Modafinil and Cocaine Interactions

Robert Malcolm Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USACorrespondence[email protected]

Karla Swayngim Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA

Jennifer L. Donovan Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, South Carolina, USA

C. Lindsay DeVane Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, South Carolina, USA

Ahmed Elkashef National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA

Nora Chiang National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA

Roberta Khan Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, South Carolina, USA

Jurij Mojsiak National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA

Donald L. Myrick Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA

Sarra Hedden Department of Biostatistics, Bioinformatics and Epidemiology, MUSC, Charleston, South Carolina, USA

Kristi Cochran Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA

Robert F. Woolson Department of Biostatistics, Bioinformatics and Epidemiology, MUSC, Charleston, South Carolina, USA

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Abstract

This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.

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Modafinil and Cocaine Interactions

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