Design and synthesis of new thiazoles by microwave-assisted method: Evaluation as an anti-breast cancer agents and molecular docking studies

Abstract

A series of novel thiazole analogues were designed and synthesized by the microwave-assisted multicomponent reaction of thiocarbohydrazide, aldehydes with substituted phenacyl bromides. Structures of all the synthesized compounds were in good agreement with their spectral (¹H and ¹³C NMR, FTIR, Mass) and analytical data. The target thiazole compounds were screened for their in vitro cytotoxic activity by testing against MCF-7, MDA-MB-231/ATCC, HS 578 T, BT-549, T-47D and MDA-MB-468 Breast cancer cell lines. From the in vitro results, it was found that the compound 4b has potent activity against MDA-MB-231/ATCC cell line. Docking studies were also done on these compounds to probe the possible binding site interactions which corroborated well with the in vitro results.

Graphical Abstract

Keywords:

• Breast cancer
• green chemistry
• microwave irradiation
• thiazole analogues
• molecular docking

Acknowledgements

One of the authors, Srikanth Mamidala, thanks the NCI, USA for one dose level test screening, MHRD for providing the fellowship. The authors thank the Director, NIT, Warangal for providing facilities. Another author Sudhir Reddy Peddi would like to thank UGC for a research fellowship.

Disclosure statement

No potential conflict of interest was reported by the author(s).