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Abstract
An unidentified metabolite of dimetridazole (DMZ), found in pig plasma, muscle and kidney, was shown by chromatography and spectroscopy to be 2‐methyl‐5‐nitroimidazole (2‐MNI), resulting from N‐demethylation of DMZ. This route of degradation competes with the oxidation pathway previously described. The concentration of 2‐MNI in the plasma of pig fed medicated diet (DMZ 0.0125%) ranged from 29 to 83 ppb, 2 hours after the morning meal, similar to DMZ, but lower than that of the major metabolite, 2‐hydroxymethyl‐l‐methyl‐5‐nitroimidazole (HMMNI). Its elimination profile in plasma was biphasic, similar to those of HMMNI and DMZ. Early and terminal half lives were 2.6 and 9.1 h respectively. None of the metabolites could be detected in any of the tissues studied 49 hours after withdrawal.
Notes
Corresponding address: Pharmaceutical Chemistry Division, Banting Building, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada.