A polymer scaffold with drug-sustained release and antibacterial activity

Abstract

Total alkaloids from Semen Strychnine (TASS), as an antibacterial drug, was loaded into polyetheretherketone (PEEK)/polyglycolide acid (PGA) scaffolds fabricated via 3 D printing technology. It focused on studying microstructure, drug-release behavior, antibacterial activity and biocompatibility of scaffolds. Results indicated that TASS had a good physiochemical compatibility with polymer matrix, and a sustained release for longtime in TASS-PEEK/PGA scaffolds. Moreover, the scaffolds manifested antimicrobial activity against E. coli and S. aureus in antibacterial tests and superb biocompatibility in vitro cell culture. These suggested that TASS-PEEK/PGA scaffolds were able to efficiently sustain TASS delivery and were a promising implant for treating bacterial infection.

Graphical Abstract

Keywords:

• Antibacterial activity
• drug-sustained release
• polymer scaffold
• total alkaloids from Semen Strychnine

Declaration of interest

The authors declare no conflict of interest.

Additional information

Funding

This work was technically supported by the following organization: Hunan Key Laboratory of Environment Friendly Chemical Process Integration Technology, National & Local United Engineering Research Centre for Chemical Process Simulation and Intensification, National Department of Education Engineering Research Centre for Chemical Process Simulation, Collaborative Innovation Center of New Chemical Technologies for Environmental Benignity Optimization and Efficient Resource Utilization, Hunan Key Laboratory of Chinese medicine oncology [2017TP1033] and Innovative platform of antitumor Chinese drugs [2018CT5005], and financially supported by the following founds: (1) the Natural Science Foundation of China [51575537]; (2) China Scholarship Council (CSC) for the State Scholarship Fund [No. 201708430071] program; (3) Xiangtan University start-up grant [16QDZ33] and Xiangtan University grant [16XZX17].