Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone

Troels T Andreassen 1Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark E-mail: [email protected]; 2Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark

Christian Fledelius 1Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark E-mail: [email protected]; 2Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark

Charlotte Ejersted 1Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark E-mail: [email protected]; 2Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark

Hans Oxlund 1Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark E-mail: [email protected]; 2Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark

Pages 304-307 | Published online: 08 Jul 2009

Cite this article
https://doi.org/10.1080/00016470152846673

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Abstract

We studied the effects of intermittent administration of parathyroid hormone (PTH(1-34)) on callus formation and mechanical strength of tibial fractures in 27-month-old rats after 3 and 8 weeks of healing. 200 &#119 g PTH(1-34)/kg was administered daily during both periods of healing, and control animals with fractures were given vehicle. At 3 weeks, PTH treatment increased maximum load and external callus volume by 160% and 208%; at 8 weeks, by 270% and 135%. It also enhanced callus bone mineral content (BMC) by 190% and 388% (3 and 8 weeks). From week 3 to week 8, callus BMC increased by 60% in the vehicle-injected animals, and by 169% in the PTH-treated animals. In the contralateral intact tibia, PTH treatment increased BMC by 18% and 21% (3 and 8 weeks). No differences in body weight were found between the vehicle-injected and the PTH-treated animals during the experiment. In conclusion, PTH treatment enhances fracture strength, callus volume and callus BMC after 3 and 8 weeks of healing.

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