mAbs, Volume 8, Issue 6 (2016)

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mAbs, Volume 8, Issue 6 (2016)

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Meeting Report

Meeting Report
Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 – April 1, 2016, Tours, France
Guillaume Desoubeaux, Janice M. Reichert, Matthew Sleeman, Karen L. Reckamp, Bernhard Ryffel, Jörg P. Adamczewski, Theresa D. Sweeney, Rita Vanbever, Patrice Diot, Caroline A. Owen, Clive Page, Stéphanie Lerondel, Alain Le Pape & Nathalie Heuze-Vourc'h
Pages: 999-1009
Published online: 01 Jul 2016
AbstractforTherapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 – April 1, 2016, Tours, France | Full Text | References | PDF (480.6 KB)
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Review

Review
The use of CrossMAb technology for the generation of bi- and multispecific antibodies
Christian Klein, Wolfgang Schaefer & Jörg T. Regula
Pages: 1010-1020
Published online: 11 Jul 2016
AbstractforThe use of CrossMAb technology for the generation of bi- and multispecific antibodies | Full Text | References | PDF (1.1 MB)
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Report

Report
Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques
Jing Fang, Catalin Doneanu, William R. Alley Jr., Ying Qing Yu, Alain Beck & Weibin Chen
Pages: 1021-1034
Published online: 01 Jul 2016
AbstractforAdvanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques | Full Text | References | PDF (1.8 MB) | Supplemental
  • 4607 Views
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Report
Discovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial VH:VL libraries from immunized animals
Bo Wang, Chang-Han Lee, Erik L. Johnson, Christien A. Kluwe, Josephine C. Cunningham, Hidetaka Tanno, Richard M. Crooks, George Georgiou & Andrew D. Ellington
Pages: 1035-1044
Published online: 24 Jun 2016
AbstractforDiscovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial VH:VL libraries from immunized animals | Full Text | References | PDF (917.3 KB) | Supplemental
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Report
Structural diversity in a human antibody germline library
Alexey Teplyakov, Galina Obmolova, Thomas J. Malia, Jinquan Luo, Salman Muzammil, Raymond Sweet, Juan Carlos Almagro & Gary L. Gilliland
Pages: 1045-1063
Published online: 17 Jun 2016
AbstractforStructural diversity in a human antibody germline library | Full Text | References | PDF (1.7 MB) | Supplemental
  • 5108 Views
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Report
Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies
Lindsay B. Avery, Mengmeng Wang, Mania S. Kavosi, Alison Joyce, Jeffrey C. Kurz, Yao-Yun Fan, Martin E. Dowty, Minlei Zhang, Yiqun Zhang, Aili Cheng, Fei Hua, Hannah M. Jones, Hendrik Neubert, Robert J. Polzer & Denise M. O'Hara
Pages: 1064-1078
Published online: 01 Jul 2016
AbstractforUtility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies | Full Text | References | PDF (1.4 MB) | Supplemental
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Report
Quantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies
Yinyin Li, Michael Monine, Yu Huang, Patrick Swann, Ivan Nestorov & Yelena Lyubarskaya
Pages: 1079-1087
Published online: 24 Jun 2016
AbstractforQuantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies | Full Text | References | PDF (908 KB)
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Report
A comparison of biophysical characterization techniques in predicting monoclonal antibody stability
Geetha Thiagarajan, Andrew Semple, Jose K. James, Jason K. Cheung & Mohammed Shameem
Pages: 1088-1097
Published online: 11 Jul 2016
AbstractforA comparison of biophysical characterization techniques in predicting monoclonal antibody stability | Full Text | References | PDF (918.6 KB)
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Report
Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation
Qian Gong, Meredith Hazen, Brett Marshall, Susan R. Crowell, Qinglin Ou, Athena W. Wong, Wilson Phung, Jean-Michel Vernes, Y. Gloria Meng, Max Tejada, Dana Andersen & Robert F. Kelley
Pages: 1098-1106
Published online: 24 Jun 2016
AbstractforIncreased in vivo effector function of human IgG4 isotype antibodies through afucosylation | Full Text | References | PDF (595.4 KB) | Supplemental
  • 2471 Views
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Report
Acid-induced aggregation propensity of nivolumab is dependent on the Fc
Boning Liu, Huaizu Guo, Jin Xu, Ting Qin, Lu Xu, Junjie Zhang, Qingcheng Guo, Dapeng Zhang, Weizhu Qian, Bohua Li, Jianxin Dai, Sheng Hou, Yajun Guo & Hao Wang
Pages: 1107-1117
Published online: 11 Jul 2016
AbstractforAcid-induced aggregation propensity of nivolumab is dependent on the Fc | Full Text | References | PDF (938.3 KB) | Supplemental
  • 5408 Views
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Report
A hingeless Fc fusion system for site-specific cleavage by IdeS
Shabazz Novarra, Luba Grinberg, Keith W. Rickert, Arnita Barnes, Susan Wilson & Manuel Baca
Pages: 1118-1125
Published online: 16 Jun 2016
AbstractforA hingeless Fc fusion system for site-specific cleavage by IdeS | Full Text | References | PDF (793.4 KB)
  • 2792 Views
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Report
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops
Bas van der Woning, Gitte De Boeck, Christophe Blanchetot, Vladimir Bobkov, Alex Klarenbeek, Michael Saunders, Magali Waelbroeck, Toon Laeremans, Jan Steyaert, Anna Hultberg & Hans De Haard
Pages: 1126-1135
Published online: 24 Jun 2016
AbstractforDNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops | Full Text | References | PDF (867.8 KB) | Supplemental
  • 3579 Views
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Report
Evaluation of the structural, physicochemical, and biological characteristics of SB4, a biosimilar of etanercept
Ick Hyun Cho, Nayoung Lee, Dami Song, Seong Young Jung, George Bou-Assaf, Zoran Sosic, Wei Zhang & Yelena Lyubarskaya
Pages: 1136-1155
Published online: 01 Jul 2016
AbstractforEvaluation of the structural, physicochemical, and biological characteristics of SB4, a biosimilar of etanercept | Full Text | References | PDF (2.5 MB)
  • 8134 Views
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Report
Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir
Huanhuan Ren, Guiqin Wang, Shuangshuang Wang, Honglin Chen, Zhiwei Chen, Hongxing Hu, Genhong Cheng & Paul Zhou
Pages: 1156-1166
Published online: 03 Jun 2016
AbstractforCross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir | Full Text | References | PDF (1.6 MB)
  • 1044 Views
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Report
Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator
Amandeep K. Gakhal, Timothy J. Jensen, Zoltan Bozoky, Ariel Roldan, Gergely L. Lukacs, Julie Forman-Kay, John R. Riordan & Sachdev S. Sidhu
Pages: 1167-1176
Published online: 17 Jun 2016
AbstractforDevelopment and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator | Full Text | References | PDF (1 MB) | Supplemental
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