OncoImmunology, Volume 10, Issue 1 (2021)

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OncoImmunology, Volume 10, Issue 1 (2021)

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Original Research

Article
Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma
Soheila Shirinbak, Randall Y. Chan, Shilpa Shahani, Sakunthala Muthugounder, Rebekah Kennedy, Long T. Hung, G. Esteban Fernandez, Michael D. Hadjidaniel, Babak Moghimi, Michael A. Sheard, Alan L. Epstein, Muller Fabbri, Hiroyuki Shimada & Shahab Asgharzadeh
Article: 1838140
Published online: 04 Jan 2021
AbstractforCombined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma | Full Text | References | PDF (8.3 MB) | EPUB
  • 4057 Views
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Open Access
Article
Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients
Chantal Reina-Ortiz, Michael Constantinides, Alexis Fayd-Herbe-de-Maudave, Jessy Présumey, Javier Hernandez, Guillaume Cartron, David Giraldos, Rosana Díez, Isabel Izquierdo, Gemma Azaceta, Luis Palomera, Isabel Marzo, Javier Naval, Alberto Anel & Martín Villalba
Article: 1853314
Published online: 29 Dec 2020
AbstractforExpanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients | Full Text | References | PDF (2.4 MB) | EPUB
  • 3715 Views
  • 20 CrossRef citations
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Open Access
Article
Immunological alternation in COVID-19 patients with cancer and its implications on mortality
Guangyao Cai, Yue Gao, Shaoqing Zeng, Yang Yu, Xingyu Liu, Dan Liu, Ya Wang, Ruidi Yu, Aakash Desai, Chunrui Li & Qinglei Gao
Article: 1854424
Published online: 04 Jan 2021
AbstractforImmunological alternation in COVID-19 patients with cancer and its implications on mortality | Full Text | References | PDF (10.4 MB) | EPUB
  • 3795 Views
  • 17 CrossRef citations
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Open Access
Article
Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response
Adeline Raynaud, Klervi Desrumeaux, Laurent Vidard, Elise Termine, Daniel Baty, Patrick Chames, Emmanuelle Vigne & Brigitte Kerfelec
Article: 1854529
Published online: 29 Dec 2020
AbstractforAnti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response | Full Text | References | PDF (1.6 MB) | EPUB
  • 5204 Views
  • 18 CrossRef citations
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Open Access
Article
Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma
Ryusuke Hayashi, Toshihiro Nagato, Takumi Kumai, Kenzo Ohara, Mizuho Ohara, Takayuki Ohkuri, Yui Hirata-Nozaki, Shohei Harabuchi, Akemi Kosaka, Marino Nagata, Yuki Yajima, Syunsuke Yasuda, Kensuke Oikawa, Michihisa Kono, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Esteban Celis, Yasuaki Harabuchi & Hiroya Kobayashi
Article: 1856545
Published online: 29 Dec 2020
AbstractforExpression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma | Full Text | References | PDF (3.9 MB) | EPUB
  • 2917 Views
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Open Access

Correction

Correction
Correction
Article: 1857947
Published online: 20 Jan 2021
CitationforCorrection | Full Text | PDF (3.7 MB) | EPUB
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Open Access

Editorial

Editorial
A major genetic accelerator of cancer diagnosis: rs867228 in FPR1
Zsofia Sztupinszki, Julie Le Naour, Erika Vacchelli, Pierre Laurent-Puig, Suzette Delaloge, Zoltan Szallasi & Guido Kroemer
Article: 1859064
Published online: 06 Jan 2021
First Page PreviewforA major genetic accelerator of cancer diagnosis: rs867228 in FPR1 | Full Text | References | PDF (495.9 KB) | EPUB
  • 2223 Views
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Open Access

Original Research

Article
Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis
Serika D Naicker, Claire L Feerick, Kevin Lynch, Dawn Swan, Cian McEllistrim, Robert Henderson, Niamh A Leonard, Oliver Treacy, Alessandro Natoni, Athina Rigalou, Joana Cabral, Christopher Chiu, Kate Sasser, Thomas Ritter, Michael O’Dwyer & Aideen E Ryan
Article: 1859263
Published online: 25 Jan 2021
AbstractforCyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis | Full Text | References | PDF (2.7 MB) | EPUB
  • 4165 Views
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Open Access
Article
Gas plasma irradiation of breast cancers promotes immunogenicity, tumor reduction, and an abscopal effect in vivo
Hamed Mahdikia, Fariba Saadati, Eric Freund, Udo S. Gaipl, Keivan Majidzadeh-a, Babak Shokri & Sander Bekeschus
Article: 1859731
Published online: 29 Dec 2020
AbstractforGas plasma irradiation of breast cancers promotes immunogenicity, tumor reduction, and an abscopal effect in vivo | Full Text | References | PDF (11.8 MB) | EPUB
  • 3604 Views
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Open Access
Article
Primary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associations
Sharon Grisaru-Tal, Michal Itan, Daniel G Grass, Javier Torres-Roca, Steven A Eschrich, Yaara Gordon, Avishay Dolitzky, Inbal Hazut, Shmuel Avlas, Elizabeth A Jacobsen, Tomer Ziv-Baran & Ariel Munitz
Article: 1859732
Published online: 30 Dec 2020
AbstractforPrimary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associations | Full Text | References | PDF (4.8 MB) | EPUB
  • 3031 Views
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Open Access

Brief Report

Brief Report
Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production
Connie C. Qiu, Kevin P. Kotredes, Tess Cremers, Sajan Patel, Alexandra Afanassiev, Michael Slifker, Stefania Gallucci & Ana M. Gamero
Article: 1860477
Published online: 29 Dec 2020
AbstractforTargeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production | Full Text | References | PDF (3.2 MB) | EPUB
  • 2214 Views
  • 5 CrossRef citations
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Open Access

Original Research

Article
T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production
Saskia D. van Asten, Rosa de Groot, Marleen M. van Loenen, Suzanne M. Castenmiller, Jeroen de Jong, Kim Monkhorst, John B.A.G. Haanen, Derk Amsen, Axel Bex, Robbert M. Spaapen & Monika C. Wolkers
Article: 1860482
Published online: 21 Jan 2021
AbstractforT cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production | Full Text | References | PDF (1.9 MB) | EPUB
  • 3461 Views
  • 14 CrossRef citations
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Open Access
Article
A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma
Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Stefan Fröhling, Solange Peters, Barbara Seliger, Peter Schirmacher, Michael Thomas, Petros Christopoulos & Albrecht Stenzinger
Article: 1860586
Published online: 11 Jan 2021
AbstractforA gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma | Full Text | References | PDF (7.8 MB) | EPUB
  • 4179 Views
  • 40 CrossRef citations
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Open Access
Article
Prognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study)
Sida Cheng, Wenlong Zhong, Kun Xia, Peng Hong, Rongcheng Lin, Bo Wang, Xinfei Li, Junyu Chen, Zining Liu, Hongxian Zhang, Cheng Liu, Liefu Ye, Lulin Ma, Tianxin Lin, Xuesong Li, Jian Huang & Liqun Zhou
Article: 1861737
Published online: 04 Jan 2021
AbstractforPrognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study) | Full Text | References | PDF (2.3 MB) | EPUB
  • 2868 Views
  • 7 CrossRef citations
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Open Access
Article
M1-like TAMs are required for the efficacy of PD-L1/PD-1 blockades in gastric cancer
Rui Zhao, Qianyi Wan, Yong Wang, Yutao Wu, Shuomeng Xiao, Qiqi Li, Xiaoding Shen, Wen Zhuang, Yong Zhou, Lin Xia, Yinghan Song, Yi Chen, Hanshuo Yang & Xiaoting Wu
Article: 1862520
Published online: 30 Dec 2020
AbstractforM1-like TAMs are required for the efficacy of PD-L1/PD-1 blockades in gastric cancer | Full Text | References | PDF (2.2 MB) | EPUB
  • 3638 Views
  • 26 CrossRef citations
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Open Access
Article
Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse
Yasmin Kamal, Dennis Dwan, Hannah J. Hoehn, Rebeca Sanz-Pamplona, M. Henar Alonso, Victor Moreno, Chao Cheng, Michael J. Schell, Youngchul Kim, Seth I. Felder, Hedy S. Rennert, Marilena Melas, Charalampos Lazaris, Joseph D. Bonner, Erin M. Siegel, David Shibata, Gad Rennert, Stephen B. Gruber, H. Robert Frost, Christopher I. Amos & Stephanie L. Schmit
Article: 1862529
Published online: 09 Mar 2021
AbstractforTumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse | Full Text | References | PDF (5 MB) | EPUB
  • 4244 Views
  • 10 CrossRef citations
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Open Access
Article
Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma
Taigo Kato, Kazuma Kiyotani, Eisuke Tomiyama, Yoko Koh, Makoto Matsushita, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Kazutoshi Fujita, Norio Nonomura & Motohide Uemura
Article: 1862948
Published online: 19 Jan 2021
AbstractforPeripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma | Full Text | References | PDF (1.4 MB) | EPUB
  • 3519 Views
  • 19 CrossRef citations
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Open Access

Editorial

Editorial
Ferroptosis becomes immunogenic: implications for anticancer treatments
Daolin Tang, Oliver Kepp & Guido Kroemer
Article: 1862949
Published online: 29 Dec 2020
AbstractforFerroptosis becomes immunogenic: implications for anticancer treatments | Full Text | References | PDF (331.6 KB) | EPUB
  • 4605 Views
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Open Access

Author’s View

Article Commentary
Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
Prathyusha Konda, Liubov M. Lifshits, John A. Roque III, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland & Shashi Gujar
Article: 1863626
Published online: 29 Dec 2020
AbstractforDiscovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy | Full Text | References | PDF (3.3 MB) | EPUB
  • 3394 Views
  • 22 CrossRef citations
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Open Access

Original Research

Article
A stratified phase I dose escalation trial of hypofractionated radiotherapy followed by ipilimumab in metastatic melanoma: long-term follow-up and final outcomes
Amit Maity, Rosemarie Mick, Ramesh Rengan, Tara C. Mitchell, Ravi K. Amaravadi, Lynn M. Schuchter, Daniel A. Pryma, Dana M. Patsch, Alisha P. Maity, Andy J. Minn, Robert H. Vonderheide & John N. Lukens
Article: 1863631
Published online: 31 Jan 2021
AbstractforA stratified phase I dose escalation trial of hypofractionated radiotherapy followed by ipilimumab in metastatic melanoma: long-term follow-up and final outcomes | Full Text | References | PDF (1.3 MB) | EPUB
  • 2951 Views
  • 16 CrossRef citations
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Open Access
Article
Anti-PD-1 antibody HX008 combined with oxaliplatin plus capecitabine for advanced gastric or esophagogastric junction cancer: a multicenter, single-arm, open-label, phase Ib trial
Jianming Xu, Nong Xu, Yuxian Bai, Rongrui Liu, Chenyu Mao, Hong Sui, Xiaofei Wang, Qian Jiang & Yiwei Dou
Article: 1864908
Published online: 31 Dec 2020
AbstractforAnti-PD-1 antibody HX008 combined with oxaliplatin plus capecitabine for advanced gastric or esophagogastric junction cancer: a multicenter, single-arm, open-label, phase Ib trial | Full Text | References | PDF (1.1 MB) | EPUB
  • 2402 Views
  • 9 CrossRef citations
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Open Access
Article
Quantitative analysis of CMTM6 expression in tumor microenvironment in metastatic melanoma and association with outcome on immunotherapy
Sandra Martinez-Morilla, Jon Zugazagoitia, Pok Fai Wong, Harriet M. Kluger & David L. Rimm
Article: 1864909
Published online: 29 Dec 2020
AbstractforQuantitative analysis of CMTM6 expression in tumor microenvironment in metastatic melanoma and association with outcome on immunotherapy | Full Text | References | PDF (4.6 MB) | EPUB
  • 2944 Views
  • 16 CrossRef citations
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Open Access
Article
Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data
Elizabeth Dudnik, Mor Moskovitz, Yakir Rottenberg, Anastasiya Lobachov, Rinat Mandelboim, Tzippy Shochat, Damien Urban, Mira Wollner, Hovav Nechushtan, Ofer Rotem, Alona Zer, Sameh Daher, Jair Bar & On behalf of the Israel Lung Cancer Group
Article: 1865653
Published online: 28 Jan 2021
AbstractforPembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data | Full Text | References | PDF (2.2 MB) | EPUB
  • 7180 Views
  • 24 CrossRef citations
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Open Access
Article
Atezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutation
Wei Nie, Lu Gan, Xin Wang, Kai Gu, Fang-Fei Qian, Min-Juan Hu, Ding Zhang, Shi-Qing Chen, Jun Lu, Shu-Hui Cao, Jing-Wen Li, Yue Wang, Bo Zhang, Shu-Yuan Wang, Chang-Hui Li, Ping Yang, Mi–Die Xu, Xue-Yan Zhang, Hua Zhong & Bao-Hui Han
Article: 1865670
Published online: 15 Jan 2021
AbstractforAtezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutation | Full Text | References | PDF (5.8 MB) | EPUB
  • 3395 Views
  • 9 CrossRef citations
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Open Access
Article
Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures
Xiaonan Wang, Carlotta Peticone, Ekaterini Kotsopoulou, Berthold Göttgens & Fernando J Calero-Nieto
Article: 1866287
Published online: 06 Jan 2021
AbstractforSingle-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures | Full Text | References | PDF (6.3 MB) | EPUB
  • 7179 Views
  • 19 CrossRef citations
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Open Access
Article
Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang & Chuanbin Guo
Article: 1868122
Published online: 15 Jan 2021
AbstractforOral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12 | Full Text | References | PDF (22.4 MB) | EPUB
  • 3676 Views
  • 24 CrossRef citations
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Open Access
Article
Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy
Peng Bai, Yongzheng Li, Qiuping Zhou, Jiaqi Xia, Peng-Cheng Wei, Hexiang Deng, Min Wu, Sanny K. Chan, John W. Kappler, Yu Zhou, Eric Tran, Philippa Marrack & Lei Yin
Article: 1868130
Published online: 15 Jan 2021
AbstractforImmune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy | Full Text | References | PDF (3.5 MB) | EPUB
  • 3836 Views
  • 17 CrossRef citations
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Open Access

Author View

Article Commentary
The dark side of ferroptosis in pancreatic cancer
Jiao Liu, Enyong Dai, Rui Kang, Guido Kroemer & Daolin Tang
Article: 1868691
Published online: 04 Jan 2021
AbstractforThe dark side of ferroptosis in pancreatic cancer | Full Text | References | PDF (1.8 MB) | EPUB
  • 7336 Views
  • 24 CrossRef citations
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Open Access

Original Research

Article
NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription
Xiaobin Zao, Jin Cheng, Congle Shen, Guiwen Guan, Xiaoyu Feng, Jun Zou, Jing Zhang, Tianxu Liu, Huiling Zheng, Ting Zhang, Jie Wang, Jia Liu, Deyao Li, Fengmin Lu, Fuping You & Xiangmei Chen
Article: 1869388
Published online: 11 Jan 2021
AbstractforNFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription | Full Text | References | PDF (7.1 MB) | EPUB
  • 3068 Views
  • 9 CrossRef citations
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Open Access

Review

Review
Advances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapies
Florian Kast, Christian Klein, Pablo Umaña, Alena Gros & Stephan Gasser
Article: 1869389
Published online: 07 Jan 2021
AbstractforAdvances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapies | Full Text | References | PDF (4.8 MB) | EPUB
  • 6053 Views
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Open Access

Original Research

Article
Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions
Tomoyo Shinkawa, Serina Tokita, Munehide Nakatsugawa, Yasuhiro Kikuchi, Takayuki Kanaseki & Toshihiko Torigoe
Article: 1870062
Published online: 18 Jan 2021
AbstractforCharacterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions | Full Text | References | PDF (1.5 MB) | EPUB
  • 2790 Views
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Open Access

Brief Report

Brief Report
Tumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spread
Zhenzi Peng, Cuiwei Liu, Aaron R. Victor, Duo-Yao Cao, Luciana C. Veiras, Ellen A. Bernstein, Zakir Khan, Jorge F. Giani, Xiaojiang Cui, Kenneth E. Bernstein & Derick Okwan-Duodu
Article: 1870811
Published online: 20 Jan 2021
AbstractforTumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spread | Full Text | References | PDF (1.6 MB) | EPUB
  • 4848 Views
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Open Access

Original Research

Article
Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome
Christoph Iselin, Yun-Tsan Chang, Tanja Schlaepfer, Christina Fassnacht, Florentia Dimitriou, Mirjam Nägeli, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz & Emmanuella Guenova
Article: 1873530
Published online: 31 Jan 2021
AbstractforEnhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome | Full Text | References | PDF (899.2 KB) | EPUB
  • 2032 Views
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Open Access
Article
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
Kaat de Jonge, Laure Tillé, Joao Lourenco, Hélène Maby-El Hajjami, Sina Nassiri, Julien Racle, David Gfeller, Mauro Delorenzi, Grégory Verdeil, Petra Baumgaertner & Daniel E. Speiser
Article: 1873585
Published online: 02 Feb 2021
AbstractforInflammatory B cells correlate with failure to checkpoint blockade in melanoma patients | Full Text | References | PDF (2.8 MB) | EPUB
  • 2935 Views
  • 14 CrossRef citations
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Open Access
Article
Addition of anti-TIM3 or anti-TIGIT Antibodies to anti-PD1 Blockade Augments Human T cell Adoptive Cell Transfer
Marina Martinez, Soyeon Kim, Naomi St. Jean, Shaun O’Brien, Lurong Lian, Jing Sun, Raluca I. Verona & Edmund Moon
Article: 1873607
Published online: 20 Jan 2021
AbstractforAddition of anti-TIM3 or anti-TIGIT Antibodies to anti-PD1 Blockade Augments Human T cell Adoptive Cell Transfer | Full Text | References | PDF (3.9 MB) | EPUB
  • 3771 Views
  • 20 CrossRef citations
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Open Access
Article
Increase of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancer
Nataliia Petriv, Lavinia Neubert, Myroslava Vatashchuk, Kai Timrott, Huizhen Suo, Inga Hochnadel, René Huber, Christina Petzold, Anastasiia Hrushchenko, Andriy S. Yatsenko, Halyna R. Shcherbata, Heiner Wedemeyer, Ralf Lichtinghagen, Halina Falfushynska, Volodymyr Lushchak, Michael P. Manns, Heike Bantel, Halyna Semchyshyn & Tetyana Yevsa
Article: 1874159
Published online: 08 Feb 2021
AbstractforIncrease of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancer | Full Text | References | PDF (5 MB) | EPUB
  • 3545 Views
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Open Access

Author View

Article Commentary
CDK1/2/5 blockade: killing two birds with one stone
Jiao Liu, Rui Kang & Daolin Tang
Article: 1875612
Published online: 20 Jan 2021
AbstractforCDK1/2/5 blockade: killing two birds with one stone | Full Text | References | PDF (867.5 KB) | EPUB
  • 1949 Views
  • 1 CrossRef citations
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Open Access

Original Research

Article
Prognostic and predictive significance of tumor infiltrating lymphocytes for ductal carcinoma in situ
Fei-Fei Xu, Sai-Fang Zheng, Cheng Xu, Gang Cai, Shu-Bei Wang, Wei-Xiang Qi, Chao-Fu Wang, Jia-Yi Chen & Cao Lu
Article: 1875637
Published online: 18 Mar 2021
AbstractforPrognostic and predictive significance of tumor infiltrating lymphocytes for ductal carcinoma in situ | Full Text | References | PDF (3.3 MB) | EPUB
  • 2489 Views
  • 7 CrossRef citations
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Open Access
Article
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer
Jia Yang, Aydin Eresen, Junjie Shangguan, Quanhong Ma, Vahid Yaghmai & Zhuoli Zhang
Article: 1875638
Published online: 02 Feb 2021
AbstractforIrreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer | Full Text | References | PDF (3.5 MB) | EPUB
  • 3595 Views
  • 28 CrossRef citations
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Open Access
Article
A multicenter characterization of hepatitis associated with immune checkpoint inhibitors
J. Randall Patrinely Jr., Ben McGuigan, Sunandana Chandra, Sarah E. Fenton, Akansha Chowdhary, Lucy B. Kennedy, Meghan J. Mooradian, Marisa Palmeri, Daniella Portal, Sara N. Horst, Elizabeth A. Scoville, Georgina V. Long, Chanjuan Shi, Janice M. Mehnert, Ryan J. Sullivan, April K. Salama, Jeffrey A. Sosman, Alexander M. Menzies & Douglas B. Johnson
Article: 1875639
Published online: 08 Feb 2021
AbstractforA multicenter characterization of hepatitis associated with immune checkpoint inhibitors | Full Text | References | PDF (432.7 KB) | EPUB
  • 3436 Views
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Open Access
Article
Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy
Gaël Boivin, Pierre-Benoit Ancey, Romain Vuillefroy de Silly, Pradeep Kalambaden, Caroline Contat, Benoit Petit, Jonathan Ollivier, Jean Bourhis, Etienne Meylan & Marie-Catherine Vozenin
Article: 1876597
Published online: 08 Feb 2021
AbstractforAnti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy | Full Text | References | PDF (3.4 MB) | EPUB
  • 3790 Views
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Open Access

Brief Report

Brief Report
Infliximab for the treatment of patients with checkpoint inhibitor associated acute tubular interstitial nephritis
Jamie S. Lin, Omar Mamlouk, Umut Selamet, Amanda Tchakarov, William F. Glass, Rahul A. Sheth, Rachel M. Layman, Ramona Dadu, Noha Abdel-Wahab, Maen Abdelrahim, Adi Diab, Cassian Yee & Ala Abudayyeh
Article: 1877415
Published online: 02 Feb 2021
AbstractforInfliximab for the treatment of patients with checkpoint inhibitor associated acute tubular interstitial nephritis | Full Text | References | PDF (2.8 MB) | EPUB
  • 4285 Views
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Open Access

Editorial

Editorial
Cross-reactivity between cancer and microbial antigens
Laurence Zitvogel & Guido Kroemer
Article: 1877416
Published online: 20 Jan 2021
First Page PreviewforCross-reactivity between cancer and microbial antigens | Full Text | References | PDF (251.9 KB) | EPUB
  • 3381 Views
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Open Access

Original Research

Article
Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting
Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh & Herbert Schwarz
Article: 1877459
Published online: 04 Feb 2021
AbstractforEctopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting | Full Text | References | PDF (3.4 MB) | EPUB
  • 2596 Views
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Open Access

Review

Review
Efficacy and safety of anti-PD-1/PD-L1 combinations versus standard of care in cancer: a systematic review and meta-analysis.
Alberto Carretero-González, Irene Otero, David Lora, Lucía Carril-Ajuria, Daniel Castellano & Guillermo de Velasco
Article: 1878599
Published online: 23 Feb 2021
AbstractforEfficacy and safety of anti-PD-1/PD-L1 combinations versus standard of care in cancer: a systematic review and meta-analysis. | Full Text | References | PDF (1.4 MB) | EPUB
  • 2762 Views
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Open Access

Original Research

Article
Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells
Claudia Cantoni, Martina Serra, Erica Parisi, Bruno Azzarone, Angela Rita Sementa, Luigi Aurelio Nasto, Lorenzo Moretta, Giovanni Candiano, Cristina Bottino, Gian Marco Ghiggeri & Grazia Maria Spaggiari
Article: 1879530
Published online: 08 Mar 2021
AbstractforStromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells | Full Text | References | PDF (3.4 MB) | EPUB
  • 2104 Views
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Article
Efficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effect
Nona Janikashvili, Claire Gérard, Marine Thébault, Andrea Brazdova, Clovis Boibessot, Claudie Cladière, Marion Ciudad, Hélène Greigert, Séthi Ouandji, Thibault Ghesquière, Maxime Samson, Sylvain Audia, Philippe Saas & Bernard Bonnotte
Article: 1880046
Published online: 19 Feb 2021
AbstractforEfficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effect | Full Text | References | PDF (1 MB) | EPUB
  • 2272 Views
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Article
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer
Galateja Jordakieva, Rodolfo Bianchini, Daniel Reichhold, Jakob Piehslinger, Alina Groschopf, Sebastian A. Jensen, Ettore Mearini, Giuseppe Nocentini, Richard Crevenna, Gerhard J. Zlabinger, Sophia N. Karagiannis, Alexander Klaus & Erika Jensen-Jarolim
Article: 1880687
Published online: 08 Feb 2021
AbstractforIgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer | Full Text | References | PDF (2.3 MB) | EPUB
  • 3438 Views
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Article
An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
Marie Bernardo, Tatiana Tolstykh, Yu-an Zhang, Dinesh S. Bangari, Hui Cao, Kerstin A. Heyl, Joon Sang Lee, Natalia V. Malkova, Katie Malley, Eladio Marquez, Jack Pollard, Hui Qu, Errin Roberts, Sue Ryan, Kuldeep Singh, Fangxian Sun, Emma Wang, Keith Bahjat, Dmitri Wiederschain & Timothy R. Wagenaar
Article: 1881268
Published online: 16 Mar 2021
AbstractforAn experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy | Full Text | References | PDF (986.4 KB) | EPUB | Supplemental
  • 5622 Views
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Article
B-cell clusters at the invasive margin associate with longer survival in early-stage oral-tongue cancer patients
C. Phanthunane, R. Wijers, M. de Herdt, T.P.M. Langeveld, S. Koljenovic, S. Dasgupta, S. Sleijfer, R. J. Baatenburg de Jong, J. Hardillo, H. E. Balcioglu & R. Debets
Article: 1882743
Published online: 17 Feb 2021
AbstractforB-cell clusters at the invasive margin associate with longer survival in early-stage oral-tongue cancer patients | Full Text | References | PDF (2.3 MB) | EPUB
  • 3136 Views
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Author’s View

Review
Activin A backs-up TGF-ß to promote regulatory T cells
Mara De Martino, Camille Daviaud & Claire Vanpouille-Box
Article: 1883288
Published online: 11 Feb 2021
AbstractforActivin A backs-up TGF-ß to promote regulatory T cells | Full Text | References | PDF (378.1 KB) | EPUB
  • 2245 Views
  • 7 CrossRef citations
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Original Research

Article
Phenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinoma
Chuqing Pan, Yu Wang, Qianwen Liu, Yihuai Hu, Jianhua Fu, Xiuying Xie, Shuishen Zhang, Mian Xi & Jing Wen
Article: 1883890
Published online: 10 Feb 2021
AbstractforPhenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinoma | Full Text | References | PDF (11.1 MB) | EPUB
  • 3516 Views
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Article
Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers
Dörthe Masemann, Ramona Meissner, Tanja Schied, Brian D Lichty, Ulf R Rapp, Viktor Wixler & Stephan Ludwig
Article: 1885778
Published online: 17 Feb 2021
AbstractforSynergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers | Full Text | References | PDF (3.5 MB) | EPUB
  • 3128 Views
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Article
Improved survival without increased toxicity with influenza vaccination in cancer patients treated with checkpoint inhibitors
Antonios Valachis, Camilla Rosén, Anthoula Koliadi, Evangelos Digkas, Alice Gustavsson, Andreas Nearchou & Gustav J Ullenhag
Article: 1886725
Published online: 17 Feb 2021
AbstractforImproved survival without increased toxicity with influenza vaccination in cancer patients treated with checkpoint inhibitors | Full Text | References | PDF (869 KB) | EPUB
  • 2771 Views
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Review
Expand to shield: IL-15 and in situ lymphocytic proliferation
Gabriela Bindea, Bernhard Mlecnik & Jérôme Galon
Article: 1886726
Published online: 12 Feb 2021
AbstractforExpand to shield: IL-15 and in situ lymphocytic proliferation | Full Text | References | PDF (523.4 KB) | EPUB
  • 2611 Views
  • 6 CrossRef citations
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Original Research

Article
Efficacy of immune-checkpoint inhibitors in PD-L1 selected or unselected patients vs. control group in patients with advanced or metastatic urothelial carcinoma
Lifang Guo, Xin Wang, Shihui Wang, Linbin Hua, Nan Song, Bin Hu & Zhaohui Tong
Article: 1887551
Published online: 05 Mar 2021
AbstractforEfficacy of immune-checkpoint inhibitors in PD-L1 selected or unselected patients vs. control group in patients with advanced or metastatic urothelial carcinoma | Full Text | References | PDF (2 MB) | EPUB
  • 2362 Views
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Review

Review
Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment
Chen Han, Cong Zhang, Hengxiao Wang & Lianmei Zhao
Article: 1887552
Published online: 22 Feb 2021
AbstractforExosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment | Full Text | References | PDF (2 MB) | EPUB
  • 5337 Views
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Review
Precision immunity: Immunoscore and neoadjuvant treatment in bladder cancer
Elise F. Nassif, Constance Thibault, Stéphane Oudard & Jérôme Galon
Article: 1888488
Published online: 17 Feb 2021
AbstractforPrecision immunity: Immunoscore and neoadjuvant treatment in bladder cancer | Full Text | References | PDF (402.7 KB) | EPUB
  • 2807 Views
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Editorial

Editorial
Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents
Giulia Petroni & Lorenzo Galluzzi
Article: 1889101
Published online: 19 Feb 2021
AbstractforImpact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents | Full Text | References | PDF (980.3 KB) | EPUB
  • 1701 Views
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Original Research

Article
TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients
Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek & Jitka Fucikova
Article: 1889822
Published online: 08 Mar 2021
AbstractforTIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients | Full Text | References | PDF (934.3 KB) | EPUB
  • 3672 Views
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Article
Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity
Elizabeth R. Sturgill, Annah S. Rolig, Stefanie N. Linch, Courtney Mick, Melissa J. Kasiewicz, Zhaoyu Sun, Peter G. Traber, Harold Shlevin & William L. Redmond
Article: 1892265
Published online: 01 Mar 2021
AbstractforGalectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity | Full Text | References | PDF (2.6 MB) | EPUB
  • 4843 Views
  • 19 CrossRef citations
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Review

Review
Tumor-intrinsic determinants of immunogenic cell death modalities
Samuel T Workenhe, Jonathan Pol & Guido Kroemer
Article: 1893466
Published online: 02 Mar 2021
AbstractforTumor-intrinsic determinants of immunogenic cell death modalities | Full Text | References | PDF (1.6 MB) | EPUB
  • 4322 Views
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Original Research

Article
A novel multimeric IL15/IL15Rα-Fc complex to enhance cancer immunotherapy
Hong Xu, Ilia N. Buhtoiarov, Hongfen Guo & Nai-Kong V. Cheung
Article: 1893500
Published online: 11 Mar 2021
AbstractforA novel multimeric IL15/IL15Rα-Fc complex to enhance cancer immunotherapy | Full Text | References | PDF (3.9 MB) | EPUB
  • 5218 Views
  • 9 CrossRef citations
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Article
BAFF receptor antibody for mantle cell lymphoma therapy
Keman Zhang, Nand K Roy, Yorleny Vicioso, Janghee Woo, Rose Beck, Marcos de Lima, Paolo Caimi, Daniel Feinberg & Reshmi Parameswaran
Article: 1893501
Published online: 05 Mar 2021
AbstractforBAFF receptor antibody for mantle cell lymphoma therapy | Full Text | References | PDF (3.4 MB) | EPUB
  • 2609 Views
  • 4 CrossRef citations
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Article
Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells
Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Ying Yu, Jeff Grein, Chunsheng Zhang, Eric S. Muise, David L. Sloman, Heidi Ferguson, Hongshi Yu, Cristina St. Pierre, Pranal J Dakle, Vincenzo Pucci, James Baker, Andrey Loboda, Doug Linn, Christopher Brynczka, Doug Wilson, Brian B Haines, Brian Long, Richard Wnek, Svetlana Sadekova, Michael Rosenzweig, Andrew Haidle, Yongxin Han & Sheila H. Ranganath
Article: 1896643
Published online: 18 Mar 2021
AbstractforCombination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells | Full Text | References | PDF (3.9 MB) | EPUB
  • 5749 Views
  • 29 CrossRef citations
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Article
Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma
Maria A Smolle, Laurin Herbsthofer, Mark Goda, Barbara Granegger, Iva Brcic, Marko Bergovec, Susanne Scheipl, Barbara Prietl, Amin El-Heliebi, Martin Pichler, Armin Gerger, Florian Posch, Martina Tomberger, Pablo López-García, Julia Feichtinger, Claudia Baumgartner, Andreas Leithner, Bernadette Liegl-Atzwanger & Joanna Szkandera
Article: 1896658
Published online: 11 Mar 2021
AbstractforInfluence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma | Full Text | References | PDF (4.5 MB) | EPUB
  • 2505 Views
  • 13 CrossRef citations
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Article
Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia
Aroa Baragaño Raneros, Ramon M Rodriguez, Aida Bernardo Flórez, Pilar Palomo, Enrique Colado, Alfredo Minguela, Beatriz Suarez-Alvarez & Carlos López-Larrea
Article: 1897294
Published online: 25 Mar 2021
AbstractforBromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia | Full Text | References | PDF (2.4 MB) | EPUB
  • 2719 Views
  • 6 CrossRef citations
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Article
The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer
Chaobin He, Shuxin Sun, Yu Zhang, Fengxiao Xie & Shengping Li
Article: 1897295
Published online: 11 Mar 2021
AbstractforThe role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer | Full Text | References | PDF (3.8 MB) | EPUB
  • 4181 Views
  • 28 CrossRef citations
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Article
Association of circulating protein biomarkers with clinical outcomes of durvalumab in head and neck squamous cell carcinoma
Rosalinda Arends, Xiang Guo, Paul G. Baverel, Ignacio González-García, James Xie, Nassim Morsli, Alejandro Yovine & Lorin K. Roskos
Article: 1898104
Published online: 17 Mar 2021
AbstractforAssociation of circulating protein biomarkers with clinical outcomes of durvalumab in head and neck squamous cell carcinoma | Full Text | References | PDF (1.7 MB) | EPUB
  • 2011 Views
  • 10 CrossRef citations
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Article
A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma
Craig L. Slingluff jr, Hassane M. Zarour, Hussein Abdul-Hassan Tawbi, John M. Kirkwood, Michael A. Postow, Philip Friedlander, Craig E. Devoe, Elizabeth M. Gaughan, Ileana S. Mauldin, Walter C. Olson jr, Kelly T. Smith, Mary J. Macri, Toni Ricciardi, Aileen Ryan, Ralph Venhaus & Jedd D. Wolchok
Article: 1898105
Published online: 26 Mar 2021
AbstractforA phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma | Full Text | References | PDF (3.8 MB) | EPUB
  • 3414 Views
  • 10 CrossRef citations
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Article
Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs
Cesar Oyarce, Ana Vizcaino-Castro, Shipeng Chen, Annemarie Boerma & Toos Daemen
Article: 1898753
Published online: 12 Mar 2021
AbstractforRe-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs | Full Text | References | PDF (1.2 MB) | EPUB
  • 6461 Views
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Article
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition
Lucia Lione, Erika Salvatori, Adriana Petrazzuolo, Alice Massacci, Roberta Maggio, Antonella Conforti, Mirco Compagnone, Luigi Aurisicchio, Gennaro Ciliberto & Fabio Palombo
Article: 1898832
Published online: 23 Mar 2021
AbstractforAntitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition | Full Text | References | PDF (2.1 MB) | EPUB
  • 2645 Views
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Article
Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine
Seung E. Cha, Maciej Kujawski, Paul J. Yazaki, Christine Brown & John E. Shively
Article: 1899469
Published online: 18 Mar 2021
AbstractforTumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine | Full Text | References | PDF (4 MB) | EPUB
  • 4066 Views
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Article
Prognostic value of the baseline circulating T cell receptor β chain diversity in advanced lung cancer
Jiaqi Wang, Zhixin Bie, Yajing Zhang, Lin Li, Yujie Zhu, Yi Zhang, Xin Nie, Ping Zhang, Gang Cheng, Xuebing Di, Xiaoguang Li, Shujun Cheng & Lin Feng
Article: 1899609
Published online: 17 Mar 2021
AbstractforPrognostic value of the baseline circulating T cell receptor β chain diversity in advanced lung cancer | Full Text | References | PDF (3.3 MB) | EPUB
  • 2073 Views
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Article
Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity
Jieun Kim, Jun-Young Lee, Suk-Youl Park, You Jeong Lee & Min-Sung Kim
Article: 1899671
Published online: 16 Mar 2021
AbstractforCrystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity | Full Text | References | PDF (2.6 MB) | EPUB
  • 3211 Views
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Review

Review
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies
Jacquelot N, Tellier J, Nutt Sl & Belz Gt
Article: 1900508
Published online: 29 Mar 2021
AbstractforTertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies | Full Text | References | PDF (2 MB) | EPUB
  • 9231 Views
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Original Research

Article
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer
Andrew J. Gunderson, Venkatesh Rajamanickam, Cynthia Bui, Brady Bernard, Joanna Pucilowska, Carmen Ballesteros-Merino, Mark Schmidt, Kayla McCarty, Michaela Philips, Brian Piening, Christopher Dubay, Terry Medler, Phillipa Newell, Paul Hansen, Eric Tran, Ephraim Tang, Carlo Bifulco, Marka Crittenden, Michael Gough & Kristina H. Young
Article: 1900635
Published online: 17 Mar 2021
AbstractforGerminal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer | Full Text | References | PDF (4.3 MB) | EPUB
  • 10539 Views
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Article
Construction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancer
Cong Chen, Yan-Mei Gu, Fan Zhang, Zheng-Chao Zhang, Ya-Ting Zhang, Yi-Di He, Ling Wang, Ning Zhou, Fu-Tian Tang, Hong-Jian Liu & Yu-Min Li
Article: 1901434
Published online: 31 Mar 2021
AbstractforConstruction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancer | Full Text | References | PDF (6.4 MB) | EPUB
  • 4736 Views
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Article
Association of TRF2 expression and myeloid-derived suppressor cells infiltration with clinical outcome of patients with cutaneous melanoma
Marius Ilié, Elisabeth Lantéri, Emmanuel Chamorey, Brice Thamphya, Marame Hamila, Henri Montaudié, Alexandra Picard-Gauci, Sophie Gardrat, Thierry Passeron, Sandra Lassalle, Elodie Long-Mira, Julien Cherfils-Vicini, Eric Gilson, Véronique Hofman & Paul Hofman
Article: 1901446
Published online: 19 Mar 2021
AbstractforAssociation of TRF2 expression and myeloid-derived suppressor cells infiltration with clinical outcome of patients with cutaneous melanoma | Full Text | References | PDF (1.8 MB) | EPUB
  • 1956 Views
  • 1 CrossRef citations
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Article
An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis
Yamei Zhao, Chao Chen, Xiaoming Xu, Xiaoxu Ge, Kefeng Ding, Shu Zheng, Jian Wang & Lifeng Sun
Article: 1901464
Published online: 22 Mar 2021
AbstractforAn Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal Metastasis | Full Text | References | PDF (2.9 MB) | EPUB
  • 2483 Views
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Article
Integrative analysis identifies an immune-relevant epigenetic signature for prognostication of non-G-CIMP glioblastomas
Anan Yin, Zhende Shang, Amandine Etcheverry, Yalong He, Marc Aubry, Nan Lu, Yuhe Liu, Jean Mosser, Wei Lin, Xiang Zhang & Yu Dong
Article: 1902071
Published online: 29 Mar 2021
AbstractforIntegrative analysis identifies an immune-relevant epigenetic signature for prognostication of non-G-CIMP glioblastomas | Full Text | References | PDF (6.6 MB) | EPUB
  • 2228 Views
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Article
Novel deep learning-based survival prediction for oral cancer by analyzing tumor-infiltrating lymphocyte profiles through CIBERSORT
Yeongjoo Kim, Ji Wan Kang, Junho Kang, Eun Jung Kwon, Mihyang Ha, Yoon Kyeong Kim, Hansong Lee, Je-Keun Rhee & Yun Hak Kim
Article: 1904573
Published online: 29 Mar 2021
AbstractforNovel deep learning-based survival prediction for oral cancer by analyzing tumor-infiltrating lymphocyte profiles through CIBERSORT | Full Text | References | PDF (1.4 MB) | EPUB
  • 5267 Views
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Article Commentary
License to kill: microsatellite instability and immune contexture
Pauline Maby, Gabriela Bindea, Bernhard Mlecnik & Jérôme Galon
Article: 1905935
Published online: 02 Apr 2021
AbstractforLicense to kill: microsatellite instability and immune contexture | Full Text | References | PDF (522.1 KB) | EPUB
  • 2639 Views
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Original Research

Article
PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells
Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka & Elke Burgermeister
Article: 1906500
Published online: 05 May 2021
AbstractforPPARγ induces PD-L1 expression in MSS+ colorectal cancer cells | Full Text | References | PDF (3.7 MB) | EPUB
  • 4085 Views
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Article
VISTA and PD-L1 synergistically predict poor prognosis in patients with extranodal natural killer/T-cell lymphoma
Hai-Xia He, Yan Gao, Jian-Chang Fu, Qiang-Hua Zhou, Xiao-Xiao Wang, Bing Bai, Peng-Fei Li, Cheng Huang, Qi-Xiang Rong, Li-Qin Ping, Yan-Xia He, Jia-Ying Mao, Xu Chen & Hui-Qiang Huang
Article: 1907059
Published online: 07 Apr 2021
AbstractforVISTA and PD-L1 synergistically predict poor prognosis in patients with extranodal natural killer/T-cell lymphoma | Full Text | References | PDF (3.4 MB) | EPUB
  • 3811 Views
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Brief Report

Brief Report
CD80 expression is upregulated by TP53 activation in human cancer epithelial cells
Melania Scarpa, Chiara Marchiori, Marco Scarpa & Ignazio Castagliuolo
Article: 1907912
Published online: 05 Apr 2021
AbstractforCD80 expression is upregulated by TP53 activation in human cancer epithelial cells | Full Text | References | PDF (1.1 MB) | EPUB
  • 3063 Views
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Original Research

Article
Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data
Yi-Quan Jiang, Zi-Xian Wang, Ming Zhong, Lu-Jun Shen, Xue Han, Xuxiazi Zou, Xin-Yi Liu, Yi-Nan Deng, Yang Yang, Gui-Hua Chen, Wuguo Deng & Jin-Hua Huang
Article: 1908010
Published online: 02 Apr 2021
AbstractforInvestigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data | Full Text | References | PDF (6.7 MB) | EPUB
  • 9835 Views
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Brief Report

Brief Report
Combination immunotherapy with ipilimumab and nivolumab in patients with advanced adrenocortical carcinoma: a subgroup analysis of CA209-538
Oliver Klein, Clare Senko, Matteo S Carlino, Ben Markman, Louise Jackett, Bo Gao, Caroline Lum, Damien Kee, Andreas Behren, Jodie Palmer & Jonathan Cebon
Article: 1908771
Published online: 12 Apr 2021
AbstractforCombination immunotherapy with ipilimumab and nivolumab in patients with advanced adrenocortical carcinoma: a subgroup analysis of CA209-538 | Full Text | References | PDF (596.5 KB) | EPUB
  • 2658 Views
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Original Research

Article
Integrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer: results from two randomized studies
Si-Cong Ma, Xin-Ran Tang, Li-Li Long, Xue Bai, Jian-Guo Zhou, Zhi-Jiao Duan, Jian Wang, Qiang John Fu, Hong-Bo Zhu, Xue-Jun Guo, Yan-Pei Zhang, Ze-Qin Guo, De-Hua Wu & Zhong-Yi Dong
Article: 1909296
Published online: 26 Apr 2021
AbstractforIntegrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer: results from two randomized studies | Full Text | References | PDF (2.5 MB) | EPUB
  • 3436 Views
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Article Commentary
Evasion before invasion: Pre-cancer immunosurveillance
Mihaela Angelova, Céline Mascaux & Jérôme Galon
Article: 1912250
Published online: 25 Apr 2021
AbstractforEvasion before invasion: Pre-cancer immunosurveillance | Full Text | References | PDF (915.8 KB) | EPUB
  • 2601 Views
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Original Research

Article
Identification and characterization of B220+/B220− subpopulations in murine Gr1+CD11b+ cells during tumorigenesis
Zhiqian Zhang, Xu Huang, Enlin Wang, Yugang Huang & Rongcun Yang
Article: 1912472
Published online: 14 Apr 2021
AbstractforIdentification and characterization of B220+/B220− subpopulations in murine Gr1+CD11b+ cells during tumorigenesis | Full Text | References | PDF (8.5 MB) | EPUB
  • 2946 Views
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Brief Report

Brief Report
Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model
Sonia Domingos-Pereira, Vincent Roh, Agnès Hiou-Feige, Gabriele Galliverti, Christian Simon, Genrich V. Tolstonog & Denise Nardelli-Haefliger
Article: 1912473
Published online: 13 Apr 2021
AbstractforVaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model | Full Text | References | PDF (1.3 MB) | EPUB
  • 2642 Views
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Article
Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803) Admixed with Bacillus Calmette-Guérin (BCG) for the Treatment of Bladder Cancer
Charles J. Rosser, Sergei Tikhonenkov, Jeffrey W. Nix, Owen T.M. Chan, Irina Ianculescu, Sandeep Reddy & Patrick Soon-Shiong
Article: 1912885
Published online: 03 May 2021
AbstractforSafety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803) Admixed with Bacillus Calmette-Guérin (BCG) for the Treatment of Bladder Cancer | Full Text | References | PDF (807.2 KB) | EPUB
  • 4164 Views
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Article
PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy
Christopher D. Zahm, Jena E Moseman, Lauren E. Delmastro & Douglas G. Mcneel
Article: 1912892
Published online: 21 Apr 2021
AbstractforPD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy
Qingyun Yuan, Qiaoyan Liang, Zujun Sun, Xingxing Yuan, Weihua Hou, Yuxiong Wang, Huijie Wang & Min Yu
Article: 1914954
Published online: 21 Jul 2021
AbstractforDevelopment of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy | Full Text | References | PDF (5.1 MB) | EPUB
  • 2423 Views
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Article
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients
Kaifeng Jin, Yifan Cao, Yun Gu, Hanji Fang, Yuchao Fei, Jieti Wang, Xin Liu, Kunpeng Lv, Xudong He, Chao Lin, Hao Liu, He Li, Hongyong He, Ruochen Li, Heng Zhang & Jiejie Xu
Article: 1915560
Published online: 27 Apr 2021
AbstractforPoor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients | Full Text | References | PDF (3.3 MB) | EPUB
  • 3995 Views
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Article
Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa
Yohei Ozawa, Kristin C. Hicks, Christine M. Minnar, Karin M. Knudson, Jeffrey Schlom & Sofia R. Gameiro
Article: 1915561
Published online: 03 May 2021
AbstractforAnalysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa | Full Text | References | PDF (3.1 MB) | EPUB
  • 2417 Views
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Article
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer
Lin Zhou, Bin Xu, Yushan Liu & Zhong Wang
Article: 1915574
Published online: 18 May 2021
AbstractforTertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer | Full Text | References | PDF (4.9 MB) | EPUB
  • 5131 Views
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Article
Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapy
Angel Charles, Christopher M. Bourne, Tanya Korontsvit, Zita E. H. Aretz, Sung Soo Mun, Tao Dao, Martin G. Klatt & David A. Scheinberg
Article: 1916243
Published online: 24 May 2021
AbstractforLow-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 3212 Views
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Editorial

Editorial
A bacterium-derived, cancer-associated immunopeptidome
Claude Perreault, Pierre Thibault & Guido Kroemer
Article: 1918373
Published online: 03 May 2021
CitationforA bacterium-derived, cancer-associated immunopeptidome | Full Text | References | PDF (420.6 KB) | EPUB
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Article Commentary
Tumor spread or siege immunity: dissemination to distant metastasis or not
Gabriela Bindea, Bernhard Mlecnik & Jérôme Galon
Article: 1919377
Published online: 25 Apr 2021
AbstractforTumor spread or siege immunity: dissemination to distant metastasis or not | Full Text | References | PDF (481.4 KB) | EPUB
  • 2071 Views
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Original Research

Article
Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma
Xin-Wen Zhang, Katrin Huck, Kristine Jähne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten & Katharina Sahm
Article: 1920739
Published online: 14 May 2021
AbstractforActivity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma | Full Text | References | PDF (2.1 MB) | EPUB
  • 2884 Views
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Correction

Correction
Correction
Article: 1921437
Published online: 06 May 2021
CitationforCorrection | Full Text | PDF (280.1 KB) | EPUB
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Original Research

Article
T cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survival
Maria Christina Svensson, Albin Lindén, Jakob Nygaard, David Borg, Charlotta Hedner, Björn Nodin, Karin Leandersson & Karin Jirström
Article: 1921443
Published online: 20 May 2021
AbstractforT cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survival | Full Text | References | PDF (1.4 MB) | EPUB
  • 2503 Views
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Article Commentary
Inhibition of RANK signaling as a potential immunotherapy in breast cancer
C Gómez-Aleza & E González-Suárez
Article: 1923156
Published online: 14 May 2021
AbstractforInhibition of RANK signaling as a potential immunotherapy in breast cancer | Full Text | References | PDF (936 KB) | EPUB
  • 2010 Views
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Original Research

Article
Cldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrity
Kun Wang, Yuhan Ding, Chang Xu, Mengdi Hao, Huimin Li & Lei Ding
Article: 1923910
Published online: 11 May 2021
AbstractforCldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrity | Full Text | References | PDF (9.2 MB) | EPUB
  • 4594 Views
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Article
The immune microenvironment and relation to outcome in patients with advanced breast cancer treated with docetaxel with or without gemcitabine
Elisabeth S Stovgaard, Karama Asleh, Nazia Riaz, Samuel Leung, Dongxia Gao, Lise B Nielsen, Anne-Vibeke Lænkholm, Eva Balslev, Maj-Britt Jensen, Dorte Nielsen & TO Nielsen
Article: 1924492
Published online: 11 May 2021
AbstractforThe immune microenvironment and relation to outcome in patients with advanced breast cancer treated with docetaxel with or without gemcitabine | Full Text | References | PDF (1 MB) | EPUB
  • 2707 Views
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Brief Report

Brief Report
What role for AHR activation in IL4I1-mediated immunosuppression ?
Flavia Castellano, Armelle Prevost-Blondel, José L. Cohen & Valérie Molinier-Frenkel
Article: 1924500
Published online: 12 May 2021
AbstractforWhat role for AHR activation in IL4I1-mediated immunosuppression ? | Full Text | References | PDF (1.7 MB) | EPUB
  • 3794 Views
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Article Commentary
An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
Shu-Fen Chiang, Kevin Chih-Yang Huang, William Tzu-Liang Chen, Tsung-Wei Chen, Tao-Wei Ke & K. S. Clifford Chao
Article: 1926074
Published online: 14 May 2021
AbstractforAn independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1) | Full Text | References | PDF (601.6 KB) | EPUB
  • 1641 Views
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Original Research

Article
Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients
Devayani Machiraju, Melanie Wiecken, Nina Lang, Ingrid Hülsmeyer, Jasmin Roth, Timo E. Schank, Rosa Eurich, Niels Halama, Alexander Enk & Jessica C. Hassel
Article: 1926762
Published online: 25 May 2021
AbstractforSoluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients | Full Text | References | PDF (1.4 MB) | EPUB
  • 5383 Views
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Article
Incidence, predictors, and survival impact of acute kidney injury in patients with melanoma treated with immune checkpoint inhibitors: a 10-year single-institution analysis
Maen Abdelrahim, Omar Mamlouk, Heather Lin, Jamie Lin, Valda Page, Noha Abdel-Wahab, Joshua Swan, Umut Selamet, Cassian Yee, Adi Diab, Wadi Suki & Ala Abudayyeh
Article: 1927313
Published online: 23 May 2021
AbstractforIncidence, predictors, and survival impact of acute kidney injury in patients with melanoma treated with immune checkpoint inhibitors: a 10-year single-institution analysis | Full Text | References | PDF (640.5 KB) | EPUB
  • 3179 Views
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Article
Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma
Hua You, Zijun Y. Xu-Monette, Li Wei, Harry Nunns, Máté L. Nagy, Govind Bhagat, Xiaosheng Fang, Feng Zhu, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Benjamin M. Parsons, J. Han Van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Qingyan Au, Bing Xu, Maher Albitar & Ken H. Young
Article: 1928365
Published online: 20 Jul 2021
AbstractforGenomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma | Full Text | References | PDF (2.2 MB) | EPUB
  • 3641 Views
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Review

Review
Double-edged effects of interferons on the regulation of cancer-immunity cycle
Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang & Xiaobo Li
Article: 1929005
Published online: 30 Jun 2021
AbstractforDouble-edged effects of interferons on the regulation of cancer-immunity cycle | Full Text | References | PDF (2.2 MB) | EPUB
  • 4005 Views
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Original Research

Article
Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors
François Bertucci, Laurys Boudin, Pascal Finetti, Christophe Van Berckelaer, Peter Van Dam, Luc Dirix, Patrice Viens, Anthony Gonçalves, Naoto T. Ueno, Steven Van Laere, Daniel Birnbaum & Emilie Mamessier
Article: 1929724
Published online: 23 May 2021
AbstractforImmune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors | Full Text | References | PDF (2.2 MB) | EPUB
  • 4585 Views
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Article
A novel role for an old target: CD45 for breast cancer immunotherapy
Annat Raiter, Oran Zlotnik, Julia Lipovetsky, Shany Mugami, Shira Dar, Ido Lubin, Eran Sharon, Cyrille J. Cohen & Rinat Yerushalmi
Article: 1929725
Published online: 25 May 2021
AbstractforA novel role for an old target: CD45 for breast cancer immunotherapy | Full Text | References | PDF (4 MB) | EPUB
  • 3264 Views
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Article
Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma
Teng Wei, Matthias Leisegang, Ming Xia, Kazuma Kiyotani, Ning Li, Chenquan Zeng, Chunyan Deng, Jinxing Jiang, Makiko Harada, Nishant Agrawal, Liangping Li, Hui Qi, Yusuke Nakamura & Lili Ren
Article: 1929726
Published online: 25 May 2021
AbstractforGeneration of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma | Full Text | References | PDF (2.3 MB) | EPUB
  • 5348 Views
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Article
Effects of concomitant proton pump inhibitor use on immune checkpoint inhibitor efficacy among patients with advanced cancer
Bao-Dong Qin, Xiao-Dong Jiao, Xin-Cheng Zhou, Bin Shi, Jian Wang, Ke Liu, Ying Wu, Yan Ling & Yuan-Sheng Zang
Article: 1929727
Published online: 21 Jul 2021
AbstractforEffects of concomitant proton pump inhibitor use on immune checkpoint inhibitor efficacy among patients with advanced cancer | Full Text | References | PDF (1.1 MB) | EPUB
  • 3175 Views
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Article
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML
F. Brauneck, F Haag, R. Woost, N. Wildner, E. Tolosa, A. Rissiek, G. Vohwinkel, J. Wellbrock, C. Bokemeyer, J. Schulze zur Wiesch, C. Ackermann & W. Fiedler
Article: 1930391
Published online: 21 Jun 2021
AbstractforIncreased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML | Full Text | References | PDF (2.8 MB) | EPUB
  • 4202 Views
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Article
Priming of pancreatic cancer cells with bispecific antibody armed activated T cells sensitizes tumors for enhanced chemoresponsiveness
Archana Thakur, Johnson Ung, Elyse N. Tomaszewski, Amy Schienschang, Timothy M. LaBrie, Dana L. Schalk & Lawrence G. Lum
Article: 1930883
Published online: 01 Jun 2021
AbstractforPriming of pancreatic cancer cells with bispecific antibody armed activated T cells sensitizes tumors for enhanced chemoresponsiveness | Full Text | References | PDF (2.2 MB) | EPUB
  • 2451 Views
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Article
Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells
Dandan Fan, Qi Yue, Jian Chen, Cong Wang, Ruilin Yu, Ziyi Jin, Shujie Yin, Qinyue Wang, Luo Chen, Xueling Liao, Chengyuan Peng, Jianpin Zhang, Zhonglian Cao, Ying Mao, Ruimin Huang, Liang Chen & Cong Li
Article: 1932061
Published online: 06 Jun 2021
AbstractforReprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells | Full Text | References | PDF (4 MB) | EPUB
  • 3525 Views
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Article
DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles
Sepehr Safaei, Malte Mohme, Judith Niesen, Ulrich Schüller & Michael Bockmayr
Article: 1932365
Published online: 17 Jun 2021
AbstractforDIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles | Full Text | References | PDF (4.7 MB) | EPUB
  • 2479 Views
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Article
Development of a novel gene signature to predict prognosis and response to PD-1 blockade in clear cell renal cell carcinoma
Xiaomao Yin, Zaoyu Wang, Jianfeng Wang, Yunze Xu, Wen Kong & Jin Zhang
Article: 1933332
Published online: 30 Jun 2021
AbstractforDevelopment of a novel gene signature to predict prognosis and response to PD-1 blockade in clear cell renal cell carcinoma | Full Text | References | PDF (5.9 MB) | EPUB
  • 5301 Views
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Article
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers
Angela Tata, Garvin Dodard, Céline Fugère, Corinne Leget, Mélody Ors, Benjamin Rossi, Eric Vivier & Laurent Brossay
Article: 1933808
Published online: 15 Jun 2021
AbstractforCombination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers | Full Text | References | PDF (1.9 MB) | EPUB
  • 4373 Views
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Article
Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients
S. T. Paijens, A. Vledder, D. Loiero, E. W. Duiker, J. Bart, A. M. Hendriks, M. Jalving, H. H. Workel, H. Hollema, N. Werner, A. Plat, G. B. A. Wisman, R. Yigit, H. Arts, A. J. Kruse, N.M. de Lange, V. H. Koelzer, M. de Bruyn & H. W. Nijman
Article: 1935104
Published online: 06 Jun 2021
AbstractforPrognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients | Full Text | References | PDF (1.3 MB) | EPUB
  • 2320 Views
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Article
Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients
Glenn F. Van Wigcheren, Nienke De Haas, Tom A. Mulder, Sophie K. Horrevorts, Martine Bloemendal, Simone Hins-Debree, Yumeng Mao, Rolf Kiessling, Carla M.L. van Herpen, Georgina Flórez-Grau, Stanleyson V. Hato & I. Jolanda M. De Vries
Article: 1935557
Published online: 27 Jun 2021
AbstractforCisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients | Full Text | References | PDF (1.8 MB) | EPUB
  • 2527 Views
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Article
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy
Xiaolei Li, Hanren Dai & Hua Wang
Article: 1935668
Published online: 06 Jun 2021
AbstractforLow-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy | Full Text | References | PDF (505.4 KB) | EPUB
  • 2308 Views
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Original Research

Article
Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer
Arjan Kol, Joyce M. Lubbers, Anouk L.J. Terwindt, Hagma H. Workel, Annechien Plat, G. Bea A. Wisman, Joost Bart, Hans W. Nijman & Marco De Bruyn
Article: 1936391
Published online: 12 Jun 2021
AbstractforCombined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer | Full Text | References | PDF (2.8 MB) | EPUB
  • 2388 Views
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Article
Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau & Christelle Retière
Article: 1936392
Published online: 14 Jun 2021
AbstractforLow number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response | Full Text | References | PDF (2 MB) | EPUB
  • 2119 Views
  • 15 CrossRef citations
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Article
Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
Pierre Dillard, Nicholas Casey, Sylvie Pollmann, Patrik Vernhoff, Gustav Gaudernack, Gunnar Kvalheim, Sébastien Wälchli & Else Marit Inderberg
Article: 1936757
Published online: 17 Jun 2021
AbstractforTargeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors | Full Text | References | PDF (1.5 MB) | EPUB
  • 4437 Views
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Article
Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer
Yuzhen Gao, Hao Wang, Huiming Li, Xinxin Ye, Yan Xia, Shijin Yuan, Jie Lu, Xinyou Xie, Liangjing Wang & Jun Zhang
Article: 1936758
Published online: 23 Jun 2021
AbstractforIntegrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer | Full Text | References | PDF (4.9 MB) | EPUB
  • 3193 Views
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Article
The clinicopathological significance and predictive value for immunotherapy of programmed death ligand-1 expression in Epstein-Barr virus-associated gastric cancer
Xiao-Li Wei, Qian-Wen Liu, Fu-Rong Liu, Sha-Sha Yuan, Xiao-Fen Li, Jia-Ning Li, An-Li Yang & Yi-Hong Ling
Article: 1938381
Published online: 17 Jun 2021
AbstractforThe clinicopathological significance and predictive value for immunotherapy of programmed death ligand-1 expression in Epstein-Barr virus-associated gastric cancer | Full Text | References | PDF (1.3 MB) | EPUB
  • 2360 Views
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Article
Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults
Aditya Arra, Maximilian Pech, Hang Fu, Holger Lingel, Franziska Braun, Christian Beyer, Myra Spiliopoulou, Barbara M. Bröker, Karen Lampe, Christoph Arens, Katrin Vogel, Mandy Pierau & Monika C. Brunner-Weinzierl
Article: 1938475
Published online: 14 Jun 2021
AbstractforImmune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults | Full Text | References | PDF (1.9 MB) | EPUB
  • 2007 Views
  • 3 CrossRef citations
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Article
Correlation between PD-L1 expression ON CTCs and prognosis of patients with cancer: a systematic review and meta-analysis
Defeng Kong, Wen Zhang, Zhenrong Yang, Guoliang Li, Shujun Cheng, Kaitai Zhang & Lin Feng
Article: 1938476
Published online: 21 Jun 2021
AbstractforCorrelation between PD-L1 expression ON CTCs and prognosis of patients with cancer: a systematic review and meta-analysis | Full Text | References | PDF (3.1 MB) | EPUB
  • 2310 Views
  • 13 CrossRef citations
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Article
YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration
Zongcheng Yang, Guangxing Yan, Lixin Zheng, Wenchao Gu, Fen Liu, Wei Chen, Xiujie Cui, Yue Wang, Yaling Yang, Xiyan Chen, Yue Fu & Xin Xu
Article: 1938890
Published online: 23 Jun 2021
AbstractforYKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration | Full Text | References | PDF (10.2 MB) | EPUB
  • 8432 Views
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Article
Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers
Juan-Pablo Cerapio, Marion Perrier, Camille-Charlotte Balança, Pauline Gravelle, Fréderic Pont, Christel Devaud, Don-Marc Franchini, Virginie Féliu, Marie Tosolini, Carine Valle, Fréderic Lopez, Anne Quillet-Mary, Loic Ysebaert, Alejandra Martinez, Jean Pierre Delord, Maha Ayyoub, Camille Laurent & Jean-Jacques Fournie
Article: 1939518
Published online: 18 Sep 2021
AbstractforPhased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers | Full Text | References | PDF (4.1 MB) | EPUB
  • 3819 Views
  • 9 CrossRef citations
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Article
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1
Diana Shah, Andrea Comba, Syed M. Faisal, Padma Kadiyala, Gregory J. Baker, Mahmoud S. Alghamri, Robert Doherty, Daniel Zamler, Gabriel Nuñez, Maria G. Castro & Pedro R. Lowenstein
Article: 1939601
Published online: 28 Jun 2021
AbstractforA novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1 | Full Text | References | PDF (4.5 MB) | EPUB
  • 3143 Views
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Article
Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma
John Choi, Ayush Pant, Ravi Medikonda, Young-Hoon Kim, Denis Routkevitch, Laura Saleh, Luqing Tong, Hok Yee Chan, Jessie Nedrow, Christopher Jackson, Christina Jackson & Michael Lim
Article: 1940673
Published online: 08 Jul 2021
AbstractforSustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma | Full Text | References | PDF (1.9 MB) | EPUB
  • 2865 Views
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Article
Prognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype
Alexandre Ghazi, Delphine Le Corre, Camilla Pilati, Julien Taieb, Thomas Aparicio, Audrey Didelot, Shoukat Dedhar, Claire Mulot, Karine Le Malicot, Fatima Djouadi, Aurélien de Reynies, Jean-Marie Launay, Pierre Laurent-Puig & Sophie Mouillet-Richard
Article: 1940674
Published online: 28 Jun 2021
AbstractforPrognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype | Full Text | References | PDF (4.1 MB) | EPUB
  • 1942 Views
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Article
T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer
Richard A O’Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Giulia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace & Ahsan R Akram
Article: 1940675
Published online: 08 Jul 2021
AbstractforT cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer | Full Text | References | PDF (3.2 MB) | EPUB
  • 4678 Views
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Brief Report

Brief Report
Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes
L Marotte, M Capitao, C Deleine, T Beauvais, G Cadiou, J. Perrin, M Chérel, E Scotet, Y Guilloux, F Bruchertseifer, A Morgenstern, A Jarry, J. Gaschet & N Labarriere
Article: 1940676
Published online: 27 Jun 2021
AbstractforAnti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes | Full Text | References | PDF (2.1 MB) | EPUB
  • 2067 Views
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Brief Report
DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee & Matthew J. Riese
Article: 1941566
Published online: 21 Jul 2021
AbstractforDGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition | Full Text | References | PDF (2.3 MB) | EPUB
  • 2921 Views
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Original Research

Article
TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma
Lihua Yu MD, Xiaoli Liu MD, Xinhui Wang MD, Fengna Yan MD, Peng Wang MD, Yuyong Jiang MD, PhD, Juan Du MD, PhD & Zhiyun Yang MD, PhD
Article: 1942673
Published online: 28 Jun 2021
AbstractforTIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma | Full Text | References | PDF (4 MB) | EPUB
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Author’s View

Review
Type 2 innate lymphoid cells: a novel actor in anti-melanoma immunity
Nicolas Jacquelot & Gabrielle T. Belz
Article: 1943168
Published online: 24 Jun 2021
AbstractforType 2 innate lymphoid cells: a novel actor in anti-melanoma immunity | Full Text | References | PDF (531.6 KB) | EPUB
  • 2685 Views
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Original Research

Article
PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity
Haiping Jiang, Haiqing Ni, Pan Zhang, Xiaoli Guo, Min Wu, Haoran Shen, Jie Wang, Weiwei Wu, Zhihai Wu, Jiazheng Ding, Rong Tang, Shuaixiang Zhou, Bingliang Chen, Michael Yu, Hua Jing & Junjian Liu
Article: 1943180
Published online: 24 Jun 2021
AbstractforPD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity | Full Text | References | PDF (2.9 MB) | EPUB
  • 7678 Views
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Article
The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia
Maria I. Edilova, Jaclyn C. Law, Safoura Zangiabadi, Kenneth Ting, Achire N. Mbanwi, Andrea Arruda, David Uehling, Methvin Isaac, Michael Prakesch, Rima Al-awar, Mark D. Minden, Ali A. Abdul-Sater & Tania H. Watts
Article: 1943234
Published online: 23 Sep 2021
AbstractforThe PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia | Full Text | References | PDF (4 MB) | EPUB
  • 2313 Views
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Article
Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers
Kwang-Yu Chang, Nai-Jung Chiang, Shang-Yin Wu, Chia-Jui Yen, Shang-Hung Chen, Yu-Min Yeh, Chien-Feng Li, Xiaoxing Feng, Katherine Wu, Amanda Johnston, John S. Bomalaski, Bor-Wen Wu, Jianjun Gao, Sumit K. Subudhi, Ahmed O. Kaseb, Jorge M. Blando, Shalini S. Yadav, Peter W. Szlosarek & Li-Tzong Chen
Article: 1943253
Published online: 12 Jul 2021
AbstractforPhase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers | Full Text | References | PDF (2.1 MB) | EPUB
  • 3521 Views
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Article
Impact of IL-1β and the IL-1R antagonist on relapse risk and survival in AML patients undergoing immunotherapy for remission maintenance
Hanna Grauers Wiktorin, Ebru Aydin, Karin Christenson, Nuttida Issdisai, Fredrik B. Thorén, Kristoffer Hellstrand & Anna Martner
Article: 1944538
Published online: 25 Jul 2021
AbstractforImpact of IL-1β and the IL-1R antagonist on relapse risk and survival in AML patients undergoing immunotherapy for remission maintenance | Full Text | References | PDF (768.1 KB) | EPUB
  • 2066 Views
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Article
CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects
Wenliang Zhang, Binghui Zeng, Huancai Lin, Wen Guan, Jing Mo, Song Wu, Yanjie Wei, Qianshen Zhang, Dongsheng Yu, Weizhong Li & Godfrey Chi-Fung Chan
Article: 1944553
Published online: 16 Jul 2021
AbstractforCanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects | Full Text | References | PDF (3.8 MB) | EPUB
  • 2473 Views
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Article
Early changes in the immune microenvironment of oral potentially malignant disorders reveal an unexpected association of M2 macrophages with oral cancer free survival
Jebrane Bouaoud, Jean-Philippe Foy, Antonin Tortereau, Lucas Michon, Vincent Lavergne, Nicolas Gadot, Sandrine Boyault, Julie Valantin, Geneviève De Souza, Philippe Zrounba, Chloé Bertolus, Nathalie Bendriss-Vermare & Pierre Saintigny
Article: 1944554
Published online: 27 Jun 2021
AbstractforEarly changes in the immune microenvironment of oral potentially malignant disorders reveal an unexpected association of M2 macrophages with oral cancer free survival | Full Text | References | PDF (3 MB) | EPUB
  • 2885 Views
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Article
Distinct microbial communities colonize tonsillar squamous cell carcinoma
Angelina De Martin, Mechthild Lütge, Yves Stanossek, Céline Engetschwiler, Jovana Cupovic, Kirsty Brown, Izadora Demmer, Martina A. Broglie, Markus B. Geuking, Wolfram Jochum, Kathy D. McCoy, Sandro J. Stoeckli & Burkhard Ludewig
Article: 1945202
Published online: 25 Jul 2021
AbstractforDistinct microbial communities colonize tonsillar squamous cell carcinoma | Full Text | References | PDF (2.4 MB) | EPUB
  • 2528 Views
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Article
Pre-clinical development of a novel CD3-CD123 bispecific T-cell engager using cross-over dual-variable domain (CODV) format for acute myeloid leukemia (AML) treatment
Hélène Bonnevaux, Stephane Guerif, Jana Albrecht, Erwan Jouannot, Thibaud De Gallier, Christian Beil, Christian Lange, Wulf Dirk Leuschner, Marion Schneider, Cendrine Lemoine, Anne Caron, Céline Amara, Cédric Barrière, Justine Siavellis, Valérie Bardet, Ernesto Luna, Pankaj Agrawal, Donald R. Drake, Ercole Rao, Peter Wonerow, Chantal Carrez, Véronique Blanc, Karl Hsu, Dmitri Wiederschain, Paula G. Fraenkel & Angéla Virone-Oddos
Article: 1945803
Published online: 31 Aug 2021
AbstractforPre-clinical development of a novel CD3-CD123 bispecific T-cell engager using cross-over dual-variable domain (CODV) format for acute myeloid leukemia (AML) treatment | Full Text | References | PDF (2.3 MB) | EPUB
  • 2825 Views
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Article
Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML
Jan-Erik Meyer, Simon Loff, Josephine Dietrich, Johannes Spehr, Gabriel Jurado Jiménez, Malte von Bonin, Gerhard Ehninger, Marc Cartellieri & Armin Ehninger
Article: 1945804
Published online: 08 Jul 2021
AbstractforEvaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML | Full Text | References | PDF (2.5 MB) | EPUB
  • 3610 Views
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Article
PD-L2 based immune signature confers poor prognosis in HNSCC
Yu Qiao, Chao Liu, Xiaoyue Zhang, Qianqian Zhou, Yatian Li, Yini Xu, Zhenyue Gao, Yiqi Xu, Lingping Kong, Aifeng Yang, Mei Mei, Yu Ren, Xudong Wang & Xuan Zhou
Article: 1947569
Published online: 04 Aug 2021
AbstractforPD-L2 based immune signature confers poor prognosis in HNSCC | Full Text | References | PDF (5.2 MB) | EPUB
  • 2817 Views
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Article
An immune-based risk-stratification system for predicting prognosis in pulmonary sarcomatoid carcinoma (PSC)
Haoyue Guo, Binglei Li, Li Diao, Hao Wang, Peixin Chen, Minlin Jiang, Lishu Zhao, Yayi He & Caicun Zhou
Article: 1947665
Published online: 13 Jul 2021
AbstractforAn immune-based risk-stratification system for predicting prognosis in pulmonary sarcomatoid carcinoma (PSC) | Full Text | References | PDF (4.5 MB) | EPUB
  • 2766 Views
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Article
A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model
Jamile Ramos da Silva, Ana Carolina Ramos Moreno, Natiely Silva Sales, Mariângela de Oliveira Silva, Luana R. M. M. Aps, Bruna F.M.M. Porchia, Karine Bitencourt Rodrigues, Natália Cestari Moreno, Aléxia Adrianne Venceslau-Carvalho, Carlos Frederico M. Menck, Mariana de Oliveira Diniz & Luís Carlos de Souza Ferreira
Article: 1949896
Published online: 25 Jul 2021
AbstractforA therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model | Full Text | References | PDF (2.8 MB) | EPUB
  • 2387 Views
  • 4 CrossRef citations
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Article
Impact of cancer cachexia on the therapeutic outcome of combined chemoimmunotherapy in patients with non-small cell lung cancer: a retrospective study
Kenji Morimoto, Junji Uchino, Takashi Yokoi, Takashi Kijima, Yasuhiro Goto, Akira Nakao, Makoto Hibino, Takayuki Takeda, Hiroyuki Yamaguchi, Chieko Takumi, Masafumi Takeshita, Yusuke Chihara, Takahiro Yamada, Osamu Hiranuma, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Tadaaki Yamada & Koichi Takayama
Article: 1950411
Published online: 08 Jul 2021
AbstractforImpact of cancer cachexia on the therapeutic outcome of combined chemoimmunotherapy in patients with non-small cell lung cancer: a retrospective study | Full Text | References | PDF (972.4 KB) | EPUB
  • 4251 Views
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Article
Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity
Linda Ziani, Stéphanie Buart, Salem Chouaib & Jerome Thiery
Article: 1950953
Published online: 25 Jul 2021
AbstractforHypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity | Full Text | References | PDF (4.3 MB) | EPUB
  • 3528 Views
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Author’s View

Article
Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer & Maria Castedo
Article: 1950954
Published online: 08 Jul 2021
AbstractforPyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers | Full Text | References | PDF (406.6 KB) | EPUB
  • 1776 Views
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Original Research

Article
Comprehensive analyses reveal TKI-induced remodeling of the tumor immune microenvironment in EGFR/ALK-positive non-small-cell lung cancer
Yisheng Fang, Yuanyuan Wang, Dongqiang Zeng, Shimeng Zhi, Tingting Shu, Na Huang, Siting Zheng, Jianhua Wu, Yantan Liu, Genjie Huang, Yichen Xue, Jianping Bin, Yulin Liao, Min Shi & Wangjun Liao
Article: 1951019
Published online: 16 Jul 2021
AbstractforComprehensive analyses reveal TKI-induced remodeling of the tumor immune microenvironment in EGFR/ALK-positive non-small-cell lung cancer | Full Text | References | PDF (2.2 MB) | EPUB
  • 5486 Views
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Article
Alternol triggers immunogenic cell death via reactive oxygen species generation
Changlin Li, Ying Zhang, Siyuan Yan, Guoan Zhang, Wei Wei, Zhi Qi & Benyi Li
Article: 1952539
Published online: 21 Jul 2021
AbstractforAlternol triggers immunogenic cell death via reactive oxygen species generation | Full Text | References | PDF (2.8 MB) | EPUB
  • 2597 Views
  • 17 CrossRef citations
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Article
Expression of the immune checkpoint receptors PD-1, LAG3, and TIM3 in the immune context of stage II and III gastric cancer by using single and chromogenic multiplex immunohistochemistry
Yujun Park, An Na Seo, Jiwon Koh, Soo Kyoung Nam, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim & Hye Seung Lee
Article: 1954761
Published online: 25 Jul 2021
AbstractforExpression of the immune checkpoint receptors PD-1, LAG3, and TIM3 in the immune context of stage II and III gastric cancer by using single and chromogenic multiplex immunohistochemistry | Full Text | References | PDF (820.4 KB) | EPUB
  • 3902 Views
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Article
Autoantibody profiling of alveolar rhabdomyosarcoma patients unveils tumor-associated antigens with diagnostic and prognostic significance
Elena Poli, Manuela Cattelan, Ilaria Zanetti, Angela Scagnellato, Giuseppe Giordano, Angelica Zin, Gianni Bisogno & Paolo Bonvini
Article: 1954765
Published online: 25 Jul 2021
AbstractforAutoantibody profiling of alveolar rhabdomyosarcoma patients unveils tumor-associated antigens with diagnostic and prognostic significance | Full Text | References | PDF (1.8 MB) | EPUB
  • 1739 Views
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Article
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove & Tessa Kerre
Article: 1954800
Published online: 25 Jul 2021
AbstractforIn vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality | Full Text | References | PDF (2.6 MB) | EPUB
  • 3294 Views
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Article
Pre-treatment tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma
R.S.A. Goedegebuure, M. Harrasser, L.K. de Klerk, T.S. van Schooten, N.C.T. van Grieken, M. Eken, M.S. Grifhorst, N. Pocorni, E.S. Jordanova, M.I. van Berge Henegouwen, R.E. Pouw, H.M.W. Verheul, J.J. van der Vliet, H.W.M. van Laarhoven, V.L.J.L Thijssen, A.J. Bass, T.D. De Gruijl & S. Derks
Article: 1954807
Published online: 04 Aug 2021
AbstractforPre-treatment tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma | Full Text | References | PDF (7.6 MB) | EPUB
  • 3440 Views
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Article
TCR repertoire characteristics predict clinical response to adoptive CTL therapy against nasopharyngeal carcinoma
Guoping Wang, Poorva Mudgal, Liuyang Wang, Timothy Wai Ho Shuen, Haiyang Wu, Peter B Alexander, Who-Whong Wang, Ying Wan, Han Chong Toh, Xiao-Fan Wang & Qi-Jing Li
Article: 1955545
Published online: 02 Aug 2021
AbstractforTCR repertoire characteristics predict clinical response to adoptive CTL therapy against nasopharyngeal carcinoma | Full Text | References | PDF (2.3 MB) | EPUB
  • 3445 Views
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Brief Report

Report
Have CD19-directed immunotherapy and haploidentical hematopoietic cell transplantation transformed pediatric B-cell acute lymphoblastic leukemia into a chronic disease?
Holly Pariury, Laurel Truscott & Emmanuel Katsanis
Article: 1956125
Published online: 25 Jul 2021
AbstractforHave CD19-directed immunotherapy and haploidentical hematopoietic cell transplantation transformed pediatric B-cell acute lymphoblastic leukemia into a chronic disease? | Full Text | References | PDF (705.9 KB) | EPUB
  • 2072 Views
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Original Research

Article
Combination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastoma
John Choi, Ravi Medikonda, Laura Saleh, Timothy Kim, Ayush Pant, Siddhartha Srivastava, Young-Hoon Kim, Christina Jackson, Luqing Tong, Denis Routkevitch, Christopher Jackson, Dimitrios Mathios, Tianna Zhao, Hyerim Cho, Henry Brem & Michael Lim
Article: 1956142
Published online: 29 Aug 2021
AbstractforCombination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastoma | Full Text | References | PDF (1.4 MB) | EPUB
  • 3551 Views
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Article
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma
Anna Sosnowska, Justyna Chlebowska-Tuz, Pawel Matryba, Zofia Pilch, Alan Greig, Artur Wolny, Tomasz M. Grzywa, Zuzanna Rydzynska, Olga Sokolowska, Tomasz P. Rygiel, Marcin Grzybowski, Paulina Stanczak, Roman Blaszczyk, Dominika Nowis & Jakub Golab
Article: 1956143
Published online: 24 Jul 2021
AbstractforInhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma | Full Text | References | PDF (3 MB) | EPUB
  • 4334 Views
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Article
Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma
Tomotaka Ugai, Melissa Zhao, Takashi Shimizu, Naohiko Akimoto, Shanshan Shi, Yasutoshi Takashima, Rong Zhong, Mai Chan Lau, Koichiro Haruki, Kota Arima, Kenji Fujiyoshi, Benjamin Langworthy, Yohei Masugi, Annacarolina da Silva, Katsuhiko Nosho, Yoshifumi Baba, Mingyang Song, Andrew T. Chan, Molin Wang, Jeffrey A. Meyerhardt, Marios Giannakis, Juha P. Väyrynen, Jonathan A. Nowak & Shuji Ogino
Article: 1956173
Published online: 02 Aug 2021
AbstractforAssociation of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma | Full Text | References | PDF (2.2 MB) | EPUB
  • 3041 Views
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Article
Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin
Jayashree V. Raghavan, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Arivusudar Everad John, Priyanka Arunachalam, Darshat Shah, Hari P. S.Akhila Lakshmikantha, Shibu Pillai, Komal Prasad Chandrachari, Kiran Mariswamappa, Sathyanarayana Lale, Nameeta Shah & Siddharth Jhunjhunwala
Article: 1957215
Published online: 02 Aug 2021
AbstractforImmuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin | Full Text | References | PDF (3.3 MB) | EPUB
  • 3003 Views
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Article
Prognostic value of Thyroid Transcription Factor-1 expression in lung adenocarcinoma in patients treated with anti PD-1/PD-L1
Loïck Galland, Anne Laure Le Page, Julie Lecuelle, Frederic Bibeau, Youssef Oulkhouir, Valentin Derangère, Caroline Truntzer & François Ghiringhelli
Article: 1957603
Published online: 02 Aug 2021
AbstractforPrognostic value of Thyroid Transcription Factor-1 expression in lung adenocarcinoma in patients treated with anti PD-1/PD-L1 | Full Text | References | PDF (2.9 MB) | EPUB
  • 2908 Views
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Article
The effect of concomitant use of statins, NSAIDs, low-dose aspirin, metformin and beta-blockers on outcomes in patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis
Yongchao Zhang, Hualei Chen, Shanshan Chen, Zhen Li, Jinglong Chen & Wei Li
Article: 1957605
Published online: 02 Aug 2021
AbstractforThe effect of concomitant use of statins, NSAIDs, low-dose aspirin, metformin and beta-blockers on outcomes in patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis | Full Text | References | PDF (960.5 KB) | EPUB
  • 4588 Views
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Article
Integrating CD4+ T cell help for therapeutic cancer vaccination in a preclinical head and neck cancer model
Hirofumi Shibata, Na Xu, Shin Saito, Liye Zhou, Ibrahim Ozgenc, Jason Webb, Cong Fu, Paul Zolkind, Ann Marie Egloff & Ravindra Uppaluri
Article: 1958589
Published online: 10 Aug 2021
AbstractforIntegrating CD4+ T cell help for therapeutic cancer vaccination in a preclinical head and neck cancer model | Full Text | References | PDF (4.3 MB) | EPUB
  • 3251 Views
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Article
Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding
Hulin Jin, Vittorio D'Urso, Berend Neuteboom, Sean D. McKenna, Rene Schweickhardt, Alec W. Gross, Yves Fomekong Nanfack, Andrea Paoletti, Carina Carter, Lars Toleikis, Markus Fluck, Juergen Scheuenpflug & Ti Cai
Article: 1958590
Published online: 29 Aug 2021
AbstractforAvelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding | Full Text | References | PDF (1.9 MB) | EPUB
  • 4675 Views
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Short Communication

Brief Report
Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies
Hannah M Knochelmann, Amalia M Rivera-Reyes, Megan M Wyatt, Aubrey S Smith, Reilley Chamness, Connor J Dwyer, Michael Bobian, Guillermo O Rangel Rivera, Joshua D Horton, Michael Lilly, Martin J Romeo, Cynthia D Timmers, Mark P Rubinstein, David M Neskey & Chrystal M Paulos
Article: 1959101
Published online: 12 Aug 2021
AbstractforModeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies | Full Text | References | PDF (2.2 MB) | EPUB
  • 3502 Views
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Original Research

Article
Novel BCMA-OR-CD38 tandem-dual chimeric antigen receptor T cells robustly control multiple myeloma
Yaru Feng, Xiuying Liu, Xiaorui Li, Yating Zhou, Zhiru Song, Jing Zhang, Bingjie Shi & Jianxun Wang
Article: 1959102
Published online: 17 Aug 2021
AbstractforNovel BCMA-OR-CD38 tandem-dual chimeric antigen receptor T cells robustly control multiple myeloma | Full Text | References | PDF (2.6 MB) | EPUB
  • 3742 Views
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Article
Differential infection of murine and human dendritic cell subsets by oncolytic vesicular stomatitis virus variants
Lisa Pipperger, Lydia Riepler, Janine Kimpel, Anita Siller, Patrizia Stoitzner, Zoltán Bánki & Dorothee von Laer
Article: 1959140
Published online: 31 Aug 2021
AbstractforDifferential infection of murine and human dendritic cell subsets by oncolytic vesicular stomatitis virus variants | Full Text | References | PDF (2.6 MB) | EPUB
  • 2429 Views
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Article
Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in lung adenocarcinoma
Weiju Zhang, Sumei Yao, Hua Huang, Hao Zhou, Haomiao Zhou, Qishuang Wei, Tingting Bian, Hui Sun, Xiaoli Li, Jianguo Zhang & Yifei Liu
Article: 1959977
Published online: 11 Sep 2021
AbstractforMolecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in lung adenocarcinoma | Full Text | References | PDF (2.9 MB) | EPUB
  • 6596 Views
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Article
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer
Natalie S Firmino, Rachel A Cederberg, Che-Min Lee, Rocky Shi, Brennan J Wadsworth, S Elizabeth Franks, Kiersten N Thomas, Lisa R Decotret & Kevin L Bennewith
Article: 1959978
Published online: 04 Aug 2021
AbstractforGerminal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer | Full Text | References | PDF (4.2 MB) | EPUB
  • 2832 Views
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Article
Durvalumab after concurrent chemotherapy and high-dose radiotherapy for locally advanced non-small cell lung cancer
Yosef Landman, Oded Jacobi, Noga Kurman, Orly Yariv, Idit Peretz, Ofer Rotem, Elizabeth Dudnik, Alona Zer & Aaron M. Allen
Article: 1959979
Published online: 10 Aug 2021
AbstractforDurvalumab after concurrent chemotherapy and high-dose radiotherapy for locally advanced non-small cell lung cancer | Full Text | References | PDF (597.6 KB) | EPUB
  • 2717 Views
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Article
Antitumor activity of the third generation EphA2 CAR-T cells against glioblastoma is associated with interferon gamma induced PD-L1
Zhijing an, Yi Hu, Yue Bai, Can Zhang, Chang Xu, Xun Kang, Shoubo Yang, Wenbin Li & Xiaosong Zhong
Article: 1960728
Published online: 16 Aug 2021
AbstractforAntitumor activity of the third generation EphA2 CAR-T cells against glioblastoma is associated with interferon gamma induced PD-L1 | Full Text | References | PDF (2.3 MB) | EPUB
  • 3480 Views
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Article
PD-1 inhibition in patient derived tissue cultures of human gastric and gastroesophageal adenocarcinoma
Marlon Hußtegge, Ngoc Anh Hoang, Jakob Rebstock, Astrid Monecke, Ines Gockel, Arved Weimann, Guido Schumacher, Ingo Bechmann, Florian Lordick, Sonja Kallendrusch & Justus Körfer
Article: 1960729
Published online: 18 Aug 2021
AbstractforPD-1 inhibition in patient derived tissue cultures of human gastric and gastroesophageal adenocarcinoma | Full Text | References | PDF (3.9 MB) | EPUB
  • 2792 Views
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Prognostic biomarker

Article
Peripheral blood and tissue assessment highlights differential tumor-circulatory gradients of IL2 and MIF with prognostic significance in resectable pancreatic ductal adenocarcinoma
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Felix Lasitschka, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger & Niels Halama
Article: 1962135
Published online: 10 Aug 2021
AbstractforPeripheral blood and tissue assessment highlights differential tumor-circulatory gradients of IL2 and MIF with prognostic significance in resectable pancreatic ductal adenocarcinoma | Full Text | References | PDF (545.4 KB) | EPUB
  • 2111 Views
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Original Research

Article
IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells
Can Fang, Tao Weng, Shaojie Hu, Zhiwei Yuan, Hui Xiong, Bing Huang, Yixin Cai, Lequn Li & Xiangning Fu
Article: 1962591
Published online: 10 Aug 2021
AbstractforIFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells | Full Text | References | PDF (5.2 MB) | EPUB
  • 8125 Views
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Article
LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells
Takahiro Yamazaki, Erik Wennerberg, Michal Hensler, Aitziber Buqué, Jeffrey Kraynak, Jitka Fucikova, Xi Kathy Zhou, Baldur Sveinbjørnsson, Øystein Rekdal, Sandra Demaria & Lorenzo Galluzzi
Article: 1962592
Published online: 10 Aug 2021
AbstractforLTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells | Full Text | References | PDF (6.7 MB) | EPUB
  • 3566 Views
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Article
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non–small-cell lung cancer
Kazuo Tsuchiya, Katsuhiro Yoshimura, Yusuke Inoue, Yuji Iwashita, Hidetaka Yamada, Akikazu Kawase, Takuya Watanabe, Masayuki Tanahashi, Hiroshi Ogawa, Kazuhito Funai, Kazuya Shinmura, Takafumi Suda & Haruhiko Sugimura
Article: 1962656
Published online: 10 Aug 2021
AbstractforYTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non–small-cell lung cancer | Full Text | References | PDF (3.9 MB) | EPUB
  • 4660 Views
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Open Access
Article
Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy
Jing Sun, Run Shi, Xiaowen Zhang, Da Fang, Josefine Rauch, Shun Lu, Xuanbin Wang, Lukas Käsmann, Jing Ma, Claus Belka, Chuan Su & Minglun Li
Article: 1964189
Published online: 07 Sep 2021
AbstractforCharacterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy | Full Text | References | PDF (9.2 MB) | EPUB
  • 5934 Views
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Article
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer
Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dusica Ristic, Sofia Raftopoulou, Ana Santiso, Thomas Bärnthaler, Luka Brcic, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Gerd Geisslinger, Julia Kargl & Rudolf Schicho
Article: 1965319
Published online: 11 Sep 2021
AbstractforMonoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer | Full Text | References | PDF (3 MB) | EPUB
  • 3051 Views
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Article
Immunoseroproteomic profiling in autoantibody to ENO1 as potential biomarker in immunodiagnosis of osteosarcoma by serological proteome analysis (SERPA) approach
Jitian Li, Liping Dai, Manyu Huang, Yan Ma, Zhiping Guo, Xiao Wang, Wuyin Li & Jian-Ying Zhang
Article: 1966969
Published online: 24 Sep 2021
AbstractforImmunoseroproteomic profiling in autoantibody to ENO1 as potential biomarker in immunodiagnosis of osteosarcoma by serological proteome analysis (SERPA) approach | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 1123 Views
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Article
In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart
Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis & Philip J. Blower
Article: 1966970
Published online: 06 Sep 2021
AbstractforIn vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart | Full Text | References | PDF (1.9 MB) | EPUB
  • 2263 Views
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Article
Clonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein–Barr virus-associated nasopharyngeal carcinoma
Yih-Lin Chung & Mei-Ling Wu
Article: 1968172
Published online: 06 Sep 2021
AbstractforClonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein–Barr virus-associated nasopharyngeal carcinoma | Full Text | References | PDF (2.9 MB) | EPUB
  • 2006 Views
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Author’s View

Article
Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma
Jonathan G. Pol, Juliette Paillet, Céleste Plantureux & Guido Kroemer
Article: 1968595
Published online: 11 Sep 2021
AbstractforBeneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma | Full Text | References | PDF (682 KB) | EPUB
  • 2041 Views
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Article
“Suffocating” tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy
Bassam Janji & Salem Chouaib
Article: 1968611
Published online: 07 Sep 2021
Abstractfor“Suffocating” tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy | Full Text | References | PDF (1 MB) | EPUB
  • 1775 Views
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Original Research

Article
Stromal infiltrating mast cells identify immunoevasive subtype high-grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic response
Kankan Cao, Guodong Zhang, Xiangyun Zhang, Moran Yang, Yiying Wang, Mengdi He, Jiaqi Lu & Haiou Liu
Article: 1969075
Published online: 11 Sep 2021
AbstractforStromal infiltrating mast cells identify immunoevasive subtype high-grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic response | Full Text | References | PDF (2.6 MB) | EPUB
  • 3813 Views
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Article
Single-cell profiling of infiltrating B cells and tertiary lymphoid structures in the TME of gastric adenocarcinomas
Lizhou Jia, Tengqi Wang, Youcai Zhao, Shuyu Zhang, Teer Ba, Xingwang Kuai, Bin Wang, Ning Zhang, Wei Zhao, Zhiping Yang & Haishi Qiao
Article: 1969767
Published online: 06 Sep 2021
AbstractforSingle-cell profiling of infiltrating B cells and tertiary lymphoid structures in the TME of gastric adenocarcinomas | Full Text | References | PDF (5.6 MB) | EPUB
  • 6704 Views
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Research Article

Article
Addition of camrelizumab to docetaxel, cisplatin, and radiation therapy in patients with locally advanced esophageal squamous cell carcinoma: a phase 1b study
Wencheng Zhang, Cihui Yan, Tian Zhang, Xi Chen, Jie Dong, Jingjing Zhao, Dong Han, Jun Wang, Gang Zhao, Fuliang Cao, Dejun Zhou, Hongjing Jiang, Peng Tang, Lujun Zhao, Zhiyong Yuan, Quanren Wang, Ping Wang & Qingsong Pang
Article: 1971418
Published online: 28 Sep 2021
AbstractforAddition of camrelizumab to docetaxel, cisplatin, and radiation therapy in patients with locally advanced esophageal squamous cell carcinoma: a phase 1b study | Full Text | References | PDF (1.9 MB) | EPUB
  • 4688 Views
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Article
Prognostic significance of OX40+ lymphocytes in tumor stroma of surgically resected small-cell lung cancer
Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Toraji Amano, Takayuki Ohkuri, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Masaharu Nishimura, Hiroyuki Suzuki, Hirotoshi Dosaka-Akita & Hiroshi Isobe
Article: 1971430
Published online: 18 Sep 2021
AbstractforPrognostic significance of OX40+ lymphocytes in tumor stroma of surgically resected small-cell lung cancer | Full Text | References | PDF (1.9 MB) | EPUB
  • 2047 Views
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Author’s View

Article
Crizotinib and ceritinib trigger immunogenic cell death via on-target effects
Adriana Petrazzuolo, Maria Perez-Lanzon, Peng Liu, M. Chiara Maiuri & Guido Kroemer
Article: 1973197
Published online: 25 Oct 2021
AbstractforCrizotinib and ceritinib trigger immunogenic cell death via on-target effects | Full Text | References | PDF (539.6 KB) | EPUB
  • 1890 Views
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Research Article

Article
Negative prognostic implications of splenomegaly in nivolumab-treated advanced or recurrent pancreatic adenocarcinoma
Shih-Hung Yang, Li-Chun Lu, Hsiang-Fong Kao, Bang-Bin Chen, Ting-Chun Kuo, Sung-Hsin Kuo, Yu-Wen Tien, Li-Yuan Bai, Ann-Lii Cheng & Kun-Huei Yeh
Article: 1973710
Published online: 27 Sep 2021
AbstractforNegative prognostic implications of splenomegaly in nivolumab-treated advanced or recurrent pancreatic adenocarcinoma | Full Text | References | PDF (1.6 MB) | EPUB
  • 1891 Views
  • 3 CrossRef citations
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Article
Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity
Margareta P. Correia, Ana Stojanovic, Winfried S. Wels & Adelheid Cerwenka
Article: 1973783
Published online: 19 Oct 2021
AbstractforInnate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity | Full Text | References | PDF (2.9 MB) | EPUB
  • 2820 Views
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Commentary

Article Commentary
Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?
Goutham Hassan Venkatesh, Raefa Abou Khouzam, Walid Shaaban Moustafa Elsayed, Nagwa Ahmed Zeinelabdin, Stéphane Terry & Salem Chouaib
Article: 1974233
Published online: 27 Sep 2021
First Page PreviewforTumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity? | Full Text | References | PDF (831.1 KB) | EPUB
  • 1688 Views
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Research Article

Article
Immune inactivation by APOBEC3B enrichment predicts response to chemotherapy and survival in gastric cancer
Siyu Xia, Yun Gu, Haijian Zhang, Yuchao Fei, Yifan Cao, Hanji Fang, Jieti Wang, Chao Lin, Heng Zhang, He Li, Hongyong He, Jiejie Xu, Ruochen Li, Hao Liu & Weijuan Zhang
Article: 1975386
Published online: 15 Sep 2021
AbstractforImmune inactivation by APOBEC3B enrichment predicts response to chemotherapy and survival in gastric cancer | Full Text | References | PDF (1.9 MB) | EPUB
  • 2894 Views
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Article
An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma
Uffe Klausen, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Shamaila Munir Ahmad, Anne Ortved Gang, Evelina Martinenaite, Stine Emilie Weis-Banke, Marie Fredslund Breinholt, Guy Wayne Novotny, Julie Westerlin Kjeldsen, Morten Orebo Holmström, Lone Bredo Pedersen, Christian Bjørn Poulsen, Per Boye Hansen, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen & Mads Hald Andersen
Article: 1975889
Published online: 25 Sep 2021
AbstractforAn immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1761 Views
  • 4 CrossRef citations
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Article
Spatial heterogeneity of immune infiltration predicts the prognosis of nasopharyngeal carcinoma patients
Ya-Qin Wang, Xu Liu, Cheng Xu, Wei Jiang, Shuo-Yu Xu, Yu Zhang, Ye Lin Liang, Jun-Yan Li, Qian Li, Yu-Pei Chen, Yin Zhao, Jing-Ping Yun, Na Liu, Ying-Qin Li & Jun Ma
Article: 1976439
Published online: 27 Oct 2021
AbstractforSpatial heterogeneity of immune infiltration predicts the prognosis of nasopharyngeal carcinoma patients | Full Text | References | PDF (1.6 MB) | EPUB
  • 2018 Views
  • 6 CrossRef citations
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Brief Report

Brief Report
Hsp70 modulates immune response in pancreatic cancer through dendritic cells
Bhuwan Giri, Prateek Sharma, Tejeshwar Jain, Anthony Ferrantella, Utpreksha Vaish, Siddharth Mehra, Bharti Garg, Srikanth Iyer, Vrishketan Sethi, Zoe Malchiodi, Rossana Signorelli, Harrys K.C Jacob, John George, Preeti Sahay, Ejas P. Bava, Rajinder Dawra, Sundaram Ramakrishnan, Ashok Saluja & Vikas Dudeja
Article: 1976952
Published online: 18 Sep 2021
AbstractforHsp70 modulates immune response in pancreatic cancer through dendritic cells | Full Text | References | PDF (2 MB) | EPUB
  • 2661 Views
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Original Research

Article
Blood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapy
Duo Yang, Xiaoli Wang, Xinna Zhou, Jing Zhao, Huabing Yang, Shuo Wang, Michael A. Morse, Jiangping Wu, Yanhua Yuan, Sha Li, Amy Hobeika, Herbert Kim Lyerly & Jun Ren
Article: 1976953
Published online: 27 Sep 2021
AbstractforBlood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapy | Full Text | References | PDF (1.6 MB) | EPUB
  • 3490 Views
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Research Article

Article
CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice
Jolien M.R. Van der Meer, Paul K.J.D. de Jonge, Anniek B. van der Waart, Alexander C. Geerlings, Jurgen P. Moonen, Jolanda Brummelman, Janne de Klein, Malou C. Vermeulen, Ralph J.A. Maas, Nicolaas P.M. Schaap, Janneke S. Hoogstad-van Evert, Petronella B. Ottevanger, Joop H. Jansen, Willemijn Hobo & Harry Dolstra
Article: 1981049
Published online: 01 Oct 2021
AbstractforCD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice | Full Text | References | PDF (1.2 MB) | EPUB
  • 2392 Views
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Article
Downregulating testosterone levels enhance immunotherapy efficiency
Luoyang Wang, Guoqiang Jiang, Nan Jing, Xuerun Liu, Huiren Zhuang, Wenfeng Zeng, Wei Liang & Zheng Liu
Article: 1981570
Published online: 27 Sep 2021
AbstractforDownregulating testosterone levels enhance immunotherapy efficiency | Full Text | References | PDF (3.1 MB) | EPUB
  • 2635 Views
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Article
Fn14-targeted BiTE and CAR-T cells demonstrate potent preclinical activity against glioblastoma
Gaowei Li, Zongliang Zhang, Linjun Cai, Xin Tang, Jianhan Huang, Lingyu Yu, Guoqing Wang, Kunhong Zhong, Yi Cao, Chang Liu, Yuelong Wang, Aiping Tong & Liangxue Zhou
Article: 1983306
Published online: 27 Sep 2021
AbstractforFn14-targeted BiTE and CAR-T cells demonstrate potent preclinical activity against glioblastoma | Full Text | References | PDF (3 MB) | EPUB
  • 3323 Views
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Article
An Open–Label, Randomized, Multi–Center Study Comparing the Sequence of High Dose Aldesleukin (Interleukin–2) and Ipilimumab (Yervoy) in Patients with Metastatic Melanoma
Merve Hasanov, Denái R. Milton, William H. Sharfman, Bret Taback, Lee D. Cranmer, Gregory A Daniels, Lawrence Flaherty, Sigrun Hallmeyer, Mohammed Milhem, Lynn Feun, Ralph Hauke, Gary Doolittle, Nancy Gregory & Sapna Patel
Article: 1984059
Published online: 09 Oct 2021
AbstractforAn Open–Label, Randomized, Multi–Center Study Comparing the Sequence of High Dose Aldesleukin (Interleukin–2) and Ipilimumab (Yervoy) in Patients with Metastatic Melanoma | Full Text | References | PDF (577.4 KB) | EPUB
  • 2489 Views
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Review

Review
Trial watch: intratumoral immunotherapy
Juliette Humeau, Julie Le Naour, Lorenzo Galluzzi, Guido Kroemer & Jonathan G. Pol
Article: 1984677
Published online: 15 Oct 2021
AbstractforTrial watch: intratumoral immunotherapy | Full Text | References | PDF (874.2 KB) | EPUB
  • 6569 Views
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Research Article

Article
CD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patients
Lourdes Gimeno, Isabel González-Lozano, María F. Soto-Ramírez, María V. Martínez-Sánchez, Pedro López-Cubillana, José L. Fuster, Jerónimo Martínez-García, Jorge Martínez-Escribano, José A. Campillo, Eduardo Pons-Fuster, Belén Ferri, Alicia López-Abad, Manuel Muro & Alfredo Minguela
Article: 1986943
Published online: 14 Oct 2021
AbstractforCD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patients | Full Text | References | PDF (3.6 MB) | EPUB
  • 2100 Views
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Article
Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer
Wei Song, Jun Ren, Rensheng Xiang, Can Kong & Tao Fu
Article: 1987636
Published online: 12 Oct 2021
AbstractforIdentification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer | Full Text | References | PDF (7.5 MB) | EPUB
  • 11238 Views
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Article
Local tumor microbial signatures and response to checkpoint blockade in non-small cell lung cancer
Maximilian Boesch, Florent Baty, Werner C. Albrich, Lukas Flatz, Regulo Rodriguez, Sacha I. Rothschild, Markus Joerger, Martin Früh & Martin H. Brutsche
Article: 1988403
Published online: 10 Dec 2021
AbstractforLocal tumor microbial signatures and response to checkpoint blockade in non-small cell lung cancer | Full Text | References | PDF (1.7 MB) | EPUB
  • 2937 Views
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Article
PD-1 checkpoint blockade enhances adoptive immunotherapy by human Vγ2Vδ2 T cells against human prostate cancer
Mohanad H. Nada, Hong Wang, Auter J. Hussein, Yoshimasa Tanaka & Craig T. Morita
Article: 1989789
Published online: 25 Oct 2021
AbstractforPD-1 checkpoint blockade enhances adoptive immunotherapy by human Vγ2Vδ2 T cells against human prostate cancer | Full Text | References | PDF (1.4 MB) | EPUB
  • 2683 Views
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Article
DNMT1 constrains IFNβ-mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapy
Kevin Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Ching-Han Hu, Pei-Chen Yang, Hsin-Yu Chang, Ji-An Liang, William Tzu-Liang Chen & K. S. Clifford Chao
Article: 1989790
Published online: 21 Oct 2021
AbstractforDNMT1 constrains IFNβ-mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapy | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 1574 Views
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Article
Apoptosis-induced translocation of centromere protein F in its corresponding autoantibody production in hepatocellular carcinoma
Xiaojin Li, Yanmeng Li, Anjian Xu, Donghu Zhou, Bei Zhang, Saiping Qi, Zhibin Chen, Xiaoming Wang, Xiaojuan Ou, Bangwei Cao, Chunfeng Qu & Jian Huang
Article: 1992104
Published online: 18 Oct 2021
AbstractforApoptosis-induced translocation of centromere protein F in its corresponding autoantibody production in hepatocellular carcinoma | Full Text | References | PDF (6.5 MB) | EPUB
  • 1663 Views
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Article
Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma
Michael G. White, Robert Szczepaniak Sloane, Russell G. Witt, Alexandre Reuben, Pierre Olivier Gaudreau, Miles C. Andrews, Ningping Feng, Sarah Johnson, Caleb A. Class, Christopher Bristow, Khalida Wani, Courtney Hudgens, Luigi Nezi, Teresa Manzo, Mariana Pettaccia De Macedo, Jianhua Hu, Richard Davis, Hong Jiang, Peter Prieto, Elizabeth Burton, Patrick Hwu, Hussein Tawbi, Jeffrey Gershenwald, Alexander J. Lazar, Michael T. Tetzlaff, Willem Overwijk, Scott E Woodman, Zachary A. Cooper, Joseph R. Marszalek, Michael A. Davies, Timothy P. Heffernan & Jennifer A. Wargo
Article: 1992880
Published online: 06 Nov 2021
AbstractforShort-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma | Full Text | References | PDF (2.5 MB) | EPUB
  • 2750 Views
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Article
Universal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell lymphoma
Ji-Wei Li, Di Shi, Xiao-Chun Wan, Jue Hu, Yi-Fan Su, Yu-Peng Zeng, Zi-Juan Hu, Bao-Hua Yu, Qun-Ling Zhang, Ping Wei & Xiao-Yan Zhou
Article: 1995166
Published online: 29 Oct 2021
AbstractforUniversal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell lymphoma | Full Text | References | PDF (1.8 MB) | EPUB
  • 2250 Views
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Article
Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency
Seung Mi Yoo, Vivan W.C. Lau, Craig Aarts, Bojana Bojovic, Gregory Steinberg, Joanne A. Hammill, Anna Dvorkin-Gheva, Raja Ghosh & Jonathan L. Bramson
Article: 1995168
Published online: 09 Nov 2021
AbstractforManufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency | Full Text | References | PDF (2.4 MB) | EPUB
  • 1991 Views
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Article
Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner
Wenjiao Xia, Xin Qi, Mingfeng Li, Yu Wu, Lulu Sun, Xinglong Fan, Yuan Yuan & Jing Li
Article: 1995999
Published online: 29 Oct 2021
AbstractforMetformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner | Full Text | References | PDF (6 MB) | EPUB
  • 3455 Views
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Article
Phase 2 trial of neoadjuvant toripalimab with chemotherapy for resectable stage III non-small-cell lung cancer
Ze-Rui Zhao, Chao-Pin Yang, Si Chen, Hui Yu, Yong-Bin Lin, Yao-Bin Lin, Han Qi, Jie-Tian Jin, Shan-Shan Lian, Yi-Zhi Wang, Jin-Qi You, Wen-Yu Zhai & Hao Long
Article: 1996000
Published online: 25 Oct 2021
AbstractforPhase 2 trial of neoadjuvant toripalimab with chemotherapy for resectable stage III non-small-cell lung cancer | Full Text | References | PDF (2.1 MB) | EPUB
  • 4119 Views
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Editorial

Editorial
Small cell lung cancer responds to immunogenic chemotherapy followed by PD-1 blockade
Guido Kroemer & Oliver Kepp
Article: 1996686
Published online: 02 Nov 2021
AbstractforSmall cell lung cancer responds to immunogenic chemotherapy followed by PD-1 blockade | Full Text | References | PDF (390.9 KB) | EPUB
  • 1793 Views
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Research Article

Article
Cancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T-cell exhaustion
Wang Gong, Christopher R. Donnelly, Blake R. Heath, Emily Bellile, Lorenza A. Donnelly, Hülya F. Taner, Luke Broses, J. Chad Brenner, Steven B. Chinn, Ru-Rong Ji, Haitao Wen, Jacques E. Nör, Jie Wang, Gregory T. Wolf, Yuying Xie & Yu Leo Lei
Article: 1997385
Published online: 13 Nov 2021
AbstractforCancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T-cell exhaustion | Full Text | References | PDF (3.3 MB) | EPUB
  • 4919 Views
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Article
Unifying heterogeneous expression data to predict targets for CAR-T cell therapy
Patrick Schreiner, Mireya Paulina Velasquez, Stephen Gottschalk, Jinghui Zhang & Yiping Fan
Article: 2000109
Published online: 14 Nov 2021
AbstractforUnifying heterogeneous expression data to predict targets for CAR-T cell therapy | Full Text | References | PDF (1.2 MB) | EPUB
  • 2509 Views
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Article
CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma
Kim De Veirman, Janik Puttemans, Ahmet Krasniqi, Thomas Ertveldt, Heleen Hanssens, Ema Romao, Dirk Hose, Cleo Goyvaert, Philip Vlummens, Serge Muyldermans, Karine Breckpot, Frank Bruchertseifer, Alfred Morgenstern, Matthias D’Huyvetter & Nick Devoogdt
Article: 2000699
Published online: 09 Nov 2021
AbstractforCS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma | Full Text | References | PDF (1.8 MB) | EPUB
  • 2305 Views
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Article
Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection
Daniel Delitto, Daniel J. Zabransky, Fangluo Chen, Elizabeth D. Thompson, Jacquelyn W. Zimmerman, Todd D. Armstrong, James M. Leatherman, Reecha Suri, Tamara Y. Lopez-Vidal, Amanda L. Huff, Melissa R. Lyman, Samantha R. Guinn, Marina Baretti, Luciane T. Kagohara, Won Jin Ho, Nilofer S. Azad, William R. Burns, Jin He, Christopher L. Wolfgang, Richard A. Burkhart, Lei Zheng, Mark Yarchoan, Neeha Zaidi & Elizabeth M. Jaffee
Article: 2001159
Published online: 08 Nov 2021
AbstractforImplantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection | Full Text | References | PDF (4.3 MB) | EPUB
  • 3595 Views
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Article
PD-1 blockade improves the anti-tumor potency of exhausted CD3+CD56+ NKT-like cells in patients with primary hepatocellular carcinoma
Longxiang Tao, Shanshan Wang, Guijie Kang, Shanyue Jiang, Wenwei Yin, Lu Zong, Jing Li & Xuefu Wang
Article: 2002068
Published online: 09 Nov 2021
AbstractforPD-1 blockade improves the anti-tumor potency of exhausted CD3+CD56+ NKT-like cells in patients with primary hepatocellular carcinoma | Full Text | References | PDF (4 MB) | EPUB
  • 2342 Views
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Article
Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting
Christian M. Seitz, Joerg Mittelstaet, Daniel Atar, Jana Hau, Selina Reiter, Clara Illi, Verena Kieble, Fabian Engert, Britta Drees, Giulia Bender, Ann-Christin Krahl, Philipp Knopf, Sarah Schroeder, Nikolas Paulsen, Alexander Rokhvarguer, Sophia Scheuermann, Elena Rapp, Anna-Sophia Mast, Armin Rabsteyn, Sabine Schleicher, Stefan Grote, Karin Schilbach, Manfred Kneilling, Bernd Pichler, Dominik Lock, Bettina Kotter, Sandra Dapa, Stefan Miltenyi, Andrew Kaiser, Peter Lang, Rupert Handgretinger & Patrick Schlegel
Article: 2003532
Published online: 02 Dec 2021
AbstractforNovel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting | Full Text | References | PDF (4.4 MB) | EPUB
  • 5078 Views
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Article
Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma
Kristin Stirm, Peter Leary, Katrin Bertram, Nicolás Gonzalo Núñez, Daria Wüst, Christophe Boudesco, Els Verhoeyen, Thorsten Zenz, Burkhard Becher, Thomas Menter, Alexandar Tzankov & Anne Müller
Article: 2003533
Published online: 22 Nov 2021
AbstractforTumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma | Full Text | References | PDF (5 MB) | EPUB
  • 3561 Views
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Article
BDNF expression in GISTs predicts poor prognosis when associated with PD-L1 positive tumor-infiltrating lymphocytes
Guang-Ang Tian, Wen-Ting Xu, Yue Sun, Jin Wang, Qing Ke, Meng-Jiao Yuan, Jin-Jin Wang, Chun Zhuang & Qian Gong
Article: 2003956
Published online: 14 Nov 2021
AbstractforBDNF expression in GISTs predicts poor prognosis when associated with PD-L1 positive tumor-infiltrating lymphocytes | Full Text | References | PDF (2.2 MB) | EPUB
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Chronic stress promotes breast carcinoma metastasis by accumulating myeloid-derived suppressor cells through activating β-adrenergic signaling
Jiale an, Lifeng Feng, Jiling Ren, Yafei Li, Guangru Li, Chang Liu, Yong Yao, Ye Yao, Zecheng Jiang, Yang Gao, Yang Xu, Yachen Wang, Jing Li, Jie Liu, Lei Cao, Zhi Qi & Liang Yang
Article: 2004659
Published online: 23 Nov 2021
AbstractforChronic stress promotes breast carcinoma metastasis by accumulating myeloid-derived suppressor cells through activating β-adrenergic signaling | Full Text | References | PDF (6.3 MB) | EPUB
  • 2929 Views
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Engineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockade
Stefan Warmuth, Tea Gunde, Daniel Snell, Matthias Brock, Christopher Weinert, Alexandre Simonin, Christian Hess, Julia Tietz, Maria Johansson, Fabio Mario Spiga, Robin Heiz, Naomi Flückiger, Sandro Wagen, Julia Zeberer, Dania Diem, Dana Mahler, Belinda Wickihalder, Simone Muntwiler, Bithi Chatterjee, Benjamin Küttner, Bettina Bommer, Yasemin Yaman, Peter Lichtlen & David Urech
Article: 2004661
Published online: 02 Dec 2021
AbstractforEngineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockade | Full Text | References | PDF (3.5 MB) | EPUB
  • 3926 Views
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Article
Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
Jeong Hun Kim, Won Suk Lee, Hye Jin Lee, Hannah Yang, Seung Joon Lee, So Jung Kong, Soyeon Je, Hyun-Jin Yang, Jongsun Jung, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon & Chan Kim
Article: 2005280
Published online: 26 Nov 2021
AbstractforDeep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway | Full Text | References | PDF (3.9 MB) | EPUB
  • 2271 Views
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Article
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis
Mark A.J.M. Hendriks, Isabel Britsch, Xiurong Ke, Anne P. van Wijngarden, Douwe F. Samplonius, Emily M. Ploeg & Wijnand Helfrich
Article: 2005344
Published online: 20 Nov 2021
AbstractforCancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis | Full Text | References | PDF (1.7 MB) | EPUB
  • 2065 Views
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Editorial

Editorial
Radiochemotherapy-induced elevations of plasma HMGB1 levels predict therapeutic responses in cancer patients
Guido Kroemer & Oliver Kepp
Article: 2005859
Published online: 23 Nov 2021
AbstractforRadiochemotherapy-induced elevations of plasma HMGB1 levels predict therapeutic responses in cancer patients | Full Text | References | PDF (422 KB) | EPUB
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Research Article

Article
CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek & Tyler J Curiel
Article: 2006529
Published online: 22 Nov 2021
AbstractforCD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation | Full Text | References | PDF (2.2 MB) | EPUB
  • 2415 Views
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Article
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival
Fiamma Berner, Rebekka Niederer, Jolien J. Luimstra, Oltin Tiberiu Pop, Ann-Kristin Jochum, Mette-Triin Purde, Omar Hasan Ali, David Bomze, Jens Bauer, Lena Katharina Freudenmann, Ana Marcu, Eva-Maria Wolfschmitt, Sebastian Haen, Thorben Gross, Marissa Lisa Dubbelaar, Marie-Therese Abdou, Petra Baumgaertner, Christina Appenzeller, Caroline Cicin-Sain, Tobias Lenz, Daniel E. Speiser, Burkhard Ludewig, Christoph Driessen, Markus Jörger, Martin Früh, Wolfram Jochum, Antonio Cozzio, Hans-Georg Rammensee, Juliane Walz, Jacques Neefjes & Lukas Flatz
Article: 2006893
Published online: 27 Nov 2021
AbstractforKeratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival | Full Text | References | PDF (1.2 MB) | EPUB
  • 2028 Views
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Article
Improving cancer immunotherapy by targeting IL-1
Zhilan Xiao, Shubhra Singh & Manisha Singh
Article: 2008111
Published online: 25 Nov 2021
AbstractforImproving cancer immunotherapy by targeting IL-1 | Full Text | References | PDF (350.6 KB) | EPUB
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