Cancer Biology & Therapy, Volume 23, Issue 1 (2022)

Browse this journal
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Cancer Biology & Therapy, Volume 23, Issue 1 (2022)

See all volumes and issues
Vol 25, 2024 Vol 24, 2023 Volume 23, 2022 Vol 22, 2021 Vol 21, 2020 Vol 20, 2019 Vol 19, 2018 Vol 18, 2017 Vol 17, 2016 Vol 16, 2015 Vol 15, 2014 Vol 14, 2013 Vol 13, 2012 Vol 12, 2011 Vol 11, 2011 Vol 10, 2010 Vol 9, 2010 Vol 8, 2009 Vol 7, 2008 Vol 6, 2007 Vol 5, 2006 Vol 4, 2005 Vol 3, 2004 Vol 2, 2003 Vol 1, 2002
Download citations Download PDFs

Research Paper

Article
Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo
Laura Patras, Aura Elena Ionescu, Cristian Munteanu, Renata Hajdu, Andreea Kosa, Alina Porfire, Emilia Licarete, Valentin Florian Rauca, Alina Sesarman, Lavinia Luput, Paul Bulzu, Paul Chiroi, Rares Andrei Tranca, Marta-Szilvia Meszaros, Giorgiana Negrea, Lucian Barbu-Tudoran, Monica Potara, Stefan Szedlacsek & Manuela Banciu
Pages: 1-16
Published online: 29 Dec 2021
AbstractforTrojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 5444 Views
  • 13 CrossRef citations
  • 0Altmetric
Open Access
Article
TRIM55 suppresses malignant biological behavior of lung adenocarcinoma cells by increasing protein degradation of Snail1
Tianxing Guo, Zhenlong Zhang, Lihuan Zhu, Wenshu Chen, Yun Ding, Wujin Li, Yangyun Huang, Jianyuan Huang & Xiaojie Pan
Pages: 17-26
Published online: 02 Jan 2022
AbstractforTRIM55 suppresses malignant biological behavior of lung adenocarcinoma cells by increasing protein degradation of Snail1 | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 5771 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access
Article
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyngeal carcinoma
Jun Yin, Jirui Xie, Jiawei Lin, Chengyin Weng, Shun Lu, Peng Xu, Shuo Zhang, Cheng Luo, Yecai Huang, Lu Li, Jinyi Lang & Mei Feng
Pages: 27-33
Published online: 06 Jan 2022
AbstractforEvaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyngeal carcinoma | Full Text | References | PDF (744.8 KB) | EPUB
  • 4071 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Review

Review
Target c-Myc to treat pancreatic cancer
Moein Ala
Pages: 34-50
Published online: 03 Jan 2022
AbstractforTarget c-Myc to treat pancreatic cancer | Full Text | References | PDF (919.6 KB) | EPUB
  • 8081 Views
  • 22 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion
Ne Guo, Meng-Zhu Li, Li-Min Wang, Hua-Dong Chen, Shan-Shan Song, Ze-Hong Miao & Jin-Xue He
Pages: 69-82
Published online: 09 Jan 2022
AbstractforRepeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
  • 3617 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15
Lei Duan, Ricardo E. Perez, Sarah Calhoun & Carl G. Maki
Pages: 65-75
Published online: 31 Jan 2022
AbstractforInhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15 | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 5162 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis
Xiaoyu Dai, Yangyang Xie & Mingjun Dong
Pages: 76-88
Published online: 31 Jan 2022
AbstractforCancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis | Full Text | References | PDF (3.8 MB) | EPUB
  • 5289 Views
  • 9 CrossRef citations
  • 0Altmetric
Open Access
Article
Treatment efficacy and safety of drug-eluting beads transarterial chemoembolization versus conventional transarterial chemoembolization in hepatocellular carcinoma patients with arterioportal fistula
Liang Cai, Honglu Li, Jiang Guo, Wenpeng Zhao, Youjia Duan, Xiaopu Hou, Long Cheng, Hongliu Du, Xihong Shao, Zhenying Diao, Yiwei Hao, Xinmei Zheng, Changqing Li & Wei Li
Pages: 89-95
Published online: 01 Mar 2022
AbstractforTreatment efficacy and safety of drug-eluting beads transarterial chemoembolization versus conventional transarterial chemoembolization in hepatocellular carcinoma patients with arterioportal fistula | Full Text | References | PDF (664.2 KB) | EPUB
  • 2899 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access

Bedside-to-Bench Report

Report
Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid
Hichul Kim, Victoria El-Khoury, Nadine Schulte, Tianzuo Zhan, Johannes Betge, Loic Cousin, Emanuele Felli, Patrick Pessaux, Arnaud Ogier, Oliver G Opitz, Bosung Ku, Matthias P Ebert & Yong-Jun Kwon
Pages: 96-102
Published online: 22 Feb 2022
AbstractforPersonalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid | Full Text | References | PDF (2.1 MB) | EPUB
  • 5212 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access

Correction

Correction
Correction
Page: 103
Published online: 09 Mar 2022
CitationforCorrection | Full Text | PDF (330.4 KB) | EPUB
  • 921 Views
  • 0 CrossRef citations
  • 0Altmetric
Free Access

Research Paper

Article
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy
Yan Zhu, Chun Yan, Xiaofei Wang, Zhijian Xu, Jianjian Lv, Xiaomei Xu, Wenjun Yu, Mi Zhou & Lu Yue
Pages: 104-111
Published online: 03 Mar 2022
AbstractforPan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy | Full Text | References | PDF (1.9 MB) | EPUB
  • 7774 Views
  • 10 CrossRef citations
  • 0Altmetric
Open Access

Bedside-to-Bench Report

Report
Partial treatment response to capmatinib in MET-amplified metastatic intrahepatic cholangiocarcinoma: case report & review of literature
Daniel S Lefler, Marni Brisson Tierno & Babar Bashir
Pages: 112-116
Published online: 06 Feb 2022
AbstractforPartial treatment response to capmatinib in MET-amplified metastatic intrahepatic cholangiocarcinoma: case report & review of literature | Full Text | References | PDF (727.1 KB) | EPUB
  • 6087 Views
  • 5 CrossRef citations
  • 0Altmetric
Open Access

Research Article

Article
Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor
Umar Hayat, Gary T. Elliott, Anthony J. Olszanski & Dario C. Altieri
Pages: 117-126
Published online: 06 Feb 2022
AbstractforFeasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 5041 Views
  • 8 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy
Ross E Staudt, Robert D Carlson & Adam E Snook
Pages: 127-133
Published online: 06 Feb 2022
AbstractforTargeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy | Full Text | References | PDF (839.4 KB) | EPUB
  • 6074 Views
  • 6 CrossRef citations
  • 0Altmetric
Open Access
Review Article
Single whole genome sequencing analysis blazes the trail for precision medicine
Giulia C. Napoli, Cindy H. Chau & William D. Figg
Pages: 134-135
Published online: 06 Feb 2022
AbstractforSingle whole genome sequencing analysis blazes the trail for precision medicine | Full Text | References | PDF (213 KB) | EPUB
  • 2280 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Review Article
Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome
Kristi Y. Lee, Cindy H. Chau, Douglas K. Price & William D. Figg
Pages: 136-138
Published online: 06 Feb 2022
AbstractforDrugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome | Full Text | References | PDF (161.9 KB) | EPUB
  • 2991 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA
Hui Xiao, Xiong Ye, Vikalp Vishwakarma, Ranjan Preet & Dan A. Dixon
Pages: 139-149
Published online: 07 Feb 2022
AbstractforCRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA | Full Text | References | PDF (2.7 MB) | EPUB
  • 6668 Views
  • 6 CrossRef citations
  • 0Altmetric
Open Access
Article
The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β
Gang Wang, Xiaowan Zhou, Zengli Guo, Nan Huang, Juan Li, Yanfang Lv, Lulu Han, Wei Zheng, Dandan Xu, Dafei Chai, Huizhong Li, Liantao Li & Junnian Zheng
Pages: 150-162
Published online: 07 Feb 2022
AbstractforThe Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β | Full Text | References | PDF (4.9 MB) | EPUB
  • 6751 Views
  • 6 CrossRef citations
  • 0Altmetric
Open Access
Article
Loading of ”cocktail siRNAs” into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer
Yanjun Diao, Gangqiang Wang, Bingbing Zhu, Zhuo Li, Shan Wang, Lijuan Yu, Rui Li, Weixiao Fan, Yue Zhang, Lei Zhou, Liu Yang, Xiaoke Hao & Jiayun Liu
Pages: 163-172
Published online: 16 Feb 2022
AbstractforLoading of ”cocktail siRNAs” into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer | Full Text | References | PDF (3.2 MB) | EPUB
  • 4430 Views
  • 5 CrossRef citations
  • 0Altmetric
Open Access
Article
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri & Lucia R. Languino PhD
Pages: 173-185
Published online: 19 Feb 2022
AbstractforSmall extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 4118 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access

Journal Club

Article
Lutetium-177-PSMA-617: A Vision of the Future
Elias Chandran, William D. Figg & Ravi Madan
Pages: 186-190
Published online: 27 Feb 2022
AbstractforLutetium-177-PSMA-617: A Vision of the Future | Full Text | References | PDF (227.7 KB) | EPUB
  • 8969 Views
  • 5 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan
Tsutomu Yoshida, Go Ogura, Mikiko Tanabe, Takuo Hayashi, Chiho Ohbayashi, Mizutomo Azuma, Chikara Kunisaki, Yoichi Akazawa, Soji Ozawa, Sohei Matsumoto, Takayoshi Suzuki, Akira Mitoro, Tetsu Fukunaga, Akiko Shimizu, Go Fujimoto & Takashi Yao
Pages: 191-200
Published online: 27 Feb 2022
AbstractforClinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 4965 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity
Yasser F. Ali, Zhiqiang Hong, Ning-Ang Liu & Guangming Zhou
Pages: 201-210
Published online: 09 Mar 2022
AbstractforClock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity | Full Text | References | PDF (435.4 KB) | EPUB
  • 2685 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway
Jingnan Liao, Huan Chen, Mingming Qi, Jinjin Wang & Mingyuan Wang
Pages: 211-224
Published online: 06 Mar 2022
AbstractforMLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 3401 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access
Article
Targeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression
Zhang Li, Ming Li, Pengcheng Xia, Lili Wang & Zhiming Lu
Pages: 225-233
Published online: 11 Mar 2022
AbstractforTargeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 4110 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
MiR-376a-3p increases cell apoptosis in acute myeloid leukemia by targeting MT1X
Xiangke Xin, Zheng Xu, Jia Wei & Yicheng Zhang
Pages: 234-242
Published online: 22 Mar 2022
AbstractforMiR-376a-3p increases cell apoptosis in acute myeloid leukemia by targeting MT1X | Full Text | References | PDF (4.2 MB) | EPUB
  • 3160 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation
Guangping Zhang, Xin Zhao & Weixian Liu
Pages: 243-253
Published online: 22 Mar 2022
AbstractforNEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 3665 Views
  • 6 CrossRef citations
  • 0Altmetric
Open Access
Article
Epigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells
Andrew Zheng, Michelle Bilbao, Janhvi Sookram, Kimberly M. Linden, Andrew B. Morgan & Olga Ostrovsky
Pages: 254-264
Published online: 07 Apr 2022
AbstractforEpigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells | Full Text | References | PDF (1.9 MB) | EPUB
  • 3393 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis
Zibo Chen, Lin Zheng, Yulong Chen, Xiuxia Liu, Masanori Kawakami, Lisa Maria Mustachio, Jason Roszik, Katherine V. Ferry-Galow, Ralph E. Parchment, Xin Liu, Thorkell Andresson, Gerard Duncan, Jonathan M. Kurie, Jaime Rodriguez-Canales, Xi Liu & Ethan Dmitrovsky
Pages: 265-280
Published online: 07 Apr 2022
AbstractforLoss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis | Full Text | References | PDF (18.7 MB) | EPUB | Supplemental
  • 7039 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma
Lili Chen, Wenzhong Hong, Siliang Duan, Yiping Li, Jian Wang & Jianmeng Zhu
Pages: 281-293
Published online: 24 Mar 2022
AbstractforGraphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma | Full Text | References | PDF (4.7 MB) | EPUB
  • 5026 Views
  • 11 CrossRef citations
  • 0Altmetric
Open Access
Article
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling
Duo Han, Shaihong Zhu, Xia Li, Zhiqiang Li, Hui Huang, Wenzhe Gao, Yunfei Liu, Hongwei Zhu & Xiao Yu
Pages: 294-309
Published online: 28 Mar 2022
AbstractforThe NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3590 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib
Myles Vigoda, Chase Mathieson, Nathaniel Evans, Carolyn Hale, Jennifer Jennings, Olivia Lucero, Sophia Jeng, Daniel Bottomly, Daniel Clayburgh, Peter Andersen, Ryan Li, Daniel Petrisor, Jeffrey W. Tyner, Shannon McWeeney & Molly Kulesz-Martin
Pages: 309-317
Published online: 28 Mar 2022
AbstractforFunctional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib | Full Text | References | PDF (638.3 KB) | EPUB | Supplemental
  • 3028 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells
Liling Jiang, Chuangyu Wen, Huan Zhou, Aochu Liu, Haichuan Zhang, Xinmei Chen, Wa Ding, Jinbao Liu & Xianping Shi
Pages: 319-327
Published online: 25 Mar 2022
AbstractforCyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 3767 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines
Yuru Zhou, Yunyuan Kong, Mei Jiang, Linju Kuang, Jinhua Wan, Shuyuan Liu, Qian Zhang, Kuai Yu, Na Li, Aiping Le & Zhanglin Zhang
Pages: 328-335
Published online: 18 Apr 2022
AbstractforCurcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines | Full Text | References | PDF (3.1 MB) | EPUB
  • 3871 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling
Simei Zhang, Shuang Cao, Mengyuan Gong, Wunai Zhang, Weifan Zhang, Zeen Zhu, Shuai Wu, Yangyang Yue, Weikun Qian, Qingyong Ma, Shengpeng Wang & Zheng Wang
Pages: 336-347
Published online: 20 Apr 2022
AbstractforMechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling | Full Text | References | PDF (7 MB) | EPUB | Supplemental
  • 2887 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8
Sagar Bajpai, Hong Ri Jin, Bartosz Mucha & J. Alan Diehl
Pages: 348-357
Published online: 19 Apr 2022
AbstractforUbiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8 | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 2571 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access
Article
Real-time luminescence enables continuous drug–response analysis in adherent and suspension cell lines
Clayton M. Wandishin, Charles John Robbins, Darren R. Tyson, Leonard A. Harris & Vito Quaranta
Pages: 358-368
Published online: 21 Apr 2022
AbstractforReal-time luminescence enables continuous drug–response analysis in adherent and suspension cell lines | Full Text | References | PDF (8.4 MB) | EPUB
  • 1774 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma
Haoji Gao, Weige Wang & Qinyu Li
Pages: 369-377
Published online: 01 May 2022
AbstractforGANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 3439 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis
Yadong Han, Xu Qian, Teng Xu & Yang Shi
Pages: 378-392
Published online: 05 May 2022
AbstractforCarcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis | Full Text | References | PDF (7.2 MB) | EPUB | Supplemental
  • 2525 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access

Bedside-to-Bench Report

Report
Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline BRCA2 frameshift mutation: a case report
Xi Cheng, Haiming Yu, Jinying Li, Xiaona Han, Erhong Meng, Houqing Zhou, Dongliang Wang, Beifang Niu & Xiaotao Zhang
Pages: 393-400
Published online: 16 May 2022
AbstractforDramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline BRCA2 frameshift mutation: a case report | Full Text | References | PDF (2 MB) | EPUB
  • 2886 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Letter to the Editor

Novel specific activity-based probes validate KLK proteases as druggable targets
Georgia Sotiropoulou, Eleni Zingkou & Georgios Pampalakis
Pages: 401-403
Published online: 02 Jun 2022
First Page PreviewforNovel specific activity-based probes validate KLK proteases as druggable targets | Full Text | References | PDF (240.8 KB) | EPUB
  • 1176 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
CAFs-derived small extracellular vesicles circN4BP2L2 promotes proliferation and metastasis of colorectal cancer via miR-664b-3p/HMGB3 pathway
Keda Yang, Fan Zhang, Baihua Luo & Zhan Qu
Pages: 404-416
Published online: 19 Jun 2022
AbstractforCAFs-derived small extracellular vesicles circN4BP2L2 promotes proliferation and metastasis of colorectal cancer via miR-664b-3p/HMGB3 pathway | Full Text | References | PDF (10.1 MB) | EPUB | Supplemental
  • 2905 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma
Andrew Hsu, Kelsey E. Huntington, Andre De Souza, Lanlan Zhou, Adam J. Olszewski, Nirav P. Makwana, Diana O. Treaba, Ludimila Cavalcante, Francis J. Giles, Howard Safran, Wafik S. El-Deiry & Benedito A. Carneiro
Pages: 417-423
Published online: 09 Jul 2022
AbstractforClinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma | Full Text | References | PDF (3.7 MB) | EPUB
  • 2825 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access
Article
Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response element binding protein
Yanping Tang, Kezhi Li, Bangli Hu, Zhengmin Cai, Jilin Li, Hao Tao & Ji Cao
Pages: 424-438
Published online: 11 Jul 2022
AbstractforFatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response element binding protein | Full Text | References | PDF (6.2 MB) | EPUB | Supplemental
  • 2739 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access
Article
TP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma
Yong Li, Junjun Wu, Enliang Li, Zhouqing Xiao, Jun Lei, Fan Zhou, Xiangbao Yin, Dandan Hu, Yilei Mao, Linquan Wu & Liao Wenjun
Pages: 439-445
Published online: 03 Aug 2022
AbstractforTP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 3608 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Colorectal cancer chemoprevention: is aspirin still in the game?
Adrien Grancher, Pierre Michel, Frederic Di Fiore & David Sefrioui
Pages: 446-461
Published online: 29 Jul 2022
AbstractforColorectal cancer chemoprevention: is aspirin still in the game? | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 4297 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status
Cassio Dejair Fleming-de-Moraes, Murilo Ramos Rocha, Josiane Weber Tessmann, Wallace Martins de Araujo & Jose Andres Morgado-Diaz
Pages: 1-13
Published online: 09 Aug 2022
AbstractforCrosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
  • 3209 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access
Article
Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice
Brandon N. VanderVeen, Thomas D. Cardaci, Sierra J. McDonald, Sarah S. Madero, Christian A. Unger, Brooke M. Bullard, Reilly T. Enos, Kandy T. Velázquez, Jason L. Kubinak, Daping Fan & E. Angela Murphy
Pages: 1-15
Published online: 13 Aug 2022
AbstractforObesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice | Full Text | References | PDF (14 MB) | EPUB | Supplemental
  • 2701 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access
Article
BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression
Shu-Cheng Liu, You-Han Cao, Li-Bo Chen, Ran Kang, Zhong-Xin Huang & Xin-Sheng Lu
Pages: 1-13
Published online: 23 Aug 2022
AbstractforBMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression | Full Text | References | PDF (10.8 MB) | EPUB
  • 3159 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access
Article
SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p
Shihui Zhang, Yunyun Chen, Qiong Hu, Tingting Zhao, Zhuo Wang, Yijian Zhou, Yuxuan Wei, Hongzhou Zhao, Junkai Wang, Yaxin Yang, Jiaying Zhang, Songlin Shi, Yujun Zhang, Ling Yang, Zhichao Fu & Kuancan Liu
Pages: 1-15
Published online: 21 Sep 2022
AbstractforSOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p | Full Text | References | PDF (6 MB) | EPUB | Supplemental
  • 1775 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer
Hanpu Zhang, Chenyuan Li, Shichong Liao, Yi Tu, Shengrong Sun, Feng Yao, Zhiyu Li & Zhong Wang
Pages: 1-11
Published online: 22 Sep 2022
AbstractforPSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer | Full Text | References | PDF (10.4 MB) | EPUB
  • 2072 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes
Li Ma, Jianwei Wang, Yongping Zhang, Fang Fang, Jing Ling, Xinran Chu, Zimu Zhang, Yanfang Tao, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Xu Sang, Kunlong Zhang, Lihui Lu, Xiaomei Wan, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Jun Lu, Jian Pan & Shaoyan Hu
Pages: 1-15
Published online: 28 Sep 2022
AbstractforBRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes | Full Text | References | PDF (7.5 MB) | EPUB | Supplemental
  • 4416 Views
  • 4 CrossRef citations
  • 0Altmetric
Open Access
Article
Targeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression
Qingxia Fang, Jingyang Lin, Liang Gao, Ruolang Pan & Xiaochun Zheng
Pages: 1-8
Published online: 25 Sep 2022
AbstractforTargeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1468 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting
Rushikesh S. Joshi, Amelie Boichard, Jacob J. Adashek & Razelle Kurzrock
Pages: 1-6
Published online: 28 Sep 2022
AbstractforHigh tumor amplification burden is associated with TP53 mutations in the pan-cancer setting | Full Text | References | PDF (921.8 KB) | EPUB | Supplemental
  • 1652 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Angiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer
Lauren T. Maloney, Emile Latour, Yiyi Chen, Douglas Rice, Alison Grossblatt-Wait, Nima Nabavizadeh, Charles R. Thomas, Kristina H. Young, Joshua M. Walker, John Holland & Aaron J. Grossberg
Pages: 1-8
Published online: 06 Oct 2022
AbstractforAngiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer | Full Text | References | PDF (977.9 KB) | EPUB | Supplemental
  • 2278 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo
Zhiyuan Zhou, Xiaofeng Wu, Riming Zhan, Xiangyong Li, Dazhao Cheng, Li Chen, Tianyu Wang, Hua Yu, Guihong Zhang & Xudong Tang
Pages: 1-13
Published online: 12 Oct 2022
AbstractforExosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo | Full Text | References | PDF (5.9 MB) | EPUB
  • 1754 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Suppressive function of bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-187 in prostate cancer
Chuangui Li, Zhen Sun, Yajun Song & Yong Zhang
Pages: 1-14
Published online: 16 Oct 2022
AbstractforSuppressive function of bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-187 in prostate cancer | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 1760 Views
  • 2 CrossRef citations
  • 0Altmetric
Open Access
Article
DDX24 regulates the chemosensitivity of hepatocellular carcinoma to sorafenib via mediating the expression of SNORA18
Hairun Gan, Luting Li, Xinyan Hu, Jianxun Cai, Xiaojun Hu, Haopei Zhang, Ni Zhao, Xiwei Xu, Hui Guo & Pengfei Pang
Pages: 1-14
Published online: 30 Oct 2022
AbstractforDDX24 regulates the chemosensitivity of hepatocellular carcinoma to sorafenib via mediating the expression of SNORA18 | Full Text | References | PDF (50.5 MB) | EPUB | Supplemental
  • 1401 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Article
LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
Changjiang Lei, Shaoting Li, Ying Fan, Li Hua, Qingyun Pan, Yuan Li, Zhixiong Long & Rui Yang
Pages: 1-13
Published online: 03 Nov 2022
AbstractforLncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway | Full Text | References | PDF (7.1 MB) | EPUB | Supplemental
  • 1420 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
STEAP2 promotes osteosarcoma progression by inducing epithelial–mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2
Dong Zhang, Haitao Liu, Weihua Wang, Gang Xu, Chenxiao Yin & Songgang Wang
Pages: 1-16
Published online: 31 Oct 2022
AbstractforSTEAP2 promotes osteosarcoma progression by inducing epithelial–mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2 | Full Text | References | PDF (7.7 MB) | EPUB | Supplemental
  • 1447 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer
Lei Duan, Sarah J. Calhoun, Ricardo E. Perez, Virgilia Macias, Fatima Mir, Paolo Gattuso & Carl G. Maki
Pages: 1-10
Published online: 04 Nov 2022
AbstractforProlylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 1115 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Perspectives

Article Commentary
Challenges documenting racial disparities in Merkel cell carcinoma
Mackenzie R. Martin, Noreen Mohsin, Serena Vilasi, Danielle Reed & Isaac Brownell
Pages: 1-3
Published online: 20 Nov 2022
AbstractforChallenges documenting racial disparities in Merkel cell carcinoma | Full Text | References | PDF (197 KB) | EPUB | Supplemental
  • 991 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Research Paper

Article
Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2
Weidong Yuan, Hewei Zhao, Ang Zhou & Shaochuang Wang
Pages: 1-12
Published online: 20 Nov 2022
AbstractforInterference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2 | Full Text | References | PDF (9.8 MB) | EPUB
  • 903 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access
Article
LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression
Zhi Yu, Xin Wang, Kai Niu, Le Sun & Dongjie Li
Pages: 1-9
Published online: 21 Nov 2022
AbstractforLncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 1100 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Explore articles

Explore the most recently published articles

NRS2002 score as a prognostic factor in solid tumors treated with immune checkpoint inhibitor therapy: a real-world evidence analysis
Wanfen Tang et al.
Article | Published online: 30 May 2024
Open Access
Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis
Jing Jiang et al.
Article | Published online: 30 May 2024
Open Access
T-Cell redirecting bispecific antibodies: a review of a novel class of immuno-oncology for advanced prostate cancer
Julia Palecki et al.
Review Article | Published online: 27 May 2024
Open Access
eIf3a mediates malignant biological behaviors in colorectal cancer through the PI3K/AKT signaling pathway
Chao Huo et al.
Article | Published online: 23 May 2024
Open Access