OncoImmunology, Volume 11, Issue 1 (2022)

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OncoImmunology, Volume 11, Issue 1 (2022)

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Review

Review
The role of NKT cells in gastrointestinal cancers
Julian Burks, Purevdorj B. Olkhanud & Jay A. Berzofsky
Article: 2009666
Published online: 30 Dec 2021
AbstractforThe role of NKT cells in gastrointestinal cancers | Full Text | References | PDF (553 KB) | EPUB
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Research Article

Article
Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinoma
Liwei Shao, Xin Yu, Qiuju Han, Xinke Zhang, Nan Lu & Cai Zhang
Article: 2010894
Published online: 02 Jan 2022
AbstractforEnhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinoma | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Article
CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith & William W. Lockwood
Article: 2010905
Published online: 30 Dec 2021
AbstractforCCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
Immunological responses to adjuvant vaccination with combined CD1c+ myeloid and plasmacytoid dendritic cells in stage III melanoma patients
Martine Bloemendal, Kalijn F. Bol, Steve Boudewijns, Mark A.J. Gorris, Johannes H.W. de Wilt, Sandra A.J. Croockewit, Michelle M. van Rossum, Anna L. de Goede, Katja Petry, Rutger H.T. Koornstra, Carl Figdor, Winald R. Gerritsen, Gerty Schreibelt & I. Jolanda M. de Vries
Article: 2015113
Published online: 30 Dec 2021
AbstractforImmunological responses to adjuvant vaccination with combined CD1c+ myeloid and plasmacytoid dendritic cells in stage III melanoma patients | Full Text | References | PDF (998.2 KB) | EPUB | Supplemental
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Brief Report

Brief Report
Reprogramming monocyte-derived macrophages through caspase inhibition
Paul Chaintreuil, Lucie Laplane, Florian Esnault, Victoria Ghesquier, Coline Savy, Nathan Furstoss, Marie-Laure Arcangeli, Thomas Cluzeau, Guillaume Robert, Nathalie Droin, Eric Solary, Patrick Auberger & Arnaud Jacquel
Article: 2015859
Published online: 30 Dec 2021
AbstractforReprogramming monocyte-derived macrophages through caspase inhibition | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Research Article

Article
Mesenchymal stem cells shuttling miR-503 via extracellular vesicles enhance glioma immune escape
Xiao-Song Wang, Xiao-Jun Yu, Kang Wei, Shan-Xi Wang, Qi-Kun Liu, Ying-Guang Wang, Han Li & Cheng Huang
Article: 1965317
Published online: 30 Dec 2021
AbstractforMesenchymal stem cells shuttling miR-503 via extracellular vesicles enhance glioma immune escape | Full Text | References | PDF (3 MB) | EPUB
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Article
T cell-mediated elimination of cancer cells by blocking CEACAM6–CEACAM1 interaction
Jessica Pinkert, Hans-Henning Boehm, Mark Trautwein, Wolf-Dietrich Doecke, Florian Wessel, Yingzi Ge, Eva Maria Gutierrez, Rafael Carretero, Christoph Freiberg, Uwe Gritzan, Merlin Luetke-Eversloh, Sven Golfier, Oliver Von Ahsen, Valentina Volpin, Antonio Sorrentino, Anchana Rathinasamy, Maria Xydia, Robert Lohmayer, Julian Sax, Ayse Nur-Menevse, Abir Hussein, Slava Stamova, Georg Beckmann, Julian Marius Glueck, Dorian Schoenfeld, Joerg Weiske, Dieter Zopf, Rienk Offringa, Bertolt Kreft, Philipp Beckhove & Joerg Willuda
Article: 2008110
Published online: 30 Dec 2021
AbstractforT cell-mediated elimination of cancer cells by blocking CEACAM6–CEACAM1 interaction | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni & Evan W. Newell
Article: 2012961
Published online: 02 Jan 2022
AbstractforBystander CD4+ T cells infiltrate human tumors and are phenotypically distinct | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Article
Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1
Jingxiang Wang, Kai Liu, Tianxiang Xiao, Penggang Liu, Richard A. Prinz & Xiulong Xu
Article: 2016159
Published online: 02 Jan 2022
AbstractforUric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1 | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor action
Injung Hwang, Hyun Tak Jin, Moon Cheol Kang, Tae Yoon Kim, Young Chul Sung & Sae Won Kim
Article: 2014655
Published online: 02 Jan 2022
AbstractforGeneration and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor action | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2652 Views
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Article
Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells
Gyu Jin Lee, Yukyung Jun, Yoon Kyung Jeon, Daekee Lee, Sanghyuk Lee & Jaesang Kim
Article: 2015170
Published online: 04 Jan 2022
AbstractforMice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 2192 Views
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Article
Association between immune-related adverse event timing and treatment outcomes
David Hsiehchen, Abdul Rafeh Naqash, Magdalena Espinoza, Mitchell S. Von Itzstein, Alessio Cortellini, Biagio Ricciuti, Dwight H. Owen, Mehak Laharwal, Yukihiro Toi, Michael Burke, Yang Xie & David E. Gerber
Article: 2017162
Published online: 05 Jan 2022
AbstractforAssociation between immune-related adverse event timing and treatment outcomes | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 3829 Views
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Article
T and NK cell abundance defines two distinct subgroups of renal cell carcinoma
Moon Hee Lee, Petrus Järvinen, Harry Nísen, Oscar Brück, Mette Ilander, Ilona Uski, Jason Theodoropoulos, Matti Kankainen, Tuomas Mirtti, Satu Mustjoki & Anna Kreutzman
Article: 1993042
Published online: 04 Jan 2022
AbstractforT and NK cell abundance defines two distinct subgroups of renal cell carcinoma | Full Text | References | PDF (21.9 MB) | EPUB | Supplemental
  • 3639 Views
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Article
CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition
Meng Liu, Mengbao Du, Jian Yu, Zijun Qian, Yang Gao, Wenjue Pan, Xiujie Zhao, Mowang Wang, Huimin Li, Jiaqi Zheng, Qianshuo Huang, Li-Mengmeng Wang & Haowen Xiao
Article: 2016158
Published online: 05 Jan 2022
AbstractforCEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 4812 Views
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Article
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity
Hanfeng Wang, Yang Fan, Weihao Chen, Zheng Lv, Shengpan Wu, Yundong Xuan, Chenfeng Wang, Yongliang Lu, Tao Guo, Donglai Shen, Fan Zhang, Qingbo Huang, Yu Gao, Hongzhao Li, Xin Ma, Baojun Wang, Yan Huang & Xu Zhang
Article: 2011673
Published online: 05 Jan 2022
AbstractforLoss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 4279 Views
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Article
Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer
Junko Matsuzaki, Shashikant Lele, Kunle Odunsi & Takemasa Tsuji
Article: 2020983
Published online: 05 Jan 2022
AbstractforIdentification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 3579 Views
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Article
CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model
Aki Furusawa, Ryuhei Okada, Fuyuki Inagaki, Hiroaki Wakiyama, Takuya Kato, Hideyuki Furumoto, Hiroshi Fukushima, Shuhei Okuyama, Peter L. Choyke & Hisataka Kobayashi
Article: 2019922
Published online: 04 Jan 2022
AbstractforCD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 2389 Views
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Article
Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer
Shaoquan Zheng, Yutian Zou, Yuhui Tang, Anli Yang, Jie-Ying Liang, Linyu Wu, Wenwen Tian, Weikai Xiao, Xinhua Xie, Lu Yang, Jindong Xie, Weidong Wei & Xiaoming Xie
Article: 2020984
Published online: 03 Jan 2022
AbstractforLandscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer | Full Text | References | PDF (6.4 MB) | EPUB | Supplemental
  • 8951 Views
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Article
Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma
Michihisa Kono, Hiroki Komatsuda, Hidekiyo Yamaki, Takumi Kumai, Ryusuke Hayashi, Risa Wakisaka, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Hiroya Kobayashi & Yasuaki Harabuchi
Article: 2021619
Published online: 03 Jan 2022
AbstractforImmunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2916 Views
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Article
Potential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapy
Hyein Jeong, So-Young Lee, Hyejun Seo, Dong Hyun Kim, Duhyung Lee & Bum-Joon Kim
Article: 2023340
Published online: 20 Jan 2022
AbstractforPotential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapy | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 2393 Views
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Article
Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanoma
Sofie Kirial Mørk, Mohammad Kadivar, Kalijn Fredrike Bol, Arianna Draghi, Marie Christine Wulff Westergaard, Signe Koggersbøl Skadborg, Nana Overgaard, Anders Bundgård Sørensen, Ida Svahn Rasmussen, Lars Vibe Andreasen, Christina Westmose Yde, Thomas Trolle, Christian Garde, Jens Friis-Nielsen, Nis Nørgaard, Dennis Christensen, Jens Vindahl Kringelum, Marco Donia, Sine Reker Hadrup & Inge Marie Svane
Article: 2023255
Published online: 10 Jan 2022
AbstractforPersonalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanoma | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 5007 Views
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Article
A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology
Jenny Sprooten, An Coosemans & Abhishek D. Garg
Article: 2024692
Published online: 10 Jan 2022
AbstractforA first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology | Full Text | References | PDF (592.2 KB) | EPUB
  • 2182 Views
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Article
Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade
Cihui Yan, Xiaoxue Ma, Zhoubo Guo, Xiaoying Wei, Dong Han, Tian Zhang, Xi Chen, Fuliang Cao, Jie Dong, Gang Zhao, Xuan Gao, Tao Wang, Yao Jiang, Ping Wang, Qingsong Pang & Wencheng Zhang
Article: 2025668
Published online: 13 Jan 2022
AbstractforTime-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 3696 Views
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Article
Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
A-Reum Kim, Seong Jin Choi, Junsik Park, Minsuk Kwon, Tamrin Chowdhury, Hyeon Jong Yu, Sojin Kim, Ho Kang, Kyung-Min Kim, Su-Hyung Park, Chul-Kee Park & Eui-Cheol Shin
Article: 2026019
Published online: 12 Jan 2022
AbstractforSpatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3322 Views
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Article
MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression
Jinti Lin, Ankai Xu, Jiakang Jin, Man Zhang, Jianan Lou, Chao Qian, Jian Zhu, Yitian Wang, Zhengming Yang, Xiumao Li, Wei Yu, Bing Liu & Huimin Tao
Article: 2024941
Published online: 12 Jan 2022
AbstractforMerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 6502 Views
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Article
Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment
Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen & Mads Hald Andersen
Article: 2026020
Published online: 27 Jan 2022
AbstractforPeptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2900 Views
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Article
A short-term follow-up CT based radiomics approach to predict response to immunotherapy in advanced non-small-cell lung cancer
Jing Gong, Xiao Bao, Ting Wang, Jiyu Liu, Weijun Peng, Jingyun Shi, Fengying Wu & Yajia Gu
Article: 2028962
Published online: 25 Jan 2022
AbstractforA short-term follow-up CT based radiomics approach to predict response to immunotherapy in advanced non-small-cell lung cancer | Full Text | References | PDF (2.9 MB) | EPUB
  • 3832 Views
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Article
Dissecting the heterogeneity of the microenvironment in primary and recurrent nasopharyngeal carcinomas using single-cell RNA sequencing
Wen-Sa Peng, Xin Zhou, Wen-Bin Yan, Yu-Jiao Li, Cheng-Run Du, Xiao-Shen Wang, Chun-Ying Shen, Qi-Feng Wang, Hong-Mei Ying, Xue-Guan Lu, Ting-Ting Xu & Chao-Su Hu
Article: 2026583
Published online: 25 Jan 2022
AbstractforDissecting the heterogeneity of the microenvironment in primary and recurrent nasopharyngeal carcinomas using single-cell RNA sequencing | Full Text | References | PDF (7.2 MB) | EPUB | Supplemental
  • 5776 Views
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Article
Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger & Niels Halama
Article: 2027148
Published online: 31 Jan 2022
AbstractforTertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3185 Views
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Article
Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc)
Nadine Aschmoneit, Katharina Kocher, Martin Siegemund, Martina S. Lutz, Lennart Kühl, Oliver Seifert & Roland E. Kontermann
Article: 2028961
Published online: 20 Jan 2022
AbstractforFc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc) | Full Text | References | PDF (1.1 MB) | EPUB
  • 1516 Views
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Editorial

Editorial
Beneficial autoimmunity and maladaptive inflammation shape epidemiological links between cancer and immune-inflammatory diseases
Jonathan Pol, Juliette Paillet, Céleste Plantureux & Guido Kroemer
Article: 2029299
Published online: 18 Jan 2022
AbstractforBeneficial autoimmunity and maladaptive inflammation shape epidemiological links between cancer and immune-inflammatory diseases | Full Text | References | PDF (330.1 KB) | EPUB
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Research Article

Article
T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice
Olmo Sonzogni, Daniel E. Zak, Maria Stella Sasso, Rochelle Lear, Alice Muntzer, Manuela Zonca, Katy West, Brian R. Champion & James B. Rottman
Article: 2029070
Published online: 10 Feb 2022
AbstractforT-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 4435 Views
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Article
LCVM infection generates tumor antigen-specific immunity and inhibits growth of nonviral tumors
Camille Jacqueline, Matthew Dracz, Jia Xue, Robert J. Binder, Jonathan Minden & Olivera Finn
Article: 2029083
Published online: 21 Jan 2022
AbstractforLCVM infection generates tumor antigen-specific immunity and inhibits growth of nonviral tumors | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1622 Views
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Article
Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1
Dafne C. A. Quixabeira, Victor Cervera-Carrascon, Joao M. Santos, James H.A. Clubb, Tatiana V. Kudling, Saru Basnet, Camilla Heiniö, Susanna Grönberg-Vähä-Koskela, Marjukka Anttila, Riikka Havunen, Anna Kanerva & Akseli Hemminki
Article: 2028960
Published online: 22 Jan 2022
AbstractforLocal therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2370 Views
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Article
MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer
Masayuki Hagiwara, Atsushi Fushimi, Atrayee Bhattacharya, Nami Yamashita, Yoshihiro Morimoto, Mototsugu Oya, Henry G. Withers, Qiang Hu, Tao Liu, Song Liu, Kwok K. Wong, Mark D. Long & Donald Kufe
Article: 2029298
Published online: 01 Feb 2022
AbstractforMUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 3924 Views
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Article
Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells
Ruben Serrano, Marcus Lettau, Michal Zarobkiewicz, Daniela Wesch, Christian Peters & Dieter Kabelitz
Article: 2030021
Published online: 01 Feb 2022
AbstractforStimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3692 Views
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Editorial

Editorial
Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy
Melanie Bourgin, Oliver Kepp & Guido Kroemer
Article: 2031500
Published online: 25 Jan 2022
AbstractforImmunostimulatory effects of vitamin B5 improve anticancer immunotherapy | Full Text | References | PDF (532.7 KB) | EPUB
  • 5256 Views
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Research Article

Article
Identification of a unique tumor cell subset employing myeloid transcriptional circuits to create an immunomodulatory microenvironment in glioblastoma
Kaidi Yang, Yu Shi, Min Luo, Min Mao, Xiaoning Zhang, Cong Chen, Yuqi Liu, Zhicheng He, Qing Liu, Wenying Wang, Chunhua Luo, Wen Yin, Chao Wang, Qin Niu, Hui Zeng, Xiu-Wu Bian & Yi-Fang Ping
Article: 2030020
Published online: 26 Jan 2022
AbstractforIdentification of a unique tumor cell subset employing myeloid transcriptional circuits to create an immunomodulatory microenvironment in glioblastoma | Full Text | References | PDF (9.5 MB) | EPUB | Supplemental
  • 5491 Views
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Original Research

Article
Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma
Tianqi Liu, Chen Zhu, Xin Chen, Jianqi Wu, Gefei Guan, Cunyi Zou, Shuai Shen, Ling Chen, Peng Cheng, Wen Cheng & Anhua Wu
Article: 2031499
Published online: 27 Jan 2022
AbstractforDual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 3100 Views
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Research Article

Article
TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth
Can-Can Zhao, Qiu-Ju Han, Hao-Yan Ying, Xiang-Xiang Gu, Na Yang, Lu-Yuan Li & Qiang-Zhe Zhang
Article: 2032918
Published online: 01 Feb 2022
AbstractforTNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 3438 Views
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Original Research

Article
CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2
Characterizing CD4+ T cells in Hodgkin lymphoma
Johanna Veldman, Jessica Rodrigues Plaça, Lauren Chong, Miente Martijn Terpstra, Mirjam Mastik, Léon C. van Kempen, Klaas Kok, Tomohiro Aoki, Christian Steidl, Anke van den Berg, Lydia Visser & Arjan Diepstra
Article: 2033433
Published online: 27 Jan 2022
AbstractforCD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2 | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 2941 Views
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Article
Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure
Tassilo L. A. Wachsmann, Anne K. Wouters, Dennis F. G. Remst, Renate S. Hagedoorn, Miranda H. Meeuwsen, Eline van Diest, Jeanette Leusen, Jürgen Kuball, J. H. Frederik Falkenburg & Mirjam H. M. Heemskerk
Article: 2033528
Published online: 01 Feb 2022
AbstractforComparing CAR and TCR engineered T cell performance as a function of tumor cell exposure | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 6972 Views
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Research Article

Article
Immune sunrise: from the immunome to the cancer immune landscape
Gabriela Bindea, Bernhard Mlecnik & Jérôme Galon
Article: 2019896
Published online: 04 Feb 2022
AbstractforImmune sunrise: from the immunome to the cancer immune landscape | Full Text | References | PDF (788.4 KB) | EPUB
  • 3050 Views
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Article
Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity
Yuan-Na Lin, Marcel O. Schmidt, Ghada M. Sharif, Eveline E. Vietsch, Amber J. Kiliti, Megan E. Barefoot, Anna T. Riegel & Anton Wellstein
Article: 2027136
Published online: 03 Feb 2022
AbstractforImpaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2744 Views
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Original Research

Article
Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer
Antonio Tapia-Galisteo, Íñigo Sánchez Rodríguez, Oscar Aguilar-Sopeña, Seandean Lykke Harwood, Javier Narbona, Mariola Ferreras Gutierrez, Rocío Navarro, Laura Martín-García, Cesáreo Corbacho, Marta Compte, Javier Lacadena, Francisco J. Blanco, Patrick Chames, Pedro Roda-Navarro, Luis Álvarez-Vallina & Laura Sanz
Article: 2034355
Published online: 07 Feb 2022
AbstractforTrispecific T-cell engagers for dual tumor-targeting of colorectal cancer | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Research Article

Article
An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation
Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W. Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P.E. Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esther C.W. Breij, Maria Jure-Kunkel & Ugur Sahin
Article: 2030135
Published online: 16 Feb 2022
AbstractforAn Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Original Research

Article
MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma
Barbara Oliviero, Stefania Varchetta, Dalila Mele, Greta Pessino, Roberta Maiello, Monica Falleni, Delfina Tosi, Matteo Donadon, Cristiana Soldani, Barbara Franceschini, Guido Torzilli, Gaetano Piccolo, Matteo Barabino, Enrico Opocher, Marcello Maestri, Stefano Bernuzzi, Kai W. Wucherpfennig, Mario U. Mondelli & Stefania Mantovani
Article: 2035919
Published online: 21 Feb 2022
AbstractforMICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Research Article

Article
Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients
Jesse J. Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Müller, Sabina Berezowska, Patrick Dorn, Thomas M. Marti, Ralph A. Schmid, Belazs Hegedüs, Abdallah Souabni, Sebastian Carotta, Mark A. Pearson, Wolfgang Sommergruber, Greg J. Kocher & Sean R.R. Hall
Article: 2019466
Published online: 09 Feb 2022
AbstractforFunctional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties
Anette Sommer, Sandra Berndt, Hans-Georg Lerchen, Sabrina Forveille, Allan Sauvat, Dominik Mumberg, Guido Kroemer & Oliver Kepp
Article: 2037216
Published online: 09 Feb 2022
AbstractforAntibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Research Article

Article
Accumulation of dysfunctional tumor-infiltrating PD-1+ DCs links PD-1/PD-L1 blockade immunotherapeutic response in cervical cancer
Yu-meng Wang, Jun-jun Qiu, Xin-yu Qu, Jing Peng, Chong Lu, Meng Zhang, Ming-Xing Zhang, Xing-ling Qi, Bin Lv, Jing-Jing Guo, Chen-yan Guo, Gui-ling Li & Ke-qin Hua
Article: 2034257
Published online: 09 Feb 2022
AbstractforAccumulation of dysfunctional tumor-infiltrating PD-1+ DCs links PD-1/PD-L1 blockade immunotherapeutic response in cervical cancer | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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Review

Review
What’s next in cancer immunotherapy? - The promise and challenges of neoantigen vaccination
Alec J. Redwood, Ian M. Dick, Jenette Creaney & Bruce W. S. Robinson
Article: 2038403
Published online: 13 Feb 2022
AbstractforWhat’s next in cancer immunotherapy? - The promise and challenges of neoantigen vaccination | Full Text | References | PDF (1.7 MB) | EPUB
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Original Research

Article
Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils
Gabrielle Leclercq, Llucia Alberti Servera, Sabrina Danilin, John Challier, Nathalie Steinhoff, Claudia Bossen, Alex Odermatt, Valeria Nicolini, Pablo Umaña, Christian Klein, Marina Bacac, Anna-Maria Giusti, Anneliese Schneider & Hélène Haegel
Article: 2039432
Published online: 14 Feb 2022
AbstractforDissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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Article
Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patients
Lior Goldberg, Eric R. Haas, Vibhuti Vyas, Ryan Urak, Stephen J. Forman & Xiuli Wang
Article: 2040772
Published online: 18 Feb 2022
AbstractforSingle-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patients | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Article
Coupling the immunomodulatory properties of the HDAC6 inhibitor ACY241 with Oxaliplatin promotes robust anti-tumor response in non-small cell lung cancer
Arup Bag, Andrew Schultz, Saloni Bhimani, Olya Stringfield, William Dominguez, Qianxing Mo, Ling Cen & Dennis Adeegbe
Article: 2042065
Published online: 22 Feb 2022
AbstractforCoupling the immunomodulatory properties of the HDAC6 inhibitor ACY241 with Oxaliplatin promotes robust anti-tumor response in non-small cell lung cancer | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Deep learning using bulk RNA-seq data expands cell landscape identification in tumor microenvironment
Xin Wang, Hongjiu Wang, Dan Liu, Na Wang, Danni He, Zheyu Wu, Xu Zhu, Xiaoling Wen, Xuhua Li, Jin Li & Zhenzhen Wang
Article: 2043662
Published online: 25 Feb 2022
AbstractforDeep learning using bulk RNA-seq data expands cell landscape identification in tumor microenvironment | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Article
Targeting coagulation to unlock antitumor immunity?
Antoine Galmiche, Zuzana Saidak & François Ghiringhelli
Article: 2045696
Published online: 24 Feb 2022
AbstractforTargeting coagulation to unlock antitumor immunity? | Full Text | References | PDF (551.5 KB) | EPUB
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Original Research

Article
Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer
Alexandr V. Bazhin, Katharina von Ahn, Jasmin Fritz, Henriette Bunge, Caroline Maier, Orkhan Isayev, Florian Neff, Jens T. Siveke & Svetlana Karakhanova
Article: 2043037
Published online: 01 Mar 2022
AbstractforPivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 1898 Views
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Article
Vasculogenic mimicry structures in melanoma support the recruitment of monocytes
Lih Y. Tan, Michaelia P. Cockshell, Eli Moore, Kay K. Myo Min, Michael Ortiz, M. Zahied Johan, Brenton Ebert, Andrew Ruszkiewicz, Michael P. Brown, Lisa M. Ebert & Claudine S. Bonder
Article: 2043673
Published online: 09 Mar 2022
AbstractforVasculogenic mimicry structures in melanoma support the recruitment of monocytes | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation
Hui Xiong, Yu Xi, Zhiwei Yuan, Boyu Wang, Shaojie Hu, Can Fang, Yixin Cai, Xiangning Fu & Lequn Li
Article: 2044103
Published online: 03 Mar 2022
AbstractforIFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation | Full Text | References | PDF (15.1 MB) | EPUB | Supplemental
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Article
Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer
Kathleen Ducoin, Romain Oger, Linda Bilonda Mutala, Cécile Deleine, Nicolas Jouand, Juliette Desfrançois, Juliette Podevin, Emilie Duchalais, Jonathan Cruard, Houssem Benlalam, Nathalie Labarrière, Céline Bossard, Anne Jarry & Nadine Gervois-Segain
Article: 2046931
Published online: 09 Mar 2022
AbstractforTargeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment
Kaspar Bresser, Meike E. W. Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers, Bjorn Siteur, Manon Boeije, Lona J. Kroese & Ton N. Schumacher
Article: 2049486
Published online: 17 Mar 2022
AbstractforQPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment | Full Text | References | PDF (10 MB) | EPUB | Supplemental
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Article
Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress
J. Cedervall, M. Herre, A. Dragomir, F. Rabelo-Melo, A. Svensson, C. Thålin, A. Rosell, V. Hjalmar, H. Wallén, H. Lindman, G. Pejler, E. Hagström, M. Hultström, A. Larsson & AK. Olsson
Article: 2049487
Published online: 14 Mar 2022
AbstractforNeutrophil extracellular traps promote cancer-associated inflammation and myocardial stress | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Editorial

Editorial
Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence
Beatriz Álvarez-Abril, Elena García-Martínez & Lorenzo Galluzzi
Article: 2052411
Published online: 17 Mar 2022
AbstractforPlatinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence | Full Text | References | PDF (406.2 KB) | EPUB
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Original Research

Article
Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells
Ze-Zhou Jiang, Zhi-Peng Peng, Xing-Chen Liu, Hao-Fan Guo, Meng-Meng Zhou, Da Jiang, Wan-Ru Ning, Yu-Fan Huang, Limin Zheng & Yan Wu
Article: 2052418
Published online: 16 Mar 2022
AbstractforNeutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway
Danfeng Sun, Weichao Wang, Fangfang Guo, Michael R. Pitter, Wan Du, Shuang Wei, Sara Grove, Linda Vatan, Yingxuan Chen, Ilona Kryczek, Eric R. Fearon, Jing-Yuan Fang & Weiping Zou
Article: 2052640
Published online: 16 Mar 2022
AbstractforDOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-γ/IL-17 release in bladder cancer treatment
Sandra Guallar-Garrido, Víctor Campo-Pérez, Míriam Pérez-Trujillo, Cecilia Cabrera, Jordi Senserrich, Alejandro Sánchez-Chardi, Rosa Maria Rabanal, Elisabet Gómez-Mora, Estela Noguera-Ortega, Marina Luquin & Esther Julián
Article: 2051845
Published online: 23 Mar 2022
AbstractforMycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-γ/IL-17 release in bladder cancer treatment | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
STING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancer
Yanyan Da, Yuxia Liu, Yuan Hu, Wenzeng Liu, Junpeng Ma, Nan Lu, Chengsheng Zhang & Cai Zhang
Article: 2054105
Published online: 21 Mar 2022
AbstractforSTING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancer | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Toll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expression
Donghwan Jeon & Douglas G. McNeel
Article: 2054758
Published online: 21 Mar 2022
AbstractforToll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expression | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Correction

Correction
Correction
Article: 2048530
Published online: 22 Mar 2022
First Page PreviewforCorrection | Full Text | PDF (5.7 MB) | EPUB
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Original Research

Article
Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies
Ángel Ramírez-Fernández, Óscar Aguilar-Sopeña, Laura Díez-Alonso, Alejandro Segura-Tudela, Carmen Domínguez-Alonso, Pedro Roda-Navarro, Luis Álvarez-Vallina & Belén Blanco
Article: 2054106
Published online: 23 Mar 2022
AbstractforSynapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes
Jin K. Kim, Chin-Tung Chen, Ajaratu Keshinro, Asama Khan, Canan Firat, Chad Vanderbilt, Neil Segal, Zsofia Stadler, Jinru Shia, Vinod P. Balachandran & Martin R. Weiser
Article: 2054757
Published online: 14 Apr 2022
AbstractforIntratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism
Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Bo Xin, Jinglu Huang, Jin Lu, Jie Li, Xipeng Sun, Chunyan Li, Yan Huo, Jianping Zhang, Yonglong Han & Cheng Guo
Article: 2055703
Published online: 25 Mar 2022
AbstractforSuperior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
PKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cells
Kenny Misael Calvillo-Rodríguez, Rodolfo Mendoza-Reveles, Luis Gómez-Morales, Ashanti Concepción Uscanga-Palomeque, Philippe Karoyan, Ana Carolina Martínez-Torres & Cristina Rodríguez-Padilla
Article: 2054305
Published online: 04 Apr 2022
AbstractforPKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cells | Full Text | References | PDF (16.1 MB) | EPUB | Supplemental
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Article
Carbon ion radiotherapy triggers immunogenic cell death and sensitizes melanoma to anti-PD-1 therapy in mice
Heng Zhou, Chen Tu, Pengfei Yang, Jin Li, Oliver Kepp, Haining Li, Liying Zhang, Lixin Zhang, Yang Zhao, Tianyi Zhang, Chengyan Sheng & Jufang Wang
Article: 2057892
Published online: 25 Mar 2022
AbstractforCarbon ion radiotherapy triggers immunogenic cell death and sensitizes melanoma to anti-PD-1 therapy in mice | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
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Article
Translocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesis
Huan Deng, Sureshkumar Muthupalani, Susan Erdman, Haibo Liu, Zhengchuan Niu, Timothy C. Wang & James G. Fox
Article: 2057399
Published online: 26 Mar 2022
AbstractforTranslocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesis | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials
Hunter C. Jonus, Rebecca E. Burnham, Andrew Ho, Adeiye A. Pilgrim, Jenny Shim, Christopher B. Doering, H. Trent Spencer & Kelly C. Goldsmith
Article: 2057012
Published online: 26 Mar 2022
AbstractforDissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Serial changes in liquid biopsy-derived variant allele frequency predict immune checkpoint inhibitor responsiveness in the pan-cancer setting
Shumei Kato, Bing Li, Jacob J. Adashek, Seong Won Cha, Daniella Bianchi-Frias, Dajun Qian, Lisa Kim, Tiffany W so, Marcus Mitchell, Naoki Kamei, Robert Hoiness, Jayne Hoo, Phillip N. Gray, Teruaki Iyama, Masahide Kashiwagi, Hsiao-Mei Lu & Razelle Kurzrock
Article: 2052410
Published online: 29 Mar 2022
AbstractforSerial changes in liquid biopsy-derived variant allele frequency predict immune checkpoint inhibitor responsiveness in the pan-cancer setting | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes
Louise Rethacker, Maxime Boy, Valeria Bisio, France Roussin, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Christine Sedlik, Eliane Piaggio, Antoine Toubert, Nicolas Dulphy & Anne Caignard
Article: 2057396
Published online: 30 Mar 2022
AbstractforInnate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis
Yang Liu, Haimeng Yan, Huiyao Gu, Enfan Zhang, Jingsong He, Wen Cao, Jianwei Qu, Ruyi Xu, Liqin Cao, Donghua He, Jinna Zhang, Yifan Hou & Zhen Cai
Article: 2057837
Published online: 31 Mar 2022
AbstractforMyeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Article
Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)
Meichen Li, Xue Hou, Ke Sai, Lihong Wu, Jing Chen, Baishen Zhang, Na Wang, Lijia Wu, Hongbo Zheng, Jiao Zhang, Yonggao Mou & Likun Chen
Article: 2059874
Published online: 31 Mar 2022
AbstractforImmune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060) | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
CXCL5-mediated accumulation of mature neutrophils in lung cancer tissues impairs the differentiation program of anticancer CD8 T cells and limits the efficacy of checkpoint inhibitors
Francesca Simoncello, Giulia Maria Piperno, Nicoletta Caronni, Roberto Amadio, Ambra Cappelletto, Giulia Canarutto, Silvano Piazza, Silvio Bicciato & Federica Benvenuti
Article: 2059876
Published online: 07 Apr 2022
AbstractforCXCL5-mediated accumulation of mature neutrophils in lung cancer tissues impairs the differentiation program of anticancer CD8 T cells and limits the efficacy of checkpoint inhibitors | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
PD-L1 blockade potentiates the antitumor effects of ALA-PDT and optimizes the tumor microenvironment in cutaneous squamous cell carcinoma
Qingyu Zeng, Jiayi Yang, Jie Ji, Peiru Wang, Linglin Zhang, Guorong Yan, Yuhao Wu, Qi Chen, Jia Liu, Guolong Zhang & Xiuli Wang
Article: 2061396
Published online: 03 Apr 2022
AbstractforPD-L1 blockade potentiates the antitumor effects of ALA-PDT and optimizes the tumor microenvironment in cutaneous squamous cell carcinoma | Full Text | References | PDF (9.9 MB) | EPUB
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Article
LILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAs
Mei-Tzu Su, Sakiko Kumata, Shota Endo, Yoshinori Okada & Toshiyuki Takai
Article: 2060907
Published online: 05 Apr 2022
AbstractforLILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAs | Full Text | References | PDF (9.3 MB) | EPUB | Supplemental
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Article
A loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patients
Julie Le Naour, Zsofia Sztupinszki, Vincent Carbonnier, Odile Casiraghi, Virginie Marty, Lorenzo Galluzzi, Zoltan Szallasi, Guido Kroemer & Erika Vacchelli
Article: 2059878
Published online: 17 Apr 2022
AbstractforA loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patients | Full Text | References | PDF (742.6 KB) | EPUB | Supplemental
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Article
Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling
Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Martina Schmittnaegel, Carola H. Ries & Karin E. de Visser
Article: 2063225
Published online: 15 Apr 2022
AbstractforTumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Article
Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system
Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Long, Lijie Zhai, Maciej S. Lesniak, Charles David James, Leonidas Platanias, Michael Curran & Amy B. Heimberger
Article: 2062827
Published online: 13 Apr 2022
AbstractforCell-directed aptamer therapeutic targeting for cancers including those within the central nervous system | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Article
Evaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA)
Jessica C. Hassel, Timo E. Schank, Heiko Smetak, Jasmin Mühlbauer, Martin Salzmann, Devayani Machiraju, Christian Menzer, Kristin Lang, Laila König, Matthias F. Haefner, Ingrid Hülsmeyer, Christian Kohler, Rainer Spang, Alexander Enk, Jürgen Debus & Philipp Beckhove
Article: 2066609
Published online: 16 Apr 2022
AbstractforEvaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA) | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Article
A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors
Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo & Heather M. Gibson
Article: 2064958
Published online: 20 Apr 2022
AbstractforA diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Article
Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis
Alberto Carretero-González, Marta Hergueta-Redondo, Sara Sánchez-Redondo, Pilar Ximénez-Embún, Luis Manso Sánchez, Eva Ciruelos Gil, Daniel Castellano, Guillermo de Velasco & Héctor Peinado
Article: 2067944
Published online: 23 Apr 2022
AbstractforCharacterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade
G. Kofla, C. Radecke, M. Frentsch, W. Walther, S. Stintzing, H. Riess, L. Bullinger & I-K. Na
Article: 2068109
Published online: 25 Apr 2022
AbstractforConventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade
Jiao Liu, Rui Kang, Guido Kroemer & Daolin Tang
Article: 2068488
Published online: 25 Apr 2022
AbstractforTargeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade | Full Text | References | PDF (447.9 KB) | EPUB
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Article
Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells
Karthikeyan Subbarayan, Chiara Massa, Sandra Leisz, André Steven, Daniel Bethmann, Katharina Biehl, Claudia Wickenhauser & Barbara Seliger
Article: 2069214
Published online: 28 Apr 2022
AbstractforBiglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Brief Report

Brief Report
Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma
Robyn D. Gartrell, Thomas Enzler, Pan S. Kim, Benjamin T. Fullerton, Ladan Fazlollahi, Andrew X. Chen, Hanna E. Minns, Subha Perni, Stuart P. Weisberg, Emanuelle M. Rizk, Samuel Wang, Eun Jeong Oh, Xinzheng V. Guo, Codruta Chiuzan, Gulam A. Manji, Susan E. Bates, John Chabot, Beth Schrope, Michael Kluger, Jean Emond, Raul Rabadán, Donna Farber, Helen E. Remotti, David P. Horowitz & Yvonne M. Saenger
Article: 2066767
Published online: 05 May 2022
AbstractforNeoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Original Research

Article
Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy
Flor Navarro, Noelia Casares, Celia Martín-Otal, Aritz Lasarte-Cía, Marta Gorraiz, Patricia Sarrión, Diana Llopiz, David Reparaz, Nerea Varo, Juan Roberto Rodriguez-Madoz, Felipe Prosper, Sandra Hervás-Stubbs, Teresa Lozano & Juan José Lasarte
Article: 2070337
Published online: 01 May 2022
AbstractforOvercoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 3541 Views
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Article
Novel approach to identify putative Epstein–Barr–virus microRNAs regulating host cell genes with relevance in tumor biology and immunology
Simon Jasinski-Bergner, Juliane Blümke, Marcus Bauer, Saskia Luise Skiebe, Ofer Mandelboim, Claudia Wickenhauser & Barbara Seliger
Article: 2070338
Published online: 01 May 2022
AbstractforNovel approach to identify putative Epstein–Barr–virus microRNAs regulating host cell genes with relevance in tumor biology and immunology | Full Text | References | PDF (4.9 MB) | EPUB
  • 1378 Views
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Article
OX40 and 4-1BB delineate distinct immune profiles in sarcoma
MJ Melake, HG Smith, D Mansfield, E Davies, MT Dillon, AC Wilkins, EC Patin, M Pedersen, R Buus, AA Melcher, K Thway, AB Miah, SH Zaidi, AJ Hayes, TR Fenton, KJ Harrington & M McLaughlin
Article: 2066050
Published online: 09 May 2022
AbstractforOX40 and 4-1BB delineate distinct immune profiles in sarcoma | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
  • 3412 Views
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Article
NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia
Kateřina Kuželová, Barbora Brodská, Jana Marková, Martina Petráčková, Johannes Schetelig, Šárka Ransdorfová, Zdenka Gašová & Cyril Šálek
Article: 2073050
Published online: 06 May 2022
AbstractforNPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia | Full Text | References | PDF (901.2 KB) | EPUB | Supplemental
  • 2363 Views
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Article
Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma
Caixu Pan, Qinchuan Wu, Shuai Wang, Zhibin Mei, Lele Zhang, Xingxing Gao, Junjie Qian, Zhentian Xu, Ke Zhang, Rong Su, Danjing Guo, Lin Zhou & Shusen Zheng
Article: 2073010
Published online: 06 May 2022
AbstractforCombination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
  • 2342 Views
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Author’s View

Article
The ART of tumor immune escape
Erik Wennerberg, Sumit Mukherjee, Ricardo M. Sainz & Brendon M. Stiles
Article: 2076310
Published online: 14 May 2022
AbstractforThe ART of tumor immune escape | Full Text | References | PDF (772.6 KB) | EPUB
  • 3041 Views
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Editorial

Editorial
Immunogenic stress induced by local anesthetics injected into neoplastic lesions
Lucillia Bezu, Oliver Kepp & Guido Kroemer
Article: 2077897
Published online: 16 May 2022
First Page PreviewforImmunogenic stress induced by local anesthetics injected into neoplastic lesions | Full Text | References | PDF (760.3 KB) | EPUB
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Original Research

Article
TH-MYCN tumors, but not tumor-derived cell lines, are adrenergic lineage, GD2+, and responsive to anti-GD2 antibody therapy
KO McNerney, S Karageorgos, GM Ferry, AJ Wolpaw, C Burudpakdee, P Khurana, CN Toland, R Vemu, A Vu, MD Hogarty & H Bassiri
Article: 2075204
Published online: 24 May 2022
AbstractforTH-MYCN tumors, but not tumor-derived cell lines, are adrenergic lineage, GD2+, and responsive to anti-GD2 antibody therapy | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2271 Views
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Review

Review
Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy
Adriana Petrazzuolo, M. Chiara Maiuri, Laurence Zitvogel, Guido Kroemer & Oliver Kepp
Article: 2077898
Published online: 26 May 2022
AbstractforTrial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy | Full Text | References | PDF (1.3 MB) | EPUB
  • 3631 Views
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Original Research

Article
Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer
Jia Bo Zheng, Chau Wei Wong, Jia Liu, Xiao-Jing Luo, Wei-Yi Zhou, Yan-Xing Chen, Hui-Yan Luo, Zhao-Lei Zeng, Chao Ren, Xiao-Ming Xie & De-Shen Wang
Article: 2079182
Published online: 25 May 2022
AbstractforGlucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancer | Full Text | References | PDF (13.3 MB) | EPUB | Supplemental
  • 2614 Views
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Article
MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy
Renato B. Baleeiro, Christian J. Bouwens, Peng Liu, Carmela Di Gioia, Louisa S. Chard Dunmall, Ai Nagano, Rathistevy Gangeswaran, Claude Chelala, Hemant M. Kocher, Nicholas R. Lemoine & Yaohe Wang
Article: 2080329
Published online: 27 May 2022
AbstractforMHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 4522 Views
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Article
Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors
Yusuke Tomita, Yoshihiko Goto, Shinya Sakata, Kosuke Imamura, Ayaka Minemura, Kentaro Oka, Atsushi Hayashi, Takayuki Jodai, Kimitaka Akaike, Moriyasu Anai, Shohei Hamada, Shinji Iyama, Koichi Saruwatari, Sho Saeki, Motomichi Takahashi, Tokunori Ikeda & Takuro Sakagami
Article: 2081010
Published online: 27 May 2022
AbstractforClostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 6032 Views
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Brief Report

Brief Report
CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma
Tobias Bexte, Jamal Alzubi, Lisa Marie Reindl, Philipp Wendel, Ralf Schubert, Emilia Salzmann-Manrique, Ivana von Metzler, Toni Cathomen & Evelyn Ullrich
Article: 2081415
Published online: 31 May 2022
AbstractforCRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 5308 Views
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Review

Review
Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors
Gabrielle Leclercq, Nathalie Steinhoff, Hélène Haegel, Donata De Marco, Marina Bacac & Christian Klein
Article: 2083479
Published online: 01 Jun 2022
AbstractforNovel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors | Full Text | References | PDF (2 MB) | EPUB
  • 5016 Views
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Original Research

Article
Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression
Zhou Liu, Zhijie Gao, Bei Li, Juanjuan Li, Yangyang Ou, Xin Yu, Zun Zhang, Siqin Liu, Xiaoyu Fu, Hongzhong Jin, Juan Wu, Si Sun, Shengrong Sun & Qi Wu
Article: 2085432
Published online: 08 Jun 2022
AbstractforLipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression | Full Text | References | PDF (9.4 MB) | EPUB | Supplemental
  • 8990 Views
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ORIGINAL RESEARCH

Article
Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy
Antonino Di Lorenzo, Elisabetta Bolli, Roberto Ruiu, Giuseppe Ferrauto, Enza Di Gregorio, Lidia Avalle, Aurora Savino, Pietro Poggio, Irene Fiore Merighi, Federica Riccardo, Mara Brancaccio, Elena Quaglino, Federica Cavallo & Laura Conti
Article: 2086752
Published online: 15 Jun 2022
AbstractforToll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy | Full Text | References | PDF (7.2 MB) | EPUB | Supplemental
  • 2671 Views
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Original Research

Article
PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors
Anna D. Staniszewska, Joshua Armenia, Matthew King, Chrysiis Michaloglou, Avinash Reddy, Maneesh Singh, Maryann San Martin, Laura Prickett, Zena Wilson, Theresa Proia, Deanna Russell, Morgan Thomas, Oona Delpuech, Mark J. O’Connor, Elisabetta Leo, Helen Angell & Viia Valge-Archer
Article: 2083755
Published online: 18 Jun 2022
AbstractforPARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors | Full Text | References | PDF (8.7 MB) | EPUB | Supplemental
  • 4731 Views
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Article
Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect
Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dunbar, Gavin F Painter & Ian F Hermans
Article: 2081009
Published online: 13 Jun 2022
AbstractforIntratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect | Full Text | References | PDF (14 MB) | EPUB | Supplemental
  • 2270 Views
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ORIGINAL RESEARCH

Article
Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1
Dandan Lin, Yu Mei, Lei Lei, Zuhairah Binte Hanafi, Ziqi Jin, Yonghao Liu, Yuan Song, Yinsheng Zhang, Bo Hu, Chunliang Liu, Jinhua Lu & Haiyan Liu
Article: 2088467
Published online: 15 Jun 2022
AbstractforImmune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1 | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 2833 Views
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Original Research

Article
Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses
Markus Zettl, Melanie Wurm, Otmar Schaaf, Sven Mostböck, Iñigo Tirapu, Ilse Apfler, Ivo C. Lorenz, Lee Frego, Cynthia Kenny, Michael Thibodeau, Elisa Oquendo Cifuentes, Markus Reschke, Jürgen Moll, Norbert Kraut, Anne Vogt, Jonathon D. Sedgwick & Irene C. Waizenegger
Article: 2080328
Published online: 16 Jun 2022
AbstractforCombination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 2912 Views
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Editorial

Editorial
The endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers?
Oliver Kepp, Lucillia Bezu & Guido Kroemer
Article: 2092328
Published online: 21 Jun 2022
First Page PreviewforThe endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers? | Full Text | References | PDF (853.3 KB) | EPUB
  • 1761 Views
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Free Access

REVIEW

Article
PD-1 blockade synergizes with oxaliplatin-based, but not cisplatin-based, chemotherapy of gastric cancer
Peng Liu, Jianzhou Chen, Liwei Zhao, Antoine Hollebecque, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
Article: 2093518
Published online: 24 Jun 2022
AbstractforPD-1 blockade synergizes with oxaliplatin-based, but not cisplatin-based, chemotherapy of gastric cancer | Full Text | References | PDF (1.1 MB) | EPUB
  • 4378 Views
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ORIGINAL RESEARCH

Article
Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality
Esther Schoutrop, Stefanie Renken, Isabella Micallef Nilsson, Paula Hahn, Thomas Poiret, Rolf Kiessling, Stina L Wickström, Jonas Mattsson & Isabelle Magalhaes
Article: 2093426
Published online: 28 Jun 2022
AbstractforTrogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 4544 Views
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Article
Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation
Teng He, Zhixing Hao, Mingjie Lin, Zhongwei Xin, Yongyuan Chen, Wei Ouyang, Qi Yang, Xiaoke Chen, Hui Zhou, Wanying Zhang, Pin Wu & Feng Xu
Article: 2093054
Published online: 01 Jul 2022
AbstractforOncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation | Full Text | References | PDF (9.2 MB) | EPUB | Supplemental
  • 3636 Views
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Article
Homologous recombination repair deficient prostate cancer represents an immunologically distinct subtype
Sandra van Wilpe, Donjetë Simnica, Peter Slootbeek, Thomas van Ee, Samhita Pamidimarri Naga, Mark A. J. Gorris, Lieke L. van der Woude, Shabaz Sultan, Rutger H. T. Koornstra, Inge M. van Oort, Winald R. Gerritsen, Leonie I. Kroeze, Michiel Simons, Geert J. L. H. van Leenders, Mascha Binder, I. Jolanda M. de Vries & Niven Mehra
Article: 2094133
Published online: 01 Jul 2022
AbstractforHomologous recombination repair deficient prostate cancer represents an immunologically distinct subtype | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1944 Views
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Article
Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
Qiuman Wang, Xinyue Ma, Huan Wu, Chen Zhao, Jingying Chen, Rongrong Li, Shi Yan, Yingwei Li, Qing Zhang, Kun Song, Cunzhong Yuan & Beihua Kong
Article: 2096362
Published online: 01 Jul 2022
AbstractforOncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer | Full Text | References | PDF (11.8 MB) | EPUB | Supplemental
  • 3337 Views
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REVIEW

Article
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
Raquel S Laureano, Jenny Sprooten, Isaure Vanmeerbeerk, Daniel M Borras, Jannes Govaerts, Stefan Naulaerts, Zwi N Berneman, Benoit Beuselinck, Kalijn F Bol, Jannie Borst, an Coosemans, Angeliki Datsi, Jitka Fučíková, Lisa Kinget, Bart Neyns, Gerty Schreibelt, Evelien Smits, Rüdiger V Sorg, Radek Spisek, Kris Thielemans, Sandra Tuyaerts, Steven De Vleeschouwer, I Jolanda M de Vries, Yanling Xiao & Abhishek D Garg
Article: 2096363
Published online: 04 Jul 2022
AbstractforTrial watch: Dendritic cell (DC)-based immunotherapy for cancer | Full Text | References | PDF (1.7 MB) | EPUB
  • 7007 Views
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ORIGINAL RESEARCH

Article
Enhancement of tumor immunogenicity by the introduction of non- proteinogenic amino acid azetidine-2-carboxylic acid
Siyu Li, Shiqing Wang, Baorui Tian, Na Li, Yanan Chen, Yanhua Liu, Weijun Su, Yan Fan, Yongjun Piao, Jia Li, Longlong Wang, Jin Zhao, Shu Wang, Yi Shi & Rong Xiang
Article: 2097460
Published online: 04 Jul 2022
AbstractforEnhancement of tumor immunogenicity by the introduction of non- proteinogenic amino acid azetidine-2-carboxylic acid | Full Text | References | PDF (6 MB) | EPUB | Supplemental
  • 1166 Views
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Article
Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressiveness
Elena Poli, Vanessa Barbon, Silvia Lucchetta, Manuela Cattelan, Luisa Santoro, Angelica Zin, Giuseppe Maria Milano, Ilaria Zanetti, Gianni Bisogno & Paolo Bonvini
Article: 2096349
Published online: 06 Jul 2022
AbstractforImmunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressiveness | Full Text | References | PDF (11.2 MB) | EPUB | Supplemental
  • 1643 Views
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Article
PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells
Cecilia Pesini, Sandra Hidalgo, Maykel A. Arias, Llipsy Santiago, Carlota Calvo, Maitane Ocariz-Díez, Dolores Isla, Pilar M. Lanuza, M José Agustín, Eva M Galvez, Ariel Ramírez-Labrada & Julián Pardo
Article: 2096359
Published online: 06 Jul 2022
AbstractforPD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 2583 Views
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Article
Helicobacter pylori serology is associated with worse overall survival in patients with melanoma treated with immune checkpoint inhibitors
Marion Tonneau, Alexis Nolin-Lapalme, Suzanne Kazandjian, Edouard Auclin, Justin Panasci, Myriam Benlaifaoui, Mayra Ponce, Afnan Al-Saleh, Wiam Belkaid, Sabrine Naimi, Catalin Mihalcioiu, Ian Watson, Mickael Bouin, Wilson Miller, Marie Hudson, Matthew K. Wong, Rossanna C. Pezo, Simon Turcotte, Karl Bélanger, Rahima Jamal, Paul Oster, Dominique Velin, Corentin Richard, Meriem Messaoudene, Arielle Elkrief & Bertrand Routy
Article: 2096535
Published online: 07 Jul 2022
AbstractforHelicobacter pylori serology is associated with worse overall survival in patients with melanoma treated with immune checkpoint inhibitors | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3149 Views
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Article
Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression
Tatiana V. Kudling, James H.A. Clubb, Dafne C.A. Quixabeira, Joao M. Santos, Riikka Havunen, Alexander Kononov, Camilla Heiniö, Victor Cervera-Carrascon, Santeri Pakola, Saru Basnet, Susanna Grönberg-Vähä-Koskela, Victor Arias, Ivan Gladwyn-Ng, Katri Aro, Leif Bäck, Jari Räsänen, Ilkka Ilonen, Kristian Borenius, Mikko Räsänen, Otto Hemminki, Antti Rannikko, Anna Kanerva, Johanna Tapper & Akseli Hemminki
Article: 2096572
Published online: 12 Jul 2022
AbstractforLocal delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression | Full Text | References | PDF (18.1 MB) | EPUB | Supplemental
  • 3157 Views
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EDITORIAL

Editorial
A nanoparticle-based tour de force for enhancing immunogenic cell death elicited by photodynamic therapy
Oliver Kepp & Guido Kroemer
Article: 2098658
Published online: 08 Jul 2022
AbstractforA nanoparticle-based tour de force for enhancing immunogenic cell death elicited by photodynamic therapy | Full Text | References | PDF (337.1 KB) | EPUB
  • 1210 Views
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Free Access

ORIGINAL RESEARCH

Article
CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors
Inken Salewski, Julia Henne, Leonie Engster, Paula Krone, Bjoern Schneider, Caterina Redwanz, Heiko Lemcke, Larissa Henze, Christian Junghanss & Claudia Maletzki
Article: 2094583
Published online: 11 Jul 2022
AbstractforCDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors | Full Text | References | PDF (12.6 MB) | EPUB | Supplemental
  • 2401 Views
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BRIEF REPORT

Brief Report
Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis
Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Assunta Cirella, Myriam Fernandez-Sendin, Celia Gomar, Joan Salvador Russo-Cabrera, Inmaculada Rodríguez, José González-Gomariz, Maite Alvarez, Álvaro Teijeira, José Medina-Echeverz, Maria Hinterberger, Hubertus Hochrein, Ignacio Melero, Pedro Berraondo & Fernando Aranda
Article: 2098657
Published online: 13 Jul 2022
AbstractforSynergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 2556 Views
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Original Research

Article
Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
Chuan Jin, Arwa Ali, Alexandros Iskantar, Grammatiki Fotaki, Hai Wang, Magnus Essand, Alex Karlsson-Parra & Di Yu
Article: 2099642
Published online: 13 Jul 2022
AbstractforIntratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2602 Views
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Article
Targeting stearoyl-coa desaturase enhances radiation induced ferroptosis and immunogenic cell death in esophageal squamous cell carcinoma
Hui Luo, Xiaohui Wang, Shuai Song, Yunhan Wang, Qinfu Dan & Hong Ge
Article: 2101769
Published online: 15 Jul 2022
AbstractforTargeting stearoyl-coa desaturase enhances radiation induced ferroptosis and immunogenic cell death in esophageal squamous cell carcinoma | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 3244 Views
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Article
Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines
Michal Hensler, Jana Rakova, Lenka Kasikova, Tereza Lanickova, Josef Pasulka, Peter Holicek, Marek Hraska, Tereza Hrnciarova, Pavla Kadlecova, Andreu Schoenenberger, Klara Sochorova, Daniela Rozkova, Ludek Sojka, Jana Drozenova, Jan Laco, Rudolf Horvath, Michal Podrazil, Guo Hongyan, Tomas Brtnicky, Michal J. Halaska, Lukas Rob, Ales Ryska, An Coosemans, Ignace Vergote, Abhishek D. Garg, David Cibula, Jirina Bartunkova, Radek Spisek & Jitka Fucikova
Article: 2101596
Published online: 22 Jul 2022
AbstractforPeripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 2692 Views
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Article
One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer
Jonas Steenbrugge, Julie Bellemans, Niels Vander Elst, Kristel Demeyere, Josephine De Vliegher, Timothy Perera, Olivier De Wever, Wim Van Den Broeck, Ward De Spiegelaere, Niek N. Sanders & Evelyne Meyer
Article: 2103277
Published online: 22 Jul 2022
AbstractforOne cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer | Full Text | References | PDF (9.9 MB) | EPUB | Supplemental
  • 2946 Views
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Article
Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs
Robert J Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L. C. Geh, Alastair D MacKenzie Ross, Ciaran Healy, Sophia Tsoka, James Spicer, Katie E Lacy & Sophia N Karagiannis
Article: 2104426
Published online: 28 Jul 2022
AbstractforEnriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs | Full Text | References | PDF (10.9 MB) | EPUB | Supplemental
  • 4673 Views
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Brief Report

Brief Report
Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis
Katja Thümmler, Mark TS Williams, Susan Kitson, Shatakshi Sood, Moeed Akbar, John J Cole, Ewan Hunter, Richard Soutar & Carl S Goodyear
Article: 2104070
Published online: 01 Aug 2022
AbstractforTargeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 1439 Views
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Original Research

Article
The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology
Florencia Secchiari, Sol Yanel Nuñez, Jessica Mariel Sierra, Andrea Ziblat, María Victoria Regge, Ximena Lucía Raffo Iraolagoitia, Agustín Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolás Richards, Hernando Ríos Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolás Bonanno, Leandro Blas, Aldana Trotta, Adrián David Friedrich, Mercedes Beatriz Fuertes, Carolina Inés Domaica & Norberto Walter Zwirner
Article: 2104991
Published online: 03 Aug 2022
AbstractforThe MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 2561 Views
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Open Access
Article
Schweinfurthin induces ICD without ER stress and caspase activation
Ruoheng Zhang, J.D. Neighbors, T.D. Schell & R.J. Hohl
Article: 2104551
Published online: 03 Aug 2022
AbstractforSchweinfurthin induces ICD without ER stress and caspase activation | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 1989 Views
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Open Access
Article
Synergistic effect of combining sunitinib with a peptide-based vaccine in cancer treatment after microenvironment remodeling
Alice Mougel, Fanny Méjean, Thi Tran, Yasmine Adimi, Isabelle Galy-Fauroux, Christelle Kaboré, Erwan Mercier, Pauline Urquia, Magali Terme, Eric Tartour & Corinne Tanchot
Article: 2110218
Published online: 09 Aug 2022
AbstractforSynergistic effect of combining sunitinib with a peptide-based vaccine in cancer treatment after microenvironment remodeling | Full Text | References | PDF (17.6 MB) | EPUB | Supplemental
  • 1429 Views
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Open Access
Article
IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+ CML stem/progenitor cells potentially through the upregulation of multiple key survival factors
Dorina Ujvari, Alena Malyukova, Ana Zovko, Elham Yektaei-Karin, Harsha S Madapura, Marton Keszei, Noemi Nagy, Kourosh Lotfi, Niclas Björn, Jonas Wallvik, Leif Stenke & Daniel Salamon
Article: 2109861
Published online: 12 Aug 2022
AbstractforIFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+ CML stem/progenitor cells potentially through the upregulation of multiple key survival factors | Full Text | References | PDF (4.2 MB) | EPUB
  • 1615 Views
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Open Access

Author’s View

Article
PARP1 inhibition elicits immune responses against non-small cell lung cancer
Pan Juncheng, Antoine Lafarge, Guido Kroemer & Maria Castedo
Article: 2111915
Published online: 11 Aug 2022
AbstractforPARP1 inhibition elicits immune responses against non-small cell lung cancer | Full Text | References | PDF (726.2 KB) | EPUB
  • 1373 Views
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Open Access

Original Research

Article
CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma
Lihe Su, Lan Wu, Roy R. Lobb, Paul D. Rennert & Christine Ambrose
Article: 2111904
Published online: 17 Aug 2022
AbstractforCAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 2965 Views
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Open Access
Article
Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion
Konstantinos S. Papadakos, Sebastian Lundgren, Chrysostomi Gialeli, Patrick Micke, Artur Mezheyeuski, Jacob Elebro, Karin Jirström & Anna M. Blom
Article: 2111906
Published online: 18 Aug 2022
AbstractforExpression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 1615 Views
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Open Access
Article
A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A. Boudreau, Ben Buelow, Karen Chang, Laura M. Davison, Suhasini Iyer, Vidyut Kalwit, Kristin Lewis Wilson, Harbani K. Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S. Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S. Ugamraj, Rodolfovan D. Yabut, Roland Buelow, Jocelyn Chapman, Nathan D. Trinklein & Katherine E. Harris
Article: 2113697
Published online: 20 Aug 2022
AbstractforA T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer | Full Text | References | PDF (8.2 MB) | EPUB | Supplemental
  • 5170 Views
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Open Access
Article
scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity
Genshen Zhong, Qi Wang, Ying Wang, Ying Guo, Meiqi Xu, Yaya Guan, Xiaoying Zhang, Minna Wu, Zhishan Xu, Weidong Zhao, Hongkai Lian, Hui Wang & Jianping Ye
Article: 2114740
Published online: 20 Aug 2022
AbstractforscRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 3708 Views
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Open Access
Article
Single-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndrome
Tianying Su, George E. Duran, Alexa C. Kwang, Nirasha Ramchurren, Steven P. Fling, Youn H. Kim & Michael S. Khodadoust
Article: 2115197
Published online: 27 Aug 2022
AbstractforSingle-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndrome | Full Text | References | PDF (21.1 MB) | EPUB | Supplemental
  • 2233 Views
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Open Access
Article
An adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasis
Mohammad Arabpour, Sanchari Paul, Hanna Grauers Wiktorin, Mustafa Kaya, Roberta Kiffin, Nils Lycke, Kristoffer Hellstrand & Anna Martner
Article: 2115618
Published online: 24 Aug 2022
AbstractforAn adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasis | Full Text | References | PDF (9 MB) | EPUB | Supplemental
  • 1963 Views
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Open Access
Article
CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironment
Inés Lecoq, Katharina L. Kopp, Marion Chapellier, Panagiotis Mantas, Evelina Martinenaite, Maria Perez-Penco, Lars Rønn Olsen, Mai-Britt Zocca, Ayako Wakatsuki Pedersen & Mads Hald Andersen
Article: 2115655
Published online: 29 Aug 2022
AbstractforCCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironment | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 1946 Views
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Open Access
Article
IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response
Adriana Martinez-Turtos, Rachel Paul, Manuel Grima-Reyes, Hussein Issaoui, Adrien Krug, Rana Mhaidly, Jozef P. Bossowski, Johanna Chiche, Sandrine Marchetti, Els Verhoeyen, Eric Chevet & Jean-Ehrland Ricci
Article: 2116844
Published online: 27 Aug 2022
AbstractforIRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response | Full Text | References | PDF (14.2 MB) | EPUB | Supplemental
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Open Access

Brief Report

Brief Report
Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patients
Hélène Salaün, Leanne de Koning, Mathilde Saint-Ghislain, Vincent Servois, Toulsie Ramtohul, Agathe Garcia, Alexandre Matet, Nathalie Cassoux, Pascale Mariani, Sophie Piperno-Neumann & Manuel Rodrigues
Article: 2116845
Published online: 31 Aug 2022
AbstractforNivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patients | Full Text | References | PDF (505 KB) | EPUB
  • 1282 Views
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Open Access

Original Research

Article
CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy
Xiaofei Li, Mingjie Lu, Manman Yuan, Jing Ye, Wei Zhang, Lingyan Xu, Xiaohan Wu, Bingqing Hui, Yuchen Yang, Bin Wei, Ciliang Guo, Min Wei, Jie Dong, Xingxin Wu & Yanhong Gu
Article: 2118210
Published online: 31 Aug 2022
AbstractforCXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy | Full Text | References | PDF (9.7 MB) | EPUB | Supplemental
  • 4897 Views
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Open Access
Article
Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
Pulak R. Nath, Dipasmita Pal-Nath, Sukhbir Kaur, Arunkumar Gangaplara, Thomas J. Meyer, Margaret C Cam & David D. Roberts
Article: 2111909
Published online: 06 Sep 2022
AbstractforLoss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 2610 Views
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Open Access
Article
Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response
Paola Storti, Valentina Marchica, Rosanna Vescovini, Valentina Franceschi, Luca Russo, Laura Notarfranchi, Vincenzo Raimondi, Denise Toscani, Jessica Burroughs Garcia, Federica Costa, Benedetta Dalla Palma, Nicolas Thomas Iannozzi, Gabriella Sammarelli, Gaetano Donofrio & Nicola Giuliani
Article: 2120275
Published online: 06 Sep 2022
AbstractforImmune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1641 Views
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Open Access
Article
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation
Marta Lopez-Pelaez, Lucy Young, Mercedes Vazquez-Chantada, Nadine Nelson, Steve Durant, Robert W. Wilkinson, Edmund Poon, Miguel Gaspar, Viia Valge-Archer, Paul Smith & Simon J. Dovedi
Article: 2117321
Published online: 13 Sep 2022
AbstractforTargeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3321 Views
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Open Access

Review

Review
Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness
Robby Barnestein, Loïck Galland, Laura Kalfeist, François Ghiringhelli, Sylvain Ladoire & Emeric Limagne
Article: 2120676
Published online: 13 Sep 2022
AbstractforImmunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness | Full Text | References | PDF (5.1 MB) | EPUB
  • 4557 Views
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Open Access

Original Research

Article
The efficacy and safety of first-line treatment in cisplatin-ineligible advanced upper tract urothelial carcinoma patients: a comparison of PD-1 inhibitor and carboplatin plus gemcitabine chemotherapy
Jiwei Huang, Ruopeng Su, Zeyu Chen, Shuai Jiang, Minfeng Chen, Yichu Yuan, Hailong Hu, Changde Fu, Zhiyang Huang, Zhenyu Wang, Bing Zheng, Chancan Li, Zaoyu Wang, Yige Bao, Ming Cai, Jianming Guo, Qiang Wei & Wei Xue
Article: 2124691
Published online: 17 Sep 2022
AbstractforThe efficacy and safety of first-line treatment in cisplatin-ineligible advanced upper tract urothelial carcinoma patients: a comparison of PD-1 inhibitor and carboplatin plus gemcitabine chemotherapy | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1721 Views
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Open Access

Brief Report

Brief Report
Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates
Shailbala Singh, Leticia C. Clemente, Edwin R. Parra, Amanda Tchakarov, Chao Yang, Yisheng Li, James P. Long, Cassian Yee & Jamie S. Lin
Article: 2124678
Published online: 22 Sep 2022
AbstractforUrinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1747 Views
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Open Access

Review

Review
Immunotherapy approaches for the treatment of diffuse midline gliomas
Joshua D. Bernstock, Samantha E. Hoffman, Ari D. Kappel, Pablo A. Valdes, Walid Ibn Essayed, Neil V. Klinger, Kyung-Don Kang, Stacie K. Totsch, Hannah E. Olsen, Charles W. Schlappi, Katharina Filipski, Florian A. Gessler, Lissa Baird, Mariella G. Filbin, Rintaro Hashizume, Oren J. Becher & Gregory K. Friedman
Article: 2124058
Published online: 26 Sep 2022
AbstractforImmunotherapy approaches for the treatment of diffuse midline gliomas | Full Text | References | PDF (2.9 MB) | EPUB
  • 5059 Views
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Open Access

Original Research

Article
Immune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant models
S. Elizabeth Franks, Kellsye P. Fabian, Ginette Santiago-Sánchez, Benjamin Wolfson & James W. Hodge
Article: 2124666
Published online: 01 Oct 2022
AbstractforImmune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant models | Full Text | References | PDF (17.7 MB) | EPUB | Supplemental
  • 2875 Views
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Open Access

Commentary

Article Commentary
Type I interferon induces cancer stem cells-mediated chemotherapy resistance
Mara De Martino & Claire Vanpouille-Box
Article: 2127274
Published online: 22 Sep 2022
AbstractforType I interferon induces cancer stem cells-mediated chemotherapy resistance | Full Text | References | PDF (736.5 KB) | EPUB
  • 1221 Views
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Original Research

Article
A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activity
Qi Xiong, Hantao Zhang, Xuanle Ji, Yong Zhang, Gang Shi, Lei Dai, Fuyi Cheng, Huiling Wang, Jieyan Luo, Jia Xu, Yanhong Ji, Xiaolan Su, Weixiao Yang, Lin Zhang & Hongxin Deng
Article: 2127282
Published online: 22 Sep 2022
AbstractforA novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activity | Full Text | References | PDF (7.9 MB) | EPUB | Supplemental
  • 2883 Views
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Open Access

Editorial

Editorial
Is ferroptosis immunogenic? The devil is in the details!
Oliver Kepp & Guido Kroemer
Article: 2127273
Published online: 23 Sep 2022
First Page PreviewforIs ferroptosis immunogenic? The devil is in the details! | Full Text | References | PDF (224.9 KB) | EPUB
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Free Access

Author’s View

Article
Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
Ernesto Gargiulo, Elodie Viry, Etienne Moussay & Jerome Paggetti
Article: 2127507
Published online: 27 Sep 2022
AbstractforSmall extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo | Full Text | References | PDF (1.8 MB) | EPUB
  • 1132 Views
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Original Research

Article
A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx)
Linlin Guo, Jay Overholser, Heather Darby, Nicholas J. Ede & Pravin T.P Kaumaya
Article: 2127691
Published online: 05 Oct 2022
AbstractforA newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx) | Full Text | References | PDF (38.5 MB) | EPUB | Supplemental
  • 3134 Views
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Open Access
Article
Tyk2 is a tumor suppressor in colorectal cancer
Stefan Moritsch, Bernadette Mödl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Müller, Birgit Strobl & Robert Eferl
Article: 2127271
Published online: 26 Sep 2022
AbstractforTyk2 is a tumor suppressor in colorectal cancer | Full Text | References | PDF (26.3 MB) | EPUB | Supplemental
  • 2163 Views
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Open Access

Review

Review
Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies
Rebecca Adams, Gabriel Osborn, Bipashna Mukhia, Roman Laddach, Zena Willsmore, Alicia Chenoweth, Jenny L C Geh, Alastair D MacKenzie Ross, Ciaran Healy, Linda Barber, Sophia Tsoka, Victoria Sanz-Moreno, Katie E Lacy & Sophia N Karagiannis
Article: 2127284
Published online: 03 Oct 2022
AbstractforInfluencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3718 Views
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Open Access

Editorial

Editorial
PDIA3 as a potential bridge between immunogenic cell death and autoreactivity
Jonathan G. Pol, Céleste Plantureux, María Pérez-Lanzón & Guido Kroemer
Article: 2130558
Published online: 30 Sep 2022
First Page PreviewforPDIA3 as a potential bridge between immunogenic cell death and autoreactivity | Full Text | References | PDF (566.9 KB) | EPUB
  • 1338 Views
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Free Access

Original Research

Article
Therapeutic Targeting of MYC in Head and Neck Squamous Cell Carcinoma
Shuo Liu, Zhen Qin, Yaqing Mao, Wenbo Zhang, Yujia Wang, Lingfei Jia & Xin Peng
Article: 2130583
Published online: 30 Sep 2022
AbstractforTherapeutic Targeting of MYC in Head and Neck Squamous Cell Carcinoma | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
  • 2134 Views
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Open Access

Editorial

Editorial
Nanoparticles releasing immunogenic cell death inducers upon near-infrared light exposure
Oliver Kepp, Giulia Cerrato, Allan Sauvat & Guido Kroemer
Article: 2131227
Published online: 04 Oct 2022
CitationforNanoparticles releasing immunogenic cell death inducers upon near-infrared light exposure | Full Text | References | PDF (636.9 KB) | EPUB
  • 930 Views
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Free Access

Original Research

Article
Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients
Lisanne Noordam, Monique T.A. de Beijer, Shanta Mancham, Isabel Vogler, Patrick P.C. Boor, Valeska de Ruiter, Robbie Luijten, Jan N.M. IJzermans, Ugur Sahin, Marco J. Bruno, Dave Sprengers, Sonja I. Buschow & Jaap Kwekkeboom
Article: 2131096
Published online: 05 Oct 2022
AbstractforSystemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
  • 1943 Views
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Open Access
Article
AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma
M.I. Strecker, K. Wlotzka, F. Strassheimer, B. Roller, G. Ludmirski, S. König, J. Röder, C. Opitz, T. Alekseeva, J. Reul, L. Sevenich, T. Tonn, W.S. Wels, J.P. Steinbach, C.J. Buchholz & M.C. Burger
Article: 2127508
Published online: 11 Oct 2022
AbstractforAAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma | Full Text | References | PDF (12.5 MB) | EPUB | Supplemental
  • 5156 Views
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Open Access
Article
Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology
Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira & Greg M. Delgoffe
Article: 2131229
Published online: 18 Oct 2022
AbstractforFully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Open Access
Article
RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism
Fenglian Que, Lihong Zhang, Taoli Wang, Meifang Xu, Wangen Li & Shengbing Zang
Article: 2134536
Published online: 11 Oct 2022
AbstractforRHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism | Full Text | References | PDF (14 MB) | EPUB | Supplemental
  • 1649 Views
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Open Access
Article
Targeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancers
Yao Tang, Cong Zhou, Qingli Li, Xiaojiao Cheng, Tinglei Huang, Fuli Li, Lina He, Baiweng Zhang & Shuiping Tu
Article: 2131084
Published online: 13 Oct 2022
AbstractforTargeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancers | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
  • 2729 Views
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Open Access
Article
Neoadjuvant PD-1 blockade plus chemotherapy induces a high pathological complete response rate and anti-tumor immune subsets in clinical stage III gastric cancer
Xiaohuan Tang, Mengyuan Li, Xiaolong Wu, Ting Guo, Li Zhang, Lei Tang, Fangzhou Jia, Ying Hu, Yan Zhang, Xiaofang Xing, Fei Shan, Xiangyu Gao & Ziyu Li
Article: 2135819
Published online: 14 Oct 2022
AbstractforNeoadjuvant PD-1 blockade plus chemotherapy induces a high pathological complete response rate and anti-tumor immune subsets in clinical stage III gastric cancer | Full Text | References | PDF (10.4 MB) | EPUB
  • 2392 Views
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Open Access

Research Article

Article
Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands
Haeyoun Choi, Yunkyung Lee, Soon A Park, Ji Hyeon Lee, Junseong Park, Jang Hyun Park, Heung Kyu Lee, Tai-Gyu Kim, Sin-Soo Jeun & Stephen Ahn
Article: 2138152
Published online: 30 Oct 2022
AbstractforHuman allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 2132 Views
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Commentary

Article Commentary
Bispecific T cell engagers kill resistant cells during KRAS-G12C blockade therapy
Xinxin Song, Zhuan Zhou, Rui Kang & Daolin Tang
Article: 2141978
Published online: 01 Nov 2022
AbstractforBispecific T cell engagers kill resistant cells during KRAS-G12C blockade therapy | Full Text | References | PDF (929.4 KB) | EPUB
  • 1268 Views
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Open Access

Original Research

Article
Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response
Adrienne O. Cohen, Seung-Hyun Woo, Junya Zhang, Jiyoon Cho, Marlon E. Ruiz, Jianli Gong, Rong Du, Olga Yarygina, Danya Z. Jafri, Michael A. Bachelor, Michael O. Finlayson, Rajesh K. Soni, Matthew S. Hayden & David M. Owens
Article: 2141011
Published online: 02 Nov 2022
AbstractforTbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1666 Views
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Open Access

Brief Report

Brief Report
Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis
Alfonso Serrano Del Valle, Manuel Beltrán-Visiedo, Victoria de Poo-Rodríguez, Nelia Jiménez-Alduán, Gemma Azaceta, Rosana Díez, Beatriz Martínez-Lázaro, Isabel Izquierdo, Luis Palomera, Javier Naval, Alberto Anel & Isabel Marzo
Article: 2141973
Published online: 01 Nov 2022
AbstractforEcto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1571 Views
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Original Research

Article
SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response
Sofía Ibáñez-Molero, Alex van Vliet, Joanna Pozniak, Karlijn Hummelink, Alexandra M. Terry, Kim Monkhorst, Joyce Sanders, Ingrid Hofland, Ewout Landeloos, Yannick Van Herck, Oliver Bechter, Thomas Kuilman, Weiwei Zhong, Jean-Christophe Marine, Lodewyk Wessels & Daniel S. Peeper
Article: 2139074
Published online: 29 Nov 2022
AbstractforSERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 2760 Views
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Open Access
Article
Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells
Niels Werchau, Bettina Kotter, Elvira Criado-Moronati, Andre Gosselink, Nicole Cordes, Dominik Lock, Simon Lennartz, Carolin Kolbe, Nora Winter, Karin Teppert, Fabian Engert, Brian Webster, Joerg Mittelstaet, Daniel Schaefer, Peter Mallmann, Michael R. Mallmann, Dominik Ratiu, Mario Assenmacher, Thomas Schaser, Michael von Bergwelt-Baildon, Pierre Abramowski & Andrew D. Kaiser
Article: 2140534
Published online: 11 Nov 2022
AbstractforCombined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 2475 Views
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Open Access
Article
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody
Jessica D. Weaver, Edward C. Stack, Joshua A. Buggé, Changyun Hu, Lara McGrath, Amy Mueller, Masie Wong, Boris Klebanov, Tanzila Rahman, Rosemary Kaufman, Christine Fregeau, Vikki Spaulding, Michelle Priess, Kristen Legendre, Sarah Jaffe, Dhruvkumar Upadhyay, Anirudh Singh, Chang-Ai Xu, Kristin Krukenberg, Yan Zhang, Yassine Ezzyat, Dorothée Saddier Axe, Michelle R. Kuhne, Michael A. Meehl, Donald R. Shaffer, Brian M. Weist, Dmitri Wiederschain, Fabien Depis & Monica Gostissa
Article: 2141007
Published online: 04 Nov 2022
AbstractforDifferential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody | Full Text | References | PDF (19.7 MB) | EPUB | Supplemental
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Correction

Correction
Correction
Article: 2145651
Published online: 18 Nov 2022
CitationforCorrection | Full Text | PDF (139.5 KB) | EPUB
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Original Research

Article
Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy
Angélique Vienot, Jean-René Pallandre, Elodie Renaude, Julien Viot, Adeline Bouard, Laurie Spehner, Marie Kroemer, Syrine Abdeljaoued, Bas van der Woning, Hans de Haard, Romain Loyon, Eric Hervouet, Paul Peixoto & Christophe Borg
Article: 2144669
Published online: 12 Nov 2022
AbstractforChemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy | Full Text | References | PDF (11.9 MB) | EPUB | Supplemental
  • 3157 Views
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Commentary

Article Commentary
Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
Francesca Castoldi, Guido Kroemer & Federico Pietrocola
Article: 2146855
Published online: 14 Nov 2022
AbstractforSpermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice | Full Text | References | PDF (456.8 KB) | EPUB
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Original Research

Article
RNA with chemotherapeutic base analogues as a dual-functional anti-cancer drug
Natalia Teresa Jarzebska, Marina Tusup, Julia Frei, Tobias Weiss, Tim Holzinger, Mark Mellett, Mustafa Diken, Simon Bredl, Michael Weller, Roberto F. Speck, Thomas M. Kündig, Ugur Sahin & Steve Pascolo
Article: 2147665
Published online: 18 Nov 2022
AbstractforRNA with chemotherapeutic base analogues as a dual-functional anti-cancer drug | Full Text | References | PDF (836.1 KB) | EPUB | Supplemental
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Article
Comprehensive evaluation of the tumor immune microenvironment and its dynamic changes in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy: From the phase II ADORE study
Hyungwoo Cho, Jeong Eun Kim, Yong Sang Hong, Sun Young Kim, Jihun Kim, Yeon-Mi Ryu, Sang-Yeob Kim & Tae Won Kim
Article: 2148374
Published online: 23 Nov 2022
AbstractforComprehensive evaluation of the tumor immune microenvironment and its dynamic changes in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy: From the phase II ADORE study | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 1486 Views
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Article
BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells
Hannes Forkel, Piotr Grabarczyk, Maren Depke, Sascha Troschke-Meurer, Stefan Simm, Elke Hammer, Stephan Michalik, Christian Hentschker, Björn Corleis, Lucie Loyal, Maxi Zumpe, Nikolai Siebert, Anca Dorhoi, Andreas Thiel, Holger Lode, Uwe Völker & Christian A. Schmidt
Article: 2148850
Published online: 05 Dec 2022
AbstractforBCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells | Full Text | References | PDF (9.2 MB) | EPUB | Supplemental
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Author’s View

Article
A role for EMT in CD73 regulation in breast cancer
Meriem Hasmim, Guy Berchem & Bassam Janji
Article: 2152636
Published online: 30 Nov 2022
AbstractforA role for EMT in CD73 regulation in breast cancer | Full Text | References | PDF (899.1 KB) | EPUB
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Original Research

Article
Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response
Takuya Kato, Hiroshi Fukushima, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Seiichiro Takao, Peter L. Choyke & Hisataka Kobayashi
Article: 2152248
Published online: 30 Nov 2022
AbstractforSelective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
  • 1213 Views
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Research Article

Article
Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastoma
Kevin Louault, Tania Porras, Meng-Hua Lee, Sakunthala Muthugounder, Rebekah J. Kennedy, Laurence Blavier, Emily Sarte, G. Esteban Fernandez, Fusheng Yang, Bruce R. Pawel, Hiroyuki Shimada, Shahab Asgharzadeh & Yves A. DeClerck
Article: 2146860
Published online: 01 Dec 2022
AbstractforFibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastoma | Full Text | References | PDF (7.9 MB) | EPUB | Supplemental
  • 2381 Views
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