Prion, Volume 8, Issue 1 (2014)

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Prion, Volume 8, Issue 1 (2014)

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Editor's Preview

Editorial
A special focus issue on the materials of PRION 2013 meeting in Banff, Alberta Canada
Kevin MW Keough & Neil R Cashman
Page: 1
Published online: 21 Mar 2014
CitationforA special focus issue on the materials of PRION 2013 meeting in Banff, Alberta Canada | Full Text | PDF (120.8 KB)
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Extra View

Is the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic?
Sofie Nyström & Per Hammarström
Pages: 2-10
Published online: 07 Jan 2014
AbstractforIs the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic? | Full Text | References | PDF (1.5 MB)
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Review

Review Article
The GPI-anchoring of PrP
Implications in sorting and pathogenesis
Berta Puig, Hermann Altmeppen & Markus Glatzel
Pages: 11-18
Published online: 07 Feb 2014
AbstractforThe GPI-anchoring of PrP | Full Text | References | PDF (1.1 MB)
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Review Article
In vitro aggregation assays for the characterization of α-synuclein prion-like properties
Joanna Narkiewicz, Gabriele Giachin & Giuseppe Legname
Pages: 19-32
Published online: 19 Feb 2014
AbstractforIn vitro aggregation assays for the characterization of α-synuclein prion-like properties | Full Text | References | PDF (884.9 KB)
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Review Article
Prion-like activity of Cu/Zn superoxide dismutase
Implications for amyotrophic lateral sclerosis
Leslie I Grad & Neil R Cashman
Pages: 33-41
Published online: 01 Jan 2014
AbstractforPrion-like activity of Cu/Zn superoxide dismutase | Full Text | References | PDF (1 MB)
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Review Article
Applying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure
Christopher J Silva
Pages: 42-50
Published online: 07 Feb 2014
AbstractforApplying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure | Full Text | References | PDF (987.8 KB)
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Review Article
Safety, specificity and immunogenicity of a PrPSc-specific prion vaccine based on the YYR disease specific epitope
Ryan Taschuk, Kristen Marciniuk, Pekka Määttänen, Claudia Madampage, Peter Hedlin, Andrew Potter, Jeremy Lee, Neil R. Cashman, Philip J Griebel & Scott Napper
Pages: 51-59
Published online: 07 Feb 2014
AbstractforSafety, specificity and immunogenicity of a PrPSc-specific prion vaccine based on the YYR disease specific epitope | Full Text | References | PDF (1.4 MB)
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Review Article
The structure of the infectious prion protein
Experimental data and molecular models
Jesús R Requena & Holger Wille
Pages: 60-66
Published online: 28 Feb 2014
AbstractforThe structure of the infectious prion protein | Full Text | References | PDF (212.5 KB)
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Review Article
Microdissection and transcriptional profiling
A window into the pathobiology of preclinical prion disease
Anna Majer & Stephanie A Booth
Pages: 67-74
Published online: 09 Jan 2014
AbstractforMicrodissection and transcriptional profiling | Full Text | References | PDF (1 MB)
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Review Article
The aggregation of mutant p53 produces prion-like properties in cancer
Luciana P Rangel, Danielly CF Costa, Tuane CRG Vieira & Jerson L Silva
Pages: 75-84
Published online: 07 Feb 2014
AbstractforThe aggregation of mutant p53 produces prion-like properties in cancer | Full Text | References | PDF (1.1 MB)
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Review Article
Exploring the zoonotic potential of animal prion diseases
In vivo and in vitro approaches
Marcelo A Barria, James W Ironside & Mark W Head
Pages: 85-91
Published online: 18 Feb 2014
AbstractforExploring the zoonotic potential of animal prion diseases | Full Text | References | PDF (891.5 KB)
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Review Article
Potential role of soil properties in the spread of CWD in western Canada
Alsu Kuznetsova, Debbie McKenzie, Pamela Banser, Tariq Siddique & Judd M. Aiken
Pages: 92-99
Published online: 11 Mar 2014
AbstractforPotential role of soil properties in the spread of CWD in western Canada | Full Text | References | PDF (1.7 MB)
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Mini Review

Review Article
Elucidating the role of cofactors in mammalian prion propagation
Surachai Supattapone
Pages: 100-105
Published online: 01 Jan 2013
AbstractforElucidating the role of cofactors in mammalian prion propagation | Full Text | References | PDF (866.3 KB)
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Review Article
Taking advantage of physiological proteolytic processing of the prion protein for a therapeutic perspective in prion and Alzheimer diseases
Maxime Béland & Xavier Roucou
Pages: 106-110
Published online: 01 Jan 2013
AbstractforTaking advantage of physiological proteolytic processing of the prion protein for a therapeutic perspective in prion and Alzheimer diseases | Full Text | References | PDF (854.2 KB)
  • 675 Views
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Review Article
Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases
M Enamul Kabir & Jiri G Safar
Pages: 111-116
Published online: 08 Jan 2014
AbstractforImplications of prion adaptation and evolution paradigm for human neurodegenerative diseases | Full Text | References | PDF (334.3 KB)
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Review Article
Design and syntheses of peptides which induce or enhance structural changes of recombinant bovine prion protein (rbPrP) and discovery of peptides from bovine brain which accelerate structural conversions of rbPrP
Kiyoshi Nokihara, Shunsuke Yajima & Akiyoshi Hirata
Pages: 117-118
Published online: 07 Feb 2014
AbstractforDesign and syntheses of peptides which induce or enhance structural changes of recombinant bovine prion protein (rbPrP) and discovery of peptides from bovine brain which accelerate structural conversions of rbPrP | Full Text | References | PDF (1.1 MB)
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Review Article
D-amino acid-based peptide inhibitors as early or preventative therapy in Alzheimer disease
Jitendra Kumar & Valerie Sim
Pages: 119-124
Published online: 19 Feb 2014
AbstractforD-amino acid-based peptide inhibitors as early or preventative therapy in Alzheimer disease | Full Text | References | PDF (1 MB)
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Research Paper

Article
Different misfolding mechanisms converge on common conformational changes
Human prion protein pathogenic mutants Y218N and E196K
Chin Jung Cheng & Valerie Daggett
Pages: 125-135
Published online: 07 Feb 2014
AbstractforDifferent misfolding mechanisms converge on common conformational changes | Full Text | References | PDF (3.9 MB)
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Article
Can plants serve as a vector for prions causing chronic wasting disease?
Jay Rasmussen, Brandon H Gilroyed, Tim Reuter, Sandor Dudas, Norman F Neumann, Aru Balachandran, Nat NV Kav, Catherine Graham, Stefanie Czub & Tim A McAllister
Pages: 136-142
Published online: 07 Feb 2014
AbstractforCan plants serve as a vector for prions causing chronic wasting disease? | Full Text | References | PDF (943.8 KB) | Supplemental
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Article
Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease
Dilshan S Harischandra, Naveen Kondru, Dustin P Martin, Arthi Kanthasamy, Huajun Jin, Vellareddy Anantharam & Anumantha G Kanthasamy
Pages: 143-153
Published online: 28 Feb 2014
AbstractforRole of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease | Full Text | References | PDF (2.4 MB)
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Article
In vitro replication highlights the mutability of prions
Ilaria Vanni, Michele Angelo Di Bari, Laura Pirisinu, Claudia D'Agostino, Umberto Agrimi & Romolo Nonno
Pages: 154-160
Published online: 11 Mar 2014
AbstractforIn vitro replication highlights the mutability of prions | Full Text | References | PDF (902.3 KB) | Supplemental
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