An evaluation of inter and intra population structure of Uttar Pradesh, inferred from 24 autosomal STRs

Abstract

Aim

The present study was designed to explore the STR diversity and genomic history of the inhabitants of the most populous subdivision of the country. A set of 24 hypervariable autosomal STRs was used to estimate the genetic diversity within the studied population. A panel of 15 autosomal STRs, which is most common in the previously reported data sets, was used to estimate the genetic diversity between the studied population, and obtained unique relations were reported here.

Method

The genetic diversity and polymorphism among 636 individuals of different ethnic groups, residing in Bareilly, Pilibhit, Shahjahanpur, Gorakhpur, Jhansi, and Varanasi regions of Uttar Pradesh, India, was investigated. This investigation was carried out via 24 autosomal STRs.

Result

The 24 loci studied showed the highest value of combined power of discrimination (CPD = 1), combined power of exclusion (CPE = 0.99999999985), combined paternity index (CPI = 6.10 × 10⁹) and lowest combined matching probability (CPM = 7.90 × 10⁻³¹).

Conclusion

The studied population showed genetic closeness with the population of Uttarakhand, the Jats of Delhi,the Jat Sikh (Punjab), and the population of Rajasthan. Among the tested loci, SE33 and Penta E were found to be most useful in terms of the highest discrimination power, lowest matching probability, the highest power of exclusion, and highest polymorphism information content for the Uttar Pradesh population .

Keywords:

• Autosomal STRs
• STR diversity
• genetic affinity
• western
• northern and southern Uttar Pradesh
• India

Acknowledgements

We thank all the participants of this investigation. We thank all the volunteers who donate their blood samples. We also thank Promega, India for providing the kit.

Ethical approval

This study was permitted by the Ethical guidelines of Maharani Laxmi Bai Medical College, Jhansi; vide letter no. 4648 dated 05.09.2020 and Central Forensic Science Laboratory, Chandigarh letter no. FSL/CHD/IEC/2020/04 dated 02/12/2020.

Disclosure statement

No potential conflict of interest was reported by the authors.