Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

Shibo Jiang1 MOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China;2 Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USACorrespondence[email protected]

Lu Lu1 MOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China

Qi Liu1 MOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China;3 Department of Medical Microbiology and Immunology, School of Basic Medicine, Dali University, Dali 671000, China

Wei Xu1 MOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China

Lanying Du2 Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA

Abstract

A number of emerging and re-emerging viruses have caused epidemics or pandemics of infectious diseases leading to major devastations throughout human history. Therefore, developing effective and safe vaccines against these viruses is clearly important for the protection of at-risk populations. Our previous studies have shown that the receptor-binding domain (RBD) in the spike protein of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is a key target for the development of SARS vaccines. In this review, we highlight some key advances in the development of antiviral vaccines targeting the RBDs of spike proteins of emerging and re-emerging viruses, using SARS-CoV, influenza virus, Hendra virus (HeV) and Nipah virus (NiV) as examples.

Keywords:

We thank Ms Qian Wang for preparing . This study was supported by grants from the National Basic Research Program of China (#2012CB519001) to Shibo Jiang, and NIH of the United States (R01 AI68002) to Shibo Jiang and (R03 AI088449) to Lanying Du.

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

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Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

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