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Research Articles

Interaction between adipoderivated mesenchymal stem cells and PLGA/PIepox scaffold with possible use in tissue engineering: in vitro study

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Pages 1132-1141 | Received 23 Dec 2021, Accepted 04 Jun 2022, Published online: 05 Jul 2022
 

Abstract

The objective of this work was to evaluate the interaction between human mesenchymal cells adipoderived with PLGA/PIepox scaffold made by the centrifugation technique. The best plating cell density was predicted between 0.32 × 105, 0.65 × 105 and 1.3 × 105 and the best culture time between 24, 48, 72 h. The metabolic activity of the tested groups was similar to their respective controls, except for the higher density and longer cultivation time, which were metabolically more active. The association between the PLGA/PIepox scaffold and adipoderived mesenchymal cells can be considered for future in vivo studies in tissue engineering.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Research and Events Incentive Fund (FIPE/HCPA 2019-0136) and by the National Council for Scientific and Technological Development (CNPq 131678/2019-1).

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