Two-photon polymerization/micromolding of microscale barbs for medical applications

R.D. BoehmJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.

B. ChenJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.

S.D. GittardJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.

B.N. ChichkovJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.;Laser Zentrum Hannover e.V., Hollerithalle 8, Hannover, 30419, Germany.

N.A. Monteiro-RiviereJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.;Department of Clinical Sciences, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, 27695, USA.

A. NasirDepartment of Dermatology, University of North Carolina, Chapel Hill, NC, 27599, USA.;Wake Research Associates, 3100 Duraleigh Rd Ste 304, Raleigh, NC, 27612, USA.

R.J. NarayanJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.Correspondence[email protected]

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Abstract

Tissue barbs are small-scale structures that may be used for sutureless joining of tissues. In this study, several types of tissue barbs were fabricated using two-photon polymerization/micromolding, including two-pronged tissue barbs, eight-pronged tissue barbs, 10-pronged tissue barbs, and 16-pronged tissue barbs. Tissue barb penetration in porcine tissue was observed using confocal laser scanning microscopy. Constructs containing medical tape and tissue barbs were created by applying tissue barbs in a parallel arrangement to Transpore™ medical tape. These results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants.

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Two-photon polymerization/micromolding of microscale barbs for medical applications

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Two-photon polymerization/micromolding of microscale barbs for medical applications

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