OncoImmunology, Volume 5, Issue 8 (2016)

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OncoImmunology, Volume 5, Issue 8 (2016)

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Author's View

Opinion
Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer
Amir A. Al-Khami, Paulo C. Rodriguez & Augusto C. Ochoa
Article: e1200771
Published online: 29 Jul 2016
AbstractforMetabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer | Full Text | References | PDF (284.1 KB)
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Opinion
CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
Marina Bacac (Dr.) , Christian Klein & Pablo Umana
Article: e1203498
Published online: 11 Aug 2016
AbstractforCEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors | Full Text | References | PDF (541 KB)
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Brief Report

Brief Report
Tertiary lymphoid structures are confined to patients presenting with unifocal Langerhans Cell Histiocytosis
Willemijn T. Quispel, Eline C. Steenwijk, Vincent van Unen, Susy J. Santos, Lianne Koens, Reina Mebius, R. Maarten Egeler & Astrid G. S. van Halteren
Article: e1164364
Published online: 29 Jul 2016
AbstractforTertiary lymphoid structures are confined to patients presenting with unifocal Langerhans Cell Histiocytosis | Full Text | References | PDF (876.1 KB)
  • 1097 Views
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MIATA Compliant Research Paper

Article
TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer
Lauren V. Wood, Antonio Fojo, Brenda D. Roberson, Meghan S. B. Hughes, William Dahut, James L. Gulley, Ravi A. Madan, Philip M. Arlen, Marianna Sabatino, David F. Stroncek, Luciano Castiello, Jane B. Trepel, Min-Jung Lee, Howard L. Parnes, Seth M. Steinberg, Masaki Terabe, Julia Wilkerson, Ira Pastan & Jay A. Berzofsky
Article: e1197459
Published online: 03 Aug 2016
AbstractforTARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer | Full Text | References | PDF (1.4 MB) | Supplemental
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Original Research

Article
Natural killer cells phenotypic characterization as an outcome predictor of HCV-linked HCC after curative treatments
Elisabetta Cariani, Massimo Pilli, Valeria Barili, Emanuela Porro, Elisabetta Biasini, Andrea Olivani, Raffaele Dalla Valle, Tommaso Trenti, Carlo Ferrari & Gabriele Missale
Article: e1154249
Published online: 29 Jul 2016
AbstractforNatural killer cells phenotypic characterization as an outcome predictor of HCV-linked HCC after curative treatments | Full Text | References | PDF (881.3 KB)
  • 1070 Views
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Article
No evidence for TSLP pathway activity in human breast cancer
Cristina Ghirelli, Benjamin Sadacca, Fabien Reyal, Raphaël Zollinger, Paula Michea, Philémon Sirven, Lucia Pattarini, Carolina Martínez-Cingolani, Maude Guillot-Delost, André Nicolas, Alix Scholer-Dahirel & Vassili Soumelis
Article: e1178438
Published online: 29 Jul 2016
AbstractforNo evidence for TSLP pathway activity in human breast cancer | Full Text | References | PDF (764.8 KB)
  • 1106 Views
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Article
Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103+ dendritic cells in late-stage ovarian cancer
Dallas B. Flies, Tomoe Higuchi, Jaryse C. Harris, Vibha Jha, Phyllis A. Gimotty & Sarah F. Adams
Article: e1185583
Published online: 29 Jul 2016
AbstractforImmune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103+ dendritic cells in late-stage ovarian cancer | Full Text | References | PDF (2 MB) | Supplemental
  • 2489 Views
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Article
Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy
Masahiro Azuma, Yohei Takeda, Hiroko Nakajima, Haruo Sugiyama, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto & Tsukasa Seya
Article: e1188244
Published online: 29 Jul 2016
AbstractforBiphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1924 Views
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Article
Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages
Bisweswar Nandi, Mia Shapiro, Mehmet K. Samur, Christine Pai, Natasha Y. Frank, Charles Yoon, Rao H. Prabhala, Nikhil C. Munshi & Jason S. Gold
Article: e1189052
Published online: 29 Jul 2016
AbstractforStromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages | Full Text | References | PDF (970.8 KB) | Supplemental
  • 1991 Views
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Article
Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing
Conor J. Kearney, Kelly M. Ramsbottom, Ilia Voskoboinik, Phillip K. Darcy & Jane Oliaro Ph.D
Article: e1196308
Published online: 29 Jul 2016
AbstractforLoss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2046 Views
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Article
Interferon alpha bioactivity critically depends on Scavenger receptor class B type I function
Marcos Vasquez, Jessica Fioravanti, Fernando Aranda, Vladimir Paredes, Celia Gomar, Nuria Ardaiz, Veronica Fernandez-Ruiz, Miriam Méndez, Estanislao Nistal-Villan, Esther Larrea, Qinshan Gao, Gloria Gonzalez-Aseguinolaza, Jesus Prieto & Pedro Berraondo
Article: e1196309
Published online: 29 Jul 2016
AbstractforInterferon alpha bioactivity critically depends on Scavenger receptor class B type I function | Full Text | References | PDF (1.7 MB) | Supplemental
  • 1940 Views
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Open Access
Article
Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells
Frederik C. Henrich, Katrin Singer, Kerstin Poller, Luise Bernhardt, Carolin D. Strobl, Katharina Limm, Axel P. Ritter, Eva Gottfried, Simon Völkl, Benedikt Jacobs, Katrin Peter, Dimitrios Mougiakakos, Katja Dettmer, Peter J. Oefner, Anja-Katrin Bosserhoff, Marina P. Kreutz, Michael Aigner & Andreas Mackensen
Article: e1184802
Published online: 05 Aug 2016
AbstractforSuppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cells | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2248 Views
  • 36 CrossRef citations
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Article
Retargeting cytokine-induced killer cell activity by CD16 engagement with clinical-grade antibodies
Elisa Cappuzzello, Anna Tosi, Paola Zanovello, Roberta Sommaggio & Antonio Rosato
Article: e1199311
Published online: 05 Aug 2016
AbstractforRetargeting cytokine-induced killer cell activity by CD16 engagement with clinical-grade antibodies | Full Text | References | PDF (1.1 MB)
  • 1929 Views
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Article
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma
Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Kong Peng Lam, Choon Kiat Ong, Ruby Y. J. Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm & Siew Cheng Wong
Article: e1191731
Published online: 11 Aug 2016
AbstractforWarburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma | Full Text | References | PDF (1.9 MB) | Supplemental
  • 4595 Views
  • 149 CrossRef citations
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Article
Ipilimumab administered to metastatic melanoma patients who progressed after dendritic cell vaccination
Steve Boudewijns, Rutger H. T. Koornstra, Harm Westdorp, Gerty Schreibelt, Alfons J. M. van den Eertwegh, Marnix H. Geukes Foppen, John B. Haanen, I. Jolanda M. de Vries, Carl G. Figdor, Kalijn F. Bol & Winald R. Gerritsen
Article: e1201625
Published online: 13 Aug 2016
AbstractforIpilimumab administered to metastatic melanoma patients who progressed after dendritic cell vaccination | Full Text | References | PDF (680 KB)
  • 1234 Views
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Open Access
Article
PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine
Shamaila Munir Ahmad, Evelina Martinenaite, Morten Hansen, Niels Junker, Troels Holz Borch, Özcan Met, Marco Donia, Inge Marie Svane & Mads Hald Andersen
Article: e1202391
Published online: 11 Aug 2016
AbstractforPD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine | Full Text | References | PDF (955.8 KB)
  • 1752 Views
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Article
Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling
Danfeng Sun, Yanwei Lin, Jie Hong, Haoyan Chen, Nisha Nagarsheth, Dongjun Peng, Shuang Wei, Emina Huang, Jingyuan Fang, Ilona Kryczek & Weiping Zou
Article: e1082704
Published online: 25 Aug 2016
AbstractforTh22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1630 Views
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Article
Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma
Ilona Kryczek, Lin Wang, Ke Wu, Wei Li, Ende Zhao, Tracy Cui, Shuang Wei, Yan Liu, Yin Wang, Linda Vatan, Wojciech Szeliga, Joel K. Greenson, Jacek Roliński, Witold Zgodzinski, Emina Huang, Kaixiong Tao, Guobin Wang & Weiping Zou
Article: e1105430
Published online: 12 Aug 2016
AbstractforInflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2290 Views
  • 23 CrossRef citations
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Article
Human CD1c+ DCs are critical cellular mediators of immune responses induced by immunogenic cell death
Stefania Di Blasio, Inge M. N. Wortel, Diede A. G. van Bladel, Laura E. de Vries, Tjitske Duiveman-de Boer, Kuntal Worah, Nienke de Haas, Sonja I. Buschow, I. Jolanda M. de Vries, Carl G. Figdor & Stanleyson V. Hato
Article: e1192739
Published online: 03 Aug 2016
AbstractforHuman CD1c+ DCs are critical cellular mediators of immune responses induced by immunogenic cell death | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2644 Views
  • 66 CrossRef citations
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Article
Carcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design
Martin G. Klatt, Daniel J. Kowalewski, Heiko Schuster, Moreno Di Marco, Jörg Hennenlotter, Arnulf Stenzl, Hans-Georg Rammensee & Stefan Stevanović
Article: e1204504
Published online: 30 Jun 2016
AbstractforCarcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1583 Views
  • 17 CrossRef citations
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Article
Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy
Lauren M. Habenicht, Tina C. Albershardt, Brian M. Iritani & Alanna Ruddell
Article: e1204505
Published online: 30 Jun 2016
AbstractforDistinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy | Full Text | References | PDF (1.5 MB)
  • 1702 Views
  • 9 CrossRef citations
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Open Access
Article
Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer
Zhenyu Xu, Jing Shen, Maggie Haitian Wang, Tao Yi, Yangyang Yu, Yinxin Zhu, Bo Chen, Jianping Chen, Longfei Li, Minxing Li, Jian Zuo, Hui Jiang, Dexi Zhou, Jiajie Luan & Zhangang Xiao
Article: e1207841
Published online: 11 Jul 2016
AbstractforComprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2525 Views
  • 27 CrossRef citations
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Article
Targeting CD73 in the tumor microenvironment with MEDI9447
Carl M. Hay, Erin Sult, Qihui Huang, Kathy Mulgrew, Stacy R. Fuhrmann, Kelly A. McGlinchey, Scott A. Hammond, Raymond Rothstein, Jonathan Rios-Doria, Edmund Poon, Nick Holoweckyj, Nicholas M. Durham, Ching Ching Leow, Gundo Diedrich, Melissa Damschroder, Ronald Herbst, Robert E. Hollingsworth & Kris F. Sachsenmeier
Article: e1208875
Published online: 11 Jul 2016
AbstractforTargeting CD73 in the tumor microenvironment with MEDI9447 | Full Text | References | PDF (916.2 KB) | Supplemental
  • 9229 Views
  • 200 CrossRef citations
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Article
Nitric oxide synthase 2 is involved in the pro-tumorigenic potential of γδ17 T cells in melanoma
Laetitia Douguet, Lloyd Bod, Renée Lengagne, Laura Labarthe, Masashi Kato, Marie-Françoise Avril & Armelle Prévost-Blondel
Article: e1208878
Published online: 10 Aug 2016
AbstractforNitric oxide synthase 2 is involved in the pro-tumorigenic potential of γδ17 T cells in melanoma | Full Text | References | PDF (1,009.9 KB) | Supplemental
  • 975 Views
  • 27 CrossRef citations
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Article
Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction
Djoke Hendriks, Yuan He, Iris Koopmans, Valerie R. Wiersma, Robert J. van Ginkel, Douwe F. Samplonius, Wijnand Helfrich & Edwin Bremer
Article: e1202390
Published online: 06 Jul 2016
AbstractforProgrammed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2442 Views
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Review

Review
Improving vaccine efficacy against malignant glioma
Erik Ladomersky, Matthew Genet, Lijie Zhai, Galina Gritsina, Kristen L. Lauing, Rishi R. Lulla, Jason Fangusaro, Alicia Lenzen, Priya Kumthekar, Jeffrey J. Raizer, David C. Binder, C. David James & Derek A. Wainwright Ph.D
Article: e1196311
Published online: 05 Aug 2016
AbstractforImproving vaccine efficacy against malignant glioma | Full Text | References | PDF (680 KB)
  • 1554 Views
  • 13 CrossRef citations
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