2024
AbstractforSafflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics | Full Text | References | PDF (3.9 MB) | EPUB
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Molecular toxicology

Article
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR
Xiaoting Xu, Reham Taha, Chenghan Chu, Li Xiao, Tao Wang, Xinzhi Wang, Xin Huang, Zhenzhou Jiang & Lixin Sun
Pages: 83-94
Published online: 08 Jan 2024
AbstractforIndirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Pharmacogenetics

Article
The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma
Khloud Shendy, Khaled Abdelkawy, Ahmed Amin Ali, Fathalla Belal, Mostafa Abdelhakiem, Galal Magdy, Nahla Anber & Fawzy Elbarbry
Pages: 95-105
Published online: 05 Mar 2024
AbstractforThe effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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