Bioengineered, Volume 12, Issue 2 (2021)

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Bioengineered, Volume 12, Issue 2 (2021)

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Research Paper

Article
Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway
Xingming Zhong & Yong Cai
Pages: 9113-9127
Published online: 21 Nov 2021
AbstractforLong non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Research paper

Article
The roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling
Chen Wang, Na Zhao, Fuyuki Sato, Keiji Tanimoto, Hiroyuki Okada, Yang Liu & Ujjal K. Bhawal
Pages: 9128-9139
Published online: 01 Dec 2021
AbstractforThe roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling | Full Text | References | PDF (2 MB) | EPUB
  • 1908 Views
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Article
Pathogenic mechanisms of preeclampsia with severe features implied by the plasma exosomal mirna profile
Zhirui Chen, Wen Zhang, Mengying Wu, Haixia Huang, Li Zou & Qingqing Luo
Pages: 9140-9149
Published online: 09 Dec 2021
AbstractforPathogenic mechanisms of preeclampsia with severe features implied by the plasma exosomal mirna profile | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Open Access
Article
YY1-induced long non-coding RNA PSMA3 antisense RNA 1 functions as a competing endogenous RNA for microRNA 214-5p to expedite the viability and restrict the apoptosis of bladder cancer cells via regulating programmed cell death-ligand 1
Mingran Zhang, Yunfeng Xu, Shuai Yin & Feng Qiu
Pages: 9150-9161
Published online: 24 Nov 2021
AbstractforYY1-induced long non-coding RNA PSMA3 antisense RNA 1 functions as a competing endogenous RNA for microRNA 214-5p to expedite the viability and restrict the apoptosis of bladder cancer cells via regulating programmed cell death-ligand 1 | Full Text | References | PDF (4.6 MB) | EPUB
  • 1573 Views
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Article
Ropivacaine suppresses tumor biological characteristics of human hepatocellular carcinoma via inhibiting IGF-1R/PI3K/AKT/mTOR signaling axis
Runze Zhang, Yanhong Lian, Kangjie Xie, Yunfang Cai, Yafei Pan & Yuntian Zhu
Pages: 9162-9173
Published online: 22 Nov 2021
AbstractforRopivacaine suppresses tumor biological characteristics of human hepatocellular carcinoma via inhibiting IGF-1R/PI3K/AKT/mTOR signaling axis | Full Text | References | PDF (2.5 MB) | EPUB
  • 1855 Views
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Article
Long non-coding RNA NORAD protects against cerebral ischemia/reperfusion injury induced brain damage, cell apoptosis, oxidative stress and inflammation by regulating miR-30a-5p/YWHAG
Xinyu Zhou, Zhonglong Wang, Bingchao Xu, Niu Ji, Pin Meng, Lei Gu & Ying Li
Pages: 9174-9188
Published online: 22 Nov 2021
AbstractforLong non-coding RNA NORAD protects against cerebral ischemia/reperfusion injury induced brain damage, cell apoptosis, oxidative stress and inflammation by regulating miR-30a-5p/YWHAG | Full Text | References | PDF (5.8 MB) | EPUB
  • 2378 Views
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Review

Review
Nanopore sensors for viral particle quantification: current progress and future prospects
Shiva Akhtarian, Saba Miri, Ali Doostmohammadi, Satinder Kaur Brar & Pouya Rezai
Pages: 9189-9215
Published online: 22 Nov 2021
AbstractforNanopore sensors for viral particle quantification: current progress and future prospects | Full Text | References | PDF (2.9 MB) | EPUB
  • 3887 Views
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Review
Biofuel production from Macroalgae: present scenario and future scope
Godvin Sharmila V, Dinesh Kumar M, Arulazhagan Pugazhendi, Amit Kumar Bajhaiya, Poornachander Gugulothu & Rajesh Banu J
Pages: 9216-9238
Published online: 24 Nov 2021
AbstractforBiofuel production from Macroalgae: present scenario and future scope | Full Text | References | PDF (2 MB) | EPUB
  • 6629 Views
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Research paper

Article
LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
Mingkun Zhang, Liu Yang, Lan Hou & Xueyuan Tang
Pages: 9239-9250
Published online: 22 Nov 2021
AbstractforLncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer | Full Text | References | PDF (2.8 MB) | EPUB
  • 1870 Views
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Article
ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma
Xiaomei Ying, Liang Chen, Jiaheng Xie, Yiming Hu, Qingqing Wu, Liyu Cao & Hongzhu Yu
Pages: 9251-9265
Published online: 27 Dec 2021
AbstractforANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
Cyanidin-3-o-glucoside (C3G) inhibits vascular leakage regulated by microglial activation in early diabetic retinopathy and neovascularization in advanced diabetic retinopathy
Fangling Zhao, Xiang Gao, XiaoJuan Ge, Jiawen Cui & Xia Liu
Pages: 9266-9278
Published online: 24 Nov 2021
AbstractforCyanidin-3-o-glucoside (C3G) inhibits vascular leakage regulated by microglial activation in early diabetic retinopathy and neovascularization in advanced diabetic retinopathy | Full Text | References | PDF (4.6 MB) | EPUB
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Research Paper

Article
The effect and mechanism of cypermethrin-induced hippocampal neurotoxicity as determined by network pharmacology analysis and experimental validation
Jianan Li & Haoran Bi
Pages: 9279-9289
Published online: 22 Nov 2021
AbstractforThe effect and mechanism of cypermethrin-induced hippocampal neurotoxicity as determined by network pharmacology analysis and experimental validation | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Expression of Cyclin D1 gene in ovarian cancer and effect of silencing its expression on ovarian cancer cells based on the Oncomine database
Li-Li Quan, Jin-Yang Liu, Li-Xia Qu, Hui La, Hai-Li Wang, Xiao-Xia Chen, Na Wang & Zhen-Zhi Wei
Pages: 9290-9300
Published online: 22 Nov 2021
AbstractforExpression of Cyclin D1 gene in ovarian cancer and effect of silencing its expression on ovarian cancer cells based on the Oncomine database | Full Text | References | PDF (2.9 MB) | EPUB
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Article
miRNA-204-5p acts as tumor suppressor to influence the invasion and migration of astrocytoma by targeting ezrin and is downregulated by DNA methylation
Haibo Jiang, Ruixiang Ge, Siwen Chen, Laiquan Huang, Jie Mao & Lili Sheng
Pages: 9301-9312
Published online: 24 Nov 2021
AbstractformiRNA-204-5p acts as tumor suppressor to influence the invasion and migration of astrocytoma by targeting ezrin and is downregulated by DNA methylation | Full Text | References | PDF (2.3 MB) | EPUB
  • 1327 Views
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Article
Uncovering potential single nucleotide polymorphisms, copy number variations and related signaling pathways in primary Sjogren’s syndrome
Xuan Qi, Xi-Qin Wang, Lu Jin, Li-Xia Gao & Hui-Fang Guo
Pages: 9313-9331
Published online: 24 Nov 2021
AbstractforUncovering potential single nucleotide polymorphisms, copy number variations and related signaling pathways in primary Sjogren’s syndrome | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1954 Views
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Article
Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis
Zhisheng Mo, Peiqing Xu & Huanyu Li
Pages: 9332-9340
Published online: 22 Nov 2021
AbstractforStigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis | Full Text | References | PDF (1.5 MB) | EPUB
  • 2975 Views
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Article
Effects of microscopic testa color and morphologyon the water uptake ability and drought tolerance of germination-stage rapeseed (Brassica napus L.)
Zong He Zhu, Abdul Sami, Zhi Peng Chen, Maliha Fatima, Wen Yin Zheng, Qing Qing Xu, Yu Hang Lei, Xue Zhi Jin, Hong Zhang, Yong Li, Yan Yu & Ke Jin Zhou
Pages: 9341-9355
Published online: 24 Dec 2021
AbstractforEffects of microscopic testa color and morphologyon the water uptake ability and drought tolerance of germination-stage rapeseed (Brassica napus L.) | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1063 Views
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Article
Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic β cells: in vitro and in vivo studies
Pan Liu, Zhengdong Zhang, Jinwu Wang, Xiao Zhang, Xiaoping Yu & Yao Li
Pages: 9356-9366
Published online: 25 Nov 2021
AbstractforEmpagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic β cells: in vitro and in vivo studies | Full Text | References | PDF (2.5 MB) | EPUB
  • 3372 Views
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Article
Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction
Zheng Xiao, Bin Kong, Jin Fang, Tianyou Qin, Chang Dai, Wei Shuai & He Huang
Pages: 9367-9376
Published online: 25 Nov 2021
AbstractforFerrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction | Full Text | References | PDF (1.5 MB) | EPUB
  • 10453 Views
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Article
CRTAC1 (Cartilage acidic protein 1) inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process in bladder cancer by downregulating Yin Yang 1 (YY1) to inactivate the TGF-β pathway
Jianghua Yang, Li Fan, Xiaoxing Liao, Gongjing Cui & Hailong Hu
Pages: 9377-9389
Published online: 24 Nov 2021
AbstractforCRTAC1 (Cartilage acidic protein 1) inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process in bladder cancer by downregulating Yin Yang 1 (YY1) to inactivate the TGF-β pathway | Full Text | References | PDF (4 MB) | EPUB
  • 1962 Views
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Article
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer
Chunyan Cai, Yumei Zhang & Xing Peng
Pages: 9390-9400
Published online: 25 Nov 2021
AbstractforKnocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer | Full Text | References | PDF (3 MB) | EPUB
  • 1600 Views
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Article
Dihydroartemisinin alleviates morphine-induced neuroinflammation in BV-2 cells
Sen Guan, Tingting Jin, Shuai Han, Wenjie Fan, Haichen Chu & Yongxin Liang
Pages: 9401-9410
Published online: 02 Dec 2021
AbstractforDihydroartemisinin alleviates morphine-induced neuroinflammation in BV-2 cells | Full Text | References | PDF (1.4 MB) | EPUB
  • 2669 Views
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Research paper

Article
MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis
Weihong Xu, Lu Ye & Huaxiang Wu
Pages: 9411-9423
Published online: 29 Nov 2021
AbstractforMicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis | Full Text | References | PDF (4.6 MB) | EPUB
  • 1339 Views
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Article
lncRNA DANCR promotes the migration an invasion and of trophoblast cells through microRNA-214-5p in preeclampsia
Qian Zhang, Zhenzhen Wang, Xianghong Cheng & Haiying Wu
Pages: 9424-9434
Published online: 29 Nov 2021
AbstractforlncRNA DANCR promotes the migration an invasion and of trophoblast cells through microRNA-214-5p in preeclampsia | Full Text | References | PDF (1.9 MB) | EPUB
  • 2072 Views
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Article
Potentiality of α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma
Weiwei Cao, Yu Chen, Wei Han, Juzheng Yuan, Weimin Xie, Kun Liu, Yan Qiu, Xudan Wang & Xiao Li
Pages: 9435-9451
Published online: 10 Dec 2021
AbstractforPotentiality of α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma | Full Text | References | PDF (3.9 MB) | EPUB
  • 1990 Views
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Article
Analysis of the role of Ly-1 antibody reactive in different cancer types
Linlin Chen, Congwen Jin, Hao Liu, Rongmei Feng, Zhengdong Li & Jiasheng Zhang
Pages: 9452-9462
Published online: 27 Dec 2021
AbstractforAnalysis of the role of Ly-1 antibody reactive in different cancer types | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1851 Views
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Article
Cullin3 (CUL3) suppresses proliferation, migration and phenotypic transformation of PDGF-BB-stimulated vascular smooth muscle cells and mitigates inflammatory response by repressing Hedgehog signaling pathway
Yuluan Xiang, Lihua Li, Shuang Xia, Jinlin Lv & Xiaoling Li
Pages: 9463-9472
Published online: 02 Dec 2021
AbstractforCullin3 (CUL3) suppresses proliferation, migration and phenotypic transformation of PDGF-BB-stimulated vascular smooth muscle cells and mitigates inflammatory response by repressing Hedgehog signaling pathway | Full Text | References | PDF (2.3 MB) | EPUB
  • 1665 Views
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Article
Analysis and verification of N6-methyladenosine-modified genes as novel biomarkers for clear cell renal cell carcinoma
Zhenyu Yang, Bo Peng, Yongbo Pan & Yinmin Gu
Pages: 9473-9483
Published online: 02 Dec 2021
AbstractforAnalysis and verification of N6-methyladenosine-modified genes as novel biomarkers for clear cell renal cell carcinoma | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2446 Views
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Article
Linc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor
Li-Hao Deng, Hui Zhao, Li-Ping Bai, Jun Xie, Kai Liu & Feng Yan
Pages: 9484-9495
Published online: 07 Dec 2021
AbstractforLinc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor | Full Text | References | PDF (2.1 MB) | EPUB
  • 1273 Views
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Article
Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression
Ping Liu, Jin Huang, Wanzhen Mei, Xingfang Zeng, Cheng Wang, Chuan Wen & Jing Xu
Pages: 9496-9506
Published online: 02 Dec 2021
AbstractforEpigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression | Full Text | References | PDF (2.1 MB) | EPUB
  • 1988 Views
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Article
MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2
Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang & Jisheng Liu
Pages: 9507-9519
Published online: 09 Dec 2021
AbstractforMicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2 | Full Text | References | PDF (2.9 MB) | EPUB
  • 1474 Views
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Article
Exosomes loaded with programmed death ligand-1 promote tumor growth by immunosuppression in osteosarcoma
Lei Zhang, Lili Xue, Yanjuan Wu, Qilong Wu, Hongwei Ren & Xiang Song
Pages: 9520-9530
Published online: 04 Dec 2021
AbstractforExosomes loaded with programmed death ligand-1 promote tumor growth by immunosuppression in osteosarcoma | Full Text | References | PDF (2 MB) | EPUB
  • 1770 Views
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Review

Review
Diatom microalgae as smart nanocontainers for biosensing wastewater pollutants: recent trends and innovations
Mohd Jahir Khan, Anshuman Rai, Ankesh Ahirwar, Vandana Sirotiya, Megha Mourya, Sudhanshu Mishra, Benoit Schoefs, Justine Marchand, Shashi Kant Bhatia, Sunita Varjani & Vandana Vinayak
Pages: 9531-9549
Published online: 07 Dec 2021
AbstractforDiatom microalgae as smart nanocontainers for biosensing wastewater pollutants: recent trends and innovations | Full Text | References | PDF (1.5 MB) | EPUB
  • 4792 Views
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Review
Sophorolipid: a glycolipid biosurfactant as a potential therapeutic agent against COVID-19
Amita Daverey, Kasturi Dutta, Sanket Joshi & Achlesh Daverey
Pages: 9550-9560
Published online: 14 Dec 2021
AbstractforSophorolipid: a glycolipid biosurfactant as a potential therapeutic agent against COVID-19 | Full Text | References | PDF (1.1 MB) | EPUB
  • 3292 Views
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Research Paper

Article
Protein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia
Yang Yang, Xiaoxia Qiu & Fang Wang
Pages: 9561-9574
Published online: 11 Dec 2021
AbstractforProtein tyrosine phosphatase receptor type O (PTPRO) knockdown enhances the proliferative, invasive and angiogenic activities of trophoblast cells by suppressing ER resident protein 44 (ERp44) expression in preeclampsia | Full Text | References | PDF (4.7 MB) | EPUB
  • 1237 Views
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Research paper

Article
Remifentanil attenuates sepsis-induced intestinal injury by inducing autophagy
Mingli Wang, Shiqi Guo, Yu Zhang, Yao Zhang & Hong Zhang
Pages: 9575-9584
Published online: 11 Dec 2021
AbstractforRemifentanil attenuates sepsis-induced intestinal injury by inducing autophagy | Full Text | References | PDF (2.6 MB) | EPUB
  • 2234 Views
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Research Paper

Article
Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis
Chen Zou, Xia Li, Xiaozhi Lv, Siyuan Wu, Jing Song, Zhe Tang, Hailing Luo, Haigang Wei & Yilong Ai
Pages: 9585-9597
Published online: 07 Dec 2021
AbstractforCircular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis | Full Text | References | PDF (4.1 MB) | EPUB
  • 1885 Views
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Article
Identification of hub genes associated with cognition in the hippocampus of Alzheimer’s Disease
Yu-Jia Liu, Tian-Tian Liu, Lin-Hao Jiang, Qian Liu, Zheng-Liang Ma, Tian-Jiao Xia & Xiao-Ping Gu
Pages: 9598-9609
Published online: 21 Dec 2021
AbstractforIdentification of hub genes associated with cognition in the hippocampus of Alzheimer’s Disease | Full Text | References | PDF (2.2 MB) | EPUB
  • 3177 Views
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Article
Analysis of immune-related key genes in Alzheimer’s disease
You Wu, Shunli Liang, Hong Zhu & Yaping Zhu
Pages: 9610-9624
Published online: 12 Dec 2021
AbstractforAnalysis of immune-related key genes in Alzheimer’s disease | Full Text | References | PDF (4.2 MB) | EPUB
  • 2641 Views
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Article
Semaphorin 3A mitigates lipopolysaccharide-induced chondrocyte inflammation, apoptosis and extracellular matrix degradation by binding to Neuropilin-1
Huiyu Zhang, Yue Lu, BingBing Wu & Fei Xia
Pages: 9641-9654
Published online: 25 Nov 2021
AbstractforSemaphorin 3A mitigates lipopolysaccharide-induced chondrocyte inflammation, apoptosis and extracellular matrix degradation by binding to Neuropilin-1 | Full Text | References | PDF (4.3 MB) | EPUB
  • 1909 Views
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Article
RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-α-dependent lipogenesis pathway
Yao Li, Yanhu Shi, Yaoli He, Xiaoming Li & Junlu Yang
Pages: 9655-9667
Published online: 02 Dec 2021
AbstractforRNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-α-dependent lipogenesis pathway | Full Text | References | PDF (2.4 MB) | EPUB
  • 1884 Views
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Article
Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
Jiayi Liu, Cuiqin Sang, Zhenyu Zhang, Ying Jiang, Shuzhen Wang, Yao Li & Xiao Shi
Pages: 9668-9677
Published online: 30 Nov 2021
AbstractforCorrelation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery | Full Text | References | PDF (321.6 KB) | EPUB
  • 1343 Views
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Article
Long non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis
Guoping Wang, Zhongchen Zhang & Chenmei Xia
Pages: 9678-9691
Published online: 29 Nov 2021
AbstractforLong non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis | Full Text | References | PDF (3 MB) | EPUB
  • 1369 Views
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Article
Identification and validation of an autophagy-related signature for predicting survival in lower-grade glioma
Shaobin Feng, Huiling Liu, Xushuai Dong, Peng Du, Hua Guo & Qi Pang
Pages: 9692-9708
Published online: 02 Dec 2021
AbstractforIdentification and validation of an autophagy-related signature for predicting survival in lower-grade glioma | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 2935 Views
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Article
Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4
Hongtao Dong, Menghua Wang & Qiuming Li
Pages: 9693-9706
Published online: 25 Dec 2021
AbstractforExosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4 | Full Text | References | PDF (5.6 MB) | EPUB
  • 1537 Views
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research paper

Article
Overexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p/Sirtuin-1 pathway
Haibo Xie, Hanfei Chai, Xiaohong Du, Rongna Cui & Yinan Dong
Pages: 9723-9738
Published online: 01 Dec 2021
AbstractforOverexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p/Sirtuin-1 pathway | Full Text | References | PDF (4.4 MB) | EPUB
  • 1997 Views
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Research paper

Article
A novel circular RNA circ_HN1/miR-628-5p/Ecto-5’-nucleotidase competing endogenous RNA network regulates gastric cancer development
Jianmin Zhang, Fang Wang, Haihui Zhang & Mingbo Cao
Pages: 9739-9752
Published online: 29 Nov 2021
AbstractforA novel circular RNA circ_HN1/miR-628-5p/Ecto-5’-nucleotidase competing endogenous RNA network regulates gastric cancer development | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1579 Views
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Article
Long non-coding RNA TRPM2-AS regulates microRNA miR-138-5p and PLAU (Plasminogen Activator, Urokinase) to promote the progression of gastric adenocarcinoma
Jun Sun, Fang Zhou, Juan Xue, Chunyan Ji, Yinzong Qu & Yuwei Pan
Pages: 9753-9765
Published online: 07 Dec 2021
AbstractforLong non-coding RNA TRPM2-AS regulates microRNA miR-138-5p and PLAU (Plasminogen Activator, Urokinase) to promote the progression of gastric adenocarcinoma | Full Text | References | PDF (13.1 MB) | EPUB | Supplemental
  • 1602 Views
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Article
MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1)
Zhiqun Li, Xiaoliu Zhou, Jiajun Huang, Zhencai Xu, Chengliang Xing, Junwei Yang & Xuejun Zhou
Pages: 9766-9778
Published online: 02 Dec 2021
AbstractforMicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1) | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Clinical correlations and prognostic value of Nudix hydroxylase 10 in patients with gastric cancer
Diqun Chen, Rouxin Zhang, Aosi Xie, Jinpeng Yuan, Jinhai Zhang, Yongjian Huang, Hongxia Zhang & Feiran Zhang
Pages: 9779-9789
Published online: 02 Dec 2021
AbstractforClinical correlations and prognostic value of Nudix hydroxylase 10 in patients with gastric cancer | Full Text | References | PDF (2.6 MB) | EPUB
  • 1344 Views
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Article
The mechanism of sevoflurane post-treatment alleviating hypoxic-ischemic encephalopathy by affecting histone methyltransferase G9a in rats
Weifeng Shan, Yini Wu, Xin Han, Qin Chen & Jimin Wu
Pages: 9790-9805
Published online: 07 Dec 2021
AbstractforThe mechanism of sevoflurane post-treatment alleviating hypoxic-ischemic encephalopathy by affecting histone methyltransferase G9a in rats | Full Text | References | PDF (2.2 MB) | EPUB
  • 1379 Views
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Article
Carbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells
Ting Huang, Lijuan Tang, Huan Wang, Lu Lin & Jing Fu
Pages: 9806-9818
Published online: 02 Dec 2021
AbstractforCarbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Long noncoding RNA SNHG8 accelerates acute gouty arthritis development by upregulating AP3D1 in mice
Li Fang, Xiangfeng Xu, Yao Lu, Yanying Wu & Jiajia Li
Pages: 9803-9815
Published online: 07 Dec 2021
AbstractforLong noncoding RNA SNHG8 accelerates acute gouty arthritis development by upregulating AP3D1 in mice | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Combination therapy with low-frequency ultrasound irradiation and radiofrequency ablation as a synergistic treatment for pancreatic cancer
Huiyang Wang, Wenxiu Ding, Hongwei Shi, Haiwei Bao, Yuting Lu & Tian an Jiang
Pages: 9832-9846
Published online: 07 Dec 2021
AbstractforCombination therapy with low-frequency ultrasound irradiation and radiofrequency ablation as a synergistic treatment for pancreatic cancer | Full Text | References | PDF (2.9 MB) | EPUB
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Review
A critical insight into the development, regulation and future prospects of biofuels in Canada
Rahul Saini, Carlos Saul Osorio-Gonzalez, Satinder Kaur Brar & Raymond Kwong
Pages: 9847-9859
Published online: 02 Dec 2021
AbstractforA critical insight into the development, regulation and future prospects of biofuels in Canada | Full Text | References | PDF (890.7 KB) | EPUB
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Article
Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
Shanshan Xiao, Hang Yu, Yunfei Xie, Yahui Guo, Jiajia Fan & Weirong Yao
Pages: 9860-9871
Published online: 09 Dec 2021
AbstractforEvaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression
Shifang Deng, Lei Yang, Ke Ma & Wei Bian
Pages: 9872-9884
Published online: 07 Dec 2021
AbstractforAstragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression | Full Text | References | PDF (3 MB) | EPUB
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Article
Essential meiotic structure-specific endonuclease1 (EME1) promotes malignant features in gastric cancer cells via the Akt/GSK3B/CCND1 pathway
Zhiguo Guo, Erbo Liang, Wei Li, Leilei Jiang & Fachao Zhi
Pages: 9869-9884
Published online: 11 Dec 2021
AbstractforEssential meiotic structure-specific endonuclease1 (EME1) promotes malignant features in gastric cancer cells via the Akt/GSK3B/CCND1 pathway | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
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Article
miRNA-144 targeting DNAJC3-AS1 reverses the resistance of the breast cancer cell line Michigan Cancer Foundation-7 to doxorubicin
Ruiping Ren, Zuguo Yuan & Zhengyang Xu
Pages: 9885-9892
Published online: 11 Dec 2021
AbstractformiRNA-144 targeting DNAJC3-AS1 reverses the resistance of the breast cancer cell line Michigan Cancer Foundation-7 to doxorubicin | Full Text | References | PDF (1.7 MB) | EPUB
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Article
MicroRNA miR-145-5p regulates cell proliferation and cell migration in colon cancer by inhibiting chemokine (C-X-C motif) ligand 1 and integrin α2
Wei Zhuang, Tao Niu & Zhen Li
Pages: 9909-9917
Published online: 03 Dec 2021
AbstractforMicroRNA miR-145-5p regulates cell proliferation and cell migration in colon cancer by inhibiting chemokine (C-X-C motif) ligand 1 and integrin α2 | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3)
Liping Li, Chao Qi, Yuanyuan Liu, Youliang Shen, Xia Zhao, Han Qin, Yi Zhang & Tengbo Yu
Pages: 9902-9913
Published online: 13 Dec 2021
AbstractforMicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3) | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Expression and significance of mammalian target of rapamycin in cutaneous squamous cell carcinoma and precancerous lesions
Gongjun Xu, Jinxian Fang, Jinlun Xu, Zhen Shen, Chiqing Huang & Yixiu Jiang
Pages: 9930-9938
Published online: 07 Dec 2021
AbstractforExpression and significance of mammalian target of rapamycin in cutaneous squamous cell carcinoma and precancerous lesions | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Exploring anti-liver cancer targets and mechanisms of oxyresveratrol: in silico and verified findings
Feilan Zhao, Jingru Qin, Yujia Liang & Rui Zhou
Pages: 9939-9948
Published online: 02 Dec 2021
AbstractforExploring anti-liver cancer targets and mechanisms of oxyresveratrol: in silico and verified findings | Full Text | References | PDF (4 MB) | EPUB
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Article
MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3
Lei Zhang, Jianjun Qiu, Jixiang Shi, Shaoyang Liu & Hanlin Zou
Pages: 9933-9948
Published online: 29 Nov 2021
AbstractforMicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3 | Full Text | References | PDF (4 MB) | EPUB
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Article
Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA
Quanbin Zhang, Lina Wang, Lili Cao & Tao Wei
Pages: 9965-9975
Published online: 27 Nov 2021
AbstractforNovel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
Role of ferroptosis-related genes in Stanford type a aortic dissection and identification of key genes: new insights from bioinformatic analysis
Hua-Xi Zou, Bai-Quan Qiu, Song-Qing Lai, Huang Huang, Xue-Liang Zhou, Cheng-Wu Gong, Li-Jun Wang, Ming-Ming Yuan, an-Di He & Ji-Chun Liu
Pages: 9976-9990
Published online: 30 Nov 2021
AbstractforRole of ferroptosis-related genes in Stanford type a aortic dissection and identification of key genes: new insights from bioinformatic analysis | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma
Haiping Zhang, Ziliang Yu, Bingbing Wu & Farui Sun
Pages: 9991-9999
Published online: 27 Nov 2021
AbstractforCircular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma | Full Text | References | PDF (1.4 MB) | EPUB
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Article
The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
Mayila Tuerxun, Ajar Muhda & Lixin Yin
Pages: 10000-10008
Published online: 27 Nov 2021
AbstractforThe molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats | Full Text | References | PDF (1,016 KB) | EPUB
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Article
Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang & Huilan Zhu
Pages: 9993-10006
Published online: 11 Dec 2021
AbstractforCurcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2 | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer
Xuyang Liang, Zhimei Zhang, Lu Wang, Shuxian Zhang, Ling Ren, Shouying Li, Jing Xu & Shengxiang Lv
Pages: 10023-10036
Published online: 27 Nov 2021
AbstractforMechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer | Full Text | References | PDF (3.7 MB) | EPUB
  • 2097 Views
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Article
Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells
Changcheng Wang, Jia Guo & Zeng’An Wu
Pages: 10037-10048
Published online: 02 Dec 2021
AbstractforCombinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Identification and in vitro validation of prognostic lncRNA signature in head and neck squamous cell carcinoma
Jian Wang, Qinjiang Bian, Jialin Liu & Adili Moming
Pages: 10049-10062
Published online: 07 Dec 2021
AbstractforIdentification and in vitro validation of prognostic lncRNA signature in head and neck squamous cell carcinoma | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 1561 Views
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Article
E2F transcription factor 1 is involved in the phenotypic modulation of esophageal squamous cell carcinoma cells via microRNA-375
Pengfei Li, Huina Lv, Yongkai Wu, Ke Xu, Min Xu & Yegang Ma
Pages: 10047-10062
Published online: 07 Dec 2021
AbstractforE2F transcription factor 1 is involved in the phenotypic modulation of esophageal squamous cell carcinoma cells via microRNA-375 | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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Article
The landscape of DNA methylation in asthma: a data mining and validation
Hui Yang, Fei-yang Na, Li Guo, Xuan Liang & Rong-Fang Zhang
Pages: 10063-10072
Published online: 07 Dec 2021
AbstractforThe landscape of DNA methylation in asthma: a data mining and validation | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 1734 Views
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Article
Screening and cellular validation of prognostic genes regulated by super enhancers in oral squamous cell carcinoma
Liru Zhang, Huanju Li, Yongle Qiu, Yuanhang Liu, Xin Liu & Wenjing Wang
Pages: 10073-10088
Published online: 30 Dec 2021
AbstractforScreening and cellular validation of prognostic genes regulated by super enhancers in oral squamous cell carcinoma | Full Text | References | PDF (5 MB) | EPUB
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Article
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway
Lixin Chen, Ji Qian, Qinghua You & Jie Ma
Pages: 10089-10100
Published online: 10 Dec 2021
AbstractforLIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 1733 Views
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Article
Effect of microrna-138 on epithelial-Mesenchymal transition and invasion of breast cancer cells by targeting semaphorin 4C
HuiJuan Liu, Hui Ye & Xinzheng Li
Pages: 10117-10125
Published online: 07 Dec 2021
AbstractforEffect of microrna-138 on epithelial-Mesenchymal transition and invasion of breast cancer cells by targeting semaphorin 4C | Full Text | References | PDF (1.1 MB) | EPUB
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Article
MicroRNA-582-5p promotes triple-negative breast cancer invasion and metastasis by antagonizing CMTM8
Xue Zeng, Xinchi Ma, Hong Guo, Linlin Wei, Yaotian Zhang, Chaonan Sun, Ning Han, Shichen Sun & Na Zhang
Pages: 10126-10135
Published online: 02 Dec 2021
AbstractforMicroRNA-582-5p promotes triple-negative breast cancer invasion and metastasis by antagonizing CMTM8 | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Exosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial–mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis
Qiuyu Lin, Qianle Qi, Sen Hou, Zhen Chen, Nan Jiang, Laney Zhang & Chenghe Lin
Pages: 10136-10149
Published online: 06 Dec 2021
AbstractforExosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial–mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
Consensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers
Bingyuan Lin & Zhijun Pan
Pages: 10134-10146
Published online: 07 Dec 2021
AbstractforConsensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Polygonatum sibiricum polysaccharides (PSP) improve the palmitic acid (PA)-induced inhibition of survival, inflammation, and glucose uptake in skeletal muscle cells
Jia-Luo Cai, Xiao-Ping Li, Yi-Lin Zhu, Gang-Qiang Yi, Wei Wang, Xin-Yu Chen, Gui-Ming Deng, Lei Yang, Hu-Zhi Cai, Qiao-Zhen Tong, Li Zhou, Mengying Tian, Xin-Hua Xia & Ping-an Liu
Pages: 10147-10159
Published online: 07 Dec 2021
AbstractforPolygonatum sibiricum polysaccharides (PSP) improve the palmitic acid (PA)-induced inhibition of survival, inflammation, and glucose uptake in skeletal muscle cells | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2835 Views
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Article
MicroRNA-506 has a suppressive effect on the tumorigenesis of nonsmall-cell lung cancer by regulating tubby-like protein 3
Zhan-Hua Li, Ji-Hong Zhou, Si-Ning Chen, Ling Pan, Yuan Feng, Mei-Qun Luo, Rui-Xiang Li & Gui-Li Sun
Pages: 10176-10186
Published online: 07 Dec 2021
AbstractforMicroRNA-506 has a suppressive effect on the tumorigenesis of nonsmall-cell lung cancer by regulating tubby-like protein 3 | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Baicalin suppresses glaucoma pathogenesis by regulating the PI3K/AKT signaling in vitro and in vivo
Ningmin Zhao, Jieran Shi, Haohang Xu, Qing Luo, Qiaoyan Li & Mingzhou Liu
Pages: 10187-10198
Published online: 03 Dec 2021
AbstractforBaicalin suppresses glaucoma pathogenesis by regulating the PI3K/AKT signaling in vitro and in vivo | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Integral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer
Yan Li, Jianhua Wang, Chengzhen Gao, Qiyan Hu & Xiaogang Mao
Pages: 10183-10193
Published online: 07 Dec 2021
AbstractforIntegral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Centromere protein U (CENPU) promotes gastric cancer cell proliferation and glycolysis by regulating high mobility group box 2 (HMGB2)
Taozhi Deng, Xuemei Jiang, Zhoutao He, Manni Cai, Chaochao Chen & Zewen Xu
Pages: 10194-10202
Published online: 07 Dec 2021
AbstractforCentromere protein U (CENPU) promotes gastric cancer cell proliferation and glycolysis by regulating high mobility group box 2 (HMGB2) | Full Text | References | PDF (2 MB) | EPUB
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Article
Knock out hepatic Krüppel-like factor 16 (KLF16) improve myocardial damage and promoted myocardial protection of myocardial ischemia-reperfusion via anti-oxidative and anti-inflammation effects by TFAM/PPARβ signal passage
Yue Xin, Pixiong Su, Yan Liu, Song Gu, Xiangguang an, Xitao Zhang, Jun Yan, Yulin Guo, Jian Zhou & Guilin Yang
Pages: 10219-10231
Published online: 25 Nov 2021
AbstractforKnock out hepatic Krüppel-like factor 16 (KLF16) improve myocardial damage and promoted myocardial protection of myocardial ischemia-reperfusion via anti-oxidative and anti-inflammation effects by TFAM/PPARβ signal passage | Full Text | References | PDF (3.5 MB) | EPUB
  • 1775 Views
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Article
Ubiquitin-associated protein 2 like (UBAP2L) enhances growth and metastasis of gastric cancer cells
Sihan Lin, Zhiyong Yan, Qiaofei Tang & Shuang Zhang
Pages: 10232-10245
Published online: 25 Nov 2021
AbstractforUbiquitin-associated protein 2 like (UBAP2L) enhances growth and metastasis of gastric cancer cells | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway
Jinfeng Liu & Liang Ning
Pages: 10246-10253
Published online: 27 Nov 2021
AbstractforProtective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Analysis of antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism
Weiping Dai, Yuliang Zhang, Jianfeng Zhang, Chengyu Xue, Jun Yan, Xin Li, Xiaohua Zheng, Rui Dong, Jing Bai, Yi Su, Pinghui Xie, Weiming Zhong, Hongyang Zhang, Zibo Yan, Weiqi Zhong & Yu Song
Pages: 10254-10263
Published online: 02 Dec 2021
AbstractforAnalysis of antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism | Full Text | References | PDF (629.6 KB) | EPUB
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Article
VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway
Wen Jiang, Jun Zhang, Xudong Zhang, Chenghong Fan & Jinlong Huang
Pages: 10264-10284
Published online: 29 Nov 2021
AbstractforVAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
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Review

Review
Bioengineered biochar as smart candidate for resource recovery toward circular bio-economy: a review
Hong Liu, Vinay Kumar, Vivek Yadav, Shasha Guo, Surendra Sarsaiya, Parameswaran Binod, Raveendran Sindhu, Ping Xu, Zengqiang Zhang, Ashok Pandey & Mukesh Kumar Awasthi
Pages: 10269-10301
Published online: 11 Dec 2021
AbstractforBioengineered biochar as smart candidate for resource recovery toward circular bio-economy: a review | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Expression, prognosis value, and immune infiltration of lncRNA ASB16-AS1 identified by pan-cancer analysis
Linyong Wu, Wei Liao, Xiaodong Wang, Yujia Zhao, Jinshu Pang, Yuji Chen, Hong Yang & Yun He
Pages: 10302-10318
Published online: 23 Dec 2021
AbstractforExpression, prognosis value, and immune infiltration of lncRNA ASB16-AS1 identified by pan-cancer analysis | Full Text | References | PDF (4.8 MB) | EPUB
  • 1880 Views
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Article
Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia
Haifeng Wang, Lina Bu, Fang Shu, Yun Bai, Feixiao Xue, Shanshan Shi & Daqing Sun
Pages: 10335-10344
Published online: 06 Dec 2021
AbstractforMolecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia | Full Text | References | PDF (943.1 KB) | EPUB
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Article
Network pharmacology and experimental validation to explore the molecular mechanisms of Bushen Huoxue for the treatment of premature ovarian insufficiency
Ying Cao, Yue Chen, Peijuan Wang, Jialin Lu, Xuan Han & Jingyao She
Pages: 10345-10362
Published online: 02 Dec 2021
AbstractforNetwork pharmacology and experimental validation to explore the molecular mechanisms of Bushen Huoxue for the treatment of premature ovarian insufficiency | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Article
LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
Ximin Fang, Xiazhen Pan, Huirong Mai, Xiuli Yuan, Sixi Liu & Feiqiu Wen
Pages: 10363-10372
Published online: 02 Dec 2021
AbstractforLINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Aberrant long non-coding RNA cancer susceptibility 15 (CASC15) plays a diagnostic biomarker and regulates inflammatory reaction in neonatal sepsis
Jia Song, Ruihua Yu, Jianhong Qi, Xiaokang Wang & Qingqing Shen
Pages: 10373-10381
Published online: 06 Dec 2021
AbstractforAberrant long non-coding RNA cancer susceptibility 15 (CASC15) plays a diagnostic biomarker and regulates inflammatory reaction in neonatal sepsis | Full Text | References | PDF (833.3 KB) | EPUB
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Review

Review
Prognostic value of programmed death ligand 1 (PD-L1) in glioblastoma: a systematic review, meta-analysis and validation based on dataset
Huan Wang, Youchao Xiao, Xingguang Ren & Dahai Wan
Pages: 10366-10378
Published online: 13 Dec 2021
AbstractforPrognostic value of programmed death ligand 1 (PD-L1) in glioblastoma: a systematic review, meta-analysis and validation based on dataset | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1400 Views
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Article
Fully human recombinant antibodies against EphA2 from a multi-tumor patient immune library suitable for tumor-targeted therapy
Yaqi Yang, Siji Nian, Lin Li, Xue Wen, Qin Liu, Bo Zhang, Yu Lan, Qing Yuan & Yingchun Ye
Pages: 10379-10400
Published online: 19 Dec 2021
AbstractforFully human recombinant antibodies against EphA2 from a multi-tumor patient immune library suitable for tumor-targeted therapy | Full Text | References | PDF (5.5 MB) | EPUB
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Review
PIWI interacting RNAs perspectives: a new avenues in future cancer investigations
Pooneh Mokarram, Maryam Niknam, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Morvarid Siri, Sanaz Dastghaib, Hassan Brim & Hassan Ashktorab
Pages: 10401-10419
Published online: 09 Dec 2021
AbstractforPIWI interacting RNAs perspectives: a new avenues in future cancer investigations | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Hsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis
Feifei Li, Yahui Chen, Zhiling He, Chuangchang Wang, Xiaoli Wang, Guangming Pan, Jiang yang Peng, Qiuxiong Chen & Xia Wang
Pages: 10420-10429
Published online: 07 Dec 2021
AbstractforHsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Review

Review
MicroRNA-mediated bioengineering for climate-resilience in crops
Suraj Patil, Shrushti Joshi, Monica Jamla, Xianrong Zhou, Mohammad J Taherzadeh, Penna Suprasanna & Vinay Kumar
Pages: 10430-10456
Published online: 09 Dec 2021
AbstractforMicroRNA-mediated bioengineering for climate-resilience in crops | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Diversity and structural characteristics of soil microbial communities in different habitats of wild Lilium regale Wilson in Wenchuan area
Jie Xie, Ze Wu, Xiaoyu Zhang, Tong Peng, Chunmei Yang, Jianjun Zhang & Jian Liang
Pages: 10457-10469
Published online: 09 Dec 2021
AbstractforDiversity and structural characteristics of soil microbial communities in different habitats of wild Lilium regale Wilson in Wenchuan area | Full Text | References | PDF (3 MB) | EPUB
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Article
High-frequency electroacupuncture improves endometrial receptivity via regulating cell adhesion molecules and leukemia inhibitory factor / signal transducer and activator of transcription signaling pathway
Fang You, Xin Du, Taiwei Zhang, Yang Wang, Yuxia Lv & Li Zeng
Pages: 10470-10479
Published online: 16 Dec 2021
AbstractforHigh-frequency electroacupuncture improves endometrial receptivity via regulating cell adhesion molecules and leukemia inhibitory factor / signal transducer and activator of transcription signaling pathway | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Characteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia
Lingling Hong, Yuqing Chen & Ling Ye
Pages: 10480-10490
Published online: 11 Dec 2021
AbstractforCharacteristics of the lung microbiota in lower respiratory tract infections with and without history of pneumonia | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function
Chunlei Li, Wei Jin, Dewei Zhang & Shoujin Tian
Pages: 10491-10500
Published online: 11 Dec 2021
AbstractforClinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function | Full Text | References | PDF (778.6 KB) | EPUB
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Article
HIG1 domain family member 1A disrupts proliferation, migration, and invasion of colon adenocarcinoma cells
Zhenyu Xu, Junjie Sun, Yong Mao, Yang Chen, Ting Zhang, Yan Qin & Dong Hua
Pages: 10501-10511
Published online: 29 Dec 2021
AbstractforHIG1 domain family member 1A disrupts proliferation, migration, and invasion of colon adenocarcinoma cells | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis
Junhua Wang & Ying Wang
Pages: 10512-10524
Published online: 11 Dec 2021
AbstractforCircular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
Jin Zhang, Rui Zhang & Yongju Ye
Pages: 10541-10552
Published online: 01 Dec 2021
AbstractforLong non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant | Full Text | References | PDF (4 MB) | EPUB
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Article
Development of epithelial-mesenchymal transition-related lncRNA signature for predicting survival and immune microenvironment in pancreatic cancerwithexperiment validation
Yong Gao, Jinhui Liu, Baobao Cai, Qun Chen, Guangfu Wang, Zipeng Lu, Kuirong Jiang & Yi Miao
Pages: 10553-10567
Published online: 02 Dec 2021
AbstractforDevelopment of epithelial-mesenchymal transition-related lncRNA signature for predicting survival and immune microenvironment in pancreatic cancerwithexperiment validation | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Article
Rotigotine protects against oxidized low-density lipoprotein(ox-LDL)-induced damages in human umbilical vein endothelial cells(HUVECs)
Hui Kang, Hui Yu, Jingxiu Fan & Ge Cao
Pages: 10568-10579
Published online: 03 Dec 2021
AbstractforRotigotine protects against oxidized low-density lipoprotein(ox-LDL)-induced damages in human umbilical vein endothelial cells(HUVECs) | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
A comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms
Jie Zhou, Hao Wu, Cheng Guo, Bing Li, Li-Li Zhou, Ai-Bin Liang & Jian-Fei Fu
Pages: 10564-10586
Published online: 14 Dec 2021
AbstractforA comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
Impacts of changes in intestinal flora on the metabolism of Sprague–Dawley rats
Chengfei Wang, Dong Yan, Jianrong Huang & Yongtao Li
Pages: 10603-10611
Published online: 02 Dec 2021
AbstractforImpacts of changes in intestinal flora on the metabolism of Sprague–Dawley rats | Full Text | References | PDF (917.5 KB) | EPUB
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Article
MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway
RongXin Xiao, Hong Wang & Biao Yang
Pages: 10596-10607
Published online: 11 Dec 2021
AbstractforMicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation
Huaqin Sun, Hongyi Hu, Xiaoping Xu, Mingsun Fang, Tao Tao & Zhehao Liang
Pages: 10608-10623
Published online: 07 Dec 2021
AbstractforProtective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner
Jianjun Wang, Kunxian Yang, Junyu Cao & Li Li
Pages: 10624-10637
Published online: 11 Dec 2021
AbstractforKnockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells
Yana Liu, Shihong Zhang, Zhiwei Xue, Xiaoxia Zhou, Lin Tong, Jiachen Liao, Huan Pan & Shu Zhou
Pages: 10654-10665
Published online: 07 Dec 2021
AbstractforBone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
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Review

Review
Interleukin-8 concentrations in obstructive sleep apnea syndrome: a systematic review and meta-analysis
Xiaoyan Li, Rong Hu, Xinyi Ren & Jie He
Pages: 10650-10665
Published online: 02 Dec 2021
AbstractforInterleukin-8 concentrations in obstructive sleep apnea syndrome: a systematic review and meta-analysis | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Clinical value of lncRNA TUG1 in temporal lobe epilepsy and its role in the proliferation of hippocampus neuron via sponging miR-199a-3p
Chunlian Li, Xiaojing Zheng, Pingping Liu & Meilian Li
Pages: 10666-10673
Published online: 07 Dec 2021
AbstractforClinical value of lncRNA TUG1 in temporal lobe epilepsy and its role in the proliferation of hippocampus neuron via sponging miR-199a-3p | Full Text | References | PDF (857.1 KB) | EPUB
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Article
N6-Methyladenosine-regulated LINC00675 suppress the proliferation, migration and invasion of breast cancer cells via inhibiting miR-513b-5p
Shenglan Fan & Liping Wang
Pages: 10690-10702
Published online: 01 Dec 2021
AbstractforN6-Methyladenosine-regulated LINC00675 suppress the proliferation, migration and invasion of breast cancer cells via inhibiting miR-513b-5p | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
MicroRNA-520d-3p suppresses melanoma cells proliferation by inhibiting the anti-silencing function 1B histone chaperone
Xian Shi, Xidan Xu, Nian Shi, Yongjun Chen & Manni Fu
Pages: 10703-10715
Published online: 07 Dec 2021
AbstractforMicroRNA-520d-3p suppresses melanoma cells proliferation by inhibiting the anti-silencing function 1B histone chaperone | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Long non-coding RNA LUADT1 promotes nasopharyngeal carcinoma cell proliferation and invasion by downregulating miR-1207-5p
Ning Jiang, Lijun Zhao, Dan Zong, Li Yin, Lirong Wu, Cheng Chen, Xue Song, Qian Zhang, Xuesong Jiang, Xia He & Jifeng Feng
Pages: 10716-10728
Published online: 01 Dec 2021
AbstractforLong non-coding RNA LUADT1 promotes nasopharyngeal carcinoma cell proliferation and invasion by downregulating miR-1207-5p | Full Text | References | PDF (2.1 MB) | EPUB
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Article
MicroRNA miR-30a inhibits cisplatin resistance in ovarian cancer cells through autophagy
Yi Cai, Baiping An, Dejiao Yao, Hong Zhou & Jie Zhu
Pages: 10713-10722
Published online: 10 Dec 2021
AbstractforMicroRNA miR-30a inhibits cisplatin resistance in ovarian cancer cells through autophagy | Full Text | References | PDF (2.1 MB) | EPUB
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Article
RASA4 inhibits the HIFα signaling pathway to suppress proliferation of cervical cancer cells
Junying Chen, Jinbing Huang, Qiaoqiao Huang, Ji Li, Erling Chen & Wensheng Xu
Pages: 10723-10733
Published online: 06 Dec 2021
AbstractforRASA4 inhibits the HIFα signaling pathway to suppress proliferation of cervical cancer cells | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Long non-coding RNA HOTAIRincreased mechanical stimulation-induced apoptosis by regulating microRNA-221/BBC3 axis in C28/I2 cells
Tiansheng Zheng, Jishang Huang, Jinliang Lai, Qingluo Zhou, Tong Liu, Qiang Xu, Guanglin Ji & Yongjun Ye
Pages: 10734-10744
Published online: 07 Dec 2021
AbstractforLong non-coding RNA HOTAIRincreased mechanical stimulation-induced apoptosis by regulating microRNA-221/BBC3 axis in C28/I2 cells | Full Text | References | PDF (2 MB) | EPUB
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Article
Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway
Yange Wu, Wenxiu Chen, Yufeng Gong, Hongxia Liu & Bo Zhang
Pages: 10761-10770
Published online: 02 Dec 2021
AbstractforTetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway | Full Text | References | PDF (2.7 MB) | EPUB
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Article
The miRNA mir-582-3p suppresses ovarian cancer progression by targeting AKT/MTOR signaling via lncRNA TUG1
Tianyu Dai, Junhui Liang, Wei Liu, Yonghui Zou, Feifei Niu, Mengqing Li, Haomeng Zhang, Changzhong Li, Mingjun Fan & Guoying Cui
Pages: 10771-10781
Published online: 02 Dec 2021
AbstractforThe miRNA mir-582-3p suppresses ovarian cancer progression by targeting AKT/MTOR signaling via lncRNA TUG1 | Full Text | References | PDF (2 MB) | EPUB
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Article
The palliative effects of folic acid on retinal microvessels in diabetic retinopathy via regulating the metabolism of DNA methylation and hydroxymethylation
Xianli Liu & Hongbao Cui
Pages: 10766-10774
Published online: 07 Dec 2021
AbstractforThe palliative effects of folic acid on retinal microvessels in diabetic retinopathy via regulating the metabolism of DNA methylation and hydroxymethylation | Full Text | References | PDF (1.5 MB) | EPUB
  • 2018 Views
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Article
Apcin inhibits the growth and invasion of glioblastoma cells and improves glioma sensitivity to temozolomide
Yiming Ding, Chuanbao Zhang, Lei He, Xinyu Song, Chengjun Zheng, Yuchu Pan & Shuqing Yu
Pages: 10791-10798
Published online: 30 Nov 2021
AbstractforApcin inhibits the growth and invasion of glioblastoma cells and improves glioma sensitivity to temozolomide | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Monocyte-related gene biomarkers for latent and active tuberculosis
Yu Li, Yaju Deng & Jie He
Pages: 10799-10811
Published online: 04 Dec 2021
AbstractforMonocyte-related gene biomarkers for latent and active tuberculosis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84
Dake Tong, Yanyin Zhao, Yang Tang, Jie Ma, Zhiwei Wang & Cheng Li
Pages: 10812-10822
Published online: 07 Dec 2021
AbstractforCirc-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84 | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1))
Li Lu, Li Cao, Yihao Liu, Yunlin Chen, Jinqi Fan & Yuehui Yin
Pages: 10823-10836
Published online: 07 Dec 2021
AbstractforAngiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)) | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
Preparation and characterization of a fully human monoclonal antibody specific for human tumor necrosis factor alpha
Xinmei Liao, Hui Liang, Jian Pan, Qian Zhang, Jiaqi Niu, Cuili Xue, Jian Ni & Daxiang Cui
Pages: 10821-10834
Published online: 09 Dec 2021
AbstractforPreparation and characterization of a fully human monoclonal antibody specific for human tumor necrosis factor alpha | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells
Yishan Ge, Wenwu Liu, Wei Yin, Xuebin Wang, Jie Wang, Xiaoqing Zhu & Shengkai Xu
Pages: 10837-10848
Published online: 30 Nov 2021
AbstractforCircular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
LINC00839/miR-144-3p/WTAP (WT1 Associated protein) axis is involved in regulating hepatocellular carcinoma progression
Xingqin Zhou, Yazhou Chang, Lirong Zhu, Chaoyan Shen, Jing Qian & Renan Chang
Pages: 10849-10861
Published online: 30 Nov 2021
AbstractforLINC00839/miR-144-3p/WTAP (WT1 Associated protein) axis is involved in regulating hepatocellular carcinoma progression | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis
Yongping Zhou, Kuan Li, Xuexia Zou, Zhiyuan Hua, Hao Wang, Wuyang Bian, Hong Wang, Fangming Chen & Tu Dai
Pages: 10862-10877
Published online: 29 Nov 2021
AbstractforLncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Cytochrome P450 2J2 inhibits the proliferation and angiogenesis of retinal vascular endothelial cells by regulating the Notch signaling pathway in a hypoxia-induced retinopathy model
Jing Zhang, Qi Xiong, Lin Yang, Yanni Xue, Min Ke & Zhi Li
Pages: 10878-10890
Published online: 30 Nov 2021
AbstractforCytochrome P450 2J2 inhibits the proliferation and angiogenesis of retinal vascular endothelial cells by regulating the Notch signaling pathway in a hypoxia-induced retinopathy model | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
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Article
Microenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: a study based on TCGA, RT‑qPCR, Western blotting, and immunohistochemistry
Di Han, Zhongjie Yu, Hong Zhang, Haipeng Liu, Bin Wang & Donmeng Qian
Pages: 10891-10904
Published online: 30 Nov 2021
AbstractforMicroenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: a study based on TCGA, RT‑qPCR, Western blotting, and immunohistochemistry | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2252 Views
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Article
Integrative Analysis of Prognostic Value and Immune Infiltration of Spindle and Kinetochore-associated Family Members in Breast Cancer
Jianfeng Ding, Xiaobo He, Jinkun Wang, Guodong Cao, Sihan Chen, Liping Yuan, Bo Chen & Maoming Xiong
Pages: 10903-10921
Published online: 30 Nov 2021
AbstractforIntegrative Analysis of Prognostic Value and Immune Infiltration of Spindle and Kinetochore-associated Family Members in Breast Cancer | Full Text | References | PDF (6.7 MB) | EPUB
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Article
Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis
Shujun Xu, Bingxin Wu, Biying Zhong, Luoqi Lin, Yining Ding, Xiao Jin, Zhiwei Huang, Miaoyang Lin, Huanlin Wu & Danping Xu
Pages: 10924-10934
Published online: 29 Nov 2021
AbstractforNaringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis | Full Text | References | PDF (1.8 MB) | EPUB
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Article
N6-methyladenosine (m6A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop
Tao Huang, Lili Cao, Ningning Feng, Bo Xu, Yujin Dong & Min Wang
Pages: 10935-10944
Published online: 04 Dec 2021
AbstractforN6-methyladenosine (m6A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
MicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1
Qiang Zhu, Yun Li, Lina Li, Mingxue Guo, Chenxi Zou, Yi Xu & Zhen Yang
Pages: 10945-10958
Published online: 27 Nov 2021
AbstractforMicroRNA-889-3p restrains the proliferation and epithelial–mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1 | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis
Tao Feng, Weifang Li, Tianyi Li, Wenjun Jiao & Sufang Chen
Pages: 10959-10970
Published online: 30 Nov 2021
AbstractforCircular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis | Full Text | References | PDF (2.1 MB) | EPUB
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Article
p-Coumaric acid regulates macrophage polarization in myocardial ischemia/reperfusion by promoting the expression of indoleamine 2, 3-dioxygenase
Na Li, Xueyuan Guo, Rui Li, Jian Zhou, Fangfang Yu & Xianliang Yan
Pages: 10971-10981
Published online: 29 Nov 2021
Abstractforp-Coumaric acid regulates macrophage polarization in myocardial ischemia/reperfusion by promoting the expression of indoleamine 2, 3-dioxygenase | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia
Weiwei Zhang, Lingxia Zhao, Jianwen Zhang, Pengfei Li & Zhigan Lv
Pages: 10982-10993
Published online: 01 Dec 2021
AbstractforMetformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Mechanism of microRNA regulating the progress of atherosclerosis in apoE-deficient mice
Xiaoqian Lou, Dawei Wang, Zehui Gu, Tengteng Li & Liqun Ren
Pages: 10992-11004
Published online: 02 Dec 2021
AbstractforMechanism of microRNA regulating the progress of atherosclerosis in apoE-deficient mice | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway
Jian Yang, Yong Hu, Lu Wang, Xiangran Sun, Ling Yu & Weichun Guo
Pages: 11007-11017
Published online: 29 Nov 2021
AbstractforHuman umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Effect of chromogranin A N-terminal fragment vasostatin-1 nano-carrier transfection on abdominal aortic aneurysm formation
Pingshan Wang, Wei Wang, Xingxing Peng, Fugui Ruan & Shiyao Yang
Pages: 11018-11029
Published online: 29 Nov 2021
AbstractforEffect of chromogranin A N-terminal fragment vasostatin-1 nano-carrier transfection on abdominal aortic aneurysm formation | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes
Ziyi Guo, Xunjin Zeng & Yu Zheng
Pages: 11030-11040
Published online: 30 Nov 2021
AbstractforZafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Mechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation
Hui Zhang, Qing-Qing Dong, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao & Li-Jun Yao
Pages: 11039-11054
Published online: 27 Nov 2021
AbstractforMechanistic insights into the renoprotective role of curcumin in cisplatin-induced acute kidney injury: network pharmacology analysis and experimental validation | Full Text | References | PDF (3.3 MB) | EPUB
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Review

Review
Functional foods as a formulation ingredients in beverages: technological advancements and constraints
Shagun Sharma, Astha Singh, Swati Sharma, Anil Kant, Surajbhan Sevda, Mohammad J. Taherzadeh & Vijay Kumar Garlapati
Pages: 11055-11075
Published online: 19 Dec 2021
AbstractforFunctional foods as a formulation ingredients in beverages: technological advancements and constraints | Full Text | References | PDF (1.8 MB) | EPUB
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Article
The eptinezumab:CGRP complex structure – the role of conformational changes in binding stabilization
Laurent David, Michelle Scalley-Kim, Andrea Olland, Andre White & Kira Misura
Pages: 11076-11086
Published online: 11 Dec 2021
AbstractforThe eptinezumab:CGRP complex structure – the role of conformational changes in binding stabilization | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Article
Hsa_circ_0030586 promotes epithelial–mesenchymal transition in prostate cancer via PI3K-AKT signaling
Guang-Cheng Luo, Lin Chen, Jiang Fang & Zhi-Jian Yan
Pages: 11089-11107
Published online: 02 Dec 2021
AbstractforHsa_circ_0030586 promotes epithelial–mesenchymal transition in prostate cancer via PI3K-AKT signaling | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Multi-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence
Zhipeng Xu, Hui Chen, Jin Sun, Weipu Mao, Shuqiu Chen & Ming Chen
Pages: 11108-11125
Published online: 30 Nov 2021
AbstractforMulti-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Article
The transcatheter arterial chemoembolization combined with targeted nanoparticle delivering sorafenib system for the treatment of microvascular invasion of hepatocellular carcinoma
Dongna Su
Pages: 11124-11135
Published online: 19 Dec 2021
AbstractforThe transcatheter arterial chemoembolization combined with targeted nanoparticle delivering sorafenib system for the treatment of microvascular invasion of hepatocellular carcinoma | Full Text | References | PDF (1.1 MB) | EPUB
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Article
DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis
Shouliang Xiong, Yong Zhao & Tiantong Xu
Pages: 11138-11155
Published online: 29 Nov 2021
AbstractforDNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Downregulation of microRNA-200c-3p alleviates the aggravation of venous thromboembolism by targeting serpin family C member 1
Xiaorong Jian, Dehua Yang, Li Wang & Hongxiang Wang
Pages: 11154-11166
Published online: 29 Nov 2021
AbstractforDownregulation of microRNA-200c-3p alleviates the aggravation of venous thromboembolism by targeting serpin family C member 1 | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Role of Rho guanine nucleotide exchange factors in non-small cell lung cancer
Rui-Jie Zeng, Wei-Jie Xie, Chun-Wen Zheng, Wan-Xian Chen, Si-Meng Wang, Zheng Li, Chi-Bin Cheng, Hai-Ying Zou, Li-Yan Xu & En-Min Li
Pages: 11169-11187
Published online: 02 Dec 2021
AbstractforRole of Rho guanine nucleotide exchange factors in non-small cell lung cancer | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
Isoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats
Leiming Sun, Zheng Yang, Jiaying Zhang & Jie Wang
Pages: 11188-11200
Published online: 30 Nov 2021
AbstractforIsoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats | Full Text | References | PDF (2.3 MB) | EPUB
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Research paper

Article
LncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p
Zhaoping Che, Jie Xueqin & Zongyu Zhang
Pages: 11201-11212
Published online: 07 Dec 2021
AbstractforLncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Cisatracurium besilate enhances the TRAIL-induced apoptosis of gastric cancer cells via p53 signaling
Qiang Zhou, Jianxia Yuan, Yi Liu & Yayun Wu
Pages: 11213-11224
Published online: 30 Nov 2021
AbstractforCisatracurium besilate enhances the TRAIL-induced apoptosis of gastric cancer cells via p53 signaling | Full Text | References | PDF (3.7 MB) | EPUB
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Article
miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis
Qingqing Xia, Quan Wang, Feng Lin & Junjuan Wang
Pages: 11225-11238
Published online: 02 Dec 2021
AbstractformiR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis | Full Text | References | PDF (2.3 MB) | EPUB
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Review
A review of the therapeutic and biological effects of edible and wild mushrooms
G Anusiya, U Gowthama Prabu, N V Yamini, N Sivarajasekar, K Rambabu, G Bharath & Fawzi Banat
Pages: 11239-11268
Published online: 07 Dec 2021
AbstractforA review of the therapeutic and biological effects of edible and wild mushrooms | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability
Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang & Guoxiang Fang
Pages: 11267-11276
Published online: 07 Dec 2021
AbstractforInsulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
MicroRNA-23a-3p influences the molecular mechanism of gastric cancer cells via CCL22/PI3K/Akt axis
Zhipeng Jiang, Min Su, Hua Chen, Limian Wu, Xinpei Yu & Zichuan Liu
Pages: 11277-11287
Published online: 07 Dec 2021
AbstractforMicroRNA-23a-3p influences the molecular mechanism of gastric cancer cells via CCL22/PI3K/Akt axis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration
Yang Luo, Qianyin Zhou, Fang Zhu, Liqing Fan, Hao Bo & Xingming Wang
Pages: 11288-11302
Published online: 09 Dec 2021
AbstractforHypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration | Full Text | References | PDF (4.2 MB) | EPUB
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Review

Review
Application of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security
Rachma Wikandari, Manikharda, Susanne Baldermann, Andriati Ningrum & Mohammad J. Taherzadeh
Pages: 11305-11330
Published online: 02 Dec 2021
AbstractforApplication of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security | Full Text | References | PDF (970.4 KB) | EPUB
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Article
Paeoniflorin ameliorates chronic stress-induced depression-like behavior in mice model by affecting ERK1/2 pathway
Meiling Tang, Min Chen & Qiang Li
Pages: 11329-11341
Published online: 07 Dec 2021
AbstractforPaeoniflorin ameliorates chronic stress-induced depression-like behavior in mice model by affecting ERK1/2 pathway | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma
Zhaoshun Wang, Zhongzheng Cao & Zhen Wang
Pages: 11342-11350
Published online: 07 Dec 2021
AbstractforSignificance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma | Full Text | References | PDF (614.3 KB) | EPUB
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Article
LncRNA KCNQ1OT1 (potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1) aggravates acute kidney injury by activating p38/NF-κB pathway via miR-212-3p/MAPK1 (mitogen-activated protein kinase 1) axis in sepsis
Haixia Wang, Hongbin Mou, Xiaolan Xu, Changhua Liu, Gang Zhou & Bo Gao
Pages: 11353-11368
Published online: 03 Dec 2021
AbstractforLncRNA KCNQ1OT1 (potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1) aggravates acute kidney injury by activating p38/NF-κB pathway via miR-212-3p/MAPK1 (mitogen-activated protein kinase 1) axis in sepsis | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Long noncoding RNAs Colorectal Neoplasia Differentially Expressed and taurine-upregulated gene 1 are downregulated in sepsis and positively regulate each other to suppress the apoptosis of cardiomyocytes
Zhenwei Xu, Xingyu Lin, Jingfa Zhu & Zhixia Zhu
Pages: 11369-11375
Published online: 07 Dec 2021
AbstractforLong noncoding RNAs Colorectal Neoplasia Differentially Expressed and taurine-upregulated gene 1 are downregulated in sepsis and positively regulate each other to suppress the apoptosis of cardiomyocytes | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Circular RNA circFLNA inhibits the development of bladder carcinoma through microRNA miR-216a-3p/BTG2 axis
Shuangquan Lin, Lei Wang, Zimin Shi, Anyi Zhu, Gan Zhang, Zhengdong Hong & Cheng Cheng
Pages: 11376-11389
Published online: 02 Dec 2021
AbstractforCircular RNA circFLNA inhibits the development of bladder carcinoma through microRNA miR-216a-3p/BTG2 axis | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models
Yuanxing Cai, Jing Xu & Qinghao Cheng
Pages: 11390-11398
Published online: 01 Dec 2021
AbstractforProto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Specificity protein 1/microRNA-92b forms a feedback loop promoting the migration and invasion of head and neck squamous cell carcinoma
Pai Pang, Hui Fang, Hong Wu, Song Wang, Minda Liu, Shan Jin, Zhongzheng Qi, Zhenning Li, Fayu Liu & Changfu Sun
Pages: 11397-11409
Published online: 14 Dec 2021
AbstractforSpecificity protein 1/microRNA-92b forms a feedback loop promoting the migration and invasion of head and neck squamous cell carcinoma | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Article
Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway
Yong Chen, Dong Wang, Tao Shu, Kangwei Sun, Jianbo Zhao, Min Wang, Yi Huang, Ping Wang, Hang Zheng, Zhixuan Cai & Zengyue Yang
Pages: 11410-11422
Published online: 10 Dec 2021
AbstractforCircular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Article
LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway
Yanli Guo, Pingping Sun, Wei Guo, Qing Yin, Junshu Han, Supeng Sheng, Jia Liang & Zhiming Dong
Pages: 11425-11440
Published online: 06 Dec 2021
AbstractforLncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Cyclic tensile strain facilitates proliferation and migration of human aortic smooth muscle cells and reduces their apoptosis via miRNA-187-3p
Di Yang, Guang-Yuan Wei, Min Li, Ming-Sheng Peng, Yuan Sun, Yan-Liang Zhang, Chuang Lu, Kai-Xiong Qing & Hong-Bo Cai
Pages: 11439-11450
Published online: 11 Dec 2021
AbstractforCyclic tensile strain facilitates proliferation and migration of human aortic smooth muscle cells and reduces their apoptosis via miRNA-187-3p | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
Diagnostic significance of microRNA-1255b-5p in prostate cancer patients and its effect on cancer cell function
Yuling Zhao, Xiaochun Tang, Yifan Zhao, Yan Yu & Shuzhen Liu
Pages: 11451-11460
Published online: 11 Dec 2021
AbstractforDiagnostic significance of microRNA-1255b-5p in prostate cancer patients and its effect on cancer cell function | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Review

Review
Bacterial nanocellulose: engineering, production, and applications
Reshmy R, Eapen Philip, Deepa Thomas, Aravind Madhavan, Raveendran Sindhu, Parameswaran Binod, Sunita Varjani, Mukesh Kumar Awasthi & Ashok Pandey
Pages: 11463-11483
Published online: 02 Dec 2021
AbstractforBacterial nanocellulose: engineering, production, and applications | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in low-grade cervical squamous intraepithelial lesion
Ziwen Zheng, Xiaorong Yang, Xinyu Yao & Ling Li
Pages: 11482-11489
Published online: 07 Dec 2021
AbstractforPrognostic value of HPV 16/18 genotyping and geminin mRNA quantification in low-grade cervical squamous intraepithelial lesion | Full Text | References | PDF (490.5 KB) | EPUB
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Article
Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury
Xiao-Lei Hu, Qian Su, de-Long Meng, Yuan-Shui Ren & Zhi-Qiang Su
Pages: 11490-11505
Published online: 07 Dec 2021
AbstractforCircular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11
Yi Chen, Weiwei Tang, Xuedan Zhu, Lele Zhang, Yinxing Zhu, Hua Xiao, Jin Xu, Yueyu Fang, Xiao Li, Cuiju Tang & Junfeng Shi
Pages: 11506-11519
Published online: 14 Dec 2021
AbstractforNuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11 | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
Expression and role of microRNA-212/nuclear factor I-A in depressive mice
Liang Si, Yanyan Wang, Min Liu, Lifeng Yang & Li Zhang
Pages: 11520-11532
Published online: 10 Dec 2021
AbstractforExpression and role of microRNA-212/nuclear factor I-A in depressive mice | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway
Dan Su & Chunye Lv
Pages: 11533-11543
Published online: 10 Dec 2021
AbstractforHydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Gastrodin attenuates perfluorooctanoic acid-induced liver injury by regulating gut microbiota composition in mice
Shumin Ma, Yanyan Sun, Xueting Zheng & Yang Yang
Pages: 11546-11556
Published online: 04 Dec 2021
AbstractforGastrodin attenuates perfluorooctanoic acid-induced liver injury by regulating gut microbiota composition in mice | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Article
Long non-coding RNA CASC7 suppresses malignant behaviors of breast cancer by regulating miR-21-5p/FASLG axis
Genjin Wang, Peng Duan, Feng Liu & Zhengkuo Wei
Pages: 11555-11566
Published online: 10 Dec 2021
AbstractforLong non-coding RNA CASC7 suppresses malignant behaviors of breast cancer by regulating miR-21-5p/FASLG axis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Inhibin subunit beta A promotes cell proliferation and metastasis of breast cancer through Wnt/β-catenin signaling pathway
Tao Xueqin, Mei Jinhong & Huang Yuping
Pages: 11567-11575
Published online: 10 Dec 2021
AbstractforInhibin subunit beta A promotes cell proliferation and metastasis of breast cancer through Wnt/β-catenin signaling pathway | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast
XiangRong Luo, JianTao She, Tao Xu, Yuan Zhou, ChuanBo Xu, JianPing Jiang, TianGang Li, Huajiang Liu, Hui Shen, Bolong Yin & Bin Dai
Pages: 11578-11585
Published online: 07 Dec 2021
AbstractforEstablishment and characterization of organoids from a patient with adenomyoepithelioma of the breast | Full Text | References | PDF (1.3 MB) | EPUB
  • 1866 Views
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Article
Long non-coding RNA NHEG1/hsa-miR-665/HMGB1 axis is involved in the regulation of neuroblastoma progression
Yuqing Zhang, Yuping Hu, Aihong Pan, Lei He, Jin Wang, Fangfang Zhou, Yongbo Lei & Yuanyuan Wang
Pages: 11584-11596
Published online: 10 Dec 2021
AbstractforLong non-coding RNA NHEG1/hsa-miR-665/HMGB1 axis is involved in the regulation of neuroblastoma progression | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation
Shanshan Li, Yang Li, Hongjian Sun, Yang Jiang, Keming Pan, Yue Su & Nan Bu
Pages: 11599-11611
Published online: 04 Dec 2021
AbstractforMulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation | Full Text | References | PDF (2.9 MB) | EPUB
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Article
ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy
Running title: Role of ADAMTS-13 and ferroptosis in AKI.
Xiaoyan Meng, Wenjing Huang, Weiwei Mo, Tingting Shu, Haoqiang Yang & Haibo Ning
Pages: 11610-11621
Published online: 07 Dec 2021
AbstractforADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Long non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis
Xiaolei Wang, Yu Su & Chuangao Yin
Pages: 11622-11633
Published online: 07 Dec 2021
AbstractforLong non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
MicroRNA MiR-130a-3p promotes gastric cancer by targeting Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-β1/SMAD3 pathway
Wei Hu, Xin Zheng, Jun Liu, Min Zhang, Yan Liang & Ming Song
Pages: 11634-11647
Published online: 07 Dec 2021
AbstractforMicroRNA MiR-130a-3p promotes gastric cancer by targeting Glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-β1/SMAD3 pathway | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Large tumor suppressor 2 is a prognostic biomarker and correlated with immune infiltrates in colorectal cancer
Chengwen Zhao, Jianping Chen, Yonghui Liu, Shaoqing Ju, Guihua Wang & Xudong Wang
Pages: 11648-11661
Published online: 19 Dec 2021
AbstractforLarge tumor suppressor 2 is a prognostic biomarker and correlated with immune infiltrates in colorectal cancer | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Long non-coding RNA OIP5-AS1 regulates smoke-related chronic obstructive pulmonary disease via targeting micro RNA -410-3p/IL-13
Wenbo Hao, Fei Lin, Hanbing Shi, Zhanjiang Guan & Yunfei Jiang
Pages: 11664-11676
Published online: 07 Dec 2021
AbstractforLong non-coding RNA OIP5-AS1 regulates smoke-related chronic obstructive pulmonary disease via targeting micro RNA -410-3p/IL-13 | Full Text | References | PDF (1.7 MB) | EPUB
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Review

Review
Non-coding RNAs and their bioengineering applications for neurological diseases
Tuhin Das, Tushar Kanti Das, Anne Khodarkovskaya & Sabyasachi Dash
Pages: 11675-11698
Published online: 23 Dec 2021
AbstractforNon-coding RNAs and their bioengineering applications for neurological diseases | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Study on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms
Qiang Su, Qiao Liu, Juan Liu, Lingyun Fu, Tao Liu, Jing Liang, Hong Peng & Xue Pan
Pages: 11700-11708
Published online: 07 Dec 2021
AbstractforStudy on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms | Full Text | References | PDF (468 KB) | EPUB
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Article
Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
Chuan Zhang, Huiping Zhu, Hui Jie, Hengyue Ding & Hongwen Sun
Pages: 11707-11715
Published online: 03 Jan 2022
AbstractforArbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS) | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Correlation between mechanism of oxidized-low density lipoprotein-induced macrophage apoptosis and inhibition of target gene platelet derived growth factor receptor-β expression by microRNA-9
Xunan Guo, Yan Chai, Yuqing Zhao, Dongying Wang, Peng Ding & Yunfei Bian
Pages: 11716-11725
Published online: 11 Dec 2021
AbstractforCorrelation between mechanism of oxidized-low density lipoprotein-induced macrophage apoptosis and inhibition of target gene platelet derived growth factor receptor-β expression by microRNA-9 | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Cyclin-Dependent Kinase 4 is expected to be a therapeutic target for hepatocellular carcinoma metastasis using integrated bioinformatic analysis
Jia-Ning Zhang, Feng Wei, Lin-Han Lei, Yang Yang, Yuan Yang & Wei-Ping Zhou
Pages: 11728-11739
Published online: 12 Dec 2021
AbstractforCyclin-Dependent Kinase 4 is expected to be a therapeutic target for hepatocellular carcinoma metastasis using integrated bioinformatic analysis | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
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Article
The long noncoding RNA noncoding RNA activated by DNA damage (NORAD)-microRNA-496-Interleukin-33 axis affects carcinoma-associated fibroblasts-mediated gastric cancer development
Chaoqun Huang, Jiuyang Liu, Liang He, Fubing Wang, Bin Xiong, Yan Li & Xiaojun Yang
Pages: 11738-11755
Published online: 11 Dec 2021
AbstractforThe long noncoding RNA noncoding RNA activated by DNA damage (NORAD)-microRNA-496-Interleukin-33 axis affects carcinoma-associated fibroblasts-mediated gastric cancer development | Full Text | References | PDF (6.1 MB) | EPUB
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Review

Review
MicroRNA miR-874-3p inhibits osteoporosis by targeting leptin (LEP)
Ling Mei, Min Li & Tao Zhang
Pages: 11756-11767
Published online: 11 Dec 2021
AbstractforMicroRNA miR-874-3p inhibits osteoporosis by targeting leptin (LEP) | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
RUNX1 (RUNX family transcription factor 1), a target of microRNA miR-128-3p, promotes temozolomide resistance in glioblastoma multiform by upregulating multidrug resistance-associated protein 1 (MRP1)
Jianglong Xu, Jia Song, Menglin Xiao, Changsheng Wang, Qisong Zhang, Xiaoye Yuan & Shaohui Tian
Pages: 11768-11781
Published online: 11 Dec 2021
AbstractforRUNX1 (RUNX family transcription factor 1), a target of microRNA miR-128-3p, promotes temozolomide resistance in glioblastoma multiform by upregulating multidrug resistance-associated protein 1 (MRP1) | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha−induced inflammation in adipocytes
Zhixing Cai & Yue Chen
Pages: 11784-11796
Published online: 04 Dec 2021
AbstractforSynergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha−induced inflammation in adipocytes | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Circular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/β-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression
Linwen Zeng, Shaofeng Yuan, Pengfei Zhou, Jianming Gong, Xiangdong Kong & Ming Wu
Pages: 11795-11810
Published online: 19 Dec 2021
AbstractforCircular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/β-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression | Full Text | References | PDF (3 MB) | EPUB
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Article
Effect and mechanism of BDNF/TrkB signaling on vestibular compensation
Dehong Mao, Zhongmei He, Wei Xuan, Jiao Deng, Weichun Li, Xiaoying Fang, Linglong Li & Feng Zhang
Pages: 11823-11836
Published online: 11 Dec 2021
AbstractforEffect and mechanism of BDNF/TrkB signaling on vestibular compensation | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
The effects of Omarigliptin on promoting osteoblastic differentiation
Fake Liao, Xiunian Hu & Rijiang Chen
Pages: 11837-11846
Published online: 19 Dec 2021
AbstractforThe effects of Omarigliptin on promoting osteoblastic differentiation | Full Text | References | PDF (1.4 MB) | EPUB
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Article
The phosphoinositide 3-kinase inhibitor ZSTK474 increases the susceptibility of osteosarcoma cells to oncolytic vesicular stomatitis virus VSVΔ51 via aggravating endoplasmic reticulum stress
Jinqiong Jiang, Weida Wang, Weineng Xiang, Lin Jiang & Qian Zhou
Pages: 11847-11857
Published online: 07 Dec 2021
AbstractforThe phosphoinositide 3-kinase inhibitor ZSTK474 increases the susceptibility of osteosarcoma cells to oncolytic vesicular stomatitis virus VSVΔ51 via aggravating endoplasmic reticulum stress | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1
Guoning Su, Yan Qu, Gang Li & Min Deng
Pages: 11858-11871
Published online: 09 Dec 2021
AbstractforSevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1 | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Long non-coding RNA MEG3 inhibits neovascularization in diabetic retinopathy by regulating microRNA miR-6720-5p and cytochrome B5 reductase 2
Jinpeng Chen, Lin Liao, Huiyong Xu, Zheng Zhang & Jian Zhang
Pages: 11872-11884
Published online: 07 Dec 2021
AbstractforLong non-coding RNA MEG3 inhibits neovascularization in diabetic retinopathy by regulating microRNA miR-6720-5p and cytochrome B5 reductase 2 | Full Text | References | PDF (7.5 MB) | EPUB
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Article
Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules
Qingqing Guo, Hao Lin, Pengcheng Chen, Songlin Tan, Zhiyong Wen, Lijian Lin, Jianquan He, Jianbo Wen & Shiyun Lu
Pages: 11885-11897
Published online: 25 Dec 2021
AbstractforDynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Simvastatin regulates the proliferation, apoptosis, migration and invasion of human acute myeloid leukemia cells via miR-19a-3p/HIF-1α axis
Hua Tian, Tiao Qiang, Jinbo Wang, Li Ji & Bo Li
Pages: 11898-11908
Published online: 11 Dec 2021
AbstractforSimvastatin regulates the proliferation, apoptosis, migration and invasion of human acute myeloid leukemia cells via miR-19a-3p/HIF-1α axis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway
Haijun Zhang, Lin Zhang & Ming Lu
Pages: 11909-11921
Published online: 19 Dec 2021
AbstractforInhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
Jiasui Wang, Yilidana Mijiti, Yalin Chen & Zaoling Liu
Pages: 11922-11935
Published online: 25 Dec 2021
AbstractforAryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
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Article
MicroRNA-381-3p signatures as a diagnostic marker in patients with sepsis and modulates sepsis-steered cardiac damage and inflammation by binding HMGB1
Jian Liu, Yadong Yang, Rong Lu, Qin Liu, Shukun Hong, Zhaolong Zhang & Guoxin Hu
Pages: 11936-11946
Published online: 11 Dec 2021
AbstractforMicroRNA-381-3p signatures as a diagnostic marker in patients with sepsis and modulates sepsis-steered cardiac damage and inflammation by binding HMGB1 | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin
Jingze Huang, Binbin Guan, Lijing Lin & Yanping Wang
Pages: 11947-11958
Published online: 19 Dec 2021
AbstractforImprovement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
MicroRNA-140-3p represses the proliferation, migration, invasion and angiogenesis of lung adenocarcinoma cells via targeting TYMS (thymidylate synthetase)
Shanzhi Wan, Zhimin Liu, Yang Chen, Zhitao Mai, Mingming Jiang, Qingguo Di & Baohua Sun
Pages: 11959-11977
Published online: 16 Dec 2021
AbstractforMicroRNA-140-3p represses the proliferation, migration, invasion and angiogenesis of lung adenocarcinoma cells via targeting TYMS (thymidylate synthetase) | Full Text | References | PDF (5.8 MB) | EPUB
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Article
Heparin-binding protein (HBP) worsens the severity of pancreatic necrosis via up-regulated M1 macrophages activation in acute pancreatitis mouse models
Liangliang Zhou, Jianjun Chen, Genhua Mu, Zhongqian Lu, Weiqin Li & Yijun Deng
Pages: 11978-11986
Published online: 11 Dec 2021
AbstractforHeparin-binding protein (HBP) worsens the severity of pancreatic necrosis via up-regulated M1 macrophages activation in acute pancreatitis mouse models | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Expression characteristic of 4Ig B7-H3 and 2Ig B7-H3 in acute myeloid leukemia
Wei Zhang, Lingyi Zhang, Jun Qian, Jiang Lin, Qiaoyun Chen, Qian Yuan, Jingdong Zhou, Tingjuan Zhang, Jinning Shi & Hong Zhou
Pages: 11987-12002
Published online: 11 Dec 2021
AbstractforExpression characteristic of 4Ig B7-H3 and 2Ig B7-H3 in acute myeloid leukemia | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Rhophilin rho GTPase binding protein 1-antisense RNA 1 (RHPN1-AS1) promotes ovarian carcinogenesis by sponging microRNA-485-5p and releasing DNA topoisomerase II alpha (TOP2A)
Yi Zhou, Jing Li, Xiaoxin Yang, Yu Song & Haigang Li
Pages: 12003-12022
Published online: 07 Dec 2021
AbstractforRhophilin rho GTPase binding protein 1-antisense RNA 1 (RHPN1-AS1) promotes ovarian carcinogenesis by sponging microRNA-485-5p and releasing DNA topoisomerase II alpha (TOP2A) | Full Text | References | PDF (15.6 MB) | EPUB | Supplemental
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Article
Integrated analysis of long non-coding RNA-microRNA-mRNA competing endogenous RNAregulatory networks in thromboangiitis obliterans
Bo Chen, Ying Deng, Bo Wang, Zhongyi Tian, Jindong Tong, Bo Yu, Weijun Shi & Jingdong Tang
Pages: 12023-12037
Published online: 09 Dec 2021
AbstractforIntegrated analysis of long non-coding RNA-microRNA-mRNA competing endogenous RNAregulatory networks in thromboangiitis obliterans | Full Text | References | PDF (4.3 MB) | EPUB
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Article
MicroRNA-223-3p is involved in fracture healing by regulating fibroblast growth factor receptor 2
Bin Wang, Wei Wu, Ke Xu & Haihao Wu
Pages: 12040-12048
Published online: 07 Dec 2021
AbstractforMicroRNA-223-3p is involved in fracture healing by regulating fibroblast growth factor receptor 2 | Full Text | References | PDF (798.4 KB) | EPUB | Supplemental
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Article
The microRNA-381(miR-381)/Spindlin1(SPIN1) axis contributes to cell proliferation and invasion of colorectal cancer cells by regulating the Wnt/β-catenin pathway
Ling Zhou, Heng Wang, Zhi Fang, Min Zhong, Yan He, Jianping Zou, Shanshan Huang, Junhe Li, Xiaojun Xiang & Ziling Fang
Pages: 12036-12048
Published online: 27 Dec 2021
AbstractforThe microRNA-381(miR-381)/Spindlin1(SPIN1) axis contributes to cell proliferation and invasion of colorectal cancer cells by regulating the Wnt/β-catenin pathway | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Ring finger 220 promotes the stemness and progression of colon cancer cells via Ubiquitin specific peptidase 22-BMI1 axis
Jianwen Yan, Min Tan, Lin Yu, Xichao Jin & Yangcheng Li
Pages: 12060-12069
Published online: 07 Dec 2021
AbstractforRing finger 220 promotes the stemness and progression of colon cancer cells via Ubiquitin specific peptidase 22-BMI1 axis | Full Text | References | PDF (2.5 MB) | EPUB
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Article
lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p
Jinfeng Zhang, Donghua Liu, Guoming Deng, Qiuming Wang, Liang Li, Jinxiang Zhang & Heming Wu
Pages: 12070-12086
Published online: 14 Dec 2021
AbstractforlncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Article
Identification of key molecular markers of acute coronary syndrome using peripheral blood transcriptome sequencing analysis and mRNA-lncRNA co-expression network construction
Ming Shen, Rui Gong, Haibin Li, Zhihui Yang, Yunpeng Wang & Dandan Li
Pages: 12087-12106
Published online: 29 Dec 2021
AbstractforIdentification of key molecular markers of acute coronary syndrome using peripheral blood transcriptome sequencing analysis and mRNA-lncRNA co-expression network construction | Full Text | References | PDF (3.2 MB) | EPUB
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Article
LINC00857 promotes colorectal cancer progression by sponging miR-150-5p and upregulating HMGB3 (high mobility group box 3) expression
Dongbing Zhou, Sijia He, Daquan Zhang, Zhenbing Lv, Jing Yu, Quanlin Li, Min Li, Wei Guo & Feng Qi
Pages: 12107-12122
Published online: 07 Dec 2021
AbstractforLINC00857 promotes colorectal cancer progression by sponging miR-150-5p and upregulating HMGB3 (high mobility group box 3) expression | Full Text | References | PDF (2.9 MB) | EPUB
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Research Article

Article
Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome
You Li, Guohui Xiong, Jun Tan, Shudi Wang, Qiongfang Wu, Lei Wan, Ziyu Zhang & Ouping Huang
Pages: 12123-12134
Published online: 07 Dec 2021
AbstractforAberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome | Full Text | References | PDF (1.6 MB) | EPUB
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Research Paper

Article
Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis
Peng Su, Feng Mao, Jian Zhang, Hui Zhang, MingBo Wang, YanZhao Xu & ZiQiang Tian
Pages: 12135-12147
Published online: 07 Dec 2021
AbstractforCircular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Exosomes derived from microRNA-129-5p-modified tumor cells selectively enhanced suppressive effect in malignant behaviors of homologous colon cancer cells
Yong Ji, Jianxiang Ji, Hongming Yin, Xu Chen, Pengcheng Zhao, Huahu Lu & Taowu Wang
Pages: 12148-12156
Published online: 09 Dec 2021
AbstractforExosomes derived from microRNA-129-5p-modified tumor cells selectively enhanced suppressive effect in malignant behaviors of homologous colon cancer cells | Full Text | References | PDF (2.1 MB) | EPUB
  • 2398 Views
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Article
Protein disulfide isomerase family 6 promotes the imatinib-resistance of renal cell carcinoma by regulation of Wnt3a-Frizzled1 axis
Yong Huang, Ping He & Juan Ding
Pages: 12157-12166
Published online: 07 Dec 2021
AbstractforProtein disulfide isomerase family 6 promotes the imatinib-resistance of renal cell carcinoma by regulation of Wnt3a-Frizzled1 axis | Full Text | References | PDF (4.6 MB) | EPUB
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Article
Value of glycogen synthase 2 in intrahepatic cholangiocarcinoma prognosis assessment and its influence on the activity of cancer cells
Sigen A, Huijun Wu, Xiaodong Wang, Xidong Wang, Jiarui Yang, Long Xia & Yijun Xia
Pages: 12167-12178
Published online: 07 Dec 2021
AbstractforValue of glycogen synthase 2 in intrahepatic cholangiocarcinoma prognosis assessment and its influence on the activity of cancer cells | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells
Qiong Xu, Zequn Liu, Zhi-qin Zhu, Yue Fan, Rui Chen, Xiao-hui Xie & Mi Cheng
Pages: 12179-12190
Published online: 07 Dec 2021
AbstractforKnockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells | Full Text | References | PDF (3.2 MB) | EPUB
  • 1537 Views
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Article
Silencing FYVE, RhoGEF, and PH domain containing 1 (FGD1) suppresses melanoma progression by inhibiting PI3K/AKT signaling pathway
Zehao Niu, Yan Li, Yujian Xu, Weiqian Jiang, Ran Tao, Youbai Chen & Yan Han
Pages: 12193-12205
Published online: 07 Dec 2021
AbstractforSilencing FYVE, RhoGEF, and PH domain containing 1 (FGD1) suppresses melanoma progression by inhibiting PI3K/AKT signaling pathway | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Article
Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation
Xiaodong Wang, Yaxian Li, Ziqing Fang & Yongxiang Li
Pages: 12204-12214
Published online: 13 Dec 2021
AbstractforElevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation | Full Text | References | PDF (2 MB) | EPUB
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Article
Sevoflurane induces inflammation in primary hippocampal neurons by regulating Hoxa5/Gm5106/miR-27b-3p positive feedback loop
Zifu Zhu & Li Ma
Pages: 12215-12226
Published online: 24 Dec 2021
AbstractforSevoflurane induces inflammation in primary hippocampal neurons by regulating Hoxa5/Gm5106/miR-27b-3p positive feedback loop | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway
Zhonghai Xie, Hongwei Li & Jin Zang
Pages: 12227-12235
Published online: 07 Dec 2021
AbstractforKnockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Long non-coding RNA anti-differentiation non-coding RNA affects proliferation, invasion, and migration of breast cancer cells by targeting miR-331
Chaoyu Jiang, Xianbiao Shi, Dandan Yi, Ru Wang, Fazhan Xu, Wenxian Guan & Jianfeng Sang
Pages: 12236-12245
Published online: 10 Dec 2021
AbstractforLong non-coding RNA anti-differentiation non-coding RNA affects proliferation, invasion, and migration of breast cancer cells by targeting miR-331 | Full Text | References | PDF (1.2 MB) | EPUB
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Article
The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis
Yanlong Shi, Wei Wei, Li Li, Qian Wei, Fei Jiang, Guozhi Xia & Hongzhu Yu
Pages: 12246-12262
Published online: 11 Dec 2021
AbstractforThe global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
Meng Gao, Yue Chen & Chenghu Wu
Pages: 12263-12273
Published online: 11 Dec 2021
AbstractforSize-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy | Full Text | References | PDF (2.7 MB) | EPUB
  • 1607 Views
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Article
Exploration of the mechanism of luteolin against ischemic stroke based on network pharmacology, molecular docking and experimental verification
Rui Dong, Renxuan Huang, Xiaohua Shi, Zhongxin Xu & Jing Mang
Pages: 12274-12293
Published online: 19 Dec 2021
AbstractforExploration of the mechanism of luteolin against ischemic stroke based on network pharmacology, molecular docking and experimental verification | Full Text | References | PDF (4.8 MB) | EPUB
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Article
Heterogeneity affects the differentiation potential of dental follicle stem cells through the TGF-β signaling pathway
Meng Zhaosong, Fu Na, Guo Shuling, Liu Jiacheng & Wei Ran
Pages: 12294-12307
Published online: 18 Dec 2021
AbstractforHeterogeneity affects the differentiation potential of dental follicle stem cells through the TGF-β signaling pathway | Full Text | References | PDF (3.2 MB) | EPUB
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Reviews

Review
Microbial engineering for the production of isobutanol: current status and future directions
Nair M Lakshmi, Parameswaran Binod, Raveendran Sindhu, Mukesh Kumar Awasthi & Ashok Pandey
Pages: 12308-12321
Published online: 19 Dec 2021
AbstractforMicrobial engineering for the production of isobutanol: current status and future directions | Full Text | References | PDF (2 MB) | EPUB
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Article
Experimental study of fat derived pellets promoting wound healing in rats
Li Zeng, Shaolong Zhou, Chen Chen, Lin-Hua Zhou, Xiujiang Shi, Zongjian Wu & Sheng-Kang Luo
Pages: 12323-12331
Published online: 11 Dec 2021
AbstractforExperimental study of fat derived pellets promoting wound healing in rats | Full Text | References | PDF (1.8 MB) | EPUB
  • 1135 Views
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Article
Maprotiline ameliorates isoflurane-induced microglial activation via regulating triggering receptor expressed in myeloid cells 2 (TREM2)
Rui Hu, Yongguan He & Zhigang Chen
Pages: 12332-12344
Published online: 11 Dec 2021
AbstractforMaprotiline ameliorates isoflurane-induced microglial activation via regulating triggering receptor expressed in myeloid cells 2 (TREM2) | Full Text | References | PDF (2 MB) | EPUB
  • 1441 Views
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Article
Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression
Fang Zuo, Yong Zhang, Jianting Li, Shaoxiang Yang & Xiaolu Chen
Pages: 12345-12356
Published online: 13 Dec 2021
AbstractforLong noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression | Full Text | References | PDF (3.7 MB) | EPUB
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Article
MicroRNA miR-4709-3p targets Large Tumor Suppressor Kinase 2 (LATS2) and induces obstructive renal fibrosis through Hippo signaling
Zexiang Jiang, Weiping Xia, Guoyu Dai, Bo Zhang, Yang Li & Xiang Chen
Pages: 12357-12371
Published online: 21 Dec 2021
AbstractforMicroRNA miR-4709-3p targets Large Tumor Suppressor Kinase 2 (LATS2) and induces obstructive renal fibrosis through Hippo signaling | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Microbial succession of lignocellulose degrading bacteria during composting of corn stalk
Fengmei Shi, Hongjiu Yu, Nan Zhang, Su Wang, Pengfei Li, Qiuyue Yu, Jie Liu & Zhanjiang Pei
Pages: 12372-12382
Published online: 11 Dec 2021
AbstractforMicrobial succession of lignocellulose degrading bacteria during composting of corn stalk | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Engineered mRNA-expressed bispecific antibody prevent intestinal cancer via lipid nanoparticle delivery
Lipei Wu, Weiwei Wang, Jiale Tian, Chunrun Qi, Zhengxin Cai, Wenhui Yan, Shihai Xuan & Anquan Shang
Pages: 12383-12393
Published online: 13 Dec 2021
AbstractforEngineered mRNA-expressed bispecific antibody prevent intestinal cancer via lipid nanoparticle delivery | Full Text | References | PDF (1.5 MB) | EPUB
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Article
miR-543 impairs breast cancer cell phenotypes by targeting and suppressing ubiquitin-conjugating enzyme E2T (UBE2T)
Li Li & Qing Li
Pages: 12394-12406
Published online: 11 Dec 2021
AbstractformiR-543 impairs breast cancer cell phenotypes by targeting and suppressing ubiquitin-conjugating enzyme E2T (UBE2T) | Full Text | References | PDF (7 MB) | EPUB
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Article
N-terminal prohormone B-type natriuretic peptide variability acts as a predictor of poor prognosis in patients with cardiorenal syndrome type 2
Mingming Ma, Qiao Luo, Xiangnan Dong, Shuang Cui, Berthold Hocher, Shufei Zeng, Wenxue Liang, Qiang Li, Xiaoyi Chen, Xin Chen, Yu Meng, Yongping Lu, Deguang Yang & Lianghong Yin
Pages: 12407-12419
Published online: 14 Dec 2021
AbstractforN-terminal prohormone B-type natriuretic peptide variability acts as a predictor of poor prognosis in patients with cardiorenal syndrome type 2 | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Regulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma
Jiawei Yan & Hongyan Xu
Pages: 12420-12430
Published online: 14 Dec 2021
AbstractforRegulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Identification of novel biomarkers in breast cancer via integrated bioinformatics analysis and experimental validation
Ningning Wang, Haichen Zhang, Dan Li, Chunteng Jiang, Haidong Zhao & Yun Teng
Pages: 12431-12446
Published online: 13 Dec 2021
AbstractforIdentification of novel biomarkers in breast cancer via integrated bioinformatics analysis and experimental validation | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
Serum hsa_circ_0087776 as a new oncologic marker for the joint diagnosis of multiple myeloma
Xingxing Gong, Xu Lu, Jing Cao, Huan Liu, Hongmei Chen, Fang Bao, Xiuying Shi & Hui Cong
Pages: 12447-12459
Published online: 14 Dec 2021
AbstractforSerum hsa_circ_0087776 as a new oncologic marker for the joint diagnosis of multiple myeloma | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19
Jingru Qin, Chao Guo, Lu Yang, Xiao Liang, Aijun Jiao, Keng Po Lai & Bin Yang
Pages: 12461-12469
Published online: 23 Dec 2021
AbstractforBioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19 | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U)
Peipei Ge, Mingxiao Gao, Juan Du, Jingbin Yu & Lei Zhang
Pages: 12469-12481
Published online: 16 Dec 2021
AbstractforDownregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U) | Full Text | References | PDF (4.7 MB) | EPUB
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Article
Knockdown of long non-coding RNA HOTAIR promotes bone marrow mesenchymal stem cell differentiation by sponging microRNA miR-378g that inhibits nicotinamide N-methyltransferase
Wei Wang, Tao Li & Shibo Feng
Pages: 12482-12497
Published online: 13 Dec 2021
AbstractforKnockdown of long non-coding RNA HOTAIR promotes bone marrow mesenchymal stem cell differentiation by sponging microRNA miR-378g that inhibits nicotinamide N-methyltransferase | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Analgesia effect of lentivirus-siSCN9A infected neurons in vincristine induced neuropathic pain rats
Baojun Fu & Rong Zhu
Pages: 12498-12508
Published online: 18 Dec 2021
AbstractforAnalgesia effect of lentivirus-siSCN9A infected neurons in vincristine induced neuropathic pain rats | Full Text | References | PDF (996.3 KB) | EPUB
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Article
Fluvastatin suppresses the proliferation, invasion, and migration and promotes the apoptosis of endometrial cancer cells by upregulating Sirtuin 6 (SIRT6)
Yu Cai & Feng Zhao
Pages: 12509-12520
Published online: 18 Dec 2021
AbstractforFluvastatin suppresses the proliferation, invasion, and migration and promotes the apoptosis of endometrial cancer cells by upregulating Sirtuin 6 (SIRT6) | Full Text | References | PDF (7 MB) | EPUB
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Article
Gut Microbiome-Based Diagnostic Model to Predict Diabetes Mellitus
Hai-Tao Yang, Jing-Kun Liu, Wen-Juan Xiu, Ting-Ting Tian, Yi Yang, Xian-Geng Hou & Xiang Xie
Pages: 12521-12534
Published online: 19 Dec 2021
AbstractforGut Microbiome-Based Diagnostic Model to Predict Diabetes Mellitus | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Effect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits
Ming Qi, Ze Song, Lei Wang & Xu Xie
Pages: 12535-12543
Published online: 21 Dec 2021
AbstractforEffect of temperature-sensitive nanogel combined with angioplasty on sICAM-1 and VE-cadherin in lower extremity arterial occlusion rabbits | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Hsp22 ameliorates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidative stress, and apoptosis
Yun Yu, Long-Long Hu, Liang Liu, Ling-Ling Yu, Jun-Pei Li, Jing-an Rao, Ling-Juan Zhu, Hui-Hui Bao & Xiao-Shu Cheng
Pages: 12544-12554
Published online: 13 Dec 2021
AbstractforHsp22 ameliorates lipopolysaccharide-induced myocardial injury by inhibiting inflammation, oxidative stress, and apoptosis | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis
Zhaoliang Zhu, Peng Duan, Huping Song, Rongle Zhou & Tao Chen
Pages: 12555-12567
Published online: 14 Dec 2021
AbstractforDownregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis | Full Text | References | PDF (3.3 MB) | EPUB
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Article
MicroRNA miR-23b-3p promotes osteosarcoma by targeting ventricular zone expressed PH domain-containing 1 (VEPH1)/phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway
Liang Fan, Xing Cao & Yanrong Lei
Pages: 12568-12582
Published online: 14 Dec 2021
AbstractforMicroRNA miR-23b-3p promotes osteosarcoma by targeting ventricular zone expressed PH domain-containing 1 (VEPH1)/phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
Long non-coding RNA PVT1/microRNA miR-3127-5p/NCK-associated protein 1-like axis participates in the pathogenesis of abdominal aortic aneurysm by regulating vascular smooth muscle cells
Youjin Huang, Li Ren, Jiajia Li & Haibo Zou
Pages: 12583-12596
Published online: 19 Dec 2021
AbstractforLong non-coding RNA PVT1/microRNA miR-3127-5p/NCK-associated protein 1-like axis participates in the pathogenesis of abdominal aortic aneurysm by regulating vascular smooth muscle cells | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma
Ran Ji, Yifei Ji, Lin Ma, Sijia Ge, Jing Chen, Shuzhen Wu, Tianxin Huang, Yu Sheng, Liyang Wang, Nan Yi & Zhaoxiu Liu
Pages: 12598-12611
Published online: 22 Dec 2021
AbstractforKeratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
Long non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin
Yang Liu, Jiangyang Sun, Peng Qi & Yang Liu
Pages: 12611-12624
Published online: 13 Dec 2021
AbstractforLong non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin | Full Text | References | PDF (3.9 MB) | EPUB
  • 1326 Views
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Article
Effect of miRNA-200a on radiosensitivity of osteosarcoma cells by targeting Bone morphogenetic protein receptor 2
Xian Tao, Jiansheng Cheng & Xinghua Wang
Pages: 12625-12635
Published online: 13 Dec 2021
AbstractforEffect of miRNA-200a on radiosensitivity of osteosarcoma cells by targeting Bone morphogenetic protein receptor 2 | Full Text | References | PDF (1.3 MB) | EPUB
  • 1066 Views
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Article
The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein
Xinde Zhao, Ming Zhou, Yong Yang & Minjie Luo
Pages: 12636-12645
Published online: 19 Dec 2021
AbstractforThe ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Downregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L)
Kai Wang, Baosong Li, Peng Fan, Xiang Ren & Hong Jiang
Pages: 12647-12658
Published online: 13 Dec 2021
AbstractforDownregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L) | Full Text | References | PDF (3.9 MB) | EPUB
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Article
microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism
Ying-Zhao Wang, Jun Lu, Yuan-Yuan Li, Yu-Juan Zhong, Cheng-Fang Yang, Yan Zhang, Li-Hua Huang, Su-Mei Huang, Qi-Ran Li, Dan Wu, Meng-Wei Song, Lin Shi, Li Li & Yong-Wen Li
Pages: 12659-12676
Published online: 20 Dec 2021
AbstractformicroRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism | Full Text | References | PDF (4.8 MB) | EPUB
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Article
MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer’s disease
Wenjun Wan, Ganzhe Liu, Xia Li, Yu Liu, Ying Wang, Haisong Pan & Jun Hu
Pages: 12678-12690
Published online: 22 Dec 2021
AbstractforMiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer’s disease | Full Text | References | PDF (2.1 MB) | EPUB
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Article
MYC-mediated miR-320a affects receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast formation by regulating phosphatase and tensin homolog (PTEN)
Hao Chen, Shaoshuo Li, Heng Yin, Zhen Hua, Yang Shao, Jie Wei & Jianwei Wang
Pages: 12677-12687
Published online: 21 Dec 2021
AbstractforMYC-mediated miR-320a affects receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast formation by regulating phosphatase and tensin homolog (PTEN) | Full Text | References | PDF (2.4 MB) | EPUB
  • 1141 Views
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Article
The nephroprotective effects of Daucus carota and Eclipta prostrata against cisplatin-induced nephrotoxicity in rats
Muhammad Omer Iqbal, Asad Saleem Sial, Imran Akhtar, Muhammad Naeem, Abu Hazafa, Rais A. Ansari & Syed A. A. Rizvi
Pages: 12702-12721
Published online: 24 Dec 2021
AbstractforThe nephroprotective effects of Daucus carota and Eclipta prostrata against cisplatin-induced nephrotoxicity in rats | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Cell membrane breakage and triggering T cell infiltration are involved in human telomerase reverse transcriptase (hTERT) promoter-driven novel peptide KK-64 for liver cancer gene therapy
Yuanhua Lu, Jie Ma, Jian Lin, Yafei Tian, Yongjun Ma, Wei Wang, Jialin Li, Hugang Zhang & Ping Jiao
Pages: 12708-12721
Published online: 14 Dec 2021
AbstractforCell membrane breakage and triggering T cell infiltration are involved in human telomerase reverse transcriptase (hTERT) promoter-driven novel peptide KK-64 for liver cancer gene therapy | Full Text | References | PDF (2.9 MB) | EPUB
  • 1447 Views
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Article
Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis
Yu-Xuan Wang, Cheng Lin, Lu-Jia Cui, Tao-Zhi Deng, Qiu-Min Li, Feng-Ying Chen & Xin-Pu Miao
Pages: 12722-12739
Published online: 11 Dec 2021
AbstractforMechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis | Full Text | References | PDF (4.5 MB) | EPUB
  • 1881 Views
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Article
Study on flow distribution pattern and conductivity of porous media in bioretention cells
Yajun Wang, Yunmei Si, Sheng Yang & Rajendra Prasad Singh
Pages: 12740-12754
Published online: 22 Dec 2021
AbstractforStudy on flow distribution pattern and conductivity of porous media in bioretention cells | Full Text | References | PDF (3 MB) | EPUB
  • 955 Views
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Article
Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis
Chao-Qun Huang, Ping Yang, Jiuyang Liu, Yin-Ping Wang, Dan-Dan Hao & Xiaojun Yang
Pages: 12755-12766
Published online: 21 Dec 2021
AbstractforCircular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1261 Views
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Article
Circular RNA hsa_circ_0002360 promotes non-small cell lung cancer progression through upregulating matrix metalloproteinase 16 and sponging multiple micorRNAs
Yunting Zhang, Shaolin Zeng & Tao Wang
Pages: 12767-12777
Published online: 25 Dec 2021
AbstractforCircular RNA hsa_circ_0002360 promotes non-small cell lung cancer progression through upregulating matrix metalloproteinase 16 and sponging multiple micorRNAs | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway
ManLi Yuan, Bei Zhao, Huaping Jia, Can Zhang & Xiaowen Zuo
Pages: 12778-12788
Published online: 13 Dec 2021
AbstractforSinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway | Full Text | References | PDF (2.5 MB) | EPUB
  • 2443 Views
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Article
Nesfatin-1 alleviates high glucose/high lipid-induced injury of trophoblast cells during gestational diabetes mellitus
Huanling He, Yingyu Liu & Minghe Sun
Pages: 12789-12799
Published online: 11 Dec 2021
AbstractforNesfatin-1 alleviates high glucose/high lipid-induced injury of trophoblast cells during gestational diabetes mellitus | Full Text | References | PDF (2.5 MB) | EPUB
  • 1675 Views
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Article
Ribonucleotide reductase subunit M2 promotes proliferation and epithelial–mesenchymal transition via the JAK2/STAT3 signaling pathway in retinoblastoma
Min Yang, Panpan Yao, Xuqiang Lang, Xue Li & Dawei Zhang
Pages: 12800-12811
Published online: 11 Dec 2021
AbstractforRibonucleotide reductase subunit M2 promotes proliferation and epithelial–mesenchymal transition via the JAK2/STAT3 signaling pathway in retinoblastoma | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 1410 Views
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Article
Celecoxib prevents tumor necrosis factor-α (TNF-α)-induced cellular senescence in human chondrocytes
Qunli Wang, Qi Chen, Jie Sui, Yuanyuan Tu, Xiang Guo & Feng Li
Pages: 12812-12820
Published online: 13 Dec 2021
AbstractforCelecoxib prevents tumor necrosis factor-α (TNF-α)-induced cellular senescence in human chondrocytes | Full Text | References | PDF (1.2 MB) | EPUB
  • 2067 Views
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Article
Excavating novel diagnostic and prognostic long non-coding RNAs (lncRNAs) for head and neck squamous cell carcinoma: an integrated bioinformatics analysis of competing endogenous RNAs (ceRNAs) and gene co-expression networks
Liu Yang, Pingan Lu, Xiaohui Yang, Kaiguo Li, Xuxia Chen & Song Qu
Pages: 12821-12838
Published online: 21 Dec 2021
AbstractforExcavating novel diagnostic and prognostic long non-coding RNAs (lncRNAs) for head and neck squamous cell carcinoma: an integrated bioinformatics analysis of competing endogenous RNAs (ceRNAs) and gene co-expression networks | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
  • 3842 Views
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Review

Review
Bioengineered microbes for soil health restoration: present status and future
Sharrel Rebello, Vinod Kumar Nathan, Raveendran Sindhu, Parameswaran Binod, Mukesh Kumar Awasthi & Ashok Pandey
Pages: 12839-12853
Published online: 14 Dec 2021
AbstractforBioengineered microbes for soil health restoration: present status and future | Full Text | References | PDF (1,003.8 KB) | EPUB
  • 7624 Views
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Research Paper

Article
The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma
Pu Wu, Jinyuan Shi, Wei Sun & Hao Zhang
Pages: 12854-12866
Published online: 16 Dec 2021
AbstractforThe prognostic value of plasma complement factor B (CFB) in thyroid carcinoma | Full Text | References | PDF (3.5 MB) | EPUB
  • 1956 Views
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Article
Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson’s disease
Lei Yan, Lei Li & Jingan Lei
Pages: 12867-12879
Published online: 16 Dec 2021
AbstractforLong noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson’s disease | Full Text | References | PDF (3.2 MB) | EPUB
  • 1854 Views
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Article
Long noncoding RNA matrilineal expression gene 3 inhibits hepatocellular carcinoma progression by targeting microRNA-5195-3p and regulating the expression of forkhead box O1
Minan Li, Hong Liao, Jian Wu, Bin Chen, Runhua Pang, Junhai Huang & Yaqing Zhu
Pages: 12880-12890
Published online: 13 Dec 2021
AbstractforLong noncoding RNA matrilineal expression gene 3 inhibits hepatocellular carcinoma progression by targeting microRNA-5195-3p and regulating the expression of forkhead box O1 | Full Text | References | PDF (2.4 MB) | EPUB
  • 1259 Views
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Article
MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling
Dongyan Sun, Zhihe Jiang, Yanling Chen, Di Shang, Pan Miao & Jian Gao
Pages: 12891-12904
Published online: 14 Dec 2021
AbstractforMiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling | Full Text | References | PDF (3.4 MB) | EPUB
  • 1995 Views
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Article
Molecular mechanism of atrial remodeling in patients with aging atrial fibrillation under the expression of microRNA-1 and microRNA-21
Kexin Yuan, Pei Zhao & Lili Wang
Pages: 12905-12916
Published online: 25 Dec 2021
AbstractforMolecular mechanism of atrial remodeling in patients with aging atrial fibrillation under the expression of microRNA-1 and microRNA-21 | Full Text | References | PDF (1.5 MB) | EPUB
  • 1608 Views
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Article
Zinc finger E-Box binding homeobox 2 (ZEB2)-induced astrogliosis protected neuron from pyroptosis in cerebral ischemia and reperfusion injury
Zhixin Zhao, Xiaoming Hu, Jie Wang, Jianfeng Wang, Yong Hou & Suyun Chen
Pages: 12917-12930
Published online: 13 Dec 2021
AbstractforZinc finger E-Box binding homeobox 2 (ZEB2)-induced astrogliosis protected neuron from pyroptosis in cerebral ischemia and reperfusion injury | Full Text | References | PDF (2.8 MB) | EPUB
  • 1778 Views
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Article
Long non-coding RNA CERS6-AS1 plays a prognostic role in promoting the progression of gastric cancer
Zhengliang Li, Xiaojing Liu, Nan Luo, Yali Pang, Yubin Hou & Guoxiang Jiang
Pages: 12931-12939
Published online: 22 Dec 2021
AbstractforLong non-coding RNA CERS6-AS1 plays a prognostic role in promoting the progression of gastric cancer | Full Text | References | PDF (1.5 MB) | EPUB
  • 1245 Views
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Article
Uncovering the action mechanism of homoharringtonine against colorectal cancer by using network pharmacology and experimental evaluation
Muwen Qu, Junyi Li & Lingling Yuan
Pages: 12940-12953
Published online: 14 Dec 2021
AbstractforUncovering the action mechanism of homoharringtonine against colorectal cancer by using network pharmacology and experimental evaluation | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 2025 Views
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Article
Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis
Haosheng Zhang, Liang Ding, Xiaoqing Shi, Wei Mei, Zhengquan Huang, Li Zhang, Xiaochen Li, Bo Xu, Li Zhang & Peimin Wang
Pages: 12954-12964
Published online: 11 Dec 2021
AbstractforImperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis | Full Text | References | PDF (2 MB) | EPUB
  • 1714 Views
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Article
Type IIA topoisomerase (TOP2A) triggers epithelial-mesenchymal transition and facilitates HCC progression by regulating Snail expression
Yinying Dong, Xiangyin Sun, Kong Zhang, Xinjia He, Qian Zhang, Hao Song, Mingjin Xu, Haijun Lu & Ruimei Ren
Pages: 12967-12979
Published online: 23 Dec 2021
AbstractforType IIA topoisomerase (TOP2A) triggers epithelial-mesenchymal transition and facilitates HCC progression by regulating Snail expression | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 2223 Views
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