Improved Solvent‐Free Dakin Oxidation Protocol

Abstract

A solvent‐free Dakin reaction with mCPBA was accomplished with various aromatic aldehydes, resulting in an easy and improved methodology for the preparation of corresponding phenols. 3,4‐Methylenedioxyphenol, 3,4‐dimethoxyphenol, 4‐methoxyphenol, 4‐chlorophenol, and other functionalized phenols were obtained in high yields from the corresponding aromatic aldehydes in a few minutes. This new methodology represents an efficient alternative for this important synthetic conversion.

Keywords:

• Dakin reaction
• mCPBA
• solvent‐free
• synthesis of phenols

Acknowledgments

Thanks are due to Conselho Nacional de Desenrolvimento Científico e Tecnológico (CNPq, BR) and Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ, BR) for financial support and fellowships.