![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
4-Aryl-NH-1,2,3-triazoles were effectively synthesized from benzyl-type ketones utilizing diphenyl phosphorazidate (DPPA) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene in solvent-free conditions. By this approach, various ketones were rapidly converted to the corresponding triazoles. This reaction enables the preparation of NH-1,2,3-triazoles without the need for toxic or explosive azidation reagents.
Graphical Abstract
Disclosure statement
The authors declare no conflict of interest.
Additional information
Funding
This work was supported by JSPS KAKENHI JP22K05469, Takahashi Industrial and Economic Research Foundation [No.11-003-020], and Ichihara International Scholarship Foundation (29th Research Grant).