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Abstract
Background: Sequence polymorphisms of mitochondrial DNA (mtDNA) are valuable in forensic medicine and anthropological genetics.
Aim: This study investigated the mtDNA control region sequences in 295 unrelated individuals living in the Yanbian Korean Autonomous Prefecture in the People’s Republic of China.
Subjects and methods: DNA was extracted from blood stained filter papers. Hypervariable regions of the mtDNA control region (HVI and HVII) were amplified and sequenced. The resulting sequences were aligned and compared with the revised Cambridge reference sequence (rCRS).
Results: A total of 182 variations were confirmed. Population comparison showed the significant difference between Yanbian Korean and other included populations.
Conclusion: These results provide useful data for human genetic studies and forensic examinations and demonstrate that the Yanbian Korean population is an endogamous Northeast Asian group.
Acknowledgements
Our heartfelt thanks go to Dr Cristina Martinez-Labarga at the University of Rome, for support during the haplogroup classification.
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
