Microwave‐Assisted Synthesis and Antiprotozoal Activity of Pyridazines Carrying Polyfluoro Substituents

Abstract

A number of 4,5‐dichloro‐ and 4,5‐dibromopyridazin‐3‐ones and ‐3,6‐diones with polyfluoro substituents at position 2 were obtained in good yields by microwave‐assisted method. The oxopyridazines as well as their respective 5‐dimethylaminoethylamino derivatives were tested for antibacterial, antiviral, and antiprotozoal activity.

Keywords:

• Antigiardial activity
• microwave
• pyridazines

Acknowledgments

The study was supported by the Foundation for Development Diagnostics and Therapy, Warsaw, Poland. The authors are grateful to S. J. Chrapusta for his critical reading of the manuscript