OncoImmunology, Volume 5, Issue 3 (2016)

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OncoImmunology, Volume 5, Issue 3 (2016)

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Author's View

Opinion
The PD1/PDL1 axis, a promising therapeutic target in aggressive breast cancers
François Bertucci, Pascal Finetti, Daniel Birnbaum & Emilie Mamessier
Article: e1085148
Published online: 21 Mar 2016
AbstractforThe PD1/PDL1 axis, a promising therapeutic target in aggressive breast cancers | Full Text | References | PDF (395.9 KB)
  • 1882 Views
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Opinion
Deploying myeloid cells against myeloma
Jeffrey L. Jensen, Chelsea Hope & Fotis Asimakopoulos
Article: e1090076
Published online: 21 Mar 2016
AbstractforDeploying myeloid cells against myeloma | Full Text | References | PDF (320.1 KB)
  • 613 Views
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Opinion
In Situ immunization by bispecific antibody targeted T cell therapy in breast cancer
Archana Thakur & Lawrence G. Lum
Article: e1055061
Published online: 21 Mar 2016
AbstractforIn Situ immunization by bispecific antibody targeted T cell therapy in breast cancer | Full Text | References | PDF (179.7 KB)
  • 1154 Views
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Opinion
Targeting immunosuppression by Tregs with monoclonal antibodies against GARP
Stéphanie Liénart, Julie Stockis, Olivier Dedobbeleer & Sophie Lucas
Article: e1074379
Published online: 21 Mar 2016
AbstractforTargeting immunosuppression by Tregs with monoclonal antibodies against GARP | Full Text | References | PDF (196 KB)
  • 1373 Views
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Opinion
Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer
Jennifer Wu
Article: e1095434
Published online: 21 Mar 2016
AbstractforAntibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer | Full Text | References | PDF (355.7 KB)
  • 993 Views
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Opinion
Cell-penetrating peptides—the Swiss Army knife of cancer vaccines
Paul R. Walker, Elodie Belnoue, Pierre-Yves Dietrich & Madiha Derouazi
Article: e1095435
Published online: 21 Mar 2016
AbstractforCell-penetrating peptides—the Swiss Army knife of cancer vaccines | Full Text | References | PDF (348.1 KB)
  • 2098 Views
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Opinion
Lactic acid polarizes macrophages to a tumor-promoting state
Oscar R Colegio
Article: e1014774
Published online: 21 Mar 2016
AbstractforLactic acid polarizes macrophages to a tumor-promoting state | Full Text | References | PDF (150.7 KB)
  • 1345 Views
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Opinion
Pharmacological DNA demethylation: Implications for cancer immunotherapy
David Roulois, Helen Loo Yau & Daniel D. De Carvalho
Article: e1090077
Published online: 21 Mar 2016
AbstractforPharmacological DNA demethylation: Implications for cancer immunotherapy | Full Text | References | PDF (447.5 KB)
  • 1926 Views
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Opinion
POLE proofreading mutation, immune response and prognosis in endometrial cancer
Inge C. van Gool, Tjalling Bosse & David N. Church
Article: e1072675
Published online: 21 Mar 2016
AbstractforPOLE proofreading mutation, immune response and prognosis in endometrial cancer | Full Text | References | PDF (386.2 KB)
  • 1798 Views
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Opinion
Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic
Siddik Sarkar, Anjan Pradhan, Swadesh K. Das, Luni Emdad, Devanand Sarkar, Maurizio Pellecchia & Paul B. Fisher
Article: e1078059
Published online: 21 Mar 2016
AbstractforNovel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic | Full Text | References | PDF (378.1 KB)
  • 701 Views
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Opinion
Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy
Juan R. Cubillos-Ruiz & Laurie H. Glimcher
Article: e1098802
Published online: 21 Mar 2016
AbstractforTargeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy | Full Text | References | PDF (268.6 KB)
  • 1531 Views
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Opinion
Tumor-induced neutrophil extracellular traps—drivers of systemic inflammation and vascular dysfunction
Jessica Cedervall, Anna Dimberg & Anna-Karin Olsson
Article: e1098803
Published online: 21 Mar 2016
AbstractforTumor-induced neutrophil extracellular traps—drivers of systemic inflammation and vascular dysfunction | Full Text | References | PDF (292.6 KB)
  • 767 Views
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Brief Report

Brief Report
Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma
Zachary A. Cooper, Alexandre Reuben, Christine N. Spencer, Peter A. Prieto, Jacob L. Austin-Breneman, Hong Jiang, Cara Haymaker, Vancheswaran Gopalakrishnan, Michael T. Tetzlaff, Dennie T. Frederick, Ryan J. Sullivan, Rodabe N. Amaria, Sapna P. Patel, Patrick Hwu, Scott E. Woodman, Isabella C. Glitza, Adi Diab, Luis M. Vence, Jaime Rodriguez-Canales, Edwin R. Parra, Ignacio I. Wistuba, Lisa M. Coussens, Arlene H. Sharpe, Keith T. Flaherty, Jeffrey E. Gershenwald, Lynda Chin, Michael A. Davies, Karen Clise-Dwyer, James P. Allison, Padmanee Sharma & Jennifer A. Wargo
Article: e1136044
Published online: 21 Mar 2016
AbstractforDistinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma | Full Text | References | PDF (1 MB) | Supplemental
  • 3216 Views
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Editorial

Editorial
Novel understanding of self-reactive T cells
Mads Hald Andersen
Article: e1083672
Published online: 21 Mar 2016
AbstractforNovel understanding of self-reactive T cells | Full Text | References | PDF (277 KB)
  • 859 Views
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MIATA Compliant Research Paper

Article
Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma
Shin Foong Ngiow, Katrina M. Meeth, Kimberley Stannard, Deborah S. Barkauskas, Gideon Bollag, Marcus Bosenberg & Mark J. Smyth
Article: e1089381
Published online: 21 Mar 2016
AbstractforCo-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma | Full Text | References | PDF (963.1 KB) | Supplemental
  • 1784 Views
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Original Research

Article
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies
Alistair M. Cook, Alison M. McDonnell, Richard A. Lake & Anna K. Nowak
Article: e1066062
Published online: 21 Mar 2016
AbstractforDexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies | Full Text | References | PDF (918.7 KB)
  • 2624 Views
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Article
A randomized controlled trial on patients with or without adjuvant autologous cytokine-induced killer cells after curative resection for hepatocellular carcinoma
Li Xu, Jun Wang, Yuhree Kim, Ze-yu Shuang, Yao-jun Zhang, Xiang-ming Lao, Yong-qiang Li, Min-shan Chen, Timothy M. Pawlik, Jian-chuan Xia, Sheng-ping Li & Wan-yee Lau
Article: e1083671
Published online: 21 Mar 2016
AbstractforA randomized controlled trial on patients with or without adjuvant autologous cytokine-induced killer cells after curative resection for hepatocellular carcinoma | Full Text | References | PDF (567 KB)
  • 1571 Views
  • 45 CrossRef citations
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Article
The presence of CXCR4+ CD1a+ cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome
Willemijn T. Quispel, Janine A. Stegehuis-Kamp, Laura Blijleven, Susy J. Santos, Magda Lourda, Cor van den Bos, Astrid G.S. van Halteren & R. Maarten Egeler
Article: e1084463
Published online: 21 Mar 2016
AbstractforThe presence of CXCR4+ CD1a+ cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome | Full Text | References | PDF (930.3 KB)
  • 808 Views
  • 9 CrossRef citations
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Open Access
Article
CD8 engineered cytotoxic T cells reprogram melanoma tumor environment
Julie Leignadier, Stephanie Favre, Sanjiv A. Luther & Immanuel F. Luescher
Article: e1086861
Published online: 21 Mar 2016
AbstractforCD8 engineered cytotoxic T cells reprogram melanoma tumor environment | Full Text | References | PDF (1.7 MB) | Supplemental
  • 1379 Views
  • 8 CrossRef citations
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Article
Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model
De-Kuan Chang, Eric Peterson, Jiusong Sun, Calum Goudie, Ronny I. Drapkin, Joyce F. Liu, Ursula Matulonis, Quan Zhu & Wayne A. Marasco
Article: e1090075
Published online: 21 Mar 2016
AbstractforAnti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model | Full Text | References | PDF (1.3 MB) | Supplemental
  • 3260 Views
  • 39 CrossRef citations
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Open Access
Article
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage
Colette Dezutter-Dambuyant, Isabelle Durand, Laurent Alberti, Nathalie Bendriss-Vermare, Jenny Valladeau-Guilemond, Adeline Duc, Audrey Magron, Anne-Pierre Morel, Vanja Sisirak, Céline Rodriguez, David Cox, Daniel Olive & Christophe Caux
Article: e1091146
Published online: 21 Mar 2016
AbstractforA novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage | Full Text | References | PDF (2.1 MB) | Supplemental
  • 3016 Views
  • 57 CrossRef citations
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Article
Opposing effects of immunotherapy in melanoma using multisubtype interferon-alpha – can tumor immune escape after immunotherapy accelerate disease progression?
Örjan Strannegård & Fredrik B. Thorén
Article: e1091147
Published online: 21 Mar 2016
AbstractforOpposing effects of immunotherapy in melanoma using multisubtype interferon-alpha – can tumor immune escape after immunotherapy accelerate disease progression? | Full Text | References | PDF (405.8 KB)
  • 809 Views
  • 12 CrossRef citations
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Article
CXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy
Zuqiang Liu, Roshni Ravindranathan, Jun Li, Pawel Kalinski, Z. Sheng Guo & David L. Bartlett
Article: e1091554
Published online: 21 Mar 2016
AbstractforCXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2512 Views
  • 72 CrossRef citations
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Article
Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer
Sarah Jacca, Valeria Rolih, Elena Quaglino, Valentina Franceschi, Giulia Tebaldi, Elisabetta Bolli, Alfonso Rosamilia, Simone Ottonello, Federica Cavallo & Gaetano Donofrio
Article: e1082705
Published online: 21 Mar 2016
AbstractforBovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer | Full Text | References | PDF (1.2 MB) | Supplemental
  • 953 Views
  • 8 CrossRef citations
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Article
Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer
J. H. Park, D. C. McMillan, J. Edwards, P. G. Horgan & C. S. D. Roxburgh
Article: e1098801
Published online: 21 Mar 2016
AbstractforComparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer | Full Text | References | PDF (881.4 KB) | Supplemental
  • 1148 Views
  • 27 CrossRef citations
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Free Access
Article
Anticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response
Jessie Thalmensi, Elodie Pliquet, Christelle Liard, Marie Escande, Thomas Bestetti, Marion Julithe, Anna Kostrzak, Anne-Sophie Pailhes-Jimenez, Emanuèle Bourges, Maria Loustau, Julien Caumartin, Abderrahim Lachgar, Thierry Huet, Simon Wain-Hobson & Pierre Langlade-Demoyen
Article: e1083670
Published online: 21 Mar 2016
AbstractforAnticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response | Full Text | References | PDF (839.5 KB)
  • 1495 Views
  • 26 CrossRef citations
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Article
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity
Tong Seng Lim, Valerie Chew, Je Lin Sieow, Siting Goh, Joe Poh-Sheng Yeong, Ai Ling Soon & Paola Ricciardi-Castagnoli
Article: e1085146
Published online: 21 Mar 2016
AbstractforPD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity | Full Text | References | PDF (1,019.8 KB) | Supplemental
  • 4160 Views
  • 115 CrossRef citations
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Article
Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition
Xiao-Xiang Rong, Fang Wei, Xiao-Lin Lin, Yu-Juan Qin, Lin Chen, Hui-Yan Wang, Hong-Fen Shen, Li-Ting Jia, Rao-Ying Xie, Tao-Yan Lin, Wei-Chao Hao, Jie Yang, Sheng Yang, Yu-Shuang Cheng, Wen-Hua Huang, Ai-min Li, Yan Sun, Rong-Cheng Luo & Dong Xiao
Article: e1086060
Published online: 21 Mar 2016
AbstractforRecognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition | Full Text | References | PDF (1.9 MB) | Supplemental
  • 1660 Views
  • 30 CrossRef citations
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Open Access
Article
Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6
Christiane R. Stadler, Hayat Bähr-Mahmud, Laura M. Plum, Kathrin Schmoldt, Anne C. Kölsch, Özlem Türeci & Ugur Sahin
Article: e1091555
Published online: 21 Mar 2016
AbstractforCharacterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6 | Full Text | References | PDF (1.5 MB) | Supplemental
  • 5873 Views
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Article
Small cell lung cancer: Recruitment of macrophages by circulating tumor cells
Gerhard Hamilton, Barbara Rath, Lukas Klameth & Maximilan J. Hochmair
Article: e1093277
Published online: 21 Mar 2016
AbstractforSmall cell lung cancer: Recruitment of macrophages by circulating tumor cells | Full Text | References | PDF (942 KB)
  • 5018 Views
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Article
Upregulation of PD-L1 by EML4-ALK fusion protein mediates the immune escape in ALK positive NSCLC: Implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients
Shaodong Hong, Nan Chen, Wenfeng Fang, Jianhua Zhan, Qing Liu, Shiyang Kang, Xiaobo He, Lin Liu, Ting Zhou, Jiaxing Huang, Ying Chen, Tao Qin, Yaxiong Zhang, Yuxiang Ma, Yunpeng Yang, Yuanyuan Zhao, Yan Huang & Li Zhang
Article: e1094598
Published online: 21 Mar 2016
AbstractforUpregulation of PD-L1 by EML4-ALK fusion protein mediates the immune escape in ALK positive NSCLC: Implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients | Full Text | References | PDF (1.3 MB) | Supplemental
  • 3813 Views
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Article
Gemcitabine enhances antitumor efficacy of recombinant lipoimmunogen-based immunotherapy
Li-Sheng Chang, Wan-Lun Yan, Yu-Wen Chang, Yi-Chen Yeh, Hsin-Wei Chen, Chih-Hsiang Leng & Shih-Jen Liu
Article: e1095433
Published online: 21 Mar 2016
AbstractforGemcitabine enhances antitumor efficacy of recombinant lipoimmunogen-based immunotherapy | Full Text | References | PDF (892.1 KB) | Supplemental
  • 1074 Views
  • 12 CrossRef citations
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Article
Immune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay
E. Verronèse, A. Delgado, J. Valladeau-Guilemond, G. Garin, S. Guillemaut, O. Tredan, I. Ray-Coquard, T. Bachelot, A. N'Kodia, C. Bardin-Dit-Courageot, C. Rigal, D. Pérol, C. Caux & C. Ménétrier-Caux
Article: e1100791
Published online: 21 Mar 2016
AbstractforImmune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2514 Views
  • 48 CrossRef citations
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Article
C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer
Moritz Rapp, Simon Grassmann, Michael Chaloupka, Patrick Layritz, Stephan Kruger, Steffen Ormanns, Felicitas Rataj, Klaus-Peter Janssen, Stefan Endres, David Anz & Sebastian Kobold
Article: e1105428
Published online: 21 Mar 2016
AbstractforC-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2758 Views
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Article
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3
Jaemoon Koh, Ji-Young Jang, Bhumsuk Keam, Sehui Kim, Moon-Young Kim, Heounjeong Go, Tae Min Kim, Dong-Wan Kim, Chul-Woo Kim, Yoon Kyung Jeon & Doo Hyun Chung
Article: e1108514
Published online: 21 Mar 2016
AbstractforEML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3 | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2849 Views
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Article
Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12
Tania L. Slatter, Michelle Wilson, Chingwen Tang, Hamish G. Campbell, Vernon K. Ward, Vivienne L. Young, David Van Ly, Nicholas I. Fleming, Antony W. Braithwaite & Margaret A. Baird
Article: e1112941
Published online: 21 Mar 2016
AbstractforAntitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12 | Full Text | References | PDF (1.6 MB)
  • 1012 Views
  • 10 CrossRef citations
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Article
G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer
Maija Hollmén, Sinem Karaman, Simon Schwager, Angela Lisibach, Ailsa J. Christiansen, Mikael Maksimow, Zsuzsanna Varga, Sirpa Jalkanen & Michael Detmar
Article: e1115177
Published online: 21 Mar 2016
AbstractforG-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer | Full Text | References | PDF (2 MB) | Supplemental
  • 5163 Views
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Point of View

Article Commentary
Commentary: IL-12-secreting tumor-targeted chimeric antigen receptor T cells: An unaddressed concern on Koneru et al. (2015)
Hamid Reza Mirzaei & Jamshid Hadjati
Article: e1100792
Published online: 21 Mar 2016
AbstractforCommentary: IL-12-secreting tumor-targeted chimeric antigen receptor T cells: An unaddressed concern on Koneru et al. (2015) | Full Text | References | PDF (187.2 KB)
  • 1044 Views
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Review

Review
Targeted immunotherapy for pediatric solid tumors
Lisa M. Kopp & Emmanuel Katsanis
Article: e1087637
Published online: 21 Mar 2016
AbstractforTargeted immunotherapy for pediatric solid tumors | Full Text | References | PDF (425.8 KB)
  • 2005 Views
  • 9 CrossRef citations
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Review
Prime time for immune-checkpoint targeted therapy at ASCO 2015
Aurélien Marabelle, Bertrand Routy, Judith Michels, Guido Kroemer & Laurence Zitvogel
Article: e1068494
Published online: 21 Mar 2016
AbstractforPrime time for immune-checkpoint targeted therapy at ASCO 2015 | Full Text | References | PDF (415.8 KB)
  • 1363 Views
  • 8 CrossRef citations
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Review
Tumor-intrinsic oncogene pathways mediating immune avoidance
Stefani Spranger & Thomas F. Gajewski
Article: e1086862
Published online: 21 Mar 2016
AbstractforTumor-intrinsic oncogene pathways mediating immune avoidance | Full Text | References | PDF (685.9 KB)
  • 4832 Views
  • 104 CrossRef citations
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Review
Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy
Kristina Iribarren, Norma Bloy, Aitziber Buqué, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Špíšek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Article: e1088631
Published online: 21 Mar 2016
AbstractforTrial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy | Full Text | References | PDF (480.4 KB)
  • 5520 Views
  • 94 CrossRef citations
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Review
IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?
Jakub Tomala & Marek Kovar
Article: e1102829
Published online: 21 Mar 2016
AbstractforIL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy? | Full Text | References | PDF (467.1 KB)
  • 2035 Views
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Review
Myeloid cells in the tumor microenvironment: Role of adenosine
Silvana Morello, Aldo Pinto, Corrado Blandizzi & Luca Antonioli
Article: e1108515
Published online: 21 Mar 2016
AbstractforMyeloid cells in the tumor microenvironment: Role of adenosine | Full Text | References | PDF (484.6 KB)
  • 1635 Views
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