Microwave‐Assisted Synthesis and Antiprotozoal Activity of Pyridazines Carrying Polyfluoro Substituents

References

• Frank , H. and Heinisch , G. 1990 . “ Pharmacologically active pyridazines, part I ” . In Progress in Medicinal Chemistry Edited by: Ellis , G. P. and West , G. B. Vol. 27 , 1 Amsterdam : Elsevier .
   Google Scholar
• Tewari , A. K. and Mishra , A. 2001 . Synthesis and anti‐inflammatory activities of N4,N5‐disubstituted‐3‐methyl‐H‐pyrazolo[3,4‐c]pyridazines . Bioorg. Med. Chem. , 11 : 715
   Google Scholar
• Ostby , O. B. , Gundersen , L. L. , Rise , F. , Antonsen , O. , Fosnes , K. , Larsen , V. , Bast , A. , Custers , I. and Haenen , G. R. 2001 . Synthesis of 5‐substituted pyrrolo[1,2‐b]pyridazines with antioxidant properties . Arch. Pharm. , 334 : 21
   PubMed Web of Science ®Google Scholar
• Kots , A. Y. , Grafov , M. A. , Khropov , Y. V. , Betin , V. L. , Belushkina , N. N. , Busygina , O. G. , Yazykova , M. Y. , Ovchinnikov , I. V. , Kulikov , A. S. , Makhova , N. N. , Medvedeva , N. A. , Bulargina , T. V. and Severina , I. S. 2000 . Vasorelaxant and antiplatelet activity of 4,7‐dimethyl‐1,2, 5‐oxadiazolo[3,4‐d]pyridazine 1,5,6‐trioxide: Role of soluble guanylate cyclase, nitric oxide and thiols . Br. J. Pharmacol. , 129 : 1163
   PubMed Web of Science ®Google Scholar
• Sivakumar , R. , Anbalagan , N. , Gunasekaran , V. and Leonard , J. T. 2003 . Synthesis and anticolvulsant activity of novel 1‐substituted 1,2‐dihydropyridazine‐3,6‐ones . Biol. Pharm. Bull. , 26 : 1407
   PubMed Web of Science ®Google Scholar
• Gil‐Longo , J. , De los Reyes Laguna , M. , Verde , I. , Castro , M. E. , Orallo , F. , Fontenla , J. A. , Calleja , J. M. , Ravina , E. and Teran , C. 1993 . Pyridazine derivatives, XI: Antihypertensive activity of 3‐hydrazinocycloheptyl[1,2‐c]pyridazine and its hydrazone derivatives . J. Pharm. Sci. , 82 : 286
   PubMed Web of Science ®Google Scholar
• Ravina , E. , Teran , C. , Dominguez , N. G. , Masaguer , C. F. , Gil‐Longo , J. , Orallo , F. and Calleja , J. M. 1991 . Pyridazine derivatives, VIII: Synthesis and antihypertensive activity of 6‐(2‐thienyl)‐5‐aminomethyl‐3‐hydrazino‐pyridazines . Arch. Pharm. , 324 : 455
   PubMedGoogle Scholar
• Sotelo , E. , Mocelo , R. , Suarez , M. and Loupy , A. 1997 . Synthesis of polyfunctional pyridazine derivatives using a solvent‐free microwave assisted method . Synth. Commun. , 27 : 2419
   Web of Science ®Google Scholar
• Meenakshi , C. , Ramamoorthy , V. , Muthusubramanian , S. and Sivasubramanian , S. 2001 . Microwave assisted synthesis of 4,6‐diarylpyridazin‐3(2H)‐ones in solid state . Synth. Commun. , 31 : 645
   Web of Science ®Google Scholar
• Kotha , S. , Lahiri , K. and Kashinath , D. 2002 . Recent applications of the Suzuki–Miyaura cross‐coupling reaction in organic synthesis . Tetrahedron , 58 : 9633
   Web of Science ®Google Scholar
• Andrzejewska , M. , Yepez‐Mulia , L. , Cedillo‐Rivera , R. , Tapia , A. , Vilpo , L. , Vilpo , J. and Kazimierczuk , Z. 2002 . Synthesis, antiprotozoal and anticancer activity of substituted 2‐trifluoromethyl‐ and 2‐pentafluoroethylbenzimidazoles . Eur. J. Med. Chem. , 37 : 973
   PubMed Web of Science ®Google Scholar
• Cedillo‐Rivera , R. and Munoz , O. 1992 . In‐vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents . J. Med. Microbiol. , 37 : 221
   PubMed Web of Science ®Google Scholar
• Chavez , B. , Espinosa‐Cantellano , M. , Cedillo‐Rivera , R. , Ramirez , A. and Martinez‐Palomo , A. 1992 . Effects of albendazole on Entamoeba histolytica and Giardia lamblia trophozoites . Arch. Med. Res. , 2 : 63
   Google Scholar