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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 9, 1979 - Issue 6
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Original Articles

Preparation of Ethyl Hypophosphite1,2

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Pages 535-538 | Received 16 Jan 1979, Published online: 05 Dec 2006
 

Abstract

We report a convenient synthesis of ethyl hypophosphite by the O-alkylation of sodium hypophosphite (eq 1). Thus, when sodium hypo-phosphite is allowed to react with triethyloxonium tetrafluoroborate in

methylene chloride at 0°, simple filtration from the inorganic salts and evaporation of the solvent gives the pure ester in 80% yield. This simple preparation employs readily available starting materials3.

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