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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 2, 1972 - Issue 4
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Original Articles

Curtius Degradation Utilizing Trimethylsilyl Azide. A facile isocyanate synthesis

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Pages 227-230 | Received 23 May 1972, Published online: 26 Jan 2007
 

Abstract

We wish to report a modification of the Curtius Degradation which facilely affords high yields of isocyanates from acid chlorides or anhydrides under “single-pot” conditions. Trimethylsilyl acide attacks the reactive carbonyl groups of cyclic anhydrides and isomaleimides according to Eqn. 1, giving formally a Curtius Degradation product.

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