Polycaprolactone, polylactic acid, and nanohydroxyapatite scaffolds obtained by electrospinning and 3D printing for tissue engineering

Abstract

There is a deficit for bone tissue natural grafts that seek to be covered with synthetic substitutes. Scaffolds generated with 3D printing and electrospinning allow adequate mechanical properties maintaining a structure appropriate for cell growth. Here, a scaffold made up of three-dimensional (3D) printed PLA frameworks added with PCL/PLA/nHA nanofibers was manufactured. The framework showed mechanical properties similar to other reported bone substitutes, while the nanofibers showed diameters between 200 and 850 nm. Scaffolds were suitable for cell adhesion and proliferation when evaluated with fibroblasts, showing cell proliferation into the nanofiber network, a fundamental aspect in tissue engineering.

Graphical Abstract

Keywords:

• Nanofibers
• polymeric scaffolds
• electrospun
• polylactic acid
• polycaprolactone
• nanohydroxyapatite
• tissue engineering
• bone

Acknowledgments

Gonzalez Rodríguez Omar A. and Ramírez Guerrero Nancy acknowledge doctoral fellowship from CONACyT, N° 001406.

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

CRediT authorship contribution statement

González Rodríguez Omar Alejandro: Conceptualization, Methodology, Ramírez Guerrero Nancy Cecilia: Methodology, Software, Casañas Pimentel Rocio Guadalupe: Visualization, Investigation, Jaime Fonseca Mónica Rosalia: Writing – Reviewing and Editing, San Martín Martínez Eduardo: Conceptualization, Data curation, Writing – Original draft preparation.

Data availability statement

Data will be made available on request.

Additional information

Funding

This work was supported by Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT), Mexico, Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional.