mAbs, Volume 5, Issue 3 (2013)

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mAbs, Volume 5, Issue 3 (2013)

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Letter to the Editor

Letter
Monoclonal antibodies targeting CD20
Chien-Hsing Chang, Edmund A. Rossi & David M. Goldenberg
Pages: 335-336
Published online: 14 Mar 2013
CitationforMonoclonal antibodies targeting CD20 | Full Text | References | PDF (264 KB)
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Letter
Response to: Monoclonal antibodies targeting CD20
Christian Klein, Alfred Lammens, Wolfgang Schäfer, Guy Georges, Manfred Schwaiger, Ekkehard Mössner, Karl-Peter Hopfner, Pablo Umaña & Gerhard Niederfellner
Pages: 337-338
Published online: 14 Mar 2013
CitationforResponse to: Monoclonal antibodies targeting CD20 | Full Text | References | PDF (268.5 KB)
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Meeting Report

Meeting Report
8th Annual European Antibody Congress 2012
November 27–28, 2012, Geneva, Switzerland
Alain Beck, Paul J. Carter, Hans-Peter Gerber, Alexey A. Lugovskoy, Thierry Wurch, Jagath R. Junutula, Roland E Kontermann & Robert Mabry
Pages: 339-357
Published online: 14 Mar 2013
Abstractfor8th Annual European Antibody Congress 2012 | Full Text | References | PDF (558.8 KB)
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Brief Report

Brief Report
Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule
Clarissa G. Jakob, Rohinton Edalji, Russell A. Judge, Enrico DiGiammarino, Yingchun Li, Jijie Gu & Tariq Ghayur
Pages: 358-363
Published online: 02 Apr 2013
AbstractforStructure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule | Full Text | References | PDF (1.9 MB) | Supplemental
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Report

Article
The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
Ivan Correia, Joyce Sung, Randall Burton, Clarissa G. Jakob, Bridget Carragher, Tariq Ghayur & Czeslaw Radziejewski
Pages: 364-372
Published online: 09 Apr 2013
AbstractforThe structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen | Full Text | References | PDF (1 MB) | Supplemental
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Article
Agonistic TAM-163 antibody targeting tyrosine kinase receptor-B
Applying mechanistic modeling to enable preclinical to clinical translation and guide clinical trial design
Yulia Vugmeyster, Cynthia Rohde, Mylene Perreault, Ruth E. Gimeno & Pratap Singh
Pages: 373-383
Published online: 25 Mar 2013
AbstractforAgonistic TAM-163 antibody targeting tyrosine kinase receptor-B | Full Text | References | PDF (1,019.3 KB) | Supplemental
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Article
Immune suppression in cynomolgus monkeys by XPro9523
An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn
Matthew J. Bernett, Seung Y. Chu, Irene Leung, Gregory L. Moore, Sung-Hyung Lee, Erik Pong, Hsing Chen, Sheryl Phung, Umesh S. Muchhal, Holly M. Horton, Greg A. Lazar, John R Desjarlais & David E. Szymkowski
Pages: 384-396
Published online: 02 Apr 2013
AbstractforImmune suppression in cynomolgus monkeys by XPro9523 | Full Text | References | PDF (2.2 MB) | Supplemental
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Article
Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities
Susan H. Tam, Stephen G. McCarthy, Kerry Brosnan, Kenneth M. Goldberg & Bernard J. Scallon
Pages: 397-405
Published online: 02 Apr 2013
AbstractforCorrelations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities | Full Text | References | PDF (1 MB)
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Article
Monovalent IgG4 molecules
Immunoglobulin Fc mutations that result in a monomeric structure
Ian C. Wilkinson, Susan B. Fowler, LeeAnn Machiesky, Kenneth Miller, David B. Hayes, Morshed Adib, Cheng Her, M. Jack Borrok, Ping Tsui, Matthew Burrell, Dominic J. Corkill, Susanne Witt, David C. Lowe & Carl I. Webster
Pages: 406-417
Published online: 08 Apr 2013
AbstractforMonovalent IgG4 molecules | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity
Yang Shen, Lin Zeng, Aiping Zhu, Tim Blanc, Dipa Patel, Anthony Pennello, Amtul Bari, Stanley Ng, Kris Persaud, Yun (Kenneth) Kang, Paul Balderes, David Surguladze, Sagit Hindi, Qinwei Zhou, Dale L. Ludwig & Marshall Snavely
Pages: 418-431
Published online: 08 Apr 2013
AbstractforRemoval of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity | Full Text | References | PDF (1.6 MB) | Supplemental
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Article
Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule
David Ouellette, Chris Chumsae, Anca Clabbers, Czeslaw Radziejewski & Ivan Correia
Pages: 432-444
Published online: 22 Apr 2013
AbstractforComparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule | Full Text | References | PDF (3.2 MB)
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Article
A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties
Thomas Tiller, Ingrid Schuster, Dorothée Deppe, Katja Siegers, Ralf Strohner, Tanja Herrmann, Marion Berenguer, Dominique Poujol, Jennifer Stehle, Yvonne Stark, Martin Heßling, Daniela Daubert, Karin Felderer, Stefan Kaden, Johanna Kölln, Markus Enzelberger & Stefanie Urlinger
Pages: 445-470
Published online: 09 Apr 2013
AbstractforA fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties | Full Text | References | PDF (5.7 MB) | Supplemental
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Article
A novel in vivo method for isolating antibodies from a phage display library by neuronal retrograde transport selectively yields antibodies against p75NTR
Hiroaki Tani, Jane K. Osbourn, Edward H. Walker, Robert A. Rush & Ian A. Ferguson
Pages: 471-478
Published online: 02 Apr 2013
AbstractforA novel in vivo method for isolating antibodies from a phage display library by neuronal retrograde transport selectively yields antibodies against p75NTR | Full Text | References | PDF (1.2 MB)
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Article
Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry
Rabah Gahoual, Alicia Burr, Jean-Marc Busnel, Lauriane Kuhn, Phillipe Hammann, Alain Beck, Yannis-Nicolas François & Emmanuelle Leize-Wagner
Pages: 479-490
Published online: 05 Apr 2013
AbstractforRapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry | Full Text | References | PDF (3.9 MB)
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Article
Aggregation of biopharmaceuticals in human plasma and human serum
Implications for drug research and development
Tudor Arvinte, Caroline Palais, Erin Green-Trexler, Sonia Gregory, Henryk Mach, Chakravarthy Narasimhan & Mohammed Shameem
Pages: 491-500
Published online: 09 Apr 2013
AbstractforAggregation of biopharmaceuticals in human plasma and human serum | Full Text | References | PDF (3.7 MB)
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Article
A high-throughput media design approach for high performance mammalian fed-batch cultures
Yolande Rouiller, Arnaud Périlleux, Natacha Collet, Martin Jordan, Matthieu Stettler & Hervé Broly
Pages: 501-511
Published online: 05 Apr 2013
AbstractforA high-throughput media design approach for high performance mammalian fed-batch cultures | Full Text | References | PDF (1.3 MB)
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