mAbs, Volume 7, Issue 2 (2015)

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mAbs, Volume 7, Issue 2 (2015)

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Editor's Corner

Editorial
Note of appreciation to reviewers
Janice M Reichert
Pages: 281-285
Published online: 11 Mar 2015
AbstractforNote of appreciation to reviewers | Full Text | PDF (48.4 KB)
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Review

Article
Clinical considerations for the development of biosimilars in oncology
Mark A Socinski, Giuseppe Curigliano, Ira Jacobs, Barry Gumbiner, Judith MacDonald & Dolca Thomas
Pages: 286-293
Published online: 11 Mar 2015
AbstractforClinical considerations for the development of biosimilars in oncology | Full Text | References | PDF (191.2 KB)
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Short Communication

Rapid Communication
 De novo isolation of antibodies with pH-dependent binding properties
Pauline Bonvin, Sophie Venet, Gaëlle Fontaine, Ulla Ravn, Franck Gueneau, Marie Kosco-Vilbois, Amanda El Proudfoot & Nicolas Fischer
Pages: 294-302
Published online: 11 Mar 2015
Abstractfor De novo isolation of antibodies with pH-dependent binding properties | Full Text | References | PDF (506.8 KB) | Supplemental
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Perspective

Macrophages are critical effectors of antibody therapies for cancer
Kipp Weiskopf & Irving L Weissman
Pages: 303-310
Published online: 11 Mar 2015
AbstractforMacrophages are critical effectors of antibody therapies for cancer | Full Text | References | PDF (228.7 KB)
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Reports

Article
Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma
Marije B Overdijk, Sandra Verploegen, Marijn Bögels, Marjolein van Egmond, Jeroen J Lammerts van Bueren, Tuna Mutis, Richard WJ Groen, Esther Breij, Anton CM Martens, Wim K Bleeker & Paul WHI Parren
Pages: 311-320
Published online: 11 Mar 2015
AbstractforAntibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma | Full Text | References | PDF (454.7 KB) | Supplemental
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Article
C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity
Valerie R Wiersma, Marco de Bruyn, Ce Shi, Marloes JM Gooden, Maartje CA Wouters, Douwe F Samplonius, Djoke Hendriks, Hans W Nijman, Yunwei Wei, Jin Zhou, Wijnand Helfrich & Edwin Bremer
Pages: 321-330
Published online: 11 Mar 2015
AbstractforC-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity | Full Text | References | PDF (954.2 KB) | Supplemental
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Article
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity
Yasmina Noubia Abdiche, Yik Andy Yeung, Javier Chaparro-Riggers, Ishita Barman, Pavel Strop, Sherman Michael Chin, Amber Pham, Gary Bolton, Dan McDonough, Kevin Lindquist, Jaume Pons & Arvind Rajpal
Pages: 331-343
Published online: 11 Mar 2015
AbstractforThe neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs
Derry C Roopenian, Benjamin E Low, Gregory J Christianson, Gabriele Proetzel, Thomas J Sproule & Michael V Wiles
Pages: 344-351
Published online: 11 Mar 2015
AbstractforAlbumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs | Full Text | References | PDF (313.8 KB)
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Article
Aggregation risk prediction for antibodies and its application to biotherapeutic development
Olga Obrezanova, Andreas Arnell, Ramón Gómez de la Cuesta, Maud E Berthelot, Thomas RA Gallagher, Jesús Zurdo & Yvette Stallwood
Pages: 352-363
Published online: 11 Mar 2015
AbstractforAggregation risk prediction for antibodies and its application to biotherapeutic development | Full Text | References | PDF (425.9 KB)
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Article
Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies
Xiufeng Wu, Arlene J Sereno, Flora Huang, Kai Zhang, Micheal Batt, Jonathan R Fitchett, Dongmei He, Heather L Rick, Elaine M Conner & Stephen J Demarest
Pages: 364-376
Published online: 11 Mar 2015
AbstractforProtein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Improving target cell specificity using a novel monovalent bispecific IgG design
Yariv Mazor, Vaheh Oganesyan, Chunning Yang, Anna Hansen, Jihong Wang, Hongji Liu, Kris Sachsenmeier, Marcia Carlson, Dhanesh V Gadre, Martin Jack Borrok, Xiang-Qing Yu, William Dall’Acqua, Herren Wu & Partha Sarathi Chowdhury
Pages: 377-389
Published online: 11 Mar 2015
AbstractforImproving target cell specificity using a novel monovalent bispecific IgG design | Full Text | References | PDF (884.3 KB) | Supplemental
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Article
Phage display-based generation of novel internalizing antibody fragments for immunotoxin-based treatment of acute myeloid leukemia
Jenny Fitting, Tobias Blume, Andre ten Haaf, Wolfgang Blau, Stefan Gattenlöhner, Mehmet Kemal Tur & Stefan Barth
Pages: 390-402
Published online: 11 Mar 2015
AbstractforPhage display-based generation of novel internalizing antibody fragments for immunotoxin-based treatment of acute myeloid leukemia | Full Text | References | PDF (829 KB)
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Article
Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells
Jake Chng, Tianhua Wang, Rui Nian, Ally Lau, Kong Meng Hoi, Steven CL Ho, Peter Gagnon, Xuezhi Bi & Yuansheng Yang
Pages: 403-412
Published online: 11 Mar 2015
AbstractforCleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells | Full Text | References | PDF (521.7 KB)
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Article
PDADMAC flocculation of Chinese hamster ovary cells: Enabling a centrifuge-less harvest process for monoclonal antibodies
Thomas McNerney, Anne Thomas, Anna Senczuk, Krista Petty, Xiaoyang Zhao, Rob Piper, Juliane Carvalho, Matthew Hammond, Satin Sawant & Jeanine Bussiere
Pages: 413-427
Published online: 11 Mar 2015
AbstractforPDADMAC flocculation of Chinese hamster ovary cells: Enabling a centrifuge-less harvest process for monoclonal antibodies | Full Text | References | PDF (1,017.8 KB)
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Article
Molecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody
Li Peng, Vaheh Oganesyan, Herren Wu, William F Dall’Acqua & Melissa M Damschroder
Pages: 428-439
Published online: 11 Mar 2015
AbstractforMolecular basis for antagonistic activity of anifrolumab, an anti-interferon–α receptor 1 antibody | Full Text | References | PDF (988.3 KB)
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Article
Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency
Yun Yang, Qingcheng Guo, Mao Xia, Yantao Li, Xiaoyun Peng, Tao Liu, Xin Tong, Jin Xu, Huaizu Guo, Weizhu Qian, Sheng Hou, Jianxin Dai, Hao Wang, Rong Liu & Yajun Guo
Pages: 440-450
Published online: 11 Mar 2015
AbstractforGeneration and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency | Full Text | References | PDF (831.6 KB) | Supplemental
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