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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 11
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Articles

Cu-mediated selective bromination of aniline derivatives and preliminary mechanism study

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Pages 1406-1415 | Received 12 Sep 2018, Accepted 19 Mar 2019, Published online: 22 Apr 2019
 

Abstract

A simple and efficient bromination of aniline, aniline derivatives, and analogs have been developed. Forty three examples were given and the highest yield reached was 98%. Different substrates including substituted aniline, pyridin-amine, N-substituted aniline, N,N-disubstituted aniline, N-phenyl-amide, N-phenyl-sulfonamide, and nitrogen-containing heterocycles were all reactive and selectively generated desired bromo-products. The method can be applied to synthesize drug intermediate and quinoxaline derivatives.

Graphical Abstract

Additional information

Funding

Financial support from The National Natural Science Foundation of China (Grant No. 81673354) is gratefully acknowledged.

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