Barbituric acids in the synthesis of naphthopyranopyrimidines: A brief review

Abstract

Naphthopyranopyrimidine derivatives are an important class of naturally occurring tetraheterocyclic organic compounds that are used as dyes, fluorescent materials for visualization of biomolecules, and in laser technology. Moreover, they are known for biological and pharmaceutical activities. Herein, we briefly reviewed the history of synthesis approaches of naphthopyranopyrimidine and spironaphthopyranopyrimidine derivatives from naphthols, aldehydes/isatins, and barbituric acid/1,3-dimethylbarbituric acid/thiobarbituric acid/1,3-dimethyl-2-thiobarbituric acid/6-amino-1,3-dimethyluracil in the presence of both homogeneous and heterogeneous catalysts reported by research groups.

GRAPHICAL ABSTRACT

Keywords:

• 6-Amino-1,3-dimethyluracil
• barbituric acid
• naphthol
• naphthopyranopyrimidine

Additional information

Funding

The authors thank the Research Council of Payame Noor University and Qazvin Islamic Azad University for financial support.