mAbs, Volume 11, Issue 7 (2019)

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mAbs, Volume 11, Issue 7 (2019)

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Short Communication

Brief Report
Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry
Steffen Lippold, Simone Nicolardi, Elena Domínguez-Vega, Anna-Katharina Heidenreich, Gestur Vidarsson, Dietmar Reusch, Markus Haberger, Manfred Wuhrer & David Falck
Pages: 1191-1196
Published online: 02 Aug 2019
AbstractforGlycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Brief Report

Report
Looking for therapeutic antibodies in next-generation sequencing repositories
Konrad Krawczyk, Matthew I. J. Raybould, Aleksandr Kovaltsuk & Charlotte M. Deane
Pages: 1197-1205
Published online: 17 Jul 2019
AbstractforLooking for therapeutic antibodies in next-generation sequencing repositories | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Report

Report
Selection and characterization of FcεRI phospho-ITAM specific antibodies
Nileena Velappan, Avanika Mahajan, Leslie Naranjo, Priyanka Velappan, Nasim Andrews, Nicholas Tiee, Subhendu Chakraborti, Colin Hemez, Tiziano Gaiotto, Bridget Wilson & Andrew Bradbury
Pages: 1206-1218
Published online: 16 Jul 2019
AbstractforSelection and characterization of FcεRI phospho-ITAM specific antibodies | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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Report
Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics
Oksana Tyshchuk, Christoph Gstöttner, Dennis Funk, Simone Nicolardi, Stefan Frost, Stefan Klostermann, Tim Becker, Elena Jolkver, Felix Schumacher, Claudia Ferrara Koller, Hans Rainer Völger, Manfred Wuhrer, Patrick Bulau & Michael Mølhøj
Pages: 1219-1232
Published online: 24 Jul 2019
AbstractforCharacterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Report
Specific and high-resolution identification of monoclonal antibody fragments detected by capillary electrophoresis–sodium dodecyl sulfate using reversed-phase HPLC with top-down mass spectrometry analysis
Wei-Han Wang, Jasmina Cheung-Lau, Yan Chen, Michael Lewis & Qing Mike Tang
Pages: 1233-1244
Published online: 02 Sep 2019
AbstractforSpecific and high-resolution identification of monoclonal antibody fragments detected by capillary electrophoresis–sodium dodecyl sulfate using reversed-phase HPLC with top-down mass spectrometry analysis | Full Text | References | PDF (7.9 MB) | EPUB | Supplemental
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Free Access
Report
Characterization of a single reporter-gene potency assay for T-cell-dependent bispecific molecules
Ho Young Lee, Ames Register, Jeongsup Shim, Edward Contreras, Qiang Wu & Guoying Jiang
Pages: 1245-1253
Published online: 26 Jul 2019
AbstractforCharacterization of a single reporter-gene potency assay for T-cell-dependent bispecific molecules | Full Text | References | PDF (2.9 MB) | EPUB
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Report
Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells
Kamal Kishore Joshi, Wilson Phung, Guanghui Han, Yiyuan Yin, Ingrid Kim, Wendy Sandoval & Paul J. Carter
Pages: 1254-1265
Published online: 26 Jul 2019
AbstractforElucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Report
Engineering an anti-CD52 antibody for enhanced deamidation stability
Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Scott VanPatten, Anders Lund, Jaime Day, Yanfeng Zhou, Tracey McSherry, Clark Q. Pan & Rebecca Sendak
Pages: 1266-1275
Published online: 18 Jul 2019
AbstractforEngineering an anti-CD52 antibody for enhanced deamidation stability | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Report
Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life
Brian C. Mackness, Julie A. Jaworski, Ekaterina Boudanova, Anna Park, Delphine Valente, Christine Mauriac, Olivier Pasquier, Thorsten Schmidt, Mostafa Kabiri, Abdullah Kandira, Katarina Radošević & Huawei Qiu
Pages: 1276-1288
Published online: 18 Jul 2019
AbstractforAntibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Report
L445P mutation on heavy chain stabilizes IgG4 under acidic conditions
Chang-Ai Xu, Andrew Z. Feng, Charan K. Ramineni, Matthew R. Wallace, Elizabeth K. Culyba, Kevin P. Guay, Kinjal Mehta, Robert Mabry, Stephen Farrand, Jin Xu & Jianwen Feng
Pages: 1289-1299
Published online: 11 Jul 2019
AbstractforL445P mutation on heavy chain stabilizes IgG4 under acidic conditions | Full Text | References | PDF (3.7 MB) | EPUB
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Report
Binding symmetry and surface flexibility mediate antibody self-association
Joseph D. Schrag, Marie-Ève Picard, Francis Gaudreault, Louis-Patrick Gagnon, Jason Baardsnes, Mahder S. Manenda, Joey Sheff, Christophe Deprez, Cassio Baptista, Hervé Hogues, John F. Kelly, Enrico O. Purisima, Rong Shi & Traian Sulea
Pages: 1300-1318
Published online: 18 Jul 2019
AbstractforBinding symmetry and surface flexibility mediate antibody self-association | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 3110 Views
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Report
Measuring the effects of macromolecular crowding on antibody function with biolayer interferometry
Dorothy M. Kim, Xiao Yao, Ram P. Vanam & Michael S. Marlow
Pages: 1319-1330
Published online: 12 Aug 2019
AbstractforMeasuring the effects of macromolecular crowding on antibody function with biolayer interferometry | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Report
Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4
Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra & Michael Foley
Pages: 1331-1340
Published online: 23 Aug 2019
AbstractforHalf-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4 | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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