Bioengineered, Volume 13, Issue 2 (2022)

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Bioengineered, Volume 13, Issue 2 (2022)

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Research paper

Article
Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis
Fei Xie, Yuyuan Xiong, Jiayin Yan, Ling Wang & Wei Yan
Pages: 1963-1974
Published online: 16 Jan 2022
AbstractforCircular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis | Full Text | References | PDF (1.8 MB) | EPUB
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Research Paper

Article
Application of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis
Xiao-Yi Chen, Qian-Long Wang, Wei-Xue Huang, Long-Wei Li, Lan-Cong Liu, Yi Yang, You-Jiao Wu, Shan-Shan Song, Hao Ma, Hua Zhou & Pei Luo
Pages: 1975-1987
Published online: 14 Jan 2022
AbstractforApplication of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Circular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma
Yongwei Zhang, Jun Li, Quanwei Cui, Panyi Hu, Shuangjiu Hu & Yeben Qian
Pages: 1988-2003
Published online: 03 Feb 2022
AbstractforCircular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2091 Views
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Open Access
Article
Human bone marrow mesenchymal stem cells-derived exosomes attenuated prostate cancer progression via the miR-99b-5p/IGF1R axis
Shichun Jiang, Haiyu Chen, Kai He & Juan Wang
Pages: 2004-2016
Published online: 14 Jan 2022
AbstractforHuman bone marrow mesenchymal stem cells-derived exosomes attenuated prostate cancer progression via the miR-99b-5p/IGF1R axis | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3
Qi Zhou, Wei Wang, Jun Wu, Shang Qiu, Shuai Yuan, Pei-Liang Fu, Qi-Rong Qian & Yao-Zeng Xu
Pages: 2017-2027
Published online: 16 Jan 2022
AbstractforUbiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3 | Full Text | References | PDF (2 MB) | EPUB
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Article
Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761
Lingling Xu, Yinling Tan, Fengxia Xu & Yong Zhang
Pages: 2028-2043
Published online: 14 Jan 2022
AbstractforLong noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761 | Full Text | References | PDF (4.6 MB) | EPUB
  • 1213 Views
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Article
New insights into aging-associated characteristics of female subcutaneous adipose tissue through integrative analysis of multi-omics data
Zichao Li, Shun Wang, Shaojie Liu, Ziwen Xu, Xiaowei Yi, Hongtao Wang, Juanli Dang, Xinxin Wei, Bingyue Feng, Zinuo Liu, Ming Zhao, Qiong Wu & Dahai Hu
Pages: 2044-2057
Published online: 09 Jan 2022
AbstractforNew insights into aging-associated characteristics of female subcutaneous adipose tissue through integrative analysis of multi-omics data | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Open Access
Article
A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury
Yu Zhang, Shiwei Jiang, Fei Liao, Zhifeng Huang, Xin Yang, Yu Zou, Xin He, Qulian Guo & Changsheng Huang
Pages: 2058-2075
Published online: 14 Jan 2022
AbstractforA transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 2259 Views
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Article
Lectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines
XiaoJing Chen, Yite Xue, Lingfang Wang, Yang Weng, Sen Li, Weiguo Lü, Xing Xie & Xiaodong Cheng
Pages: 2076-2086
Published online: 17 Jan 2022
AbstractforLectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines | Full Text | References | PDF (1.9 MB) | EPUB
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Article
tRF-19-W4PU732S promotes breast cancer cell malignant activity by targeting inhibition of RPL27A (ribosomal protein-L27A)
Zhengxiang Zhang, Zhiping Liu, WeiDong Zhao, Xiaohan Zhao & Yunxiang Tao
Pages: 2087-2098
Published online: 14 Jan 2022
AbstractfortRF-19-W4PU732S promotes breast cancer cell malignant activity by targeting inhibition of RPL27A (ribosomal protein-L27A) | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p
Kai Bai, Yubo Ma & Jian Li
Pages: 2099-2113
Published online: 16 Jan 2022
AbstractforCircular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Activating transcription factor 3-activated long noncoding RNA forkhead box P4-antisense RNA 1 aggravates colorectal cancer progression by regulating microRNA-423-5p/nucleus accumbens associated 1 axis
Zhouyang Cheng, Song Jiang, Ran Tao, Haipeng Ge & Jun Qin
Pages: 2114-2129
Published online: 16 Jan 2022
AbstractforActivating transcription factor 3-activated long noncoding RNA forkhead box P4-antisense RNA 1 aggravates colorectal cancer progression by regulating microRNA-423-5p/nucleus accumbens associated 1 axis | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1337 Views
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Article
The clinical significance of circulating tumor cells and T lymphocyte subtypes in pancreatic cancer patients
Yasi Xing, Xinfa Zhang, Fangyuan Qin, Jingwen Yang, Lei Ai, Qingsong Wang & Yaping Zhai
Pages: 2128-2136
Published online: 16 Jan 2022
AbstractforThe clinical significance of circulating tumor cells and T lymphocyte subtypes in pancreatic cancer patients | Full Text | References | PDF (477.6 KB) | EPUB
  • 1988 Views
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Review

Review
Recent advancements in prebiotic oligomers synthesis via enzymatic hydrolysis of lignocellulosic biomass
Reetu Saini, Anil Kumar Patel, Jitendra Kumar Saini, Chiu-Wen Chen, Sunita Varjani, Reeta Rani Singhania & Cheng Di Dong
Pages: 2139-2172
Published online: 16 Jan 2022
AbstractforRecent advancements in prebiotic oligomers synthesis via enzymatic hydrolysis of lignocellulosic biomass | Full Text | References | PDF (1.3 MB) | EPUB
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Research Paper

Article
Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure
Lili Zhang, Bin Mao, Xiaodong Zhao, Yue Yuan, Wei Wang & Shaohua Lin
Pages: 2173-2180
Published online: 16 Jan 2022
AbstractforTranslation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure | Full Text | References | PDF (1.2 MB) | EPUB
  • 1402 Views
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Article
Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis
Weifu He, Xiaoyan Shi, Zhenye Guo, Huan Wang, Mingming Kang & Zhi Lv
Pages: 2181-2193
Published online: 14 Jan 2022
AbstractforCirc_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis | Full Text | References | PDF (4 MB) | EPUB
  • 1746 Views
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Article
Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway
Guoming Deng, Yufeng Luo, Yaoming Zhang, Jinfeng Zhang & Zongyun He
Pages: 2194-2206
Published online: 14 Jan 2022
AbstractforEnabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway | Full Text | References | PDF (3.3 MB) | EPUB
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Article
DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin
Yi Liu, Jun Ma, Jiu-Shan Song, Hai-Ying Zhou, Jing-Hui Li, Cheng Luo, Xin Geng & He-Xiang Zhao
Pages: 2207-2216
Published online: 11 Jan 2022
AbstractforDNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction
Lijie Ma, Chengfei Zhang, Lili Wu, Lingling Qin & Tonghua Liu
Pages: 2217-2225
Published online: 14 Jan 2022
AbstractforDiosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction | Full Text | References | PDF (1.7 MB) | EPUB
  • 1351 Views
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Article
Recent advances of natural biopolymeric culture scaffold: synthesis and modification
Jia Xin Yap, C.P. Leo, Nazlina Haiza Mohd Yasin, Pau Loke Show, Dinh-Toi Chu, Vijai Singh & C.J.C. Derek
Pages: 2226-2247
Published online: 14 Jan 2022
AbstractforRecent advances of natural biopolymeric culture scaffold: synthesis and modification | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage
Jingjing Wu, Dongmei Zhang, Linlin Hu, Xiaowei Zheng & Caihong Chen
Pages: 2248-2258
Published online: 14 Jan 2022
AbstractforPaeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage | Full Text | References | PDF (2.3 MB) | EPUB
  • 1904 Views
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Article
Prospero homeobox 1 promotes proliferation, migration, and invasion of osteosarcoma cells and its clinical significance
Dawei Liu, Ran Wang, Yuefeng Wang, Ye Wang & Liantang Wang
Pages: 2259-2271
Published online: 14 Jan 2022
AbstractforProspero homeobox 1 promotes proliferation, migration, and invasion of osteosarcoma cells and its clinical significance | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1050 Views
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Article
The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression
Shaolei Wang, Dehua Liu, Hong Wei, Yang Hua, Guodong Shi & Jinhan Qiao
Pages: 2272-2284
Published online: 16 Jan 2022
AbstractforThe hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling
Yuanliang Xue, Chuanliang Zhao & Tao Liu
Pages: 2285-2295
Published online: 16 Jan 2022
AbstractforInterferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling | Full Text | References | PDF (2.3 MB) | EPUB
  • 1441 Views
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Article
Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia
Yabo Liu, Huibo Li, Yanqiu Zhao, Dandan Li, Qian Zhang, Jinyue Fu & Shengjin Fan
Pages: 2296-2307
Published online: 16 Jan 2022
AbstractforKnockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 1186 Views
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Article
LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis
Yu Tang, Jingxuan Cai & Bo Lv
Pages: 2308-2320
Published online: 16 Jan 2022
AbstractforLncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis | Full Text | References | PDF (6.7 MB) | EPUB
  • 872 Views
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Article
Circular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p
Hao Shen, Haifeng Li & Jiahua Zhou
Pages: 2321-2335
Published online: 14 Jan 2022
AbstractforCircular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1897 Views
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Article
The role of long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) in chronic periodontitis progression
Lei Zhang, Hui Lv, Yongxin Cui & Rongji Shi
Pages: 2336-2345
Published online: 16 Jan 2022
AbstractforThe role of long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) in chronic periodontitis progression | Full Text | References | PDF (1.7 MB) | EPUB
  • 1145 Views
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Article
Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release
Wei Wei, Zhentao Sun, Shifeng He, Wanyue Zhang, Sai Chen, Ya-Nan Cao & Ning Wang
Pages: 2346-2359
Published online: 16 Jan 2022
AbstractforMechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release | Full Text | References | PDF (3.4 MB) | EPUB
  • 2107 Views
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Article
E2F transcription factor 1 (E2F1) enhances the proliferation, invasion and EMT of trophoblast cells by binding to Zinc Finger E-Box Binding Homeobox 1 (ZEB1)
Han Gong, Fan Lu, Xiaoling Zeng & Qing Bai
Pages: 2360-2370
Published online: 14 Jan 2022
AbstractforE2F transcription factor 1 (E2F1) enhances the proliferation, invasion and EMT of trophoblast cells by binding to Zinc Finger E-Box Binding Homeobox 1 (ZEB1) | Full Text | References | PDF (4.7 MB) | EPUB
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Article
miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression
Yuan Qi, Yan Tang, Lu Yin, Keke Ding, Cuimei Zhao, Wenwen Yan & Yi’an Yao
Pages: 2371-2386
Published online: 16 Jan 2022
AbstractformiR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression | Full Text | References | PDF (5.1 MB) | EPUB
  • 1170 Views
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Article
Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis
Xinxing Duan, Xiong Yu & Zhengrong Li
Pages: 2387-2397
Published online: 14 Jan 2022
AbstractforCircular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis | Full Text | References | PDF (2.9 MB) | EPUB
  • 1754 Views
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Article
CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis
Lanfang Fu, Juyun Zhang, Zhu Lin, Yi Li & Guijun Qin
Pages: 2398-2411
Published online: 16 Jan 2022
AbstractforCircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis | Full Text | References | PDF (3.3 MB) | EPUB
  • 1798 Views
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Article
ADAM metallopeptidase domain 12 overexpression correlates with prognosis and immune cell infiltration in clear cell renal cell carcinoma
Junjie Gao, Dandan Yang, Haonan Xu, Kunpeng Yang, Jia Ma, Jun Xia & Xueshan Pan
Pages: 2412-2429
Published online: 30 Jan 2022
AbstractforADAM metallopeptidase domain 12 overexpression correlates with prognosis and immune cell infiltration in clear cell renal cell carcinoma | Full Text | References | PDF (4.3 MB) | EPUB
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Article
CircCAMSAP1 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis by sponging miR-1182 and regulating BIRC5
Yunfei Wang, Xiaobo Li, Huaqi Wang & Guojun Zhang
Pages: 2428-2439
Published online: 08 Feb 2022
AbstractforCircCAMSAP1 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis by sponging miR-1182 and regulating BIRC5 | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Exosomes derived from calcium oxalate-treated macrophages promote apoptosis of HK-2 cells by promoting autophagy
Lei Yan, Jinhu Chen & Weihua Fang
Pages: 2442-2450
Published online: 17 Jan 2022
AbstractforExosomes derived from calcium oxalate-treated macrophages promote apoptosis of HK-2 cells by promoting autophagy | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Insulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy
Cuifeng Xia, Qiang Li, Xianshuo Cheng, Tao Wu, Pin Gao & Yongfang Gu
Pages: 2450-2469
Published online: 11 Jan 2022
AbstractforInsulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy | Full Text | References | PDF (6.5 MB) | EPUB
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Article
BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis
Xiaolei Zhou, Yanli Yuan, Hongping Kuang, Bingxiang Tang, Hui Zhang & Manlin Zhang
Pages: 2471-2485
Published online: 22 Jan 2022
AbstractforBUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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Article
Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium
Rui Zhang, Xi Chen, Wenjie Zuo, Zhenjun Ji, Yangyang Qu, Yamin Su, Mingming Yang, Pengfei Zuo, Genshan Ma & Yongjun Li
Pages: 2486-2497
Published online: 17 Jan 2022
AbstractforInflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1955 Views
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Article
Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients
Songtao Du, Furong Zeng, Huiyan Sun, Yanlong Liu, Peng Han, Bomiao Zhang, Weinan Xue, Guangtong Deng, Mingzhu Yin & Binbin Cui
Pages: 2498-2512
Published online: 22 Jan 2022
AbstractforPrognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
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Article
Inhibition of Candida albicans in vivo and in vitro by antimicrobial peptides chromogranin A-N12 through microRNA-155/suppressor of cytokine signaling 1 axis
Xiaohua Li, Qun Hu, Qiong Lin, Jianxiong Luo, Junping Xu, Lifang Chen, Liyu Xu & Xin Lin
Pages: 2513-2524
Published online: 16 Jan 2022
AbstractforInhibition of Candida albicans in vivo and in vitro by antimicrobial peptides chromogranin A-N12 through microRNA-155/suppressor of cytokine signaling 1 axis | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Transcriptional activation of Proteasome 26S non-ATPase subunit 7 by forkhead box P3 participates in gastric cancer cell proliferation and apoptosis
Yujie Xu, Dingmao Wang & Guodong Zhao
Pages: 2525-2536
Published online: 17 Jan 2022
AbstractforTranscriptional activation of Proteasome 26S non-ATPase subunit 7 by forkhead box P3 participates in gastric cancer cell proliferation and apoptosis | Full Text | References | PDF (2.3 MB) | EPUB
  • 868 Views
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Article
Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer
Xiaomin Ren, Liyuan Zhang, Xiaolin Ma, Jiaqiu Li & Zhong Lu
Pages: 2536-2552
Published online: 10 Jan 2022
AbstractforIntegrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1913 Views
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Article
LncRNA LINC00525 activates HIF-1α through miR-338-3p / UBE2Q1 / β-catenin axis to regulate the Warburg effect in colorectal cancer
Fanqi Meng, Xiaofan Luo, Chenyao Li & Guangyi Wang
Pages: 2552-2565
Published online: 13 Feb 2022
AbstractforLncRNA LINC00525 activates HIF-1α through miR-338-3p / UBE2Q1 / β-catenin axis to regulate the Warburg effect in colorectal cancer | Full Text | References | PDF (3.1 MB) | EPUB
  • 1191 Views
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Article
The LOXL1 antisense RNA 1 (LOXL1-AS1)/microRNA-423-5p (miR-423-5p)/ectodermal-neural cortex 1 (ENC1) axis promotes cervical cancer through the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway
Ping Zhang, Fang Zhao, Ke Jia & Xiaoli Liu
Pages: 2567-2584
Published online: 11 Jan 2022
AbstractforThe LOXL1 antisense RNA 1 (LOXL1-AS1)/microRNA-423-5p (miR-423-5p)/ectodermal-neural cortex 1 (ENC1) axis promotes cervical cancer through the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway | Full Text | References | PDF (5.8 MB) | EPUB
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Article
Effects of wogonin on the growth and metastasis of colon cancer through the Hippo signaling pathway
Wenli You, Aiting Di, Lize Zhang & Gang Zhao
Pages: 2586-2597
Published online: 17 Jan 2022
AbstractforEffects of wogonin on the growth and metastasis of colon cancer through the Hippo signaling pathway | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells
Xueyao Zhang & Yingxian Sun
Pages: 2597-2609
Published online: 09 Jan 2022
AbstractforChromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells | Full Text | References | PDF (4.2 MB) | EPUB
  • 1195 Views
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Article
Circular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway
Kang Shujuan, Li Zhongxin, Ma Jingfang, Cui Zhili, Wei Wei, Qian Liu & Yan Li
Pages: 2611-2622
Published online: 03 Feb 2022
AbstractforCircular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway | Full Text | References | PDF (2.5 MB) | EPUB
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Review

Review
Noncoding RNAs and hyperthermic intraperitoneal chemotherapy in advanced gastric cancer
Lisi Zeng, Quanxing Liao, Xiaohui Zeng, Jiacai Ye, Xianzi Yang, Siyu Zhu, Hongsheng Tang, Gaojie Liu, Weiwen Cui, Shaohua Ma & Shuzhong Cui
Pages: 2623-2638
Published online: 28 Jan 2022
AbstractforNoncoding RNAs and hyperthermic intraperitoneal chemotherapy in advanced gastric cancer | Full Text | References | PDF (1 MB) | EPUB
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Research Paper

Article
FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway
Licheng Ding & Jie Li
Pages: 2639-2647
Published online: 18 Jan 2022
AbstractforFXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Abnormal expression of long non-coding RNA rhabdomyosarcoma 2-associated transcript (RMST) participates in the pathological mechanism of atherosclerosis by regulating miR-224-3p
Tao Zhang, Cuina Feng, Xiang Zhang, Bin Sun & Ying Bian
Pages: 2648-2657
Published online: 22 Jan 2022
AbstractforAbnormal expression of long non-coding RNA rhabdomyosarcoma 2-associated transcript (RMST) participates in the pathological mechanism of atherosclerosis by regulating miR-224-3p | Full Text | References | PDF (730.5 KB) | EPUB
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Article
Calcipotriol attenuates liver fibrosis through the inhibition of vitamin D receptor-mediated NF-κB signaling pathway
Jian Gong, HuanYu Gong, Yang Liu, XinLan Tao & Hao Zhang
Pages: 2658-2672
Published online: 19 Jan 2022
AbstractforCalcipotriol attenuates liver fibrosis through the inhibition of vitamin D receptor-mediated NF-κB signaling pathway | Full Text | References | PDF (2.4 MB) | EPUB
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Article
MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang & Yingcai Hong
Pages: 2673-2685
Published online: 19 Jan 2022
AbstractforMicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3 | Full Text | References | PDF (3.2 MB) | EPUB
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Article
3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation
Bo Yang, Shihao Hou, Jingjing Zhao & Yepeng Li
Pages: 2685-2695
Published online: 09 Jan 2022
Abstractfor3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Protective effects of Dapagliflozin on the vulnerability of ventricular arrhythmia in rats with pulmonary artery hypertension induced by monocrotaline
Tianyou Qin, Bin Kong, Chang Dai, Zheng Xiao, Jin Fang, Wei Shuai & He Huang
Pages: 2697-2709
Published online: 18 Jan 2022
AbstractforProtective effects of Dapagliflozin on the vulnerability of ventricular arrhythmia in rats with pulmonary artery hypertension induced by monocrotaline | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Perillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines
Zhuoyuan Lin, Sheng Huang, Xitao LingHu, Yixiao Wang, Bin Wang, Shaowen Zhong, Shangyan Xie, Xiaohong Xu, Aorigele Yu, Atsushi Nagai, Yuta Kobayashi, Qingde Wa & Shuai Huang
Pages: 2710-2719
Published online: 26 Jan 2022
AbstractforPerillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition
Zhenkui Zuo, Lulu He, Xiaoyu Duan, Zining Peng & Jiarui Han
Pages: 2720-2731
Published online: 26 Jan 2022
AbstractforGlycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy
Weizhong Ma, Xing Liang & Zhuowei Su
Pages: 2732-2745
Published online: 22 Jan 2022
AbstractforEffects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy | Full Text | References | PDF (2.3 MB) | EPUB
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Article
LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation
Longlong Du, Xuefeng Li, Qimeng Gao, Puwei Yuan, Yindi Sun, Yingpu Chen, Bo Huang, Yu Deng & Baohui Wang
Pages: 2746-2762
Published online: 30 Jan 2022
AbstractforLncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer
Shaoran Song, Jie Liu, Miao Zhang, Xiaoqian Gao, Wei Sun, Peijun Liu, Yaochun Wang & Juan Li
Pages: 2762-2776
Published online: 18 Jan 2022
AbstractforEukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration
Haibo Ruan, Zhenzhen Dai, Jinyu Yan, Xiaoxi Long, Yi Chen, Youlin Yang, Qian Yang, Jun Zhu, Meiyun Zheng & Xiahui Zhang
Pages: 2777-2790
Published online: 17 Jan 2022
AbstractforZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis
Geng Li, Wenxia Zong, Lei Liu, Juan Wu & Jing Pang
Pages: 2791-2802
Published online: 18 Jan 2022
AbstractforKnockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression
Mingyi Li, Chenxia Li, Huarong Zheng, Zhen Zhou, Wenjian Yang, Yu Gong, Xia Wu & Leyu Li
Pages: 2803-2815
Published online: 18 Jan 2022
AbstractforCircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Calcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury
Zhijuan Xie, Lanji Wei, Jianying Chen & Zhong Chen
Pages: 2816-2826
Published online: 18 Jan 2022
AbstractforCalcium dobesilate alleviates renal dysfunction and inflammation by targeting nuclear factor kappa B (NF-κB) signaling in sepsis-associated acute kidney injury | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement
Hengchi Chen, Fang Li & Qi Xue
Pages: 2826-2838
Published online: 22 Jan 2022
AbstractforCirc-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Protective effect of liquiritin on coronary heart disease through regulating the proliferation of human vascular smooth muscle cells via upregulation of sirtuin1
Liang Yuan, Dajie Wang & Chunyang Wu
Pages: 2840-2850
Published online: 18 Jan 2022
AbstractforProtective effect of liquiritin on coronary heart disease through regulating the proliferation of human vascular smooth muscle cells via upregulation of sirtuin1 | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
Novel protein kinase C phosphorylated kinase inhibitor-matrine suppresses replication of hepatitis B virus via modulating the mitogen-activated protein kinase signal
Shen Zhou, Yuan Li, Jing Gao, Yanyan Wang, Xinping Ma, Hui Ding, Xiuling Li & Suofeng Sun
Pages: 2851-2865
Published online: 17 Jan 2022
AbstractforNovel protein kinase C phosphorylated kinase inhibitor-matrine suppresses replication of hepatitis B virus via modulating the mitogen-activated protein kinase signal | Full Text | References | PDF (3.5 MB) | EPUB
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Article
4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress
Jing Chen, Hongbo Wu, Xudong Tang & Lei Chen
Pages: 2866-2877
Published online: 19 Jan 2022
Abstractfor4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress | Full Text | References | PDF (2.8 MB) | EPUB
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Article
GATA binding protein 5 (GATA5) induces Rho GTPase activating protein 9 (ARHGAP9) to inhibit the malignant process of lung adenocarcinoma cells
Wenfei Ji, Lili Zhang & Hongjun Zhu
Pages: 2878-2888
Published online: 18 Jan 2022
AbstractforGATA binding protein 5 (GATA5) induces Rho GTPase activating protein 9 (ARHGAP9) to inhibit the malignant process of lung adenocarcinoma cells | Full Text | References | PDF (4.1 MB) | EPUB
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Article
lncRNA TMPO antisense RNA 1 promotes the malignancy of cholangiocarcinoma cells by regulating let-7g-5p/ high-mobility group A1 axis
Hongbin Chang & Yixin Yao
Pages: 2889-2901
Published online: 18 Jan 2022
AbstractforlncRNA TMPO antisense RNA 1 promotes the malignancy of cholangiocarcinoma cells by regulating let-7g-5p/ high-mobility group A1 axis | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial–mesenchymal transition in gastric cancer
Xiaobo He, Xiao Cheng, Jianfeng Ding, Maoming Xiong, Bo Chen & Guodong Cao
Pages: 2902-2917
Published online: 30 Jan 2022
AbstractforHyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial–mesenchymal transition in gastric cancer | Full Text | References | PDF (4.7 MB) | EPUB
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Article
Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages
Feng Gao, Yongcheng Zhao, Bin Zhang, Chunwei Xiao, Zhanfa Sun, Yuan Gao & Xueyong Dou
Pages: 2917-2926
Published online: 19 Jan 2022
AbstractforForkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages | Full Text | References | PDF (2.9 MB) | EPUB
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Article
MicroRNA-665-3p exacerbates nonalcoholic fatty liver disease in mice
Yuanjie Yu, Tian Tian, Shiyun Tan, Pengbo Wu, Yitian Guo, Ming Li & Mengjun Huang
Pages: 2927-2942
Published online: 18 Jan 2022
AbstractforMicroRNA-665-3p exacerbates nonalcoholic fatty liver disease in mice | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Article
Effects of I125 seed stent implantation combined with arterial infusion chemoembolization on tumor markers, p53 expression, and prognosis in patients with cholangiocarcinoma
Zhe Xu, Minglin Xu, Meng Li, Zhe Cui, Haisheng Bai, Heqing Shang, Jianyu Zhao, Lei Wu & Fan Zhang
Pages: 2943-2950
Published online: 17 Jan 2022
AbstractforEffects of I125 seed stent implantation combined with arterial infusion chemoembolization on tumor markers, p53 expression, and prognosis in patients with cholangiocarcinoma | Full Text | References | PDF (378.6 KB) | EPUB
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Article
Combination therapy of Ulinastatin with Thrombomodulin alleviates endotoxin (LPS) - induced liver and kidney injury via inhibiting apoptosis, oxidative stress and HMGB1/TLR4/NF-κB pathway
Xiong Zhang, Chenlin Su, Shuxin Zhao, Ji Li & Feng Yu
Pages: 2951-2970
Published online: 11 Feb 2022
AbstractforCombination therapy of Ulinastatin with Thrombomodulin alleviates endotoxin (LPS) - induced liver and kidney injury via inhibiting apoptosis, oxidative stress and HMGB1/TLR4/NF-κB pathway | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3
Lijun Zhong, Lin Tang & Xiaoxia He
Pages: 2971-2980
Published online: 18 Jan 2022
AbstractforAngiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3 | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Log (Lactobacillus crispatus/ Gardnerella vaginalis): a new indicator of diagnosing bacterial vaginosis
Tongyang Deng, Anquan Shang, Ying Zheng, Lianzhen Zhang, Hong Sun & Wei Wang
Pages: 2981-2991
Published online: 18 Jan 2022
AbstractforLog (Lactobacillus crispatus/ Gardnerella vaginalis): a new indicator of diagnosing bacterial vaginosis | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways
Jun Zhao, Boyu Pan, Xinglu Zhou, Chunnuan Wu, Fengcheng Hao, Jie Zhang & Liren Liu
Pages: 2992-3006
Published online: 07 Feb 2022
AbstractforPolygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
Long intergenic non-protein coding RNA 662 accelerates the progression of gastric cancer through up-regulating centrosomal protein 55 by sponging microRNA-195-5p
Fei Tao, Likun Qi & Guoqing Liu
Pages: 3007-3018
Published online: 17 Jan 2022
AbstractforLong intergenic non-protein coding RNA 662 accelerates the progression of gastric cancer through up-regulating centrosomal protein 55 by sponging microRNA-195-5p | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia
Fan Lu, Han Gong, Houkang Lei & Juan Li
Pages: 3019-3028
Published online: 17 Jan 2022
AbstractforDownregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5
Xue Li, Ting Bi & Shuo Yang
Pages: 3029-3042
Published online: 13 Feb 2022
AbstractforExosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5 | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Review

Review
miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2)
Yanhong Tu & Fan Mei
Pages: 3044-3056
Published online: 17 Jan 2022
AbstractformiR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2) | Full Text | References | PDF (3.4 MB) | EPUB
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Research Paper

Article
Foxhead box D1 promotes the partial epithelial-to-mesenchymal transition of laryngeal squamous cell carcinoma cells via transcriptionally activating the expression of zinc finger protein 532
Liang Fan, Jinxiu Wang, Pingping Deng, Yuanyuan Wang, Aiping Zhang, Mengsheng Yang & Gang Zeng
Pages: 3057-3069
Published online: 03 Feb 2022
AbstractforFoxhead box D1 promotes the partial epithelial-to-mesenchymal transition of laryngeal squamous cell carcinoma cells via transcriptionally activating the expression of zinc finger protein 532 | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
High hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway
Zongting Shi, Jun He, Jian He & Yuan Xu
Pages: 3070-3081
Published online: 31 Jan 2022
AbstractforHigh hydrostatic pressure (30 atm) enhances the apoptosis and inhibits the proteoglycan synthesis and extracellular matrix level of human nucleus pulposus cells via promoting the Wnt/β-catenin pathway | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1111 Views
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Article
Circular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway
Ling Jin, Yuan Zhang, Yun Jiang, Mingjuan Tan & Caidong Liu
Pages: 3082-3092
Published online: 22 Jan 2022
AbstractforCircular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway | Full Text | References | PDF (3 MB) | EPUB
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Article
N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1
Zedong Hu, Liang Zhu, Yilin Zhang & Bing Chen
Pages: 3093-3107
Published online: 22 Jan 2022
AbstractforN6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1 | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
Long intergenic non-protein coding RNA 1273 confers sorafenib resistance in hepatocellular carcinoma via regulation of methyltransferase 3
Huifang Kong, Jie Sun, Wei Zhang, Huixin Zhang & Hong Li
Pages: 3108-3121
Published online: 17 Jan 2022
AbstractforLong intergenic non-protein coding RNA 1273 confers sorafenib resistance in hepatocellular carcinoma via regulation of methyltransferase 3 | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 1894 Views
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Article
BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression
Zhibing Lu, Hui Peng, Ruijuan Li, Xinyan Xu & Jiyong Peng
Pages: 3122-3136
Published online: 17 Jan 2022
AbstractforBarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression | Full Text | References | PDF (6 MB) | EPUB
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Article
SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network
Yuebin Wang, Huike Yang, Xian Su, Anqiang Cao, Feng Chen, Peng Chen, Fangtao Yan & Huirong Hu
Pages: 3137-3147
Published online: 17 Jan 2022
AbstractforSREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Utilizing network pharmacology and experimental validation to explore the potential molecular mechanisms of BanXia-YiYiRen in treating insomnia
Liang Wang, Peng Wang, Yingfan Chen, Chen Li, Xuelin Wang, Yin Zhang, Shaodan Li & Minghui Yang
Pages: 3148-3170
Published online: 22 Jan 2022
AbstractforUtilizing network pharmacology and experimental validation to explore the potential molecular mechanisms of BanXia-YiYiRen in treating insomnia | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Tandem mass tag-based serum proteomic profiling revealed diabetic foot ulcer pathogenesis and potential therapeutic targets
Xiao-Ting Yu, Feng Wang, Jia-Tong Ding, Bo Cai, Juan-Juan Xing, Guang-Hua Guo & Fei Guo
Pages: 3171-3182
Published online: 22 Jan 2022
AbstractforTandem mass tag-based serum proteomic profiling revealed diabetic foot ulcer pathogenesis and potential therapeutic targets | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Calcium-activated nucleotides 1 (CANT1)-driven nuclear factor-k-gene binding (NF-ĸB) signaling pathway facilitates the lung cancer progression
Fangfang Gao, Xiufeng Hu, Wenjing Liu, Hongbo Wu, Yu Mu & Yanqiu Zhao
Pages: 3183-3193
Published online: 22 Jan 2022
AbstractforCalcium-activated nucleotides 1 (CANT1)-driven nuclear factor-k-gene binding (NF-ĸB) signaling pathway facilitates the lung cancer progression | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Bone marrow mesenchymal stem cells-derived exosomal microRNA-124-3p attenuates hypoxic-ischemic brain damage through depressing tumor necrosis factor receptor associated factor 6 in newborn rats
Weijie Min, Yina Wu, Yibin Fang, Bo Hong, Dongwei Dai, Yu Zhou, Jianmin Liu & Qiang Li
Pages: 3195-3207
Published online: 22 Jan 2022
AbstractforBone marrow mesenchymal stem cells-derived exosomal microRNA-124-3p attenuates hypoxic-ischemic brain damage through depressing tumor necrosis factor receptor associated factor 6 in newborn rats | Full Text | References | PDF (7.1 MB) | EPUB | Supplemental
  • 2013 Views
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Article
Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation
Hao Yang, Huairong Zhang, Zhuomiaoyu Chen, Yuan Wang & Bo Gao
Pages: 3207-3220
Published online: 19 Jan 2022
AbstractforEffects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers
Ping Zeng, Xujun Zhang, Tianxin Xiang, Zongxin Ling, Chenhong Lin & Hongyan Diao
Pages: 3221-3239
Published online: 22 Jan 2022
AbstractforSecreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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Article
Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis
Zhiqin Ye, Lu Wei, Xietian Yin, Huiling Li, Guifu Qin, Siqi Li, Tingting Peng, Bo Liu, Shichao Zhao & Qin Zhuo
Pages: 3240-3250
Published online: 19 Jan 2022
AbstractforLong non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Protective effect of glucagon-like peptide-1 mediated by ultrasound microbubbles on myocardial injury in rats with diabetic cardiomyopathy
Yanjie Liu, Li Chen, Hao Wu & Hebin Zhang
Pages: 3251-3261
Published online: 22 Jan 2022
AbstractforProtective effect of glucagon-like peptide-1 mediated by ultrasound microbubbles on myocardial injury in rats with diabetic cardiomyopathy | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Optimization of endothelial growth factor receptor monoclonal antibody-gold nanorods photothermal therapy for laryngeal squamous cell carcinoma
Yun Hai, Hao Wang, Youyu Qiu, Renchao Huang, Liufang Zhao, Hongyang Xu, Zichen Dong, Lu Zhang, Weidi Sun & Shiwen Zhang
Pages: 3262-3274
Published online: 22 Jan 2022
AbstractforOptimization of endothelial growth factor receptor monoclonal antibody-gold nanorods photothermal therapy for laryngeal squamous cell carcinoma | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Expression and Significance of N-myc downstream regulated gene 2 in the process of Esophageal Squamous Cell Carcinogenesis
Rui-Bing Feng, Qiao-Zhi Zhou, Rui Cheng, Peng Li, Sheng-Tao Zhu, Li Min & Shu-Tian Zhang
Pages: 3275-3283
Published online: 20 Jan 2022
AbstractforExpression and Significance of N-myc downstream regulated gene 2 in the process of Esophageal Squamous Cell Carcinogenesis | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Evaluation and modeling of fungi towards wood degradation
Weichen Ran, Junhong Lian & Jiaqi Zhang
Pages: 3284-3299
Published online: 31 Jan 2022
AbstractforEvaluation and modeling of fungi towards wood degradation | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Specificity protein 1-induced serine peptidase inhibitor, Kunitz Type 1 antisense RNA1 regulates colorectal cancer cell proliferation, migration, invasion and apoptosis through targeting heparin binding growth factor via sponging microRNA-214
Ying Fang & Qianqian Yang
Pages: 3309-3322
Published online: 22 Jan 2022
AbstractforSpecificity protein 1-induced serine peptidase inhibitor, Kunitz Type 1 antisense RNA1 regulates colorectal cancer cell proliferation, migration, invasion and apoptosis through targeting heparin binding growth factor via sponging microRNA-214 | Full Text | References | PDF (5.1 MB) | EPUB
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Article
The miR-133b/brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) axis represses proliferation, invasion, and migration in cervical cancer cells
Lingling Jiang & Xuexin Wang
Pages: 3323-3332
Published online: 20 Jan 2022
AbstractforThe miR-133b/brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) axis represses proliferation, invasion, and migration in cervical cancer cells | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Human Plasma Metabolomics Identify 9-cis-retinoic Acid and Dehydrophytosphingosine Levels as Novel biomarkers for Early Ventricular Fibrillation after ST-elevated Myocardial Infarction
Jieying Luo, Junaid Ahmed Shaikh, Lei Huang, Lei Zhang, Shahid Iqbal, Yu Wang, Bojiang Liu, Quan Zhou, Aisha Ajmal, Maryam Rizvi, Maryam Ajmal & Yingwu Liu
Pages: 3334-3350
Published online: 30 Jan 2022
AbstractforHuman Plasma Metabolomics Identify 9-cis-retinoic Acid and Dehydrophytosphingosine Levels as Novel biomarkers for Early Ventricular Fibrillation after ST-elevated Myocardial Infarction | Full Text | References | PDF (2.1 MB) | EPUB
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Apigenin analogues as SARS-CoV-2 main protease inhibitors: In-silico screening approach
Ameny Farhat, Hajer Ben Hlima, Bassem Khemakhem, Youssef Ben Halima, Philippe Michaud, Slim Abdelkafi & Imen Fendri
Pages: 3350-3361
Published online: 20 Jan 2022
AbstractforApigenin analogues as SARS-CoV-2 main protease inhibitors: In-silico screening approach | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis
Yu Cai & Yuanyuan Jia
Pages: 3362-3370
Published online: 20 Jan 2022
AbstractforCircular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p
Yin Zhang, Yaxuan Zhang, Sen Wang, Boqiang Cao, Daling Hu, Junli Jia, Yuhang Wang, Luyao Chen, Jiaming Li, Huamin Tang & Hongyi Liu
Pages: 3370-3382
Published online: 13 Feb 2022
AbstractforLINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis
Yonghong Wu, Yan Liang, Min Li & Haidong Zhang
Pages: 3384-3394
Published online: 22 Jan 2022
AbstractforKnockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-κB signaling
Zhao Zhu, Guoxiu Zhang, Dahuan Li, Xiaojun Yin & Tianzhong Wang
Pages: 3395-3409
Published online: 20 Jan 2022
AbstractforSilencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-κB signaling | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis
Bai Jing & Zhou Hui
Pages: 3410-3421
Published online: 26 Jan 2022
AbstractforCircular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Long non-coding RNA terminal differentiation-induced non-coding RNA regulates cisplatin resistance of choroidal melanoma by positively modulating extracellular signal-regulated kinase 2 via sponging microRNA-19b-3p
Wei Li, Aiqin Nie, Longyu Jin, Yubo Cui, Ning Xie & Gaohua Liang
Pages: 3422-3433
Published online: 22 Jan 2022
AbstractforLong non-coding RNA terminal differentiation-induced non-coding RNA regulates cisplatin resistance of choroidal melanoma by positively modulating extracellular signal-regulated kinase 2 via sponging microRNA-19b-3p | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Knockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage
Rile Wu, Qiang Yun, Jianping Zhang, Zhong Wang, Xiaojun Zhang & Jingang Bao
Pages: 3434-3449
Published online: 22 Jan 2022
AbstractforKnockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro
Xinwei Liu, Dulei Xiang, Wenming Jin, Gen Zhao, Han Li, Bing Xie & Xiaochuan Gu
Pages: 3450-3461
Published online: 30 Jan 2022
AbstractforTimosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
The effect and mechanisms of melatonin on the proliferation and apoptosis of lung cancer cells
Hui Liu, Fang Wang, Jun Zhao, Xiaoling Zhang, Zhen Zeng, Shasha Wang, Jingzhi Guan & Haifeng Qin
Pages: 3462-3469
Published online: 22 Jan 2022
AbstractforThe effect and mechanisms of melatonin on the proliferation and apoptosis of lung cancer cells | Full Text | References | PDF (1 MB) | EPUB
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Article
2-Methoxyestradiol combined with ascorbic acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/phosphatidylinositol-3 kinase/protein kinase B axis
Suwei Zhang, Hanhui Yu, Jiazhen Li, Jingru Fan & Jingchao Chen
Pages: 3470-3485
Published online: 22 Jan 2022
Abstractfor2-Methoxyestradiol combined with ascorbic acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/phosphatidylinositol-3 kinase/protein kinase B axis | Full Text | References | PDF (4 MB) | EPUB
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Article
Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells
Jie Xiang, Chunling Zhang, Tietao Di, Lu Chen, Wei Zhao, Lianggang Wei, Shiyong Zhou, Xueli Wu, Gengxin Wang & Yun Zhang
Pages: 3486-3502
Published online: 22 Jan 2022
AbstractforSalvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells | Full Text | References | PDF (7.6 MB) | EPUB
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Article
Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p
Fei Liu, Tao Li & Xiaoan Zhan
Pages: 3503-3515
Published online: 22 Jan 2022
AbstractforSilencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p | Full Text | References | PDF (2.1 MB) | EPUB
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RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension
Sheng Hu, Youguang Zhao, Chenming Qiu & Ying Li
Pages: 3516-3526
Published online: 30 Jan 2022
AbstractforRAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
Knockdown of nuclear receptor binding SET domain-containing protein 1 (NSD1) inhibits proliferation and facilitates apoptosis in paclitaxel-resistant breast cancer cells via inactivating the Wnt/β-catenin signaling pathway
Yi Chen, Xiao Li, Jin Xu, Hua Xiao, Cuiju Tang, Wei Liang, Xuedan Zhu, Yueyu Fang, Hanjin Wang & Junfeng Shi
Pages: 3526-3536
Published online: 24 Feb 2022
AbstractforKnockdown of nuclear receptor binding SET domain-containing protein 1 (NSD1) inhibits proliferation and facilitates apoptosis in paclitaxel-resistant breast cancer cells via inactivating the Wnt/β-catenin signaling pathway | Full Text | References | PDF (2 MB) | EPUB
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Regulatory Mechanism of MicroRNA-9 / Long Non-Coding RNA XIST Expression on Mouse Macrophage RAW264.7 Apoptosis Induced by Oxidized Low Density Lipoprotein
Xiaoling Zhang, Si Wang, Yuyan Cai, Weihong He, Qing Yang & Chen Li
Pages: 3537-3550
Published online: 02 Feb 2022
AbstractforRegulatory Mechanism of MicroRNA-9 / Long Non-Coding RNA XIST Expression on Mouse Macrophage RAW264.7 Apoptosis Induced by Oxidized Low Density Lipoprotein | Full Text | References | PDF (1.3 MB) | EPUB
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Article
In vivo biocompatibility analysis of the recellularized canine tracheal scaffolds with canine epithelial and endothelial progenitor cells
Gustavo de Sá Schiavo Matias, Ana Claudia O. Carreira, Vitória Frias Batista, Hianka Jasmyne Costa de Carvalho, Maria Angelica Miglino & Paula Fratini
Pages: 3551-3565
Published online: 02 Feb 2022
AbstractforIn vivo biocompatibility analysis of the recellularized canine tracheal scaffolds with canine epithelial and endothelial progenitor cells | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Article
Endothelial progenitor cells-derived exosomes transfer microRNA-30e-5p to regulate Erastin-induced ferroptosis in human umbilical vein endothelial cells via the specificity protein 1/adenosine monophosphate-activated protein kinase axis
Jia Xia, Xiaoying Song, Jing Meng & Danfei Lou
Pages: 3566-3580
Published online: 22 Jan 2022
AbstractforEndothelial progenitor cells-derived exosomes transfer microRNA-30e-5p to regulate Erastin-induced ferroptosis in human umbilical vein endothelial cells via the specificity protein 1/adenosine monophosphate-activated protein kinase axis | Full Text | References | PDF (3 MB) | EPUB
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Differential expression analysis of microRNAs and mRNAs in the mouse hippocampus of post-stroke depression (PSD) based on transcriptome sequencing
Fan Qinlin, Xie Qi, Chen Qiong, Xie Lexing, Shi Peixia, Hu Linlin, Diao Yupu, Yang Lijun & Yang Qingwu
Pages: 3582-3596
Published online: 31 Jan 2022
AbstractforDifferential expression analysis of microRNAs and mRNAs in the mouse hippocampus of post-stroke depression (PSD) based on transcriptome sequencing | Full Text | References | PDF (2.6 MB) | EPUB
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Mitophagy alleviates ischemia/reperfusion-induced microvascular damage through improving mitochondrial quality control
Dan Wu, Haizhe Ji, Wenjuan Du, Lina Ren & Geng Qian
Pages: 3596-3607
Published online: 03 Feb 2022
AbstractforMitophagy alleviates ischemia/reperfusion-induced microvascular damage through improving mitochondrial quality control | Full Text | References | PDF (4.1 MB) | EPUB
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Upstream stimulatory factor 2 (USF2) induced upregulation of triggering receptor expressed on myeloid cells 1 (TREM1) promotes endometritis by regulating toll-like receptor (TLR) 2/4-nuclear factor-kappaB (NF-κB) signaling pathway
Miao Zhang, Chengkun Yin, Yan Chen, Juan Wang & Jing Jiang
Pages: 3609-3619
Published online: 31 Jan 2022
AbstractforUpstream stimulatory factor 2 (USF2) induced upregulation of triggering receptor expressed on myeloid cells 1 (TREM1) promotes endometritis by regulating toll-like receptor (TLR) 2/4-nuclear factor-kappaB (NF-κB) signaling pathway | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells
GuoQing Chen, Lu Chen, Yan Huang, XiongShan Zhu & YuanLan Yu
Pages: 3620-3633
Published online: 30 Jan 2022
AbstractforIncreased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells | Full Text | References | PDF (3.1 MB) | EPUB
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CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC)
Yongfu Wang, Yuanlin Wu & Shaoqiang Xie
Pages: 3651-3664
Published online: 01 Mar 2022
AbstractforCircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC) | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Long non-coding RNA (lncRNA) CYTOR promotes hepatocellular carcinoma proliferation by targeting the microRNA-125a-5p/LASP1 axis
Yadong Liu & Xiaoling Geng
Pages: 3666-3679
Published online: 26 Jan 2022
AbstractforLong non-coding RNA (lncRNA) CYTOR promotes hepatocellular carcinoma proliferation by targeting the microRNA-125a-5p/LASP1 axis | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability
Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia & Yiming Qian
Pages: 3680-3693
Published online: 26 Jan 2022
AbstractforThe protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Krüppel-like transcription factor 16 transcriptional up-regulation of cellular retinoic acid-binding proteins-2 promotes the invasion and migration and inhibits apoptosis of retinoblastoma cells by regulating integrin-β1/focal adhesion kinase /extracellular signal-regulated kinase pathway
Lu Ye, Ru Liu, Ping Lin & Wenjun Wang
Pages: 3694-3706
Published online: 27 Jan 2022
AbstractforKrüppel-like transcription factor 16 transcriptional up-regulation of cellular retinoic acid-binding proteins-2 promotes the invasion and migration and inhibits apoptosis of retinoblastoma cells by regulating integrin-β1/focal adhesion kinase /extracellular signal-regulated kinase pathway | Full Text | References | PDF (5 MB) | EPUB
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Article
Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis
Jun Fang, Gaohui Jiang, Weiguo Mao, Lili Huang, Chen Huang, Shanshan Wang, Huimin Xue, Jing Ke & Qichao Ni
Pages: 3707-3723
Published online: 30 Jan 2022
AbstractforUp-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis | Full Text | References | PDF (4.8 MB) | EPUB
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Article
Aging affects the biological activity of fibroblast growth factor (FGF) in gastric epithelial cell, which is partially rescued by uridine
Xiaomei Zhang, Huifeng Zhang, Jingli Gong, Huan Yu, Di Wu, Junyu Hou, Minghui Li & Xin Sun
Pages: 3724-3738
Published online: 01 Feb 2022
AbstractforAging affects the biological activity of fibroblast growth factor (FGF) in gastric epithelial cell, which is partially rescued by uridine | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer
Xuemei Liu, Zhiping Yin, Yanjun Wu, Qian Zhan, Honghong Huang & Jiangtao Fan
Pages: 3739-3750
Published online: 26 Jan 2022
AbstractforCircular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer | Full Text | References | PDF (2.6 MB) | EPUB
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Article
The activity level of follicular helper T cells in the peripheral blood of osteosarcoma patients is associated with poor prognosis
Jianshu Lu, Xiuqin Kang, Zhitao Wang, Gang Zhao & Baoen Jiang
Pages: 3751-3759
Published online: 26 Jan 2022
AbstractforThe activity level of follicular helper T cells in the peripheral blood of osteosarcoma patients is associated with poor prognosis | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer
Xizhong Sui, Zongzhi Liu, Lei Niu, Bo Yin & Chengyu Huo
Pages: 3760-3774
Published online: 26 Jan 2022
AbstractforHsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer | Full Text | References | PDF (4.9 MB) | EPUB
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Article
Linagliptin ameliorated interleukin-29-induced reduction of extracellular matrix genes through the nuclear factor erythroid 2-related factor 2 (Nrf2)/sry-type high-mobility-group box (SOX)-9 axis in an in vitro study on C-28/I2 chondrocytes
Ying Li, Peng Zhan, Qiang Wang, Minghua Zhang, Shiming Huang & Dongfeng Chen
Pages: 3775-3784
Published online: 26 Jan 2022
AbstractforLinagliptin ameliorated interleukin-29-induced reduction of extracellular matrix genes through the nuclear factor erythroid 2-related factor 2 (Nrf2)/sry-type high-mobility-group box (SOX)-9 axis in an in vitro study on C-28/I2 chondrocytes | Full Text | References | PDF (1.8 MB) | EPUB
  • 1142 Views
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Article
Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2
Yu Zheng, Ziyi Guo & Ying Li
Pages: 3785-3796
Published online: 26 Jan 2022
AbstractforLong non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2 | Full Text | References | PDF (3.7 MB) | EPUB
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Review

Review
COVID-19 in Southeast Asia: current status and perspectives
Dinh-Toi Chu, Suong-Mai Vu Ngoc, Hue Vu Thi, Yen-Vy Nguyen Thi, Thuy-Tien Ho, Van-Thuan Hoang, Vijai Singh & Jaffar A. Al-Tawfiq
Pages: 3797-3809
Published online: 26 Jan 2022
AbstractforCOVID-19 in Southeast Asia: current status and perspectives | Full Text | References | PDF (879.4 KB) | EPUB
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Research Paper

Article
MicroRNA-656-3p inhibits colorectal cancer cell migration, invasion, and chemo-resistance by targeting sphingosine-1-phosphate phosphatase 1
Baoming Zhang, Shanting Gao, Zengtao Bao, Cheng Pan, Qingshui Tian & Qiang Tang
Pages: 3810-3826
Published online: 26 Jan 2022
AbstractforMicroRNA-656-3p inhibits colorectal cancer cell migration, invasion, and chemo-resistance by targeting sphingosine-1-phosphate phosphatase 1 | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Long noncoding RNA H19 suppresses cardiac hypertrophy through the MicroRNA-145-3p/SMAD4 axis
Hao Wang, Xiaoqing Lian, Wei Gao, Jie Gu, Haojie Shi, Yao Ma, Yafei Li, Yi Fan, Qiming Wang & Liansheng Wang
Pages: 3826-3839
Published online: 09 Feb 2022
AbstractforLong noncoding RNA H19 suppresses cardiac hypertrophy through the MicroRNA-145-3p/SMAD4 axis | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Article
Long non-coding RNA ZFAS1 regulates cell proliferation and invasion in cervical cancer via the miR-190a-3p/KLF6 axis
Yuehui Su, Wenjing Hou, Chunyan Zhang, Pengcheng Ji, Rui Hu, Qiongying Zhang, Yao Wang, Panpan Li, Huiping Zhang, Yueyue Chen, Xiaodong Zhang & Mengzhen Zhang
Pages: 3840-3851
Published online: 03 Feb 2022
AbstractforLong non-coding RNA ZFAS1 regulates cell proliferation and invasion in cervical cancer via the miR-190a-3p/KLF6 axis | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
Inhibitory activity of Halobacillus trueperi S61 and its active extracts on potato dry rot
Shuo Shen, Wei Li & Jian Wang
Pages: 3852-3867
Published online: 15 Feb 2022
AbstractforInhibitory activity of Halobacillus trueperi S61 and its active extracts on potato dry rot | Full Text | References | PDF (3.7 MB) | EPUB
  • 653 Views
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Article
Fumitremorgin C alleviates advanced glycation end products (AGE)-induced chondrocyte inflammation and collagen II and aggrecan degradation through sirtuin-1 (SIRT1)/nuclear factor (NF)-κB/ mitogen-activated protein kinase (MAPK)
Yeli Zhou, Jing Li, Chenglong Wang & Zheer Pan
Pages: 3867-3876
Published online: 02 Feb 2022
AbstractforFumitremorgin C alleviates advanced glycation end products (AGE)-induced chondrocyte inflammation and collagen II and aggrecan degradation through sirtuin-1 (SIRT1)/nuclear factor (NF)-κB/ mitogen-activated protein kinase (MAPK) | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Uric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process
Yuan Li, Linru Zhao & Wufang Qi
Pages: 3877-3895
Published online: 13 Feb 2022
AbstractforUric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 1350 Views
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Article
Ultrasound targeted microbubble destruction-mediated SOCS3 attenuates biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells
Xiaojiang Tang, Na Hao, Yuhui Zhou & Yang Liu
Pages: 3896-3910
Published online: 02 Feb 2022
AbstractforUltrasound targeted microbubble destruction-mediated SOCS3 attenuates biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Article
Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease
Yi Song, Feng Guo, Yifan Liu, Fengjuan Huang, Xunjie Fan, Lin Zhao & Guijun Qin
Pages: 3911-3929
Published online: 07 Feb 2022
AbstractforIdentification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Serum miR-96-5p is a novel and non-invasive marker of acute myocardial infarction associated with coronary artery disease
Hui Ding, Wen Chen & Xin Chen
Pages: 3930-3943
Published online: 02 Feb 2022
AbstractforSerum miR-96-5p is a novel and non-invasive marker of acute myocardial infarction associated with coronary artery disease | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy
Jintao Liu, Pengfei Yu, Feng Dai, Hong Jiang & Zhijia Ma
Pages: 3944-3957
Published online: 02 Feb 2022
AbstractforTetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy | Full Text | References | PDF (3 MB) | EPUB
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Article
Effect of α-tocopherol in alleviating the lipopolysaccharide-induced acute lung injury via inhibiting nuclear factor kappa-B signaling pathways
Mu Hu, Jielai Yang & Yang Xu
Pages: 3958-3968
Published online: 03 Feb 2022
AbstractforEffect of α-tocopherol in alleviating the lipopolysaccharide-induced acute lung injury via inhibiting nuclear factor kappa-B signaling pathways | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Knockdown of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 protects against intracerebral hemorrhage through microRNA-146a-mediated inhibition of inflammation and oxidative stress
Zhanyi Xu, Baoshuai Zhao, Jianhui Mao & Zhaosheng Sun
Pages: 3969-3980
Published online: 03 Feb 2022
AbstractforKnockdown of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 protects against intracerebral hemorrhage through microRNA-146a-mediated inhibition of inflammation and oxidative stress | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Knockdown of receptor interacting protein 140 (RIP140) alleviated lipopolysaccharide-induced inflammation, apoptosis and permeability in pulmonary microvascular endothelial cells by regulating C-terminal binding protein 2 (CTBP2)
Qizheng Wang & Qiong Wu
Pages: 3981-3992
Published online: 03 Feb 2022
AbstractforKnockdown of receptor interacting protein 140 (RIP140) alleviated lipopolysaccharide-induced inflammation, apoptosis and permeability in pulmonary microvascular endothelial cells by regulating C-terminal binding protein 2 (CTBP2) | Full Text | References | PDF (4 MB) | EPUB
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Article
Pleckstrin homology-like domain family A, member 3, a miR-19a-3p-regulated gene, suppresses tumor growth in osteosarcoma by downregulating the Akt pathway
Peng Wang, Yu Huang, Xin Xia, Jian Han, Lu Zhang & Wenzhi Zhao
Pages: 3993-4009
Published online: 03 Feb 2022
AbstractforPleckstrin homology-like domain family A, member 3, a miR-19a-3p-regulated gene, suppresses tumor growth in osteosarcoma by downregulating the Akt pathway | Full Text | References | PDF (7.8 MB) | EPUB
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Article
DNA methyltransferase 3 beta regulates promoter methylation of microRNA-149 to augment esophageal squamous cell carcinoma development through the ring finger protein 2/Wnt/β-catenin axis
Junfeng Yang, Quan Zhang, Pu Zhao, Tong Qiao, Zhikun Cao, Fei Gao, Mengbo Liu & Sen Wu
Pages: 4010-4027
Published online: 06 Feb 2022
AbstractforDNA methyltransferase 3 beta regulates promoter methylation of microRNA-149 to augment esophageal squamous cell carcinoma development through the ring finger protein 2/Wnt/β-catenin axis | Full Text | References | PDF (6.7 MB) | EPUB
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Article
Methylprednisolone up-regulates annexin A1 (ANXA1) to inhibit the inflammation, apoptosis and oxidative stress of cigarette smoke extract (CSE)-induced bronchial epithelial cells, a chronic obstructive pulmonary disease in vitro model, through the formyl peptide receptor 2 (FPR2) receptors and the adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) pathway
Chan Yu & Linghui Zhang
Pages: 4028-4038
Published online: 06 Feb 2022
AbstractforMethylprednisolone up-regulates annexin A1 (ANXA1) to inhibit the inflammation, apoptosis and oxidative stress of cigarette smoke extract (CSE)-induced bronchial epithelial cells, a chronic obstructive pulmonary disease in vitro model, through the formyl peptide receptor 2 (FPR2) receptors and the adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) pathway | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Comprehensive analysis of peripheral blood non-coding RNAs identifies a diagnostic panel for fungal infection after transplantation
Anli Yang, Huadi Chen, Jianwei Lin, Ming Han, Xiaopeng Yuan, Tao Zhang, Qingwei Nian, Mengran Peng, Dian Li, Chenglin Wu & Xiaoshun He
Pages: 4039-4050
Published online: 06 Feb 2022
AbstractforComprehensive analysis of peripheral blood non-coding RNAs identifies a diagnostic panel for fungal infection after transplantation | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression
Wei Chen, Haotian Zheng, Xuan Zhang, Yude Xu, Zhibin Fu, Xing Ji, Changhao Wei, Guoyao An, Mingyuan Tan & Mingwang Zhou
Pages: 4051-4062
Published online: 07 Feb 2022
AbstractforColumbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Depletion of mmu_circ_0001751 (circular RNA Carm1) protects against acute cerebral infarction injuries by binding with microRNA-3098-3p to regulate acyl-CoA synthetase long-chain family member 4
Rui Mao & Hua Liu
Pages: 4063-4075
Published online: 03 Feb 2022
AbstractforDepletion of mmu_circ_0001751 (circular RNA Carm1) protects against acute cerebral infarction injuries by binding with microRNA-3098-3p to regulate acyl-CoA synthetase long-chain family member 4 | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Ezrin expression in circulating tumor cells is a predictor of prostate cancer metastasis
Zheng Chen, Jue Wang, Yangbai Lu, Caiyong Lai, Lijun Qu & Yumin Zhuo
Pages: 4076-4084
Published online: 12 Feb 2022
AbstractforEzrin expression in circulating tumor cells is a predictor of prostate cancer metastasis | Full Text | References | PDF (1.3 MB) | EPUB
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Article
16S rDNA sequencing analyzes differences in intestinal flora of human immunodeficiency virus (HIV) patients and association with immune activation
Zhang Mingjun, Mo Fei, Xu Zhousong, Xu Wei, Xu Jian, Yi Yuanxue, Shen Youfeng, Chen Zhongping, Long Yiqin, Zhao Xiaohong, Cheng Ying, Wang Zhenbing, Deng Zehu & Li Lanjuan
Pages: 4085-4099
Published online: 06 Feb 2022
Abstractfor16S rDNA sequencing analyzes differences in intestinal flora of human immunodeficiency virus (HIV) patients and association with immune activation | Full Text | References | PDF (4 MB) | EPUB
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Article
Angiotensin-(1-7) ameliorates high glucose-induced vascular endothelial injury through suppressing chloride channel 3
Fei Cheng, Jing Liu, Zhuolin Guo, Shicheng Li, Jingfu Chen, Chang Tu, Fengzhou Fu, Bai Shen, Xiaojie Zhang, Guohua Lai & Jun Lan
Pages: 4100-4111
Published online: 15 Feb 2022
AbstractforAngiotensin-(1-7) ameliorates high glucose-induced vascular endothelial injury through suppressing chloride channel 3 | Full Text | References | PDF (2.9 MB) | EPUB
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Article
The phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with β3 –tubulin
Zhenying Ge, Tingxuan Gu, Lingge Zhang, Qingfang Fan, Li Ma & Na Fang
Pages: 4112-4121
Published online: 12 Feb 2022
AbstractforThe phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with β3 –tubulin | Full Text | References | PDF (853.2 KB) | EPUB
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Article
Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection
Yunshu Yang, Mengdong Liu, Fangfang Yang, Xujie Wang, Xiaozhi Bai, Shengzhi Mu, Yang Liu & Dahai Hu
Pages: 4122-4136
Published online: 25 Feb 2022
AbstractforCircular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection | Full Text | References | PDF (5.3 MB) | EPUB
  • 1652 Views
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Article
Carvedilol alleviates lipopolysaccharide (LPS)-induced acute lung injury by inhibiting Ras homolog family member A (RhoA)/ROCK activities
Jing Xu, Shipin Zhao, Li Zhao & Mengxiu Sun
Pages: 4137-4145
Published online: 21 Feb 2022
AbstractforCarvedilol alleviates lipopolysaccharide (LPS)-induced acute lung injury by inhibiting Ras homolog family member A (RhoA)/ROCK activities | Full Text | References | PDF (1.8 MB) | EPUB
  • 1060 Views
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Article
Long non-coding RNA growth arrest specific 5 is downregulated in sepsis-ALI and inhibits apoptosis by up-regulating miR-146a
Jiaqiong Li, Hongyang Xu, Na Li, Wenjing Du, Junxiang Ti & Jingyu Chen
Pages: 4146-4152
Published online: 03 Feb 2022
AbstractforLong non-coding RNA growth arrest specific 5 is downregulated in sepsis-ALI and inhibits apoptosis by up-regulating miR-146a | Full Text | References | PDF (1.3 MB) | EPUB
  • 890 Views
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Article
Long non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis
Xing Huang, Zihe Wang, Shengzhong Hou, Chao Yue, ZhenLu Li, Weiming Hu & Huimin Lu
Pages: 4153-4165
Published online: 10 Feb 2022
AbstractforLong non-coding RNA DSCAM-AS1 promotes pancreatic cancer progression via regulating the miR-136-5p/PBX3 axis | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Long non-coding RNA TSPEAR Antisense RNA 2 is downregulated in rheumatoid arthritis and inhibits the apoptosis of fibroblast-like synoviocytes by downregulating microRNA-212-3p (miR-212-3p)
Zhifen Lv, Shibao Ye, Zhiwen Wang, Panpan Xin, Yuhang Chen, Zhiming Tan & Yu Zhuang
Pages: 4166-4172
Published online: 03 Feb 2022
AbstractforLong non-coding RNA TSPEAR Antisense RNA 2 is downregulated in rheumatoid arthritis and inhibits the apoptosis of fibroblast-like synoviocytes by downregulating microRNA-212-3p (miR-212-3p) | Full Text | References | PDF (1.7 MB) | EPUB
  • 711 Views
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Article
Role and mechanism of lncRNA under magnetic nanoparticles in atrial autonomic nerve remodeling during radiofrequency ablation of recurrent atrial fibrillation
Weifeng Jiang, Ming Xu, Mu Qin, Daoliang Zhang, Shaohui Wu, Xu Liu & Yu Zhang
Pages: 4173-4184
Published online: 03 Feb 2022
AbstractforRole and mechanism of lncRNA under magnetic nanoparticles in atrial autonomic nerve remodeling during radiofrequency ablation of recurrent atrial fibrillation | Full Text | References | PDF (1.1 MB) | EPUB
  • 1134 Views
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Article
Upregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis
Chuankui Li, Guowen Wang, Xiaoxiao Ma, Tao Tao, Qicai Li, Yifan Yang, Haiwei Sang & Zuyi Wang
Pages: 4185-4200
Published online: 03 Feb 2022
AbstractforUpregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Ataxia-televangelist mutated (ATM)/ ATR serine/threonine kinase (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic differentiation and inhibits osteoclastogenesis in osteoporosis
Minli Qiu, Liudan Tu, Minjing Zhao, Mingcan Yang, Jun Qi, Ya Xie & Jieruo Gu
Pages: 4201-4211
Published online: 17 Feb 2022
AbstractforAtaxia-televangelist mutated (ATM)/ ATR serine/threonine kinase (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic differentiation and inhibits osteoclastogenesis in osteoporosis | Full Text | References | PDF (2.7 MB) | EPUB
  • 1089 Views
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Article
Hsa_circ_0039569 facilitates the progression of endometrial carcinoma by targeting the miR-197/high mobility group protein A1 axis
Yi Zhou, Anyi Pan, Yudong Zhang & Xinchun Li
Pages: 4212-4225
Published online: 07 Feb 2022
AbstractforHsa_circ_0039569 facilitates the progression of endometrial carcinoma by targeting the miR-197/high mobility group protein A1 axis | Full Text | References | PDF (4 MB) | EPUB
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Article
Circular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma
Lixin Guo, Qing Lin, Xiqun Zhao & Jing Xu *
Pages: 4226-4234
Published online: 13 Feb 2022
AbstractforCircular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma | Full Text | References | PDF (2.1 MB) | EPUB
  • 827 Views
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Article
Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4
Zhijian Xu, Fengduo Zhang, Hu Xu, Fan Yang, Gezhi Zhou, Minfeng Tong, Yaqiang Li & Song Yang
Pages: 4235-4247
Published online: 16 Feb 2022
AbstractforMelatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4 | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1381 Views
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Article
MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury
Ruihong Wang, Yang Liu & Li Jing
Pages: 4248-4259
Published online: 08 Feb 2022
AbstractforMiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury | Full Text | References | PDF (2.8 MB) | EPUB
  • 1507 Views
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Article
Tanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3
Meiqi Zhang, Yun Chen, Huan Chen, Ye Shen, Lingxiao Pang, Weihua Wu & Zhenfei Yu
Pages: 4260-4270
Published online: 22 Feb 2022
AbstractforTanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3 | Full Text | References | PDF (3 MB) | EPUB
  • 1984 Views
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Article
miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma
Guodong Liu, Honggang Mao, Yan Liu, Zun Zhang, Si Ha & Xiaoyan Zhang
Pages: 4271-4284
Published online: 13 Feb 2022
AbstractformiR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma | Full Text | References | PDF (4.2 MB) | EPUB
  • 984 Views
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Article
LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer
Jia-Hong Liang, Qiao-Dong Xu & Song-Gang Gu
Pages: 4285-4300
Published online: 14 Feb 2022
AbstractforLncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer | Full Text | References | PDF (3.2 MB) | EPUB
  • 1123 Views
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Article
Long non-coding RNA BRCAT54 sponges microRNA-21 in vestibular schwannoma to suppress cell proliferation
Gang Xiao, Bin Huang, Ming Guo, Chaoxin Long, Pingan Li, Bin Zhong & Chuncheng Guan
Pages: 4301-4308
Published online: 09 Feb 2022
AbstractforLong non-coding RNA BRCAT54 sponges microRNA-21 in vestibular schwannoma to suppress cell proliferation | Full Text | References | PDF (1.3 MB) | EPUB
  • 801 Views
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Review Article

Review Article
Active pharmaceutical ingredient (API) chemicals: a critical review of current biotechnological approaches
Vinod Kumar, Vasudha Bansal, Aravind Madhavan, Manoj Kumar, Raveendran Sindhu, Mukesh Kumar Awasthi, Parameswaran Binod & Saurabh Saran
Pages: 4309-4327
Published online: 08 Feb 2022
AbstractforActive pharmaceutical ingredient (API) chemicals: a critical review of current biotechnological approaches | Full Text | References | PDF (1.2 MB) | EPUB
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Research Paper

Article
Effects of wound dressing based on the combination of silver@curcumin nanoparticles and electrospun chitosan nanofibers on wound healing
Chuanliang Liu, Yuhua Zhu, Xuejie Lun, Huan Sheng & Anquan Yan
Pages: 4328-4339
Published online: 09 Feb 2022
AbstractforEffects of wound dressing based on the combination of silver@curcumin nanoparticles and electrospun chitosan nanofibers on wound healing | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Long non-coding RNA LINRIS is upregulated in non-small cell lung cancer and its silencing inhibits cell proliferation by suppressing microRNA-10a maturation
Yajie Zhu, Ke Ma, Yingxue Ye, Jianning Tang & Jiang Zhu
Pages: 4340-4346
Published online: 09 Feb 2022
AbstractforLong non-coding RNA LINRIS is upregulated in non-small cell lung cancer and its silencing inhibits cell proliferation by suppressing microRNA-10a maturation | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Article
DNA methylation of RNA-binding protein for multiple splicing 2 functions as diagnosis biomarker in gastric cancer pathogenesis and its potential clinical significance
Ming Cheng, Xiaoan Zhan, Yi Xu, Saishan Wang, Hongcheng Zhang, Limin Fang, Hao Jin & Wei Chen
Pages: 4347-4360
Published online: 09 Feb 2022
AbstractforDNA methylation of RNA-binding protein for multiple splicing 2 functions as diagnosis biomarker in gastric cancer pathogenesis and its potential clinical significance | Full Text | References | PDF (5.3 MB) | EPUB
  • 1197 Views
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Article
MicroRNA-29c-3p participates in insulin function to modulate polycystic ovary syndrome via targeting Forkhead box O 3
HongXia Chen, YunFeng Fu, ZiXiang Guo & XiaoDong Zhou
Pages: 4361-4371
Published online: 10 Feb 2022
AbstractforMicroRNA-29c-3p participates in insulin function to modulate polycystic ovary syndrome via targeting Forkhead box O 3 | Full Text | References | PDF (2.9 MB) | EPUB
  • 1386 Views
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Article
CircRNA ZNF609 promotes the growth and metastasis of thyroid cancer in vivo and in vitro by downregulating miR-514a-5p
Ping Shi, Yan Liu, Dongqiang Yang, Yanzhao Wu, Lan Zhang, Shanghua Jing, Huijing Shi & Cuizhi Geng
Pages: 4372-4384
Published online: 08 Feb 2022
AbstractforCircRNA ZNF609 promotes the growth and metastasis of thyroid cancer in vivo and in vitro by downregulating miR-514a-5p | Full Text | References | PDF (4.7 MB) | EPUB
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Article
Metformin attenuates high glucose-induced injury in islet microvascular endothelial cells
Wenyu Zou, Bingkun Liu, Yulu Wang, Fangbin Shi & Shuguang Pang
Pages: 4385-4396
Published online: 09 Feb 2022
AbstractforMetformin attenuates high glucose-induced injury in islet microvascular endothelial cells | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 1422 Views
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Article
Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer
Wei Wang, Yukai Dai, Xin Yang & Xinming Xiong
Pages: 4397-4410
Published online: 13 Feb 2022
AbstractforLong non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 1079 Views
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Article
Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis
Weiguo Ma, Xin Zhao, Yun Gao, Xiaobin Yao, Junhua Zhang & Qingxia Xu
Pages: 4411-4427
Published online: 03 Feb 2022
AbstractforCircular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis | Full Text | References | PDF (5 MB) | EPUB
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Article
Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway
Jieke Cui, Rong Guo, Yingjun Wang, Yue Song, Xuewen Song, Hongwen Li, Xiaoqin Song & Jiwei Li
Pages: 4428-4440
Published online: 09 Feb 2022
AbstractforAcetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 871 Views
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Article
Zebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin
Xiangliang Zeng, Guohua He, Xirong Yang, Guoyao Xu, Yidan Tang, Hanwen Li, Bing Yu, Zhen Wang, Wei Xu & Kangping Song
Pages: 4441-4454
Published online: 03 Feb 2022
AbstractforZebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin | Full Text | References | PDF (2.2 MB) | EPUB
  • 2389 Views
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Article
Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway
Jiachen Duan, Mengyuan Jin, Dongjing Yang, Jihua Shi, Jie Gao, Danfeng Guo, Hongwei Tang, Shuijun Zhang & Baoping Qiao
Pages: 4455-4467
Published online: 12 Feb 2022
AbstractforUbiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 1216 Views
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Article
Astragalus polysaccharide (APS) exerts protective effect against acute ischemic stroke (AIS) through enhancing M2 micoglia polarization by regulating adenosine triphosphate (ATP)/ purinergic receptor (P2X7R) axis
Xiang Jia, Liying Xie, Yuan Liu, Tianfu Liu, Peiqun Yang, Jianfang Hu, Zhichao Peng, Kangrui Luo, Min Du & Chaojun Chen
Pages: 4468-4480
Published online: 15 Feb 2022
AbstractforAstragalus polysaccharide (APS) exerts protective effect against acute ischemic stroke (AIS) through enhancing M2 micoglia polarization by regulating adenosine triphosphate (ATP)/ purinergic receptor (P2X7R) axis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Circular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma
Yang Li & Bing Wang
Pages: 4481-4492
Published online: 09 Feb 2022
AbstractforCircular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 1391 Views
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Article
LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson’s disease
Jianzhong Zhang, Yun Yang, Chaoyang Zhou, Ronglan Zhu, Xiang Xiao, Bin Zhou & Dengfeng Wan
Pages: 4493-4516
Published online: 09 Feb 2022
AbstractforLncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson’s disease | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 1908 Views
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Article
Exosomes from miR-374a-5p-modified mesenchymal stem cells inhibit the progression of renal fibrosis by regulating MAPK6/MK5/YAP axis
Mingzhu Liang, Di Zhang, Danna Zheng, Wenfang He & Juan Jin
Pages: 4517-4527
Published online: 09 Feb 2022
AbstractforExosomes from miR-374a-5p-modified mesenchymal stem cells inhibit the progression of renal fibrosis by regulating MAPK6/MK5/YAP axis | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1722 Views
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Article
miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer
Hailin Ke, Songling Wu, Yueyi Zhang & Guowei Zhang
Pages: 4528-4536
Published online: 09 Feb 2022
AbstractformiR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1123 Views
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Article
Biodegradation of pharmaceuticals in photobioreactors – a systematic literature review
Katarzyna Chojnacka, Dawid Skrzypczak, Grzegorz Izydorczyk, Katarzyna Mikula, Daniel Szopa, Konstantinos Moustakas & Anna Witek-Krowiak
Pages: 4537-4556
Published online: 08 Feb 2022
AbstractforBiodegradation of pharmaceuticals in photobioreactors – a systematic literature review | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Cilengitide, an αvβ3-integrin inhibitor, enhances the efficacy of anti-programmed cell death-1 therapy in a murine melanoma model
Xin Pan, Minxiao Yi, Chaofan Liu, Yu Jin, Bo Liu, Guangyuan Hu & Xianglin Yuan
Pages: 4557-4572
Published online: 10 Feb 2022
AbstractforCilengitide, an αvβ3-integrin inhibitor, enhances the efficacy of anti-programmed cell death-1 therapy in a murine melanoma model | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 2301 Views
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Article
LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP)
Wen Cao, Xiaojing Liu, Weijia Su, Hao Liang, Huiru Tang, Weiliang Zhang, Shuhong Huang, Ningning Dang & Aiguo Qiao
Pages: 4573-4586
Published online: 12 Feb 2022
AbstractforLINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP) | Full Text | References | PDF (3.6 MB) | EPUB
  • 1387 Views
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Article
Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) modulates the proliferation and apoptosis of acute lymphoblastic leukemia cells by sponging miR-486-5p
Jin-Ke Ju, Wei-Na Han & Cai-Ling Shi
Pages: 4587-4597
Published online: 13 Feb 2022
AbstractforLong non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) modulates the proliferation and apoptosis of acute lymphoblastic leukemia cells by sponging miR-486-5p | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1021 Views
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Article
Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice
Heng Song, Xiaojuan Zhang, Ruiqing Zhai, Huoyan Liang, Gaofei Song, Yangyang Yuan, Yanan Xu, Yan Yan, Lingxiao Qiu & Tongwen Sun
Pages: 4598-4609
Published online: 13 Feb 2022
AbstractforMetformin attenuated sepsis-associated liver injury and inflammatory response in aged mice | Full Text | References | PDF (2.2 MB) | EPUB
  • 3401 Views
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Article
Exosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14
Yuwei Shou, Xiaoqian Wang, Yinghao Liang, Xiaonan Liu & Kuisheng Chen
Pages: 4610-4620
Published online: 14 Feb 2022
AbstractforExosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14 | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1343 Views
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