Comparative green analysis between different catalytic methodologies used in stereoselective reduction reaction of acetophenone

ABSTRACT

The acetophenone stereoselective reduction reactions carried out by different chemical or biochemical methodologies reported in the literature were analyzed. This study showed the importance of evaluation in each reaction step, both holistically and quantitatively, even if the amounts used are at the mmol level. It is clear that the use of catalysts does not guarantee that the chemical process is environmentally friendly, as well as that the benefits of bio-driven processes can be diminished due to the complications of product purification. This work shows that the development of tools to determine the sustainability of a process is extremely important.

KEYWORDS:

• Acetophenone
• stereoselective reduction
• chiral alcohols
• ecoscale
• green star
• atom economy

Acknowledgments

María F. Decarlini and Ana M. Vazquez gratefully acknowledge financial support from the Universidad Católica de Córdoba, (UCC), Argentina. Mario L. Aimar and Laura I. Rossi gratefully acknowledge financial support from Secretaría de Ciencia y Tecnología de la Universidad Nacional de Córdoba, (SECyT-UNC), Argentina (Grant Nº 30720150100338CB) (Grant Nº 30720150100712CB). Laura I. Rossi is a researcher from CONICET. We thank Dr. Paul Hobson, a native English speaker, for the revision of this manuscript. This work is dedicated in the teaching career of Prof. Dr. Roberto Rossi.

Conflicts of interest

There are no conflicts to declare.