OncoImmunology, Volume 9, Issue 1 (2020)

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OncoImmunology, Volume 9, Issue 1 (2020)

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Correction

Correction
Correction
Pages: i-ii
Published online: 03 May 2020
CitationforCorrection | Full Text | PDF (1.3 MB) | EPUB
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Back Matter

Close proximity of immune and tumor cells underlies response to anti-PD-1 based therapies in metastatic melanoma patients
Tuba N. Gide, Ines P. Silva, Camelia Quek, Tasnia Ahmed, Alexander M. Menzies, Matteo S. Carlino, Robyn P.M. Saw, John F. Thompson, Marcel Batten, Georgina V. Long, Richard A. Scolyer & James S. Wilmott
Article: 1659093
Published online: 16 Oct 2019
AbstractforClose proximity of immune and tumor cells underlies response to anti-PD-1 based therapies in metastatic melanoma patients | Full Text | References | PDF (4.5 MB) | EPUB
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Open Access
Calreticulin arms NK cells against leukemia
Jitka Fucikova, Justin P. Kline, Lorenzo Galluzzi & Radek Spisek
Article: 1671763
Published online: 09 Oct 2019
AbstractforCalreticulin arms NK cells against leukemia | Full Text | References | PDF (379.7 KB) | EPUB
  • 2019 Views
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Research Article

Article
A classification based on tumor budding and immune score for patients with hepatocellular carcinoma
Li Wei, Zhang Delin, Yuan Kefei, Wu Hong, Huang Jiwei & Zhang Yange
Article: 1672495
Published online: 07 Nov 2019
AbstractforA classification based on tumor budding and immune score for patients with hepatocellular carcinoma | Full Text | References | PDF (6.4 MB) | EPUB
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Brief Report

Brief Report
Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer
Brett J. Hos, Marcel G.M. Camps, Jitske van den Bulk, Elena Tondini, Thomas C. van den Ende, Dina Ruano, Kees Franken, George M.C. Janssen, Arnoud Ru, Dmitri V. Filippov, Ramon Arens, Peter A. van Veelen, Noel Miranda & Ferry Ossendorp
Article: 1673125
Published online: 13 Oct 2019
AbstractforIdentification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Review

Review
The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
Peter G. Hendrickson, Michael Olson, Tim Luetkens, Siani Weston, Tiffany Han, Djordje Atanackovic & Gabriel C. Fine
Article: 1673129
Published online: 13 Oct 2019
AbstractforThe promise of adoptive cellular immunotherapies in hepatocellular carcinoma | Full Text | References | PDF (1.8 MB) | EPUB
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Back Matter

Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
Yuting Ma, Heng Yang & Guido Kroemer
Article: 1673635
Published online: 11 Oct 2019
AbstractforEndogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies | Full Text | References | PDF (731 KB) | EPUB
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Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma
M. Kazim Panjwani, Matthew J. Atherton, Martha A. MaloneyHuss, Kumudhini P. Haran, Ailian Xiong, Minnal Gupta, Irina Kulikovsaya, Simon F. Lacey & Nicola J. Mason
Article: 1676615
Published online: 23 Oct 2019
AbstractforEstablishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma | Full Text | References | PDF (3.6 MB) | EPUB
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Open Access
Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer
Anne-Sophie Hamy, Lisa Derosa, Constance Valdelièvre, Satoru Yonekura, Paule Opolon, Maël Priour, Julien Guerin, Jean-Yves Pierga, Bernard Asselain, Diane De Croze, Alice Pinheiro, Marick Lae, Laure-Sophie Talagrand, Enora Laas, Lauren Darrigues, Beatriz Grandal, Elisabetta Marangoni, Elodie Montaudon, Guido Kroemer, Laurence Zitvogel & Fabien Reyal
Article: 1677427
Published online: 14 Nov 2019
AbstractforComedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer | Full Text | References | PDF (3.4 MB) | EPUB
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Open Access
TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity
Jun-Young Lee, Eunjin Lee, Sung-Wook Hong, Daeun Kim, O. Eunju, Jonathan Sprent, Sin-Hyeog Im, You Jeong Lee & Charles D. Surh
Article: 1681869
Published online: 04 Nov 2019
AbstractforTCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity | Full Text | References | PDF (3.2 MB) | EPUB
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Open Access
Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer
Byung-Seok Kim, Jelita Clinton, Qing Wang & Seon Hee Chang
Article: 1682380
Published online: 02 Nov 2019
AbstractforTargeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer | Full Text | References | PDF (4 MB) | EPUB
  • 2736 Views
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Open Access
Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy
Joseph P Sanderson, Darragh J Crowley, Guy E Wiedermann, Laura L Quinn, Katherine L Crossland, Helen M Tunbridge, Terri V Cornforth, Christopher S Barnes, Tina Ahmed, Karen Howe, Manoj Saini, Rachel J Abbott, Victoria E Anderson, Barbara Tavano, Miguel Maroto & Andrew B Gerry
Article: 1682381
Published online: 24 Nov 2019
AbstractforPreclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy | Full Text | References | PDF (3.8 MB) | EPUB
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Open Access
Establishment and validation of an immunodiagnostic model for prediction of breast cancer
Cuipeng Qiu, Peng Wang, Bofei Wang, Jianxiang Shi, Xiao Wang, Tiandong Li, Jiejie Qin, Liping Dai, Hua Ye & Jianying Zhang
Article: 1682382
Published online: 28 Oct 2019
AbstractforEstablishment and validation of an immunodiagnostic model for prediction of breast cancer | Full Text | References | PDF (2.7 MB) | EPUB
  • 2257 Views
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Open Access
The prognostic impact of immune-related adverse events during anti-PD1 treatment in melanoma and non–small-cell lung cancer: a real-life retrospective study
R. Dupont, E. Bérard, F. Puisset, T. Comont, J.-P. Delord, R. Guimbaud, N. Meyer, J. Mazieres & L. Alric
Article: 1682383
Published online: 05 Nov 2019
AbstractforThe prognostic impact of immune-related adverse events during anti-PD1 treatment in melanoma and non–small-cell lung cancer: a real-life retrospective study | Full Text | References | PDF (842.8 KB) | EPUB
  • 3146 Views
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Open Access
GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells
Christian M. Seitz, Sarah Schroeder, Philipp Knopf, Ann-Christin Krahl, Jana Hau, Sabine Schleicher, Manuela Martella, Leticia Quintanilla-Martinez, Manfred Kneilling, Bernd Pichler, Peter Lang, Daniel Atar, Karin Schilbach, Rupert Handgretinger & Patrick Schlegel
Article: 1683345
Published online: 07 Nov 2019
AbstractforGD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells | Full Text | References | PDF (4.6 MB) | EPUB
  • 5595 Views
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Research Article

Article
Epstein–Barr virus-positive diffuse large B-cell lymphoma features disrupted antigen capture/presentation and hijacked T-cell suppression
Xiang-Nan Jiang, Bao-Hua Yu, Wan-Hui Yan, Jimmy Lee, Xiao-Yan Zhou & Xiao-Qiu Li
Article: 1683346
Published online: 03 Nov 2019
AbstractforEpstein–Barr virus-positive diffuse large B-cell lymphoma features disrupted antigen capture/presentation and hijacked T-cell suppression | Full Text | References | PDF (1.8 MB) | EPUB
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Back Matter

The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia
Zi-Jun Xu, Yu Gu, Cui-Zhu Wang, Ye Jin, Xiang-Mei Wen, Ji-Chun Ma, Li-Juan Tang, Zhen-Wei Mao, Jun Qian & Jiang Lin
Article: 1683347
Published online: 03 Nov 2019
AbstractforThe M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia | Full Text | References | PDF (2.2 MB) | EPUB
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Open Access
Isolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with melanoma in-transit metastasis
Junko Johansson, Roberta Kiffin, Ebru Aydin, Malin S. Nilsson, Kristoffer Hellstrand, Per Lindnér, Peter Naredi, Roger Olofsson Bagge & Anna Martner
Article: 1684126
Published online: 03 Nov 2019
AbstractforIsolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with melanoma in-transit metastasis | Full Text | References | PDF (6.2 MB) | EPUB
  • 1895 Views
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Open Access
B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models
Baozhu Huang, Liqun Luo, Jun Wang, Bailin He, Rui Feng, Na Xian, Qiong Zhang, Lieping Chen & Gangxiong Huang
Article: 1684127
Published online: 04 Nov 2019
AbstractforB7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models | Full Text | References | PDF (5.4 MB) | EPUB
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Open Access
Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma
Sophie Sneddon, Craig M. Rive, Shaokang Ma, Ian M. Dick, Richard J. N. Allcock, Scott D. Brown, Robert A. Holt, Mark Watson, Shay Leary, Y. C. Gary Lee, Bruce W. S. Robinson & Jenette Creaney
Article: 1684713
Published online: 03 Nov 2019
AbstractforIdentification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma | Full Text | References | PDF (2.8 MB) | EPUB
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Open Access
Pre-treatment tumor neo-antigen responses in draining lymph nodes are infrequent but predict checkpoint blockade therapy outcome
Shaokang Ma, Jonathan Chee, Vanessa S. Fear, Catherine A. Forbes, Louis Boon, Ian M. Dick, Bruce W. S. Robinson & Jenette Creaney
Article: 1684714
Published online: 07 Nov 2019
AbstractforPre-treatment tumor neo-antigen responses in draining lymph nodes are infrequent but predict checkpoint blockade therapy outcome | Full Text | References | PDF (2.7 MB) | EPUB
  • 1983 Views
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Open Access
A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer
Christa I. DeVette, Harika Gundlapalli, Shu-Chin Alicia Lai, Curtis P. McMurtrey, Ashley R. Hoover, Hem R. Gurung, Wei R. Chen, Alana L. Welm & William H. Hildebrand
Article: 1685300
Published online: 29 Nov 2019
AbstractforA pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer | Full Text | References | PDF (4.6 MB) | EPUB
  • 3627 Views
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Open Access
Destroy, what destroys you
Khang Luu, Emily Nickles & Herbert Schwarz
Article: 1685301
Published online: 03 Nov 2019
AbstractforDestroy, what destroys you | Full Text | References | PDF (415.4 KB) | EPUB
  • 1544 Views
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Open Access

Review

Review
Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology
Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg
Article: 1703449
Published online: 09 Jan 2020
AbstractforTrial watch: chemotherapy-induced immunogenic cell death in immuno-oncology | Full Text | References | PDF (3 MB) | EPUB
  • 10910 Views
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Open Access

Correction

Correction
Correction
Article: 1703612
Published online: 14 Dec 2019
CitationforCorrection | Full Text | PDF (1.5 MB) | EPUB
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Back Matter

Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
Min Yang, Wenwen Du, Lixian Yi, Shaoxian Wu, Chunyan He, Wensi Zhai, Cuihua Yue, Runzi Sun, Ashley V. Menk, Greg M. Delgoffe, Jingting Jiang & Binfeng Lu
Article: 1708064
Published online: 30 Jan 2020
AbstractforCheckpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment | Full Text | References | PDF (5.5 MB) | EPUB
  • 3685 Views
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Open Access
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity
Shumei Kato, Ryosuke Okamura, Yuichi Kumaki, Sadakatsu Ikeda, Mina Nikanjam, Ramez Eskander, Aaron Goodman, Suzanna Lee, Sean T. Glenn, Devin Dressman, Antonios Papanicolau-Sengos, Felicia L. Lenzo, Carl Morrison & Razelle Kurzrock
Article: 1708065
Published online: 17 Feb 2020
AbstractforExpression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity | Full Text | References | PDF (2 MB) | EPUB
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Open Access
In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma
Bas D. Koster, Tamarah D. de Jong, Mari F. C. M. van den Hout, Berbel J. R. Sluijter, Ronald J. C. L. M. Vuylsteke, Barbara G. Molenkamp, Saskia Vosslamber, M. Petrousjka van den Tol, Alfons J. M. van den Eertwegh & Tanja D. de Gruijl
Article: 1708066
Published online: 26 Dec 2019
AbstractforIn the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma | Full Text | References | PDF (1.2 MB) | EPUB
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Open Access

Editorial

Editorial
Secreted calreticulin mutants subvert anticancer immunosurveillance
Peng Liu, Liwei Zhao, Guido Kroemer & Oliver Kepp
Article: 1708126
Published online: 28 Dec 2019
AbstractforSecreted calreticulin mutants subvert anticancer immunosurveillance | Full Text | References | PDF (1,018.5 KB) | EPUB
  • 2327 Views
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Open Access

Back Matter

Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds
Denis L. Jardim, Débora De Melo Gagliato, Mina Nikanjam, Donald A. Barkauskas & Razelle Kurzrock
Article: 1710052
Published online: 13 Jan 2020
AbstractforEfficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds | Full Text | References | PDF (7.4 MB) | EPUB
  • 3048 Views
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Open Access
Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6
Patrycja Czerwinska, Marcin Rucinski, Nikola Wlodarczyk, Anna Jaworska, Iga Grzadzielewska, Katarzyna Gryska, Lukasz Galus, Jacek Mackiewicz & Andrzej Mackiewicz
Article: 1710063
Published online: 11 Jan 2020
AbstractforTherapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6 | Full Text | References | PDF (4.6 MB) | EPUB
  • 2642 Views
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Brief Report

Brief Report
Durable tumor regression in highly refractory metastatic KIT/PDGFRA wild-type GIST following treatment with nivolumab
Brett A. Schroeder, Karan Kohli, Ryan B. O’Malley, Theresa S. Kim, Robin L. Jones, Robert H. Pierce & Seth M. Pollack
Article: 1710064
Published online: 13 Jan 2020
AbstractforDurable tumor regression in highly refractory metastatic KIT/PDGFRA wild-type GIST following treatment with nivolumab | Full Text | References | PDF (3.2 MB) | EPUB
  • 2404 Views
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Back Matter

Evaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: the multicenter FAMI-L1 study
Alessio Cortellini, Sebastiano Buti, Melissa Bersanelli, Raffaele Giusti, Fabiana Perrone, Pietro Di Marino, Nicola Tinari, Michele De Tursi, Antonino Grassadonia, Katia Cannita, Alessandra Tessitore, Federica Zoratto, Enzo Veltri, Francesco Malorgio, Marco Russano, Cecilia Anesi, Tea Zeppola, Marco Filetti, Paolo Marchetti, Andrea Botticelli, Gian Carlo Antonini Cappellini, Federica De Galitiis, Maria Giuseppa Vitale, Francesca Rastelli, Federica Pergolesi, Rossana Berardi, Silvia Rinaldi, Marianna Tudini, Rosa Rita Silva, Annagrazia Pireddu, Francesco Atzori, Daniela Iacono, Maria Rita Migliorino, Alain Gelibter, Mario Alberto Occhipinti, Francesco Martella, Alessandro Inno, Stefania Gori, Sergio Bracarda, Cristina Zannori, Claudia Mosillo, Alessandro Parisi, Giampiero Porzio, Domenico Mallardo, Maria Concetta Fargnoli, Marcello Tiseo, Daniele Santini, Paolo A Ascierto & Corrado Ficorella
Article: 1710389
Published online: 07 Jan 2020
AbstractforEvaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: the multicenter FAMI-L1 study | Full Text | References | PDF (1.2 MB) | EPUB
  • 1731 Views
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Open Access
ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer
Wenda Ye, Sreenivasulu Gunti, Clint T. Allen, Youji Hong, Paul E. Clavijo, Carter Van Waes & Nicole C. Schmitt
Article: 1710398
Published online: 09 Jan 2020
AbstractforASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer | Full Text | References | PDF (16.3 MB) | EPUB
  • 3357 Views
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Open Access
PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer
Ding-Xin Liu, Dan-Dan Li, Wan He, Chuan-Feng Ke, Wu Jiang, Jing-Hua Tang, Ling-Heng Kong, Yuan Li, Qiao-Qi Sui, Bin-Yi Xiao, Wei-Rong Li, Zhi-Gang Hong, Rui-Hua Xu, Zhi-Zhong Pan, Xiao-Shi Zhang & Pei-Rong Ding
Article: 1711650
Published online: 22 Jan 2020
AbstractforPD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer | Full Text | References | PDF (725.2 KB) | EPUB
  • 3490 Views
  • 37 CrossRef citations
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Open Access
Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy
Mara De Martino, Mercedes Tkach, Sofía Bruni, Darío Rocha, María F. Mercogliano, Mauro E. Cenciarini, María F. Chervo, Cecilia J. Proietti, Florent Dingli, Damarys Loew, Elmer A. Fernández, Patricia V. Elizalde, Eliane Piaggio & Roxana Schillaci
Article: 1715767
Published online: 29 Jan 2020
AbstractforBlockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy | Full Text | References | PDF (3 MB) | EPUB
  • 2810 Views
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Open Access

Brief Report

Brief Report
PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models
Takahiro Yamazaki, Aitziber Buqué, Tyler D. Ames & Lorenzo Galluzzi
Article: 1721810
Published online: 11 Feb 2020
AbstractforPT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models | Full Text | References | PDF (1.3 MB) | EPUB
  • 4404 Views
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Open Access
Brief Report
Moderate-to-severe eosinophilia induced by treatment with immune checkpoint inhibitors: 37 cases from a national reference center for hypereosinophilic syndromes and the French pharmacovigilance database
Quentin Scanvion, Johana Béné, Sophie Gautier, Aurélie Grandvuillemin, Christine Le Beller, Chouki Chenaf, Nicolas Etienne, Solenn Brousseau, Alexis B. Cortot, Laurent Mortier, Delphine Staumont-Sallé, Franck Morschhauser, Alexandra Forestier, Matthieu Groh, David Launay, Eric Hachulla, Myriam Labalette, Jean-Emmanuel Kahn, Guillaume Lefèvre & the French Pharmacovigilance Network, and the French reference center for hypereosinophilic syndromes (CEREO)
Article: 1722022
Published online: 07 Apr 2020
AbstractforModerate-to-severe eosinophilia induced by treatment with immune checkpoint inhibitors: 37 cases from a national reference center for hypereosinophilic syndromes and the French pharmacovigilance database | Full Text | References | PDF (936.7 KB) | EPUB
  • 2324 Views
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Open Access

Back Matter

Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment
Kyung Hwan Kim, Joon Young Hur, Jinhyun Cho, Bo Mi Ku, Jiae Koh, June Young Koh, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn & Eui-Cheol Shin
Article: 1722023
Published online: 02 Feb 2020
AbstractforImmune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment | Full Text | References | PDF (4.2 MB) | EPUB
  • 3544 Views
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Open Access
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system
Sjoerd Klarenbeek, Chris W. Doornebal, Sjors M. Kas, Nicola Bonzanni, Jinhyuk Bhin, Tanya M. Braumuller, Ingrid van der Heijden, Mark Opdam, Philip C. Schouten, Kelly Kersten, Roebi de Bruijn, Daniel Zingg, Julia Yemelyanenko, Lodewyk F.A. Wessels, Karin E. de Visser & Jos Jonkers
Article: 1724049
Published online: 12 Feb 2020
AbstractforResponse of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system | Full Text | References | PDF (5.6 MB) | EPUB
  • 2269 Views
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Open Access
Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation
Maciej Kujawski, Mark Sherman, Susanta Hui, Darren Zuro, Wen-Hui Lee, Paul Yazaki, Anakim Sherman, Barbara Szpikowska, Junie Chea, Desiree Lasiewski, Kofi Poku, Harry Li, David Colcher, Jeffrey Wong & John E. Shively
Article: 1724052
Published online: 14 Feb 2020
AbstractforPotent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation | Full Text | References | PDF (5.4 MB) | EPUB
  • 2594 Views
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Open Access
Overexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancer
Johnie Hodge, Fang Wang, Junfeng Wang, Qing Liu, Fatma Saaoud, Yuzhen Wang, Udai P. Singh, Hexin Chen, Ming Luo, Walden Ai & Daping Fan
Article: 1724761
Published online: 09 Feb 2020
AbstractforOverexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancer | Full Text | References | PDF (5.8 MB) | EPUB
  • 2674 Views
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Open Access
Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer
Kyoko Yamaguchi, Mamoru Ito, Hirofumi Ohmura, Fumiyasu Hanamura, Michitaka Nakano, Kenji Tsuchihashi, Shuntaro Nagai, Hiroshi Ariyama, Hitoshi Kusaba, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura, Koichi Akashi & Eishi Baba
Article: 1724763
Published online: 17 Feb 2020
AbstractforHelper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer | Full Text | References | PDF (3.7 MB) | EPUB
  • 3961 Views
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Open Access
S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness
Yanan Li, Jun Wang, Kun Song, Shuangqing Liu, Huilei Zhang, Fei Wang, Chen Ni, Wenlong Zhai, Jialu Liang, Zhihai Qin & Jinhua Zhang
Article: 1725355
Published online: 14 Feb 2020
AbstractforS100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness | Full Text | References | PDF (7.3 MB) | EPUB
  • 2968 Views
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Open Access
Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens
Yong Luo, Chaolong Lin, Yidi Zou, Fei Ju, Wenfeng Ren, Yanhua Lin, Yale Wang, Xiaoxuan Huang, Huiling Liu, Zeng Yu, Pingguo Liu, Guowei Tan, Quan Yuan, Jun Zhang, Chenghao Huang & Ningshao Xia
Article: 1726168
Published online: 12 Feb 2020
AbstractforTumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens | Full Text | References | PDF (9.6 MB) | EPUB
  • 3378 Views
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Open Access
Metabolism in the tumor microenvironment: insights from single-cell analysis
Zhengtao Xiao, Jason W. Locasale & Ziwei Dai
Article: 1726556
Published online: 09 Feb 2020
AbstractforMetabolism in the tumor microenvironment: insights from single-cell analysis | Full Text | References | PDF (599.9 KB) | EPUB
  • 2702 Views
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T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove & Tessa Kerre
Article: 1727078
Published online: 17 Feb 2020
AbstractforT-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources | Full Text | References | PDF (4.2 MB) | EPUB
  • 2600 Views
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Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors
Sonja C. S. Simon, Xiaoying Hu, Jasper Panten, Mareike Grees, Simon Renders, Daniel Thomas, Rebekka Weber, Torsten J. Schulze, Jochen Utikal & Viktor Umansky
Article: 1727116
Published online: 15 Feb 2020
AbstractforEosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors | Full Text | References | PDF (3.6 MB) | EPUB
  • 3955 Views
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Brief Report

Brief Report
Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53
Justine Habault, Anna Kaci, Ewa Pasquereau-Kotula, Claire Fraser, Christine Chomienne, Hervé Dombret, Thorsten Braun, Marika Pla & Jean-Luc Poyet
Article: 1728871
Published online: 02 Mar 2020
AbstractforProphylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53 | Full Text | References | PDF (7.2 MB) | EPUB
  • 1533 Views
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Open Access

Editorial

Editorial
A novel platinum-based chemotherapeutic inducing immunogenic cell death
Oliver Kepp & Guido Kroemer
Article: 1729022
Published online: 15 Feb 2020
CitationforA novel platinum-based chemotherapeutic inducing immunogenic cell death | Full Text | References | PDF (498.2 KB) | EPUB
  • 1564 Views
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Open Access

Back Matter

PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis
Fatmah A. Mansour, Amer Al-Mazrou, Falah Al-Mohanna, Monther Al-Alwan & Hazem Ghebeh
Article: 1729299
Published online: 03 Mar 2020
AbstractforPD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis | Full Text | References | PDF (3.5 MB) | EPUB
  • 3955 Views
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Open Access
Oncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer model
Shyambabu Chaurasiya, Annie Yang, Seonah Kang, Jianming Lu, Sang-In Kim, Anthony K. Park, Venkatesh Sivanandam, Zhifang Zhang, Yanghee Woo, Susanne G. Warner & Yuman Fong
Article: 1729300
Published online: 24 Feb 2020
AbstractforOncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer model | Full Text | References | PDF (4.2 MB) | EPUB
  • 3853 Views
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Open Access
Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
Maria Georganaki, Mohanraj Ramachandran, Sander Tuit, Nicolás Gonzalo Núñez, Alexandros Karampatzakis, Grammatiki Fotaki, Luuk van Hooren, Hua Huang, Roberta Lugano, Thomas Ulas, Aura Kaunisto, Eric C Holland, Peter Ellmark, Sara M Mangsbo, Joachim Schultze, Magnus Essand, Sonia Tugues & Anna Dimberg
Article: 1730538
Published online: 09 Mar 2020
AbstractforTumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy | Full Text | References | PDF (4.7 MB) | EPUB
  • 3184 Views
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Open Access
A non-linear association between blood tumor mutation burden and prognosis in NSCLC patients receiving atezolizumab
Wei Nie, Jie Qian, Mi-Die Xu, Kai Gu, Fang-Fei Qian, Min-Juan Hu, Jun Lu, Lu Gan, Xue-Yan Zhang, Shu-Hui Cao, Jing-Wen Li, Yue Wang, Bo Zhang, Shu-Yuan Wang, Fang Hu, Chang-Hui Li, Hua Zhong & Bao-Hui Han
Article: 1731072
Published online: 20 Feb 2020
AbstractforA non-linear association between blood tumor mutation burden and prognosis in NSCLC patients receiving atezolizumab | Full Text | References | PDF (2.5 MB) | EPUB
  • 2315 Views
  • 27 CrossRef citations
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Open Access

Research Article

Article
Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages
Karolina I. Smolag, Christine M. Mueni, Karin Leandersson, Karin Jirström, Catharina Hagerling, Matthias Mörgelin, Paul N. Barlow, Myriam Martin & Anna M. Blom
Article: 1731135
Published online: 06 Mar 2020
AbstractforComplement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages | Full Text | References | PDF (7.6 MB) | EPUB
  • 2320 Views
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Open Access

Review

Review
Lactate dehydrogenase: a marker of diminished antitumor immunity
Sandra Van Wilpe, Rutger Koornstra, Martijn Den Brok, Jan Willem De Groot, Christian Blank, Jolanda De Vries, Winald Gerritsen & Niven Mehra
Article: 1731942
Published online: 26 Feb 2020
AbstractforLactate dehydrogenase: a marker of diminished antitumor immunity | Full Text | References | PDF (1.8 MB) | EPUB
  • 15527 Views
  • 100 CrossRef citations
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Back Matter

A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma
Feng Xu, Haoyu Lin, Pei He, Lulu He, Jiexin Chen, Ling Lin & Yongsong Chen
Article: 1731943
Published online: 02 Mar 2020
AbstractforA TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma | Full Text | References | PDF (5 MB) | EPUB
  • 6946 Views
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Open Access
Deep neural network classification based on somatic mutations potentially predicts clinical benefit of immune checkpoint blockade in lung adenocarcinoma
Jie Peng, Dan Zou, Wuxing Gong, Shuai Kang & Lijie Han
Article: 1734156
Published online: 29 Feb 2020
AbstractforDeep neural network classification based on somatic mutations potentially predicts clinical benefit of immune checkpoint blockade in lung adenocarcinoma | Full Text | References | PDF (6.3 MB) | EPUB
  • 2742 Views
  • 17 CrossRef citations
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Open Access
Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression
Zhiqi Xie, Tamami Ikegami, Yukio Ago, Naoki Okada & Masashi Tachibana
Article: 1734268
Published online: 29 Feb 2020
AbstractforValproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression | Full Text | References | PDF (3 MB) | EPUB
  • 2296 Views
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Open Access

Research Article

Article
LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures
Nicolas Gestermann, Damien Saugy, Christophe Martignier, Laure Tillé, Silvia A. Fuertes Marraco, Markus Zettl, Iñigo Tirapu, Daniel E. Speiser & Grégory Verdeil
Article: 1736792
Published online: 12 Mar 2020
AbstractforLAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures | Full Text | References | PDF (4.1 MB) | EPUB
  • 3456 Views
  • 31 CrossRef citations
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Back Matter

Integration of intratumoral RASSF10 expression and tumor-associated macrophages into the established clinical indicators better predicts the prognosis of clear cell renal cell carcinoma patients
Chao Wang, Tianyu Hong, Yuning Wang, Sishun Gan, Qifeng Wang, Jian Li, Li Zuo & Xingang Cui
Article: 1736793
Published online: 11 Mar 2020
AbstractforIntegration of intratumoral RASSF10 expression and tumor-associated macrophages into the established clinical indicators better predicts the prognosis of clear cell renal cell carcinoma patients | Full Text | References | PDF (4.8 MB) | EPUB
  • 1519 Views
  • 6 CrossRef citations
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Open Access
Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells
SeongJun Han, Douglas C. Chung, Michael St. Paul, Zhe Qi Liu, Carlos Garcia-Batres, Alisha R. Elford, Charles W. Tran, Laurence Chapatte & Pamela S. Ohashi
Article: 1737368
Published online: 07 Apr 2020
AbstractforOverproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells | Full Text | References | PDF (4.2 MB) | EPUB
  • 2792 Views
  • 10 CrossRef citations
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Open Access
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq
Santiago J. Carmona, Imran Siddiqui, Mariia Bilous, Werner Held & David Gfeller
Article: 1737369
Published online: 12 Mar 2020
AbstractforDeciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq | Full Text | References | PDF (4.1 MB) | EPUB
  • 11925 Views
  • 28 CrossRef citations
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Open Access
Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation
Jay S. Wunder, Minji J. Lee, Junghyun Nam, Beatrice Y. Lau, Brendan C. Dickson, Dushanthi Pinnaduwage, Shelley B. Bull, Peter C. Ferguson, Andrew Seto, Nalan Gokgoz & Irene L. Andrulis
Article: 1737385
Published online: 18 Mar 2020
AbstractforOsteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation | Full Text | References | PDF (5.8 MB) | EPUB
  • 2444 Views
  • 22 CrossRef citations
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Open Access
Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation
Ieva Saulite, Desislava Ignatova, Yun-Tsan Chang, Christina Fassnacht, Florentia Dimitriou, Eleni Varypataki, Florian Anzengruber, Mirjam Nägeli, Antonio Cozzio, Reinhard Dummer, Julia Scarisbrick, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz & Emmanuella Guenova
Article: 1738797
Published online: 18 Mar 2020
AbstractforBlockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation | Full Text | References | PDF (3.4 MB) | EPUB
  • 1985 Views
  • 29 CrossRef citations
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Open Access

Research Article

Article
Evaluation of PD-L1 expression on circulating tumor cells (CTCs) in patients with advanced urothelial carcinoma (UC)
Sonja Bergmann, Anja Coym, Leonie Ott, Armin Soave, Michael Rink, Melanie Janning, Malgorzata Stoupiec, Cornelia Coith, Sven Peine, Gunhild von Amsberg, Klaus Pantel & Sabine Riethdorf
Article: 1738798
Published online: 23 Mar 2020
AbstractforEvaluation of PD-L1 expression on circulating tumor cells (CTCs) in patients with advanced urothelial carcinoma (UC) | Full Text | References | PDF (4.5 MB) | EPUB
  • 3139 Views
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Back Matter

An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial
Julie Charles, Laurence Chaperot, Dalil Hannani, Juliana Bruder Costa, Isabelle Templier, Sabiha Trabelsi, Hugo Gil, Anaick Moisan, Virginie Persoons, Harald Hegelhofer, Edith Schir, Jean-Louis Quesada, Christophe Mendoza, Caroline Aspord, Olivier Manches, Pierre G. Coulie, Amir Khammari, Brigitte Dreno, Marie-Thérèse Leccia & Joel Plumas
Article: 1738812
Published online: 12 Apr 2020
AbstractforAn innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial | Full Text | References | PDF (5.5 MB) | EPUB
  • 3818 Views
  • 36 CrossRef citations
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Open Access
Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses
Yusuf Dölen, Michael Valente, Oya Tagit, Eliezer Jäger, Eric A. W. Van Dinther, N. Koen van Riessen, Martin Hruby, Uzi Gileadi, Vincenzo Cerundolo & Carl G. Figdor
Article: 1738813
Published online: 17 Mar 2020
AbstractforNanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses | Full Text | References | PDF (4 MB) | EPUB
  • 3477 Views
  • 36 CrossRef citations
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Open Access
Response and survival of metastatic melanoma patients treated with immune checkpoint inhibition for recurrent disease on adjuvant dendritic cell vaccination
Wouter W. van Willigen, Martine Bloemendal, Marye J. Boers-Sonderen, Jan Willem B. de Groot, Rutger H.T. Koornstra, Astrid A.M. van der Veldt, John B. A. G. Haanen, Steve Boudewijns, Gerty Schreibelt, Winald R. Gerritsen, I. Jolanda M. de Vries & Kalijn F. Bol
Article: 1738814
Published online: 22 Mar 2020
AbstractforResponse and survival of metastatic melanoma patients treated with immune checkpoint inhibition for recurrent disease on adjuvant dendritic cell vaccination | Full Text | References | PDF (1.8 MB) | EPUB
  • 1941 Views
  • 13 CrossRef citations
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Open Access
Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1
Lijun Xu, Shanlong Wang, Jufeng Li, Jie Li & Bingyu Li
Article: 1740477
Published online: 07 Apr 2020
AbstractforCancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1 | Full Text | References | PDF (2.9 MB) | EPUB
  • 3982 Views
  • 27 CrossRef citations
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Open Access
Immune co-culture cell microarray – a feasible tool for high-throughput functional investigation of lymphocyte–cancer interactions
Erez Nissim Baruch, Rona Ortenberg, Camila Avivi, Liat Anafi, Daniela Dick-Necula, Chani Stossel, Yonatan Moshkovits, Orit Itzhaki, Michal Judith Besser, Jacob Schachter, Iris Barshack & Gal Markel
Article: 1741267
Published online: 25 Mar 2020
AbstractforImmune co-culture cell microarray – a feasible tool for high-throughput functional investigation of lymphocyte–cancer interactions | Full Text | References | PDF (2.1 MB) | EPUB
  • 1614 Views
  • 2 CrossRef citations
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Open Access
UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells
Claudia Arndt, Liliana R. Loureiro, Anja Feldmann, Justyna Jureczek, Ralf Bergmann, Domokos Máthé, Nikolett Hegedüs, Nicole Berndt, Stefanie Koristka, Nicola Mitwasi, Frederick Fasslrinner, Chris Lamprecht, Alexandra Kegler, Anja Hoffmann, Tabea Bartsch, Ayşe Sedef Köseer, Gary Egan, Marc Schmitz, Vaclav Hořejší, Mechthild Krause, Anna Dubrovska & Michael Bachmann
Article: 1743036
Published online: 05 Apr 2020
AbstractforUniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells | Full Text | References | PDF (4.6 MB) | EPUB
  • 4000 Views
  • 25 CrossRef citations
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Open Access
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma
Joseph R. Podojil, Alexander P. Glaser, Dylan Baker, Elise T. Courtois, Damiano Fantini, Yanni Yu, Valerie Eaton, Santhosh Sivajothi, Mingyi Chiang, Arighno Das, Kimberly A. McLaughlin, Paul Robson, Stephen D. Miller & Joshua J. Meeks
Article: 1744897
Published online: 16 Apr 2020
AbstractforAntibody targeting of B7-H4 enhances the immune response in urothelial carcinoma | Full Text | References | PDF (4.2 MB) | EPUB
  • 4315 Views
  • 23 CrossRef citations
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Open Access
Effectiveness and safety of nivolumab in the treatment of lung cancer patients in France: preliminary results from the real-world EVIDENS study
Fabrice Barlesi, Adrien Dixmier, Didier Debieuvre, Christophe Raspaud, Jean-Bernard Auliac, Nicolas Benoit, Pierre Bombaron, Denis Moro-Sibilot, Clarisse Audigier-Valette, Bernard Asselain, Thomas Egenod, Audrey Rabeau, Jérôme Fayette, Myriam Locatelli Sanchez, Jean-Luc Labourey, Virginie Westeel, Pauline Lamoureux, François-Emery Cotte, Victoria Allan, Melinda Daumont, Juliette Dumanoir, Dorothée Reynaud, Christophe Yannick Calvet, Nicolas Ozan & Maurice Pérol
Article: 1744898
Published online: 12 Apr 2020
AbstractforEffectiveness and safety of nivolumab in the treatment of lung cancer patients in France: preliminary results from the real-world EVIDENS study | Full Text | References | PDF (1.3 MB) | EPUB
  • 3383 Views
  • 24 CrossRef citations
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Open Access
Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody
Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D. Sood, Hong Wang, Xinyan Zhao, Molly H. Jenkins, Qingyong Ji, Youbin Wang, David P. Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G. Derner, Qi An, Christel Iffland & Joern-Peter Halle
Article: 1744921
Published online: 01 Apr 2020
AbstractforIdentification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody | Full Text | References | PDF (3.9 MB) | EPUB
  • 5476 Views
  • 22 CrossRef citations
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Open Access
Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses
Ivan Shevchenko, Andreas Mathes, Christopher Groth, Svetlana Karakhanova, Verena Müller, Jochen Utikal, Jens Werner, Alexandr V. Bazhin & Viktor Umansky
Article: 1744946
Published online: 09 Apr 2020
AbstractforEnhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses | Full Text | References | PDF (3.2 MB) | EPUB
  • 5876 Views
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Open Access
HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer
Yingxue Ren, Yesesri Cherukuri, Daniel P. Wickland, Vivekananda Sarangi, Shulan Tian, Jodi M. Carter, Aaron S. Mansfield, Matthew S. Block, Mark E. Sherman, Keith L. Knutson, Yi Lin & Yan W. Asmann
Article: 1744947
Published online: 01 Apr 2020
AbstractforHLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer | Full Text | References | PDF (5.5 MB) | EPUB
  • 4205 Views
  • 22 CrossRef citations
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Open Access
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance
Jacob J. Orme, Khalid A. Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M. Cristine Charlesworth, Tariq U. Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S. Mansfield, Roxana S. Dronca & Haidong Dong
Article: 1744980
Published online: 14 Apr 2020
AbstractforADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance | Full Text | References | PDF (4.8 MB) | EPUB
  • 4610 Views
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Open Access

Review

Review
Identifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysis
Jie Liu, Chengming Li, Samuel Seery, Jinming Yu & Xue Meng
Article: 1746112
Published online: 07 Apr 2020
AbstractforIdentifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysis | Full Text | References | PDF (1.2 MB) | EPUB
  • 6375 Views
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Open Access

Back Matter

Liver metastases and the efficacy of the PD-1 or PD-L1 inhibitors in cancer: a meta-analysis of randomized controlled trials
Shan Li, Shanquan Sun, Hui Xiang, Jing Yang, Minyong Peng & Qing Gao
Article: 1746113
Published online: 09 Apr 2020
AbstractforLiver metastases and the efficacy of the PD-1 or PD-L1 inhibitors in cancer: a meta-analysis of randomized controlled trials | Full Text | References | PDF (1.7 MB) | EPUB
  • 2783 Views
  • 15 CrossRef citations
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Open Access
Prognostic value of CD73 expression in resected colorectal cancer liver metastasis
Nouredin Messaoudi, Isabelle Cousineau, Elizabeth Arslanian, David Henault, David Stephen, Franck Vandenbroucke-Menu, Michel Dagenais, Richard Létourneau, Marylène Plasse, André Roy, Réal Lapointe, Dirk Ysebaert, Dominique Trudel, Geneviève Soucy, John Stagg & Simon Turcotte
Article: 1746138
Published online: 23 Apr 2020
AbstractforPrognostic value of CD73 expression in resected colorectal cancer liver metastasis | Full Text | References | PDF (1.5 MB) | EPUB
  • 2373 Views
  • 21 CrossRef citations
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Open Access
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response
Mei Song, Chao Wang, Huan Wang, Tuo Zhang, Jiuqi Li, Robert Benezra, Lotfi Chouchane, Yin-Hao Sun, Xin-Gang Cui & Xiaojing Ma
Article: 1746148
Published online: 14 Apr 2020
AbstractforTargeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response | Full Text | References | PDF (5.2 MB) | EPUB
  • 2822 Views
  • 12 CrossRef citations
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Open Access
Regulatory T cells and cytotoxic T cells close to the epithelial–stromal interface are associated with a favorable prognosis
Julian Rudolf, Maike Büttner-Herold, Katharina Erlenbach-Wünsch, Rebecca Posselt, Jonas Jessberger, Marlen Haderlein, Markus Hecht, Arndt Hartmann, Rainer Fietkau & Luitpold Distel
Article: 1746149
Published online: 14 Apr 2020
AbstractforRegulatory T cells and cytotoxic T cells close to the epithelial–stromal interface are associated with a favorable prognosis | Full Text | References | PDF (4.6 MB) | EPUB
  • 1201 Views
  • 10 CrossRef citations
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Open Access
 RRx-001, a first-in-class small molecule inhibitor of MYC and a downregulator of CD47, is an "erythrophagoimmunotherapeutic"
Bryan Oronsky, Corey A. Carter, Scott Caroen, Curtis Scribner, Arnold Oronsky & Tony R. Reid
Article: 1746172
Published online: 03 Apr 2020
Abstractfor RRx-001, a first-in-class small molecule inhibitor of MYC and a downregulator of CD47, is an "erythrophagoimmunotherapeutic" | Full Text | References | PDF (282 KB) | EPUB
  • 2482 Views
  • 8 CrossRef citations
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Open Access

Research Article

Article
Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation
Gyu Jin Lee, Yukyung Jun, Hae Yong Yoo, Yoon Kyung Jeon, Daekee Lee, Sanghyuk Lee & Jaesang Kim
Article: 1746553
Published online: 13 May 2020
AbstractforAngioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation | Full Text | References | PDF (3.6 MB) | EPUB
  • 2122 Views
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Open Access

Back Matter

CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer
Katsuhiro Yoshimura, Yuzo Suzuki, Yusuke Inoue, Kazuo Tsuchiya, Masato Karayama, Yuji Iwashita, Tomoaki Kahyo, Akikazu Kawase, Masayuki Tanahashi, Hiroshi Ogawa, Naoki Inui, Kazuhito Funai, Kazuya Shinmura, Hiroshi Niwa, Haruhiko Sugimura & Takafumi Suda
Article: 1746554
Published online: 07 Apr 2020
AbstractforCD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer | Full Text | References | PDF (4.8 MB) | EPUB
  • 2739 Views
  • 18 CrossRef citations
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Open Access
Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma
Fangming Liu, Weiren Liu, David E. Sanin, Guangshuai Jia, Mengxin Tian, Han Wang, Bijun Zhu, Yan Lu, Tiankui Qiao, Xiangdong Wang, Yinghong Shi & Duojiao Wu
Article: 1746573
Published online: 05 Apr 2020
AbstractforHeterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma | Full Text | References | PDF (6.3 MB) | EPUB
  • 4207 Views
  • 19 CrossRef citations
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Open Access
Tumor-infiltrating IL-17A+ cells determine favorable prognosis and adjuvant chemotherapeutic response in muscle-invasive bladder cancer
Zewei Wang, Quan Zhou, Han Zeng, Hongyu Zhang, Zhaopei Liu, Qiuren Huang, Ying Xiong, Jiajun Wang, Yuan Chang, Qi Bai, Yu Xia, Yiwei Wang, Yu Zhu, Le Xu, Bo Dai, Li Liu, Jianming Guo & Jiejie Xu
Article: 1747332
Published online: 10 Apr 2020
AbstractforTumor-infiltrating IL-17A+ cells determine favorable prognosis and adjuvant chemotherapeutic response in muscle-invasive bladder cancer | Full Text | References | PDF (3.8 MB) | EPUB
  • 1688 Views
  • 6 CrossRef citations
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Open Access
Identification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin+ cell abundance
Quan Zhou, Zewei Wang, Han Zeng, Hongyu Zhang, Zhaopei Liu, Qiuren Huang, Jiajun Wang, Yuan Chang, Qi Bai, Li Liu, Yu Zhu, Le Xu, Bo Dai, Jianming Guo, Yu Xia, Yiwei Wang & Jiejie Xu
Article: 1747333
Published online: 03 Apr 2020
AbstractforIdentification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin+ cell abundance | Full Text | References | PDF (3.8 MB) | EPUB
  • 2869 Views
  • 12 CrossRef citations
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Open Access
Tumor-associated tertiary lymphoid structure predicts postoperative outcomes in patients with primary gastrointestinal stromal tumors
Qiaowei Lin, Ping Tao, Jiongyuan Wang, Lijie Ma, Quan Jiang, Jinglei Li, Ge Zhang, Ju Liu, Yong Zhang, Yingyong Hou, Weiqi Lu, Ruyi Xue & Hanxing Tong
Article: 1747339
Published online: 07 Apr 2020
AbstractforTumor-associated tertiary lymphoid structure predicts postoperative outcomes in patients with primary gastrointestinal stromal tumors | Full Text | References | PDF (4.9 MB) | EPUB
  • 2555 Views
  • 25 CrossRef citations
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Open Access
Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen & Elizabeth G. Demicco
Article: 1747340
Published online: 12 Apr 2020
AbstractforTumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas | Full Text | References | PDF (4.7 MB) | EPUB
  • 8007 Views
  • 92 CrossRef citations
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Open Access
The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis
Sangeeta K. Bisheshar, Emma J. De Ruiter, Lot A. Devriese & Stefan M. Willems
Article: 1747345
Published online: 23 Apr 2020
AbstractforThe prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis | Full Text | References | PDF (1.2 MB) | EPUB
  • 2901 Views
  • 31 CrossRef citations
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Open Access

Review

Review
Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
Mumtaz Y. Balkhi
Article: 1747349
Published online: 14 Apr 2020
AbstractforReceptor signaling, transcriptional, and metabolic regulation of T cell exhaustion | Full Text | References | PDF (3 MB) | EPUB
  • 5051 Views
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Back Matter

Doxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer model
Fei Geng, Xin Bao, Ling Dong, Qian-Qian Guo, Jie Guo, Yu Xie, Yi Zhou, Bin Yu, Hui Wu, Jia-Xin Wu, Hai-Hong Zhang, Xiang-Hui Yu & Wei Kong
Article: 1747350
Published online: 16 Apr 2020
AbstractforDoxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer model | Full Text | References | PDF (7.6 MB) | EPUB
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Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions
Kerri Wolf-Dennen, Nancy Gordon & Eugenie S. Kleinerman
Article: 1747677
Published online: 12 Apr 2020
AbstractforExosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions | Full Text | References | PDF (5.6 MB) | EPUB
  • 3800 Views
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CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models
Zhuangwei Lv, Ping Zhang, Dandan Li, Mengting Qin, Longzhu Nie, Xiaoqian Wang, Li Ai, Zhaozu Feng, Woodvine Otieno Odhiambo, Yunfeng Ma & Yanhong Ji
Article: 1747688
Published online: 21 Apr 2020
AbstractforCD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models | Full Text | References | PDF (8.9 MB) | EPUB
  • 2798 Views
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Brief Report

Brief Report
The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients
Camilla Margaroli, Maria A. Cardenas, Caroline S. Jansen, Adriana Moon Reyes, Fares Hosseinzadeh, Gordon Hong, Yilin Zhang, Haydn Kissick, Rabindra Tirouvanziam & Viraj A. Master
Article: 1747731
Published online: 05 Apr 2020
AbstractforThe immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients | Full Text | References | PDF (3.7 MB) | EPUB
  • 2184 Views
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Back Matter

CD44v3 protein-carrying tumor-derived exosomes in HNSCC patients’ plasma as potential noninvasive biomarkers of disease activity
Marie-Nicole Theodoraki, Akihiro Matsumoto, Inga Beccard, Thomas K. Hoffmann & Theresa L. Whiteside
Article: 1747732
Published online: 07 Apr 2020
AbstractforCD44v3 protein-carrying tumor-derived exosomes in HNSCC patients’ plasma as potential noninvasive biomarkers of disease activity | Full Text | References | PDF (2.5 MB) | EPUB
  • 2095 Views
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Brief Report

Brief Report
Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guérin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy
Cyrill A. Rentsch, Piet Bosshard, Grégoire Mayor, Malte Rieken, Heike Püschel, Grégory Wirth, Richard Cathomas, Gerald P. Parzmair, Leander Grode, Bernd Eisele, Hitt Sharma, Manish Gupta, Sunil Gairola, Umesh Shaligram, Daniel Goldenberger, François Spertini, Régine Audran, Milica Enoiu, Simona Berardi, Stefanie Hayoz, Andreas Wicki & for the Swiss Group for Clinical Cancer Research (SAKK)
Article: 1748981
Published online: 21 Apr 2020
AbstractforResults of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guérin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy | Full Text | References | PDF (2 MB) | EPUB
  • 2065 Views
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Review

Review
Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis
Boris Shulgin, Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Sergey Aksenov, Rodrigo Pimentel, Garrett DeYulia, Geoffrey Kim, Kirill Peskov & Gabriel Helmlinger
Article: 1748982
Published online: 21 May 2020
AbstractforDose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis | Full Text | References | PDF (3.4 MB) | EPUB
  • 3847 Views
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Back Matter

B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells
Huimin Lu, Tongguo Shi, Mingyuan Wang, Xiaomi Li, Yanzheng Gu, Xueguang Zhang, Guangbo Zhang & Weichang Chen
Article: 1748991
Published online: 14 Apr 2020
AbstractforB7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells | Full Text | References | PDF (5.1 MB) | EPUB
  • 2580 Views
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T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma
Yang Zhang, Poorva Mudgal, Liuyang Wang, Haiyang Wu, Na Huang, Peter B. Alexander, Zhixian Gao, Nan Ji & Qi-Jing Li
Article: 1749476
Published online: 12 Apr 2020
AbstractforT cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma | Full Text | References | PDF (2.8 MB) | EPUB
  • 1840 Views
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Hypoxia increases mutational load of breast cancer cells through frameshift mutations
Goutham Hassan Venkatesh, Pamela Bravo, Walid Shaaban Moustafa Elsayed, Francis Amirtharaj, Bartosz Wojtas, Raefa Abou Khouzam, Husam Hussein Nawafleh, Sandeep Mallya, Kapaettu Satyamoorthy, Philippe Dessen, Filippo Rosselli, Jerome Thiery & Salem Chouaib
Article: 1750750
Published online: 16 Apr 2020
AbstractforHypoxia increases mutational load of breast cancer cells through frameshift mutations | Full Text | References | PDF (4.7 MB) | EPUB
  • 2424 Views
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Effect of excess weight and immune-related adverse events on the efficacy of cancer immunotherapy with anti-PD-1 antibodies
Jacobo Rogado, Nuria Romero-Laorden, José Miguel Sanchez-Torres, Ana María Ramos-Levi, Vilma Pacheco-Barcia, Ana Isabel Ballesteros, Reyes Arranz, Alicia Lorenzo, Pedro Gullon, Ana Garrido, José María Serra López-Matencio, Olga Donnay, Magdalena Adrados, Pablo Costas, Javier Aspa, Arantzazu Alfranca, Rebeca Mondejar & Ramon Colomer
Article: 1751548
Published online: 16 Apr 2020
AbstractforEffect of excess weight and immune-related adverse events on the efficacy of cancer immunotherapy with anti-PD-1 antibodies | Full Text | References | PDF (1.1 MB) | EPUB
  • 2337 Views
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Brief Report

Brief Report
Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma
Edda Blümel, Shamaila Munir Ahmad, Claudia Nastasi, Andreas Willerslev-Olsen, Maria Gluud, Simon Fredholm, Tengpeng Hu, Bas G. J. Surewaard, Lise M. Lindahl, Hanne Fogh, Sergei B. Koralov, Lise Mette Rahbek Gjerdrum, Rachael A. Clark, Lars Iversen, Thorbjørn Krejsgaard, Charlotte Menné Bonefeld, Carsten Geisler, Jürgen C. Becker, Anders Woetmann, Mads Hald Andersen, Terkild Brink Buus & Niels Ødum
Article: 1751561
Published online: 17 Apr 2020
AbstractforStaphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma | Full Text | References | PDF (4.6 MB) | EPUB
  • 2684 Views
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Back Matter

Efficacy of adjuvant cytokine-induced killer cell immunotherapy in patients with colorectal cancer after radical resection
Qiu-Zhong Pan, Jing-Jing Zhao, Chao-Pin Yang, Yu-Qing Zhou, Jun-Zhong Lin, Yan Tang, Jia-Mei Gu, Qi-Jing Wang, Yong-Qiang Li, Jia He, Shi-Ping Chen, Meng-Jia Song, Yue Huang, Jie-Ying Yang, De-Sheng Weng & Jian-Chuan Xia
Article: 1752563
Published online: 17 Apr 2020
AbstractforEfficacy of adjuvant cytokine-induced killer cell immunotherapy in patients with colorectal cancer after radical resection | Full Text | References | PDF (2.3 MB) | EPUB
  • 2027 Views
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Development of CAR-T cell therapy for B-ALL using a point-of-care approach
Luiza de Macedo Abdo, Luciana Rodrigues Carvalho Barros, Mariana Saldanha Viegas, Luisa Vieira Codeço Marques, Priscila de Sousa Ferreira, Leonardo Chicaybam & Martín Hernán Bonamino
Article: 1752592
Published online: 17 Apr 2020
AbstractforDevelopment of CAR-T cell therapy for B-ALL using a point-of-care approach | Full Text | References | PDF (3.7 MB) | EPUB
  • 5315 Views
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Research Article

Article
MMP2 as an independent prognostic stratifier in oral cavity cancers
Caroline Hoffmann, Sophie Vacher, Philémon Sirven, Charlotte Lecerf, Lucile Massenet, Aurélie Moreira, Aurore Surun, Anne Schnitzler, Jerzy Klijanienko, Odette Mariani, Emmanuelle Jeannot, Nathalie Badois, Maria Lesnik, Olivier Choussy, Christophe Le Tourneau, Maude Guillot-Delost, Maud Kamal, Ivan Bieche & Vassili Soumelis
Article: 1754094
Published online: 13 May 2020
AbstractforMMP2 as an independent prognostic stratifier in oral cavity cancers | Full Text | References | PDF (2.9 MB) | EPUB
  • 1787 Views
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Editorial

Editorial
FLT3LG - a biomarker reflecting clinical responses to the immunogenic cell death inducer oxaliplatin
Jonathan G. Pol, Julie Le Naour & Guido Kroemer
Article: 1755214
Published online: 21 Apr 2020
AbstractforFLT3LG - a biomarker reflecting clinical responses to the immunogenic cell death inducer oxaliplatin | Full Text | References | PDF (1 MB) | EPUB
  • 2613 Views
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Brief Report

Brief Report
Genomic and immunologic correlates of LAG-3 expression in cancer
Anshuman Panda, Jeffrey A. Rosenfeld, Eric A. Singer, Gyan Bhanot & Shridar Ganesan
Article: 1756116
Published online: 22 May 2020
AbstractforGenomic and immunologic correlates of LAG-3 expression in cancer | Full Text | References | PDF (2.7 MB) | EPUB
  • 3809 Views
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Research Article

Article
Heat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravis
Jürgen Thanner, Christine Bekos, Cecilia Veraar, Stefan Janik, Maria Laggner, Panja M Boehm, Ana-Iris Schiefer, Leonhard Müllauer, Walter Klepetko, Hendrik Jan Ankersmit & Bernhard Moser
Article: 1756130
Published online: 13 May 2020
AbstractforHeat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravis | Full Text | References | PDF (4.7 MB) | EPUB
  • 1936 Views
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Article
Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model
Surya Murty, Samuel T. Haile, Corinne Beinat, Amin Aalipour, Israt S. Alam, Tara Murty, Travis M. Shaffer, Chirag B. Patel, Edward E. Graves, Crystal L. Mackall & Sanjiv S. Gambhir
Article: 1757360
Published online: 13 May 2020
AbstractforIntravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model | Full Text | References | PDF (2.7 MB) | EPUB
  • 5870 Views
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Article
ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer
Zheng Liu, Kejia Zhao, Shiyou Wei, Chengwu Liu, Jiankang Zhou, Qiheng Gou, Xia Wu, Zhenyu Yang, Yanbo Yang, Yong Peng, Qing Cheng & Lunxu Liu
Article: 1758003
Published online: 06 May 2020
AbstractforROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer | Full Text | References | PDF (3.5 MB) | EPUB
  • 2856 Views
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Article
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
Mathias Vormehr, Sophie Lehar, Lena M. Kranz, Siri Tahtinen, Yoko Oei, Vincent Javinal, Lélia Delamarre, Kerstin C. Walzer, Mustafa Diken, Sebastian Kreiter, Ira Mellman, Ugur Sahin, Jill M. Schartner & Özlem Türeci
Article: 1758004
Published online: 13 May 2020
AbstractforDexamethasone premedication suppresses vaccine-induced immune responses against cancer | Full Text | References | PDF (2.4 MB) | EPUB
  • 3922 Views
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Article
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia
Jessica Stokes, Emely A. Hoffman, Megan S. Molina, Nicole Kummet, Richard J. Simpson, Yi Zeng & Emmanuel Katsanis
Article: 1758011
Published online: 30 Apr 2020
AbstractforBendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia | Full Text | References | PDF (5.9 MB) | EPUB
  • 1725 Views
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Article
Progesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancer
Katherine R. Walter, Justin M. Balko & Christy R. Hagan
Article: 1758547
Published online: 30 Apr 2020
AbstractforProgesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancer | Full Text | References | PDF (2.8 MB) | EPUB
  • 1912 Views
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Article
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model
Xuan Ye, Janelle C. Waite, Ankur Dhanik, Namita Gupta, Maggie Zhong, Christina Adler, Evangelia Malahias, Min Ni, Yi Wei, Cagan Gurer, Wen Zhang, Lynn E. Macdonald, Andrew J. Murphy, Matthew A. Sleeman & Dimitris Skokos
Article: 1758602
Published online: 13 May 2020
AbstractforEndogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model | Full Text | References | PDF (3 MB) | EPUB
  • 4827 Views
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Article
IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses
Gilles Dadaglio, Catherine Fayolle, Marine Oberkampf, Alexandre Tang, Francesc Rudilla, Isabelle Couillin, Eirik A. Torheim, Pierre Rosenbaum & Claude Leclerc
Article: 1758606
Published online: 12 May 2020
AbstractforIL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses | Full Text | References | PDF (5.9 MB) | EPUB
  • 1767 Views
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Article
Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer
Ayesha B. Alvero, Douglas Hanlon, Mary Pitruzzello, Renata Filler, Eve Robinson, Olga Sobolev, Roslyn Tedja, Alessandra Ventura, Marcus Bosenberg, Patrick Han, Richard L. Edelson & Gil Mor
Article: 1758869
Published online: 13 May 2020
AbstractforTransimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer | Full Text | References | PDF (3.7 MB) | EPUB
  • 2994 Views
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Editorial

Editorial
The ambiguous role of FPR1 in immunity and inflammation
Erika Vacchelli, Julie Le Naour & Guido Kroemer
Article: 1760061
Published online: 30 Apr 2020
First Page PreviewforThe ambiguous role of FPR1 in immunity and inflammation | Full Text | References | PDF (758.7 KB) | EPUB
  • 2591 Views
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Back Matter

Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective study
Yue Gao, Lingxi Chen, Guangyao Cai, Xiaoming Xiong, Yuan Wu, Ding Ma, Shuai Cheng Li & Qinglei Gao
Article: 1760067
Published online: 30 Apr 2020
AbstractforHeterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective study | Full Text | References | PDF (3.1 MB) | EPUB
  • 3005 Views
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Brief Report

Brief Report
Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors
Carlos Eduardo de Andrea, Jose Luis Perez-Gracia, Eduardo Castanon, Mariano Ponz-Sarvise, Jose I. Echeveste, Ignacio Melero, Miguel F. Sanmamed & Maria Esperanza Rodriguez-Ruiz
Article: 1760676
Published online: 13 May 2020
AbstractforEndoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors | Full Text | References | PDF (978.7 KB) | EPUB
  • 1709 Views
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Research Article

Article
Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide
Adam C. Mirando, Akash Patil, Christine I. Rafie, Brian J. Christmas, Niranjan B. Pandey, Vered Stearns, Elizabeth M. Jaffee, Evanthia T. Roussos Torres & Aleksander S. Popel
Article: 1760685
Published online: 14 May 2020
AbstractforRegulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide | Full Text | References | PDF (3.8 MB) | EPUB
  • 2695 Views
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Editorial

Editorial
COVID-19: a challenge for oncology services
Bertrand Routy, Lisa Derosa, Laurence Zitvogel & Guido Kroemer
Article: 1760686
Published online: 05 May 2020
First Page PreviewforCOVID-19: a challenge for oncology services | Full Text | References | PDF (916.7 KB) | EPUB
  • 1838 Views
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Research Article

Article
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome
Kim L. Brunekreeft, Sterre T. Paijens, Maartje C.A. Wouters, Fenne L. Komdeur, Florine A. Eggink, Joyce M. Lubbers, Hagma H. Workel, Elisabeth C. Van Der Slikke, Noor E.J. Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W. Nijman & Marco De Bruyn
Article: 1760705
Published online: 13 May 2020
AbstractforDeep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome | Full Text | References | PDF (2.5 MB) | EPUB
  • 2162 Views
  • 11 CrossRef citations
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Article
Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse
Concetta Elisa Onesti, Claire Josse, Delphine Boulet, Jérôme Thiry, Barbara Beaumecker, Vincent Bours & Guy Jerusalem
Article: 1761176
Published online: 13 May 2020
AbstractforBlood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse | Full Text | References | PDF (2.8 MB) | EPUB
  • 3097 Views
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Article
Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3
Mathilde Boulpicante, Romain Darrigrand, Alison Pierson, Valérie Salgues, Marine Rouillon, Benoit Gaudineau, Mehdi Khaled, Angela Cattaneo, Angela Bachi, Paolo Cascio & Sébastien Apcher
Article: 1761205
Published online: 21 May 2020
AbstractforTumors escape immunosurveillance by overexpressing the proteasome activator PSME3 | Full Text | References | PDF (4.1 MB) | EPUB
  • 2676 Views
  • 13 CrossRef citations
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Article
Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition
Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Joao Manuel Santos, Riikka Havunen, Sadia Zafar, Otto Hemminki, Camilla Heiniö, Eleonora Munaro, Mikko Siurala, Suvi Sorsa, Tuomas Mirtti, Petrus Järvinen, Markus Mildh, Harry Nisen, Antti Rannikko, Marjukka Anttila, Anna Kanerva & Akseli Hemminki
Article: 1761229
Published online: 22 May 2020
AbstractforTumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition | Full Text | References | PDF (3.7 MB) | EPUB
  • 2638 Views
  • 21 CrossRef citations
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Article
Anti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedule
Xitlally Popa, Beatriz García, Karla P. Fuentes, Vivian Huerta, Karen Alvarez, Carmen E. Viada, Elia Neninger, Pedro C. Rodríguez, Zuyen González, Amnely González, Tania Crombet & Zaima Mazorra
Article: 1762465
Published online: 25 May 2020
AbstractforAnti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedule | Full Text | References | PDF (3 MB) | EPUB
  • 2870 Views
  • 9 CrossRef citations
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Article
A novel gene signature to predict immune infiltration and outcome in patients with prostate cancer
Ning Shao, Hong Tang, Yuanyuan Mi, Yao Zhu, Fangning Wan & Dingwei Ye
Article: 1762473
Published online: 01 Jun 2020
AbstractforA novel gene signature to predict immune infiltration and outcome in patients with prostate cancer | Full Text | References | PDF (4.9 MB) | EPUB
  • 4112 Views
  • 31 CrossRef citations
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Article
A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy
Ana Victoria Casadesús, Claire Deligne, Béré Kadjdiatou Diallo, Katya Sosa, Nathalie Josseaume, Circe Mesa, Kalet León, Tays Hernández & Jean-Luc Teillaud
Article: 1770565
Published online: 02 Jun 2020
AbstractforA rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy | Full Text | References | PDF (889.4 KB) | EPUB
  • 1843 Views
  • 2 CrossRef citations
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Article
The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen & Mads Hald Andersen
Article: 1771142
Published online: 01 Jun 2020
AbstractforThe metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines | Full Text | References | PDF (3 MB) | EPUB
  • 3333 Views
  • 18 CrossRef citations
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Review

Review
Trial watch: TLR3 agonists in cancer therapy
Julie Le Naour, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer & Erika Vacchelli
Article: 1771143
Published online: 02 Jun 2020
AbstractforTrial watch: TLR3 agonists in cancer therapy | Full Text | References | PDF (577.8 KB) | EPUB
  • 7356 Views
  • 55 CrossRef citations
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Research Article

Article
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice
Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Mathias Vormehr, Juliane Quinkhardt, Thomas Bukur, Barbara Schrörs, Martin Löewer, Mustafa Diken, Özlem Türeci, Ugur Sahin & Sebastian Kreiter
Article: 1771925
Published online: 22 Jun 2020
AbstractforA liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice | Full Text | References | PDF (10.7 MB) | EPUB
  • 5497 Views
  • 31 CrossRef citations
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Article
Cancer immunotherapy using a polysaccharide from Codium fragile in a murine model
Hae-Bin Park, Seong-Min Lim, Juyoung Hwang, Wei Zhang, SangGuan You & Jun-O Jin
Article: 1772663
Published online: 01 Jun 2020
AbstractforCancer immunotherapy using a polysaccharide from Codium fragile in a murine model | Full Text | References | PDF (4.4 MB) | EPUB
  • 3123 Views
  • 23 CrossRef citations
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Other

Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms
Mrinmoy Das, Emmanuel Stephen-Victor & Jagadeesh Bayry
Article: 1773193
Published online: 05 Jun 2020
AbstractforRegulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms | Full Text | References | PDF (599.6 KB) | EPUB
  • 1355 Views
  • 4 CrossRef citations
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Research Article

Article
Proliferative potential and response to nivolumab in clear cell renal cell carcinoma patients
Tian Zhang, Sarabjot Pabla, Felicia L. Lenzo, Jeffrey M. Conroy, Mary K. Nesline, Sean T. Glenn, Antonios Papanicolau-Sengos, Blake Burgher, Vincent Giamo, Jonathan Andreas, Yirong Wang, Wiam Bshara, Katherine G. Madden, Keisuke Shirai, Konstantin Dragnev, Laura J. Tafe, Rajan Gupta, Jason Zhu, Matthew Labriola, Shannon McCall, Daniel J. George, Pooja Ghatalia, Farshid Dayyani, Robert Edwards, Michelle S Park, Rajbir Singh, Robin Jacob, Saby George, Bo Xu, Matthew Zibelman, Razelle Kurzrock & Carl Morrison
Article: 1773200
Published online: 10 Jun 2020
AbstractforProliferative potential and response to nivolumab in clear cell renal cell carcinoma patients | Full Text | References | PDF (1.8 MB) | EPUB
  • 2402 Views
  • 10 CrossRef citations
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Article
Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patients
Lawrence G. Lum, Archana Thakur, Minsig Choi, Abhinav Deol, Vidya Kondadasula, Dana Schalk, Kristie Fields, Melissa Dufrense, Philip Philip, Gregory Dyson, Hussein D. Aon & Anthony F. Shields
Article: 1773201
Published online: 10 Jun 2020
AbstractforClinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patients | Full Text | References | PDF (6.1 MB) | EPUB
  • 3393 Views
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Article
Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells
Luis Augusto Aguirre, Karla Montalbán-Hernández, José Avendaño-Ortiz, Elvira Marín, Roberto Lozano, Víctor Toledano, Laura Sánchez-Maroto, Verónica Terrón, Jaime Valentín, Elisa Pulido, José Carlos Casalvilla, Carolina Rubio, Luke Diekhorst, Fernando Laso-García, Carlos del Fresno, Ana Collazo-Lorduy, Beatriz Jiménez-Munarriz, Paloma Gómez-Campelo, Emilio Llanos-González, María Fernández-Velasco, Carlos Rodríguez-Antolín, Rebeca Pérez de Diego, Ramón Cantero-Cid, Enrique Hernádez-Jimenez, Enrique Álvarez, Rocío Rosas, Blanca dies López-Ayllón, Javier de Castro, Stefanie K. Wculek, Carolina Cubillos-Zapata, Inmaculada Ibáñez de Cáceres, Prudencio Díaz-Agero, María Gutiérrez Fernández, María Paz de Miguel, David Sancho, Leon Schulte, Rosario Perona, Cristóbal Belda-Iniesta, Lisardo Boscá & Eduardo López-Collazo
Article: 1773204
Published online: 16 Jun 2020
AbstractforTumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells | Full Text | References | PDF (10.4 MB) | EPUB
  • 5117 Views
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Review

Review
Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer
Tingting Liang, Weihua Tong, Siyang Ma & Pengyu Chang
Article: 1773205
Published online: 03 Jun 2020
AbstractforStandard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer | Full Text | References | PDF (919.6 KB) | EPUB
  • 1540 Views
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Research Article

Article
Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization
Yuexi He, Juan Du & Zhongjun Dong
Article: 1774281
Published online: 03 Jun 2020
AbstractforMyeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization | Full Text | References | PDF (2.6 MB) | EPUB
  • 1942 Views
  • 9 CrossRef citations
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Review

Review
Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy
Romain Daillère, Lisa Derosa, Mélodie Bonvalet, Nicola Segata, Bertrand Routy, Manuela Gariboldi, Eva Budinská, I. Jolanda M. De Vries, Alessio Gordon Naccarati, Valérie Zitvogel, Carlos Caldas, Lars Engstrand, Sibylle Loibl, Jacques Fieschi, Lucie Heinzerling, Guido Kroemer & Laurence Zitvogel
Article: 1774298
Published online: 03 Jun 2020
AbstractforTrial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy | Full Text | References | PDF (760.3 KB) | EPUB
  • 4458 Views
  • 22 CrossRef citations
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Research Article

Article
Efficacy and safety of immune checkpoint inhibitors in patients with advanced non–small cell lung cancer (NSCLC): a systematic literature review
Gernot Wagner, Hannah Karolina Stollenwerk, Irma Klerings, Martin Pecherstorfer, Gerald Gartlehner & Josef Singer
Article: 1774314
Published online: 16 Jun 2020
AbstractforEfficacy and safety of immune checkpoint inhibitors in patients with advanced non–small cell lung cancer (NSCLC): a systematic literature review | Full Text | References | PDF (3.8 MB) | EPUB
  • 4201 Views
  • 28 CrossRef citations
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Article
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients
Maria-Filothei Lazaridou, Evamaria Gonschorek, Chiara Massa, Michael Friedrich, Diana Handke, Anja Mueller, Simon Jasinski-Bergner, Reinhard Dummer, Peter Koelblinger & Barbara Seliger
Article: 1774323
Published online: 03 Jun 2020
AbstractforIdentification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients | Full Text | References | PDF (4.5 MB) | EPUB
  • 1989 Views
  • 25 CrossRef citations
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Article
Impact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitors
Sang Eun Won, Hyo Jung Park, Sangil Byun, Junhee Pyo, Jwa Hoon Kim, Chang-Min Choi, Jae Cheol Lee, Dae Ho Lee, Sang-We Kim, Shinkyo Yoon & Kyung Won Kim
Article: 1776058
Published online: 19 Jun 2020
AbstractforImpact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitors | Full Text | References | PDF (1.8 MB) | EPUB
  • 2523 Views
  • 19 CrossRef citations
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Article
IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils
Melanie Kienzl, Carina Hasenoehrl, Paulina Valadez-Cosmes, Kathrin Maitz, Arailym Sarsembayeva, Eva Sturm, Akos Heinemann, Julia Kargl & Rudolf Schicho
Article: 1776059
Published online: 16 Jun 2020
AbstractforIL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils | Full Text | References | PDF (4.5 MB) | EPUB
  • 4150 Views
  • 38 CrossRef citations
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Article
Serum CCL27 predicts the response to Bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancer
Wenlong Zhong, Bo Wang, Hao Yu, Jianxun Lin, Kun Xia, Weibin Hou, Meihua Yang, Junyu Chen, Meng Yang, Xiaofei Wang, Jian Huang & Tianxin Lin
Article: 1776060
Published online: 27 Jun 2020
AbstractforSerum CCL27 predicts the response to Bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancer | Full Text | References | PDF (6.3 MB) | EPUB
  • 1802 Views
  • 10 CrossRef citations
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Article
Modeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockade
Xiaoyan Lan, Dorota A. Kedziorek, Chengyan Chu, Anna Jablonska, Shen Li, Mihoko Kai, Yajie Liang, Miroslaw Janowski & Piotr Walczak
Article: 1776577
Published online: 05 Jun 2020
AbstractforModeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockade | Full Text | References | PDF (4.3 MB) | EPUB
  • 2297 Views
  • 7 CrossRef citations
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Article
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells
Roberta Sommaggio, Elisa Cappuzzello, Anna Dalla Pietà, Anna Tosi, Pierangela Palmerini, Debora Carpanese, Lorenzo Nicolè & Antonio Rosato
Article: 1777046
Published online: 11 Jun 2020
AbstractforAdoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells | Full Text | References | PDF (5.2 MB) | EPUB
  • 7078 Views
  • 19 CrossRef citations
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Review

Review
Current Clinical Evidence and Potential Solutions to Increase Benefit of CAR T-Cell Therapy for Patients with Solid Tumors
Marion Alcantara, Pauline Du Rusquec & Emanuela Romano
Article: 1777064
Published online: 10 Jun 2020
AbstractforCurrent Clinical Evidence and Potential Solutions to Increase Benefit of CAR T-Cell Therapy for Patients with Solid Tumors | Full Text | References | PDF (496.4 KB) | EPUB
  • 3877 Views
  • 25 CrossRef citations
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Review
Trial watch: STING agonists in cancer therapy
Julie Le Naour, Laurence Zitvogel, Lorenzo Galluzzi, Erika Vacchelli & Guido Kroemer
Article: 1777624
Published online: 16 Jun 2020
AbstractforTrial watch: STING agonists in cancer therapy | Full Text | References | PDF (921.4 KB) | EPUB
  • 16810 Views
  • 136 CrossRef citations
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Review
Trial watch: IDO inhibitors in cancer therapy
Julie Le Naour, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer & Erika Vacchelli
Article: 1777625
Published online: 14 Jun 2020
AbstractforTrial watch: IDO inhibitors in cancer therapy | Full Text | References | PDF (618.3 KB) | EPUB
  • 7768 Views
  • 83 CrossRef citations
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Review
Immunotherapy with NK cells: recent developments in gene modification open up new avenues
Lisa Marie Reindl, Nawid Albinger, Tobias Bexte, Stephan Müller, Jessica Hartmann & Evelyn Ullrich
Article: 1777651
Published online: 02 Sep 2020
AbstractforImmunotherapy with NK cells: recent developments in gene modification open up new avenues | Full Text | References | PDF (2.3 MB) | EPUB
  • 5488 Views
  • 24 CrossRef citations
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Other

Turning tolerogenic into immunogenic ileal cell death through ileal microbiota: the key to unlock the mystery of colon cancer immunoscore?
Maria Paula Roberti, Marion Picard, Satoru Yonekura & Laurence Zitvogel
Article: 1778834
Published online: 14 Jun 2020
AbstractforTurning tolerogenic into immunogenic ileal cell death through ileal microbiota: the key to unlock the mystery of colon cancer immunoscore? | Full Text | References | PDF (696.8 KB) | EPUB
  • 1794 Views
  • 1 CrossRef citations
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Research Article

Article
Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma
Eliana Marinari, Mathilde Allard, Robin Gustave, Valérie Widmer, Géraldine Philippin, Doron Merkler, Petros Tsantoulis, Valérie Dutoit & Pierre-Yves Dietrich
Article: 1779990
Published online: 21 Jun 2020
AbstractforInflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma | Full Text | References | PDF (5.2 MB) | EPUB
  • 2815 Views
  • 24 CrossRef citations
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Review

Review
Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy
Marzieh Naseri, Mahmood Bozorgmehr, Margot Zöller, Ehsan Ranaei Pirmardan & Zahra Madjd
Article: 1779991
Published online: 16 Jun 2020
AbstractforTumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy | Full Text | References | PDF (2.6 MB) | EPUB
  • 5162 Views
  • 77 CrossRef citations
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Research Article

Article
A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy
Ling Peng, Bao-Dong Qin, Kui Xiao, Song Xu, Jin-Song Yang, Yuan-Sheng Zang, Justin Stebbing & Li-Ping Xie
Article: 1781333
Published online: 26 Jun 2020
AbstractforA meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy | Full Text | References | PDF (1.8 MB) | EPUB
  • 4542 Views
  • 33 CrossRef citations
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Review

Review
The role of trogocytosis in immune surveillance of Hodgkin lymphoma
Qun Zeng & Herbert Schwarz
Article: 1781334
Published online: 17 Jun 2020
AbstractforThe role of trogocytosis in immune surveillance of Hodgkin lymphoma | Full Text | References | PDF (686.6 KB) | EPUB
  • 2227 Views
  • 9 CrossRef citations
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Brief Report

Brief Report
Tumor mutational burden is not predictive of cytotoxic chemotherapy response
Mina Nikanjam, Paul Riviere, Aaron Goodman, Donald A. Barkauskas, Garrett Frampton & Razelle Kurzrock
Article: 1781997
Published online: 24 Jun 2020
AbstractforTumor mutational burden is not predictive of cytotoxic chemotherapy response | Full Text | References | PDF (668.9 KB) | EPUB
  • 1486 Views
  • 8 CrossRef citations
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Research Article

Article
Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy
Ava Vila-Leahey, Alecia MacKay, Liliana Portales-Cervantes, Genevieve M. Weir, Alexandra Merkx-Jacques & Marianne M. Stanford
Article: 1782574
Published online: 27 Jun 2020
AbstractforGeneration of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy | Full Text | References | PDF (4.2 MB) | EPUB
  • 2026 Views
  • 1 CrossRef citations
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Article
The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis
Martina Barone, Lucia Catani, Francesca Ricci, Marco Romano, Dorian Forte, Giuseppe Auteri, Daniela Bartoletti, Emanuela Ottaviani, Pier Luigi Tazzari, Nicola Vianelli, Michele Cavo & Francesca Palandri
Article: 1782575
Published online: 23 Jun 2020
AbstractforThe role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis | Full Text | References | PDF (5 MB) | EPUB
  • 2443 Views
  • 17 CrossRef citations
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Article
Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer
Päivi Sirniö, Juha P. Väyrynen, Shivaprakash J. Mutt, Karl-Heinz Herzig, Jaroslaw Walkowiak, Kai Klintrup, Jyrki Mäkelä, Tuomo J. Karttunen, Markus J. Mäkinen & Anne Tuomisto
Article: 1783046
Published online: 24 Jun 2020
AbstractforSystemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer | Full Text | References | PDF (1.5 MB) | EPUB
  • 1647 Views
  • 8 CrossRef citations
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Article
Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data
Xi Tian, Wenhao Xu, Yuchen Wang, Aihetaimujiang Anwaier, Hongkai Wang, Fangning Wan, Yu Zhu, Dalong Cao, Guohai Shi, Yiping Zhu, Yuanyuan Qu, Hailiang Zhang & Dingwei Ye
Article: 1784529
Published online: 23 Jun 2020
AbstractforIdentification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data | Full Text | References | PDF (13.8 MB) | EPUB
  • 2913 Views
  • 25 CrossRef citations
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Article
Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy
Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto & Michael Bachmann
Article: 1785608
Published online: 03 Jul 2020
AbstractforVersatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy | Full Text | References | PDF (10.5 MB) | EPUB
  • 3437 Views
  • 34 CrossRef citations
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Article
PD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidates
Yago Pico de Coaña, Maria Wolodarski, Irene van der Haar Àvila, Takahiro Nakajima, Stamatina Rentouli, Andreas Lundqvist, Giuseppe Masucci, Johan Hansson & Rolf Kiessling
Article: 1786888
Published online: 28 Aug 2020
AbstractforPD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidates | Full Text | References | PDF (1.7 MB) | EPUB
  • 2833 Views
  • 27 CrossRef citations
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Article
Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer
Hao Chen, Wei Chong, Xiaorong Yang, Yuan Zhang, Shaowei Sang, Xiangchun Li & Ming Lu
Article: 1788252
Published online: 30 Jun 2020
AbstractforAge-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer | Full Text | References | PDF (6 MB) | EPUB
  • 3493 Views
  • 19 CrossRef citations
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Review

Review
The consensus immunoscore: toward a new classification of colorectal cancer
Anastasia Lanzi, Franck Pagès, Christine Lagorce-Pagès & Jérôme Galon
Article: 1789032
Published online: 11 Jul 2020
AbstractforThe consensus immunoscore: toward a new classification of colorectal cancer | Full Text | References | PDF (1.2 MB) | EPUB
  • 3356 Views
  • 25 CrossRef citations
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Research Article

Article
Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses
Peng Liu, Liwei Zhao, Gladys Ferrere, Carolina Alves-Costa-Silva, Pierre Ly, Qi Wu, Ai-Ling Tian, Lisa Derosa, Laurence Zitvogel, Oliver Kepp & Guido Kroemer
Article: 1789284
Published online: 08 Jul 2020
AbstractforCombination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses | Full Text | References | PDF (6.7 MB) | EPUB
  • 2746 Views
  • 4 CrossRef citations
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Article
Colon-specific immune microenvironment regulates cancer progression versus rejection
Giulia Trimaglio, Anne-Françoise Tilkin-Mariamé, Virginie Feliu, Françoise Lauzéral-Vizcaino, Marie Tosolini, Carine Valle, Maha Ayyoub, Olivier Neyrolles, Nathalie Vergnolle, Yoann Rombouts & Christel Devaud
Article: 1790125
Published online: 12 Jul 2020
AbstractforColon-specific immune microenvironment regulates cancer progression versus rejection | Full Text | References | PDF (5 MB) | EPUB
  • 2606 Views
  • 15 CrossRef citations
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Review

Review
IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection
Karsten A. Pilones, Maud Charpentier, Elena Garcia-Martinez & Sandra Demaria
Article: 1790716
Published online: 09 Jul 2020
AbstractforIL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection | Full Text | References | PDF (703.2 KB) | EPUB
  • 1616 Views
  • 4 CrossRef citations
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Open Access

Research Article

Article
Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma
A. Dufresne, T. Lesluyes, C. Ménétrier-Caux, M. Brahmi, E. Darbo, M. Toulmonde, A. Italiano, O. Mir, A. Le Cesne, S. Le Guellec, T. Valentin, C. Chevreau, S. Bonvalot, Y.M. Robin, J-M Coindre, C. Caux, J.Y. Blay & F. Chibon
Article: 1792036
Published online: 12 Jul 2020
AbstractforSpecific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma | Full Text | References | PDF (6.7 MB) | EPUB
  • 2447 Views
  • 28 CrossRef citations
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Brief Report

Brief Report
Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis
Oliver Kepp, Peng Liu, Liwei Zhao, Isabelle Plo & Guido Kroemer
Article: 1792037
Published online: 20 Jul 2020
AbstractforSurface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis | Full Text | References | PDF (1.4 MB) | EPUB
  • 2356 Views
  • 17 CrossRef citations
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Research Article

Article
An integrated classifier improves prognostic accuracy in non-metastatic gastric cancer
Xiaofang Xing, Shuqin Jia, Yuxin Leng, Qian Wang, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Hong Du, Ying Hu, Qin Feng, Shenyi Lian, Fengming Luan, Xiaoxiao Ma, Zhe Li, Ming Ni, Ziyu Li & Jiafu Ji
Article: 1792038
Published online: 30 Aug 2020
AbstractforAn integrated classifier improves prognostic accuracy in non-metastatic gastric cancer | Full Text | References | PDF (5.9 MB) | EPUB
  • 4458 Views
  • 8 CrossRef citations
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Open Access

Editorial

Editorial
An unexpected link between immunogenic cell death and inhibition of gene transcription
Juliette Humeau, Allan Sauvat, Oliver Kepp & Guido Kroemer
Article: 1792039
Published online: 08 Jul 2020
First Page PreviewforAn unexpected link between immunogenic cell death and inhibition of gene transcription | Full Text | References | PDF (1.6 MB) | EPUB
  • 1223 Views
  • 3 CrossRef citations
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Open Access

Research Article

Article
Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination
Tanja Lövgren, Maria Wolodarski, Stina Wickström, Ulrika Edbäck, Mette Wallin, Eva Martell, Katrin Markland, Pontus Blomberg, Maria Nyström, Andreas Lundqvist, Hans Jacobsson, Gustav Ullenhag, Per Ljungman, Johan Hansson, Giuseppe Masucci, Roger Tell, Isabel Poschke, Lars Adamson, Jonas Mattsson & Rolf Kiessling
Article: 1792058
Published online: 11 Jul 2020
AbstractforComplete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination | Full Text | References | PDF (3.6 MB) | EPUB
  • 5666 Views
  • 28 CrossRef citations
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Open Access

Review

Review
RNA-electroporated T cells for cancer immunotherapy
Fernanda Pohl-Guimarães, Lan B. Hoang-Minh & Duane A. Mitchell
Article: 1792625
Published online: 07 Oct 2020
AbstractforRNA-electroporated T cells for cancer immunotherapy | Full Text | References | PDF (3.4 MB) | EPUB
  • 2459 Views
  • 6 CrossRef citations
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Review
SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4
Lorena Carmona-Rodríguez, Diego Martínez-Rey, Emilia Mira & Santos Mañes
Article: 1794163
Published online: 12 Jul 2020
AbstractforSOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4 | Full Text | References | PDF (1.9 MB) | EPUB
  • 2050 Views
  • 8 CrossRef citations
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Research Article

Article
B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma
Claudia Minici, Elena Rigamonti, Marco Lanzillotta, Antonella Monno, Lucrezia Rovati, Takashi Maehara, Naoki Kaneko, Vikram Deshpande, Maria Pia Protti, Lucia De Monte, Cristina Scielzo, Stefano Crippa, Paolo Giorgio Arcidiacono, Erica Dugnani, Lorenzo Piemonti, Massimo Falconi, Shiv Pillai, Angelo A. Manfredi & Emanuel Della-Torre
Article: 1794359
Published online: 16 Jul 2020
AbstractforB lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma | Full Text | References | PDF (8.7 MB) | EPUB
  • 2954 Views
  • 22 CrossRef citations
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Open Access

Review

Review
Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors
Romain Daillère, Bertrand Routy, Anne-Gaëlle Goubet, Alexandria Cogdill, Gladys Ferrere, Carolina Alves-Costa Silva, Aurélie Fluckiger, Pierre Ly, Yacine Haddad, Eugenie Pizzato, Cassandra Thelemaque, Marine Fidelle, Marine Mazzenga, Maria Paula Roberti, Cléa Melenotte, Peng Liu, Safae Terrisse, Oliver Kepp, Guido Kroemer, Laurence Zitvogel & Lisa Derosa
Article: 1794423
Published online: 20 Jul 2020
AbstractforElucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors | Full Text | References | PDF (1.1 MB) | EPUB
  • 2894 Views
  • 7 CrossRef citations
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Review
Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?
Shashi Gujar, Jonathan G. Pol, Youra Kim & Guido Kroemer
Article: 1794424
Published online: 16 Jul 2020
AbstractforRepurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic? | Full Text | References | PDF (1 MB) | EPUB
  • 4656 Views
  • 9 CrossRef citations
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Open Access

Editorial

Editorial
Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancer
Oliver Kepp, Laurence Zitvogel & Guido Kroemer
Article: 1795995
Published online: 21 Jul 2020
AbstractforLurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancer | Full Text | References | PDF (745.2 KB) | EPUB
  • 2410 Views
  • 28 CrossRef citations
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Open Access

Review

Review
Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
Giorgio Frega, Qi Wu, Julie Le Naour, Erika Vacchelli, Lorenzo Galluzzi, Guido Kroemer & Oliver Kepp
Article: 1796002
Published online: 21 Jul 2020
AbstractforTrial Watch: experimental TLR7/TLR8 agonists for oncological indications | Full Text | References | PDF (717.2 KB) | EPUB
  • 7961 Views
  • 59 CrossRef citations
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Open Access
Review
The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions
Anastasia Lanzi, F. A. Sinicrope, A. B. Benson & Jérôme Galon
Article: 1796003
Published online: 20 Jul 2020
AbstractforThe consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions | Full Text | References | PDF (888.2 KB) | EPUB
  • 1737 Views
  • 1 CrossRef citations
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Open Access

Editorial

Editorial
Mitochondrial control of innate immune signaling by irradiated cancer cells
Takahiro Yamazaki & Lorenzo Galluzzi
Article: 1797292
Published online: 22 Jul 2020
AbstractforMitochondrial control of innate immune signaling by irradiated cancer cells | Full Text | References | PDF (748.5 KB) | EPUB
  • 2170 Views
  • 22 CrossRef citations
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Open Access

Brief Report

Brief Report
Anti-tumor immunity influences cancer cell reliance upon ATG7
Michael D. Arensman, Xiaoran S. Yang, Wenyan Zhong, Stephanie Bisulco, Erik Upeslacis, Edward C. Rosfjord, Shibing Deng, Robert T. Abraham & Christina H. Eng
Article: 1800162
Published online: 23 Aug 2020
AbstractforAnti-tumor immunity influences cancer cell reliance upon ATG7 | Full Text | References | PDF (5.2 MB) | EPUB
  • 2460 Views
  • 15 CrossRef citations
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Open Access

Review

Review
Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria
Ilana Livyatan, Deborah Nejman, Noam Shental & Ravid Straussman
Article: 1800957
Published online: 29 Jul 2020
AbstractforCharacterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria | Full Text | References | PDF (1.3 MB) | EPUB
  • 3705 Views
  • 24 CrossRef citations
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Research Article

Article
Intratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responses
Zhuoyi Xiang, Quan Zhou, Han Zeng, Zewei Wang, Hongyu Zhang, Zhaopei Liu, Qiuren Huang, Yuan Chang, Qi Bai, Yu Xia, Yiwei Wang, Li Liu, Yu Zhu, Le Xu, Bo Dai, Jiajun Wang, Jianming Guo & Jiejie Xu
Article: 1802176
Published online: 12 Aug 2020
AbstractforIntratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responses | Full Text | References | PDF (3.6 MB) | EPUB
  • 1796 Views
  • 4 CrossRef citations
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Open Access

Brief Report

Brief Report
Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice
Lien Van Hoecke, Stephanie Riederer, Xavier Saelens, Gerd Sutter & Juan J. Rojas
Article: 1802968
Published online: 20 Aug 2020
AbstractforRecombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice | Full Text | References | PDF (2.2 MB) | EPUB
  • 2460 Views
  • 15 CrossRef citations
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Open Access
Brief Report
Primary and metastatic breast tumors cross-talk to influence immunotherapy responses
Amanda J Oliver, Simon P Keam, Bianca von Scheidt, Damien J Zanker, Aaron J Harrison, Daniela GM Tantalo, Phillip K Darcy, Michael H Kershaw & Clare Y Slaney
Article: 1802979
Published online: 30 Aug 2020
AbstractforPrimary and metastatic breast tumors cross-talk to influence immunotherapy responses | Full Text | References | PDF (4.5 MB) | EPUB
  • 2111 Views
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Research Article

Article
Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells
Chih-Long Chang, Chao-Chih Wu, Yun-Ting Hsu & Yi-Chiung Hsu
Article: 1803530
Published online: 20 Aug 2020
AbstractforImmune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells | Full Text | References | PDF (6.9 MB) | EPUB
  • 1995 Views
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Article
Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response
Andromachi Kotsafti, Melania Scarpa, Francesco Cavallin, Matteo Fassan, Roberta Salmaso, Andrea Porzionato, Luca Saadeh, Matteo Cagol, Rita Alfieri, Carlo Castoro, Massimo Rugge, Ignazio Castagliuolo & Marco Scarpa
Article: 1804169
Published online: 12 Aug 2020
AbstractforImmune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response | Full Text | References | PDF (4.4 MB) | EPUB
  • 1480 Views
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Brief Report

Brief Report
Tropomyosin autoantibodies associated with checkpoint inhibitor myositis
Pauline Zaenker, David Prentice & Melanie Ziman
Article: 1804703
Published online: 12 Aug 2020
AbstractforTropomyosin autoantibodies associated with checkpoint inhibitor myositis | Full Text | References | PDF (283.4 KB) | EPUB
  • 1333 Views
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Research Article

Article
Metastasis immune-based scores predict patient survival
Bernhard Mlecnik, Gabriela Bindea, Marc Van den Eynde & Jérôme Galon
Article: 1806000
Published online: 20 Aug 2020
AbstractforMetastasis immune-based scores predict patient survival | Full Text | References | PDF (1.2 MB) | EPUB
  • 1460 Views
  • 4 CrossRef citations
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Article
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models
Diyuan Qin, Dan Li, Benxia Zhang, Yue Chen, Xuelian Liao, Xiaoyu Li, Peter B. Alexander, Yongsheng Wang & Qi-Jing Li
Article: 1806009
Published online: 15 Aug 2020
AbstractforPotential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models | Full Text | References | PDF (3.6 MB) | EPUB
  • 3848 Views
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Editorial

Editorial
NK cells beat T cells at early breast cancer control
Aitziber Buque, Norma Bloy, Giulia Petroni, Guido Kroemer & Lorenzo Galluzzi
Article: 1806010
Published online: 23 Aug 2020
AbstractforNK cells beat T cells at early breast cancer control | Full Text | References | PDF (558.5 KB) | EPUB
  • 1746 Views
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Brief Report

Brief Report
IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice
Leland G. Richardson, Linda T. Nieman, Anat O. Stemmer-Rachamimov, Xijin S. Zheng, Khalifa Stafford, Hiroaki Nagashima, Julie J. Miller, Juri Kiyokawa, David T. Ting, Hiroaki Wakimoto, Daniel P. Cahill, Bryan D. Choi & William T. Curry
Article: 1806662
Published online: 20 Aug 2020
AbstractforIDH-mutant gliomas harbor fewer regulatory T cells in humans and mice | Full Text | References | PDF (2.2 MB) | EPUB
  • 2969 Views
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Original Research

Article
Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC)
Carl Christoph Schimanski, Stefan Kasper, Susanna Hegewisch-Becker, Jan Schröder, Friedrich Overkamp, Frank Kullmann, Wolf Otto Bechstein, Matthias Vöhringer, Robert Öllinger, Florian Lordick, Volker Heinemann, Michael Geißler, Armin Schulz-Abelius, Helga Bernhard, Michael R. Schön, Richard Greil, Peter Galle, Hauke Lang, Irene Schmidtmann & Markus Moehler
Article: 1806680
Published online: 23 Aug 2020
AbstractforAdjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC) | Full Text | References | PDF (1.1 MB) | EPUB
  • 2650 Views
  • 9 CrossRef citations
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Article
Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis
Baihui Li, Bailu Zhang, Xuezhou Wang, Ziqing Zeng, Ziqi Huang, Lin Zhang, Feng Wei, Xiubao Ren & Lili Yang
Article: 1807291
Published online: 28 Aug 2020
AbstractforExpression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis | Full Text | References | PDF (5.3 MB) | EPUB
  • 8950 Views
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Review

Review
Immune responses during COVID-19 infection
Cléa Melenotte, Aymeric Silvin, Anne-Gaëlle Goubet, Imran Lahmar, Agathe Dubuisson, Alimuddin Zumla, Didier Raoult, Mansouria Merad, Bertrand Gachot, Clémence Hénon, Eric Solary, Michaela Fontenay, Fabrice André, Markus Maeurer, Giuseppe Ippolito, Mauro Piacentini, Fu-Sheng Wang, Florent Ginhoux, Aurélien Marabelle, Guido Kroemer, Lisa Derosa & Laurence Zitvogel
Article: 1807836
Published online: 25 Aug 2020
AbstractforImmune responses during COVID-19 infection | Full Text | References | PDF (5.9 MB) | EPUB
  • 18141 Views
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Research Article

Article
Human innate immune cell crosstalk induces melanoma cell senescence
Felix Funck, Jens Pahl, Lenka Kyjacova, Lukas Freund, Stephanie Oehrl, Galina Gräbe, Silvia Pezer, Jessica C. Hassel, Jonathan Sleeman, Adelheid Cerwenka & Knut Schäkel
Article: 1808424
Published online: 30 Aug 2020
AbstractforHuman innate immune cell crosstalk induces melanoma cell senescence | Full Text | References | PDF (6.9 MB) | EPUB
  • 2063 Views
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Brief Report

Brief Report
Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
Zoila A. Lopez-Bujanda, Matthew G. Chaimowitz, Todd D. Armstrong, Jeremy B. Foote, Leisha A. Emens & Charles G. Drake
Article: 1809926
Published online: 06 Sep 2020
AbstractforRobust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen | Full Text | References | PDF (3.9 MB) | EPUB
  • 2119 Views
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Review

Review
Firing up the cold tumors by targeting Vps34
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem & Muhammad Zaeem Noman
Article: 1809936
Published online: 31 Aug 2020
AbstractforFiring up the cold tumors by targeting Vps34 | Full Text | References | PDF (792 KB) | EPUB
  • 3334 Views
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Brief Report

Brief Report
β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer
Caihong Wang, Jingjing Yan, Pan Yin, Liming Gui, Lu Ji, Bin Ma & Wei-Qiang Gao
Article: 1809947
Published online: 31 Aug 2020
Abstractforβ-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer | Full Text | References | PDF (2.3 MB) | EPUB
  • 3544 Views
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Research Article

Article
Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer
Sarah Schmidt, Weldy V. Bonilla, Andrea Reiter, Felix Stemeseder, Theresa Kleissner, Daniel Oeler, Ursula Berka, Ahmed El-Gazzar, Bettina Kiefmann, Sophie C. Schulha, Josipa Raguz, Mohamed Habbeddine, Marilies Scheinost, Xiaoping Qing, Henning Lauterbach, Igor Matushansky, Daniel D. Pinschewer & Klaus K. Orlinger
Article: 1809960
Published online: 15 Sep 2020
AbstractforLive-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancer | Full Text | References | PDF (1.2 MB) | EPUB
  • 3926 Views
  • 9 CrossRef citations
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Article
Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundance
Qiuren Huang, Quan Zhou, Hongyu Zhang, Zhaopei Liu, Han Zeng, Yifan Chen, Yang Qu, Ying Xiong, Jiajun Wang, Yuan Chang, Yu Xia, Yiwei Wang, Li Liu, Yu Zhu, Le Xu, Bo Dai, Jianming Guo, Zewei Wang, Qi Bai & Weijuan Zhang
Article: 1810489
Published online: 28 Aug 2020
AbstractforIdentification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundance | Full Text | References | PDF (3.2 MB) | EPUB
  • 1874 Views
  • 7 CrossRef citations
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Article
Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade
Rita Greco, Hongjing Qu, Hui Qu, Joachim Theilhaber, Gary Shapiro, Richard Gregory, Christopher Winter, Natalia Malkova, Frank Sun, Julie Jaworski, Annie Best, Lily Pao, Andrew Hebert, Mikhail Levit, Alexei Protopopov, Jack Pollard, Keith Bahjat, Dmitri Wiederschain & Sharad Sharma
Article: 1811605
Published online: 13 Sep 2020
AbstractforPan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade | Full Text | References | PDF (9.6 MB) | EPUB
  • 4399 Views
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Review

Review
The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisions
Franck Pagès, Julien Taieb, Pierre Laurent-Puig & Jérôme Galon
Article: 1812221
Published online: 28 Aug 2020
AbstractforThe consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisions | Full Text | References | PDF (590.1 KB) | EPUB
  • 1979 Views
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Research Article

Article
Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma
Guiying Sun, Hua Ye, Xiao Wang, Lin Cheng, Pengfei Ren, Jianxiang Shi, Liping Dai, Peng Wang & Jianying Zhang
Article: 1814515
Published online: 09 Sep 2020
AbstractforIdentification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
  • 1486 Views
  • 7 CrossRef citations
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Article
Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response
Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Yuichiro Hagiya, Hirotake Tsukamoto, Tianyi Liu, Tatsuaki Iwama, Masateru Yamamoto, Chiahsuan Lin, Ryusuke Nakatsuka, Yuta Mishima, Noriko Watanabe, Takashi Yamada, Satoru Senju, Shin Kaneko, Alimjan Idiris, Tetsuya Nakatsura, Hideki Ohdan & Yasushi Uemura
Article: 1814620
Published online: 06 Sep 2020
AbstractforGeneration of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response | Full Text | References | PDF (13.7 MB) | EPUB
  • 3248 Views
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Brief Report

Brief Report
Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model
Renske J. E. van den Bijgaart, Michiel Kroesen, Ingrid C. Brok, Daphne Reijnen, Melissa Wassink, Louis Boon, Peter M. Hoogerbrugge & Gosse J Adema
Article: 1817653
Published online: 20 Sep 2020
AbstractforAnti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma model | Full Text | References | PDF (6.9 MB) | EPUB
  • 2085 Views
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Original Research

Article
Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse model
Pravin T. P. Kaumaya, Linlin Guo, Jay Overholser, Manuel L. Penichet & Tanios Bekaii-Saab
Article: 1818437
Published online: 01 Oct 2020
AbstractforImmunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse model | Full Text | References | PDF (3.6 MB) | EPUB
  • 7714 Views
  • 19 CrossRef citations
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Review

Review
Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
Xing Huang, Gang Zhang, Xueli Bai & Tingbo Liang
Article: 1818438
Published online: 13 Sep 2020
AbstractforReviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective | Full Text | References | PDF (611.8 KB) | EPUB
  • 2002 Views
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Author's View

Article
Multiverse of immune microenvironment in metastatic colorectal cancer
Marc Van den Eynde, Bernhard Mlecnik, Gabriela Bindea & Jérôme Galon
Article: 1824316
Published online: 29 Sep 2020
AbstractforMultiverse of immune microenvironment in metastatic colorectal cancer | Full Text | References | PDF (964.2 KB) | EPUB
  • 1692 Views
  • 9 CrossRef citations
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Original Research

Article
Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation
Mark A. J. M. Hendriks, Emily M. Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F. Samplonius & Wijnand Helfrich
Article: 1824323
Published online: 29 Sep 2020
AbstractforBispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation | Full Text | References | PDF (4.1 MB) | EPUB
  • 3692 Views
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Article
Pirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in mice
Wan Qin, Jun Zou, Yongbiao Huang, Chaofan Liu, Yalin Kang, Hu Han, Yang Tang, Long Li, Bo Liu, Weiheng Zhao & Xianglin Yuan
Article: 1824631
Published online: 22 Sep 2020
AbstractforPirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in mice | Full Text | References | PDF (8.6 MB) | EPUB
  • 3121 Views
  • 16 CrossRef citations
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Article
Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression
M. Pötzsch, E. Berg, M. Hummel, U. Stein, M. von Winterfeld, K. Jöhrens, B. Rau, S. Daum & C. Treese
Article: 1824632
Published online: 30 Sep 2020
AbstractforBetter prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression | Full Text | References | PDF (9.3 MB) | EPUB
  • 1656 Views
  • 8 CrossRef citations
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Article
Identification of a costimulatory molecule-based signature for predicting prognosis risk and immunotherapy response in patients with lung adenocarcinoma
Chaoqi Zhang, Zhihui Zhang, Nan Sun, Zhen Zhang, Guochao Zhang, Feng Wang, Yuejun Luo, Yun Che & Jie He
Article: 1824641
Published online: 29 Sep 2020
AbstractforIdentification of a costimulatory molecule-based signature for predicting prognosis risk and immunotherapy response in patients with lung adenocarcinoma | Full Text | References | PDF (5.8 MB) | EPUB
  • 4414 Views
  • 33 CrossRef citations
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Article
Cancer testis antigens in myelodysplastic syndromes revisited: a targeted RNA-seq approach
Ana María Hurtado López, Tzu Hua Chen-Liang, María Zurdo, Salvador Carrillo-Tornel, Joaquín Panadero, Eduardo José Salido, Victor Beltrán, Begoña Muiña, MariLuz Amigo, Noelia Navarro-Villamor, Rosa Cifuentes, Inés Calabria, Ana Isabel Antón, Raúl Teruel, Manuel Muro, Vicente Vicente & Andrés Jerez
Article: 1824642
Published online: 01 Oct 2020
AbstractforCancer testis antigens in myelodysplastic syndromes revisited: a targeted RNA-seq approach | Full Text | References | PDF (2.5 MB) | EPUB
  • 1730 Views
  • 5 CrossRef citations
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Article
Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway
Na Li, Na Tang, Chen Cheng, Tao Hu, Xiaofei Wei, Weidong Han & Haoyi Wang
Article: 1824643
Published online: 24 Sep 2020
AbstractforImproving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway | Full Text | References | PDF (4 MB) | EPUB
  • 3817 Views
  • 21 CrossRef citations
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Article
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
Mari Tinholt, Benedicte Stavik, Xavier Tekpli, Øystein Garred, Elin Borgen, Vessela Kristensen, Kristine Kleivi Sahlberg, Per Morten Sandset & Nina Iversen
Article: 1824644
Published online: 29 Sep 2020
AbstractforCoagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer | Full Text | References | PDF (7.4 MB) | EPUB
  • 2183 Views
  • 16 CrossRef citations
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Article
Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinoma
Alexandra Drakaki, Preet K Dhillon, Heather Wakelee, Stephen Y Chui, Jinjoo Shim, Matthew Kent, Viraj Degaonkar, Tien Hoang, Virginia McNally, Patricia Luhn & Ralf Gutzmer
Article: 1824645
Published online: 05 Oct 2020
AbstractforAssociation of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinoma | Full Text | References | PDF (987.4 KB) | EPUB
  • 2536 Views
  • 28 CrossRef citations
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Article
Immunotherapy or other anti-cancer treatments and risk of exacerbation and mortality in cancer patients with COVID-19: a systematic review and meta-analysis
Bolin Wang & Yan Huang
Article: 1824646
Published online: 22 Sep 2020
AbstractforImmunotherapy or other anti-cancer treatments and risk of exacerbation and mortality in cancer patients with COVID-19: a systematic review and meta-analysis | Full Text | References | PDF (2.6 MB) | EPUB
  • 3364 Views
  • 16 CrossRef citations
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Article
Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients
Suresh Gopi Kalathil, Katy Wang, Alan Hutson, Renuka Iyer & Yasmin Thanavala
Article: 1824863
Published online: 30 Sep 2020
AbstractforTivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients | Full Text | References | PDF (1.7 MB) | EPUB
  • 2360 Views
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Brief Report

Brief Report
Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting
Stefan Grote, Joerg Mittelstaet, Caroline Baden, Kenneth Chun-Ho Chan, Christian Seitz, Patrick Schlegel, Andrew Kaiser, Rupert Handgretinger & Sabine Schleicher
Article: 1825177
Published online: 29 Sep 2020
AbstractforAdapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting | Full Text | References | PDF (2.6 MB) | EPUB
  • 3449 Views
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Original Research

Article
Differential gene expression of tumor-infiltrating CD4+ T cells in advanced versus early stage colorectal cancer and identification of a gene signature of poor prognosis
Varun Sasidharan Nair, Reem Saleh, Rowaida Z Taha, Salman M Toor, Khaled Murshed, Ayman A Ahmed, Mohamed A Kurer, Mohamed Abu Nada, Fares Al Ejeh & Eyad Elkord
Article: 1825178
Published online: 30 Sep 2020
AbstractforDifferential gene expression of tumor-infiltrating CD4+ T cells in advanced versus early stage colorectal cancer and identification of a gene signature of poor prognosis | Full Text | References | PDF (8.2 MB) | EPUB
  • 1676 Views
  • 5 CrossRef citations
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Author's View

Review
No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international study
Paolo A. Ascierto, Francesco M. Marincola, Bernard A. Fox & Jérôme Galon
Article: 1826132
Published online: 13 Oct 2020
AbstractforNo time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international study | Full Text | References | PDF (1 MB) | EPUB
  • 2556 Views
  • 9 CrossRef citations
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Open Access
Review
Immunity to live: an immunopathoscore using the consensus Immunoscore to best define the risk of recurrence and death in stage IV metastatic patients
Pamela Baldin, Marc Van den Eynde, Bernhard Mlecnik & Jérôme Galon
Article: 1826133
Published online: 13 Oct 2020
AbstractforImmunity to live: an immunopathoscore using the consensus Immunoscore to best define the risk of recurrence and death in stage IV metastatic patients | Full Text | References | PDF (1.1 MB) | EPUB
  • 1487 Views
  • 4 CrossRef citations
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Original Research

Article
Significantly different immunological score in lung adenocarcinoma and squamous cell carcinoma and a proposal for a new immune staging system
Ziqing Zeng, Fan Yang, Yunliang Wang, Hua Zhao, Feng Wei, Peng Zhang, Xiying Zhang & Xiubao Ren
Article: 1828538
Published online: 07 Oct 2020
AbstractforSignificantly different immunological score in lung adenocarcinoma and squamous cell carcinoma and a proposal for a new immune staging system | Full Text | References | PDF (8.9 MB) | EPUB
  • 3183 Views
  • 19 CrossRef citations
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Open Access
Article
Resveratrol exerts antitumor effects by downregulating CD8+CD122+ Tregs in murine hepatocellular carcinoma
Qunfang Zhang, Haiding Huang, Fang Zheng, Huazhen Liu, Feifei Qiu, Yuchao Chen, Chun-Ling Liang & Zhenhua Dai
Article: 1829346
Published online: 24 Oct 2020
AbstractforResveratrol exerts antitumor effects by downregulating CD8+CD122+ Tregs in murine hepatocellular carcinoma | Full Text | References | PDF (12.5 MB) | EPUB
  • 2580 Views
  • 38 CrossRef citations
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Article
Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes
Yen-Liang Li, Chung-Hsing Chen, Jing-Yi Chen, You-Syuan Lai, Shao-Chun Wang, Shih-Sheng Jiang & Wen-Chun Hung
Article: 1830513
Published online: 19 Oct 2020
AbstractforSingle-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes | Full Text | References | PDF (8.8 MB) | EPUB
  • 7269 Views
  • 18 CrossRef citations
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Open Access
Article
Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade
Karsten A. Pilones, Michal Hensler, Camille Daviaud, Jeffrey Kraynak, Jitka Fucikova, Lorenzo Galluzzi, Sandra Demaria & Silvia C. Formenti
Article: 1830524
Published online: 20 Oct 2020
AbstractforConverging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade | Full Text | References | PDF (2 MB) | EPUB
  • 3445 Views
  • 32 CrossRef citations
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Article
Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER export
Fang-Fang Chen, Zheng Li, Dawei Ma & Qiang Yu
Article: 1831153
Published online: 14 Oct 2020
AbstractforSmall-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER export | Full Text | References | PDF (4.6 MB) | EPUB
  • 5540 Views
  • 28 CrossRef citations
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Author's View

Review
Usefulness and robustness of Immunoscore for personalized management of cancer patients
Florence Marliot, Franck Pagès & Jérôme Galon
Article: 1832324
Published online: 13 Oct 2020
AbstractforUsefulness and robustness of Immunoscore for personalized management of cancer patients | Full Text | References | PDF (1.2 MB) | EPUB
  • 1869 Views
  • 11 CrossRef citations
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Open Access

Original Research

Article
Immune infiltration and immune gene signature predict the response to fluoropyrimidine-based chemotherapy in colorectal cancer patients
Xianwei Mo, Xiaoliang Huang, Yan Feng, Chunyin Wei, Haizhou Liu, Haiming Ru, Haiquan Qin, Hao Lai, Guo Wu, Weishun Xie, Franco Jeen, Yuan Lin, Jungang Liu & Weizhong Tang
Article: 1832347
Published online: 19 Oct 2020
AbstractforImmune infiltration and immune gene signature predict the response to fluoropyrimidine-based chemotherapy in colorectal cancer patients | Full Text | References | PDF (9.2 MB) | EPUB
  • 2409 Views
  • 16 CrossRef citations
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Open Access
Article
Baseline plasma levels of soluble PD-1, PD-L1, and BTN3A1 predict response to nivolumab treatment in patients with metastatic renal cell carcinoma: a step toward a biomarker for therapeutic decisions
Lorena Incorvaia, Daniele Fanale, Giuseppe Badalamenti, Camillo Porta, Daniel Olive, Ida De Luca, Chiara Brando, Mimma Rizzo, Carlo Messina, Mattia Rediti, Antonio Russo, Viviana Bazan & Juan Lucio Iovanna
Article: 1832348
Published online: 27 Oct 2020
AbstractforBaseline plasma levels of soluble PD-1, PD-L1, and BTN3A1 predict response to nivolumab treatment in patients with metastatic renal cell carcinoma: a step toward a biomarker for therapeutic decisions | Full Text | References | PDF (2.5 MB) | EPUB
  • 3239 Views
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Open Access

Review

Review
Immunotherapy as sensitizer for local radiotherapy
Ben G.L. Vanneste, Evert J Van Limbergen, Ludwig Dubois, Iryna V. Samarska, L. Wieten, M. J.B. Aarts, T. Marcelissen & Dirk De Ruysscher
Article: 1832760
Published online: 30 Oct 2020
AbstractforImmunotherapy as sensitizer for local radiotherapy | Full Text | References | PDF (886.8 KB) | EPUB
  • 2447 Views
  • 20 CrossRef citations
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Original Research

Article
Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis
Sandrine Nugteren, Jeroen A.C.M. Goos, Pien M. Delis-van Diemen, Ytje Simons-Oosterhuis, Dicky J. Lindenbergh-Kortleve, Daniëlle H. van Haaften, Joyce Sanders, Gerrit A. Meijer, Remond J.A. Fijneman & Janneke N. Samsom
Article: 1832761
Published online: 13 Oct 2020
AbstractforExpression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis | Full Text | References | PDF (15.5 MB) | EPUB
  • 1651 Views
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Article
Angiotensin-converting enzyme (ACE) inhibitor prescription affects non-small-cell lung cancer (NSCLC) patients response to PD-1/PD-L1 immune checkpoint blockers
Soleine Medjebar, Caroline Truntzer, Anaïs Perrichet, Emeric Limagne, Jean-David Fumet, Corentin Richard, Arielle Elkrief, Bertrand Routy, Cédric Rébé & François Ghiringhelli
Article: 1836766
Published online: 27 Oct 2020
AbstractforAngiotensin-converting enzyme (ACE) inhibitor prescription affects non-small-cell lung cancer (NSCLC) patients response to PD-1/PD-L1 immune checkpoint blockers | Full Text | References | PDF (2.9 MB) | EPUB
  • 2292 Views
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Article
Reduction of CD11b+ myeloid suppressive cells augments anti-neuroblastoma immune response induced by the anti-GD2 antibody ch14.18/CHO
Nikolai Siebert, Maxi Zumpe, Leon von Lojewski, Sascha Troschke-Meurer, Madlen Marx & Holger N. Lode
Article: 1836768
Published online: 24 Oct 2020
AbstractforReduction of CD11b+ myeloid suppressive cells augments anti-neuroblastoma immune response induced by the anti-GD2 antibody ch14.18/CHO | Full Text | References | PDF (2.2 MB) | EPUB
  • 1475 Views
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Article
Tumor-infiltrating TNFRSF9+ CD8+ T cells define different subsets of clear cell renal cell carcinoma with prognosis and immunotherapeutic response
Yaohui Li, Zewei Wang, Wenbin Jiang, Han Zeng, Zhaopei Liu, Zhiyuan Lin, Yang Qu, Ying Xiong, Jiajun Wang, Yuan Chang, Qi Bai, Yiwei Wang, Li Liu, Yu Zhu, Le Xu, Yu Xia, Jianming Guo & Jiejie Xu
Article: 1838141
Published online: 27 Oct 2020
AbstractforTumor-infiltrating TNFRSF9+ CD8+ T cells define different subsets of clear cell renal cell carcinoma with prognosis and immunotherapeutic response | Full Text | References | PDF (11.1 MB) | EPUB
  • 3693 Views
  • 21 CrossRef citations
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Article
Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2]
Satoshi Takeuchi, Masahiro Kagabu, Tadahiro Shoji, Yukari Nitta, Toru Sugiyama, Junya Sato & Yusuke Nakamura
Article: 1838189
Published online: 11 Nov 2020
AbstractforAnti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2] | Full Text | References | PDF (11.3 MB) | EPUB
  • 2731 Views
  • 7 CrossRef citations
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Article
IAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunity
Kosei Nakajima, Yoshinori Ino, Rie Yamazaki-Itoh, Chie Naito, Mari Shimasaki, Mami Takahashi, Minoru Esaki, Satoshi Nara, Yoji Kishi, Kazuaki Shimada & Nobuyoshi Hiraoka
Article: 1838812
Published online: 27 Oct 2020
AbstractforIAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunity | Full Text | References | PDF (7.6 MB) | EPUB
  • 1681 Views
  • 10 CrossRef citations
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Article
Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse
Qianqian Guo, Lizheng Wang, Ping Xu, Fei Geng, Jie Guo, Ling Dong, Xin Bao, Yi Zhou, Mengfan Feng, Jiaxin Wu, Hui Wu, Bin Yu, Haihong Zhang, Xianghui Yu & Wei Kong
Article: 1841392
Published online: 09 Nov 2020
AbstractforHeterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse | Full Text | References | PDF (8.8 MB) | EPUB
  • 1943 Views
  • 8 CrossRef citations
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Editorial

Editorial
Regulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell death
Lígia C. Gomes-da-Silva, Oliver Kepp & Guido Kroemer
Article: 1841393
Published online: 27 Oct 2020
AbstractforRegulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell death | Full Text | References | PDF (650.2 KB) | EPUB
  • 3351 Views
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Original Research

Article
Hist-Immune signature: a prognostic factor in colorectal cancer using immunohistochemical slide image analysis
Ke Zhao, Zhenhui Li, Yong Li, Su Yao, Yanqi Huang, Yingyi Wang, Fang Zhang, Lin Wu, Xin Chen, Changhong Liang & Zaiyi Liu
Article: 1841935
Published online: 30 Oct 2020
AbstractforHist-Immune signature: a prognostic factor in colorectal cancer using immunohistochemical slide image analysis | Full Text | References | PDF (951.8 KB) | EPUB
  • 1449 Views
  • 3 CrossRef citations
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Article
Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
Rosa M. Jimenez-Rodriguez, Sujata Patil, Ajaratu Keshinro, Jinru Shia, Efsevia Vakiani, Zsofia Stadler, Neil H. Segal, Rona Yaeger, Tsuyoshi Konishi, Yoshifumi Shimada, Maria Widmar, Iris Wei, Emmanouil Pappou, J. Joshua Smith, Garrett Nash, Philip Paty, Julio Garcia-Aguilar & Martin R. Weiser
Article: 1841948
Published online: 11 Nov 2020
AbstractforQuantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer | Full Text | References | PDF (2.8 MB) | EPUB
  • 1686 Views
  • 2 CrossRef citations
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Article
TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer
Ralph Ja Maas, Janneke S Hoogstad-van Evert, Jolien Mr Van der Meer, Vera Mekers, Somayeh Rezaeifard, Alan J Korman, Paul Kjd de Jonge, Jeannette Cany, Rob Woestenenk, Nicolaas Pm Schaap, Leon F Massuger, Joop H Jansen, Willemijn Hobo & Harry Dolstra
Article: 1843247
Published online: 08 Nov 2020
AbstractforTIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer | Full Text | References | PDF (2.3 MB) | EPUB
  • 4046 Views
  • 45 CrossRef citations
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Article
Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients
Yun Gu, Yifan Chen, Kaifeng Jin, Yifan Cao, Xin Liu, Kunpeng Lv, Xudong He, Chao Lin, Hao Liu, He Li, Hongyong He, Jing Qin, Ruochen Li, Heng Zhang & Weijuan Zhang
Article: 1844402
Published online: 22 Nov 2020
AbstractforIntratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients | Full Text | References | PDF (4.3 MB) | EPUB
  • 1784 Views
  • 13 CrossRef citations
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Review

Review
PD-L1 expression in the microenvironment and the response to checkpoint inhibitors in head and neck squamous cell carcinoma
D. Evrard, M. Hourseau, A. Couvelard, V. Paradis, H. Gauthier, E. Raymond, C. Halimi, B. Barry & S. Faivre
Article: 1844403
Published online: 19 Nov 2020
AbstractforPD-L1 expression in the microenvironment and the response to checkpoint inhibitors in head and neck squamous cell carcinoma | Full Text | References | PDF (2.2 MB) | EPUB
  • 2489 Views
  • 17 CrossRef citations
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Original Research

Article
Tumor-infiltrating podoplanin+ cells in gastric cancer: clinical outcomes and association with immune contexture
Xin Liu, Yifan Cao, Kunpeng Lv, Yun Gu, Kaifeng Jin, Xudong He, Hanji Fang, Yuchao Fei, Mingsu Shi, Chao Lin, Hao Liu, He Li, Hongyong He, Jiejie Xu, Ruochen Li & Heng Zhang
Article: 1845038
Published online: 13 Nov 2020
AbstractforTumor-infiltrating podoplanin+ cells in gastric cancer: clinical outcomes and association with immune contexture | Full Text | References | PDF (9.1 MB) | EPUB
  • 1894 Views
  • 6 CrossRef citations
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Article
NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype
Francesca Marcon, Jianmin Zuo, Hayden Pearce, Samantha Nicol, Sandra Margielewska-Davies, Mustafa Farhat, Brinder Mahon, Gary Middleton, Rachel Brown, Keith J. Roberts & Paul Moss
Article: 1845424
Published online: 19 Nov 2020
AbstractforNK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype | Full Text | References | PDF (6.8 MB) | EPUB
  • 3935 Views
  • 37 CrossRef citations
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Editorial

Editorial
Novel galenic formulations for delivering immunochemotherapies: kill intelligently, remove the checkpoint and let the T cells in!
Oliver Kepp & Guido Kroemer
Article: 1846358
Published online: 16 Nov 2020
CitationforNovel galenic formulations for delivering immunochemotherapies: kill intelligently, remove the checkpoint and let the T cells in! | Full Text | References | PDF (709.6 KB) | EPUB
  • 717 Views
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Original Research

Article
Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma
Christopher Montemagno, Anais Hagege, Delphine Borchiellini, Brice Thamphya, Olivia Rastoin, Damien Ambrosetti, Juan Iovanna, Nathalie Rioux-Leclercq, Camillio Porta, Sylvie Negrier, Jean-Marc Ferrero, Emmanuel Chamorey, Gilles Pagès & Maeva Dufies
Article: 1846901
Published online: 25 Nov 2020
AbstractforSoluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma | Full Text | References | PDF (1,015.5 KB) | EPUB
  • 2306 Views
  • 20 CrossRef citations
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Article
Is the survival of patients treated with ipilimumab affected by antibiotics? An analysis of 1585 patients from the French National hospital discharge summary database (PMSI)
Pierre-Yves Cren, Nicolas Bertrand, Marie-Cécile Le Deley, Michaël Génin, Laurent Mortier, Pascal Odou, Nicolas Penel & Emmanuel Chazard
Article: 1846914
Published online: 22 Nov 2020
AbstractforIs the survival of patients treated with ipilimumab affected by antibiotics? An analysis of 1585 patients from the French National hospital discharge summary database (PMSI) | Full Text | References | PDF (780.8 KB) | EPUB
  • 1522 Views
  • 5 CrossRef citations
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Article
MIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma
Ricardo A. de Azevedo, Einav Shoshan, Shanzhi Whang, Gal Markel, Ashvin R. Jaiswal, Arthur Liu, Michael A. Curran, Luiz R. Travassos & Menashe Bar-Eli
Article: 1846915
Published online: 06 Dec 2020
AbstractforMIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma | Full Text | References | PDF (9.8 MB) | EPUB
  • 5242 Views
  • 39 CrossRef citations
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Article
Efficacy and biomarker analysis of CD133-directed CAR T cells in advanced hepatocellular carcinoma: a single-arm, open-label, phase II trial
Hanren Dai, Chuan Tong, Daiwei Shi, Meixia Chen, Yelei Guo, Deyun Chen, Xiao Han, Hua Wang, Yao Wang & Pingping Shen
Article: 1846926
Published online: 25 Nov 2020
AbstractforEfficacy and biomarker analysis of CD133-directed CAR T cells in advanced hepatocellular carcinoma: a single-arm, open-label, phase II trial | Full Text | References | PDF (651.7 KB) | EPUB
  • 4684 Views
  • 70 CrossRef citations
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Article
Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4
Sung Hee Choi, Emily C. Barker, Kyle J. Gerber, John J. Letterio & Byung-Gyu Kim
Article: 1847832
Published online: 03 Dec 2020
AbstractforLoss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4 | Full Text | References | PDF (8.7 MB) | EPUB
  • 1590 Views
  • 5 CrossRef citations
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Article
A Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1
Neeta Somaiah, Sant P. Chawla, Matthew S. Block, John C. Morris, Khanh Do, Joseph W. Kim, Mihaela Druta, Kamalesh K. Sankhala, Patrick Hwu, Robin L. Jones, Sacha Gnjatic, Seunghee Kim-Schulze, Kevin Tuballes, Mahlet Yishak, Hailing Lu, Adam Yakovich, Jan Ter Meulen, Michael Chen, Richard T. Kenney, Chet Bohac & Seth M. Pollack
Article: 1847846
Published online: 19 Nov 2020
AbstractforA Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1 | Full Text | References | PDF (1.4 MB) | EPUB
  • 2006 Views
  • 20 CrossRef citations
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Article
Skin inflammatory response and efficacy of anti-epidermal growth factor receptor therapy in metastatic colorectal cancer (CUTACETUX)
David Tougeron, Sheik Emambux, Laure Favot, Thierry Lecomte, Ewa Wierzbicka-Hainaut, Mahtab Samimi, Eric Frouin, Nicolas Azzopardi, Jocelyn Chevrier, Laura Serres, Julie Godet, Pierre Levillain, Gilles Paintaud, Aurélie Ferru, Laetitia Rouleau, Adriana Delwail, Christine Silvain, Jean-Pierre Tasu, Franck Morel, Stéphanie Ragot & Jean-Claude Lecron
Article: 1848058
Published online: 29 Nov 2020
AbstractforSkin inflammatory response and efficacy of anti-epidermal growth factor receptor therapy in metastatic colorectal cancer (CUTACETUX) | Full Text | References | PDF (1 MB) | EPUB
  • 1932 Views
  • 5 CrossRef citations
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Article
Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression
Frida Björk Gunnarsdottir, Nathalie Auoja, Pär-Ola Bendahl, Lisa Rydén, Mårten Fernö & Karin Leandersson
Article: 1848067
Published online: 22 Nov 2020
AbstractforCo-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression | Full Text | References | PDF (5.8 MB) | EPUB
  • 1891 Views
  • 7 CrossRef citations
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Article
Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies
Zhenyu Huo, Caichen Li, Xin Xu, Fan Ge, Runchen Wang, Yaokai Wen, Haoxin Peng, Xiangrong Wu, Hengrui Liang, Guilin Peng, Run Li, Danxia Huang, Ying Chen, Ran Zhong, Bo Cheng, Shan Xiong, Weiyi Lin, Jianxing He & Wenhua Liang
Article: 1848068
Published online: 29 Nov 2020
AbstractforCancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies | Full Text | References | PDF (2.2 MB) | EPUB
  • 3082 Views
  • 27 CrossRef citations
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Open Access

Brief Report

Brief Report
Increased occurrence of status epilepticus in patients with brain metastases and checkpoint inhibition
Hans Urban, Laurent M. Willems, Michael W. Ronellenfitsch, Felix Rosenow, Joachim P. Steinbach & Adam Strzelczyk
Article: 1851517
Published online: 29 Nov 2020
AbstractforIncreased occurrence of status epilepticus in patients with brain metastases and checkpoint inhibition | Full Text | References | PDF (574.4 KB) | EPUB
  • 1119 Views
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Original Research

Article
Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy
Marie-Laurence Tremblay, Zoe O’Brien-Moran, James A. Rioux, Andrea Nuschke, Christa Davis, W. Martin Kast, Genevieve Weir, Marianne Stanford & Kimberly D. Brewer
Article: 1851539
Published online: 29 Nov 2020
AbstractforQuantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy | Full Text | References | PDF (4.5 MB) | EPUB
  • 1849 Views
  • 5 CrossRef citations
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Article
Immune-focused multi-omics analysis of prostate cancer: leukocyte Ig-Like receptors are associated with disease progression
Benjamin Vittrant, Alain Bergeron, Oscar Eduardo Molina, Mickael Leclercq, Xavier-Philippe Légaré, Hélène Hovington, Valérie Picard, Marie-Laure Martin-Magniette, Julie Livingstone, Paul C. Boutros, Colin Collins, Yves Fradet & Arnaud Droit
Article: 1851950
Published online: 01 Dec 2020
AbstractforImmune-focused multi-omics analysis of prostate cancer: leukocyte Ig-Like receptors are associated with disease progression | Full Text | References | PDF (6.1 MB) | EPUB
  • 2714 Views
  • 7 CrossRef citations
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Article
Presence of tumor-infiltrating CD8+ T cells and macrophages correlates to longer overall survival in patients undergoing isolated hepatic perfusion for uveal melanoma liver metastasis
Junko Johansson, Jan Siarov, Roberta Kiffin, Johan Mölne, Jan Mattsson, Peter Naredi, Roger Olofsson Bagge, Anna Martner & Per Lindnér
Article: 1854519
Published online: 10 Dec 2020
AbstractforPresence of tumor-infiltrating CD8+ T cells and macrophages correlates to longer overall survival in patients undergoing isolated hepatic perfusion for uveal melanoma liver metastasis | Full Text | References | PDF (3 MB) | EPUB
  • 1630 Views
  • 14 CrossRef citations
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Article
Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response
H. Fang, R. Li, Y. Gu, Yuchao Fei, Kaifeng Jin, Yifan Chen, Yifan Cao, Xin Liu, Kunpeng Lv, Jieti Wang, Kuan Yu, Chao Lin, Hao Liu, He Li, Hongyong He, Weijuan Zhang, Heng Zhang & Zhenbin Shen
Article: 1856468
Published online: 15 Dec 2020
AbstractforIntratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response | Full Text | References | PDF (3.9 MB) | EPUB
  • 1422 Views
  • 8 CrossRef citations
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Article
No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19
Adriana Petrazzuolo, Julie Le Naour, Erika Vacchelli, Pascale Gaussem, Syrine Ellouze, Georges Jourdi, Eric Solary, Michaela Fontenay, David M. Smadja & Guido Kroemer
Article: 1857112
Published online: 08 Dec 2020
AbstractforNo impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19 | Full Text | References | PDF (376.6 KB) | EPUB
  • 1944 Views
  • 2 CrossRef citations
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