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Original Article

Gradients of HLA diversity in South American Indians

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Pages 197-208 | Received 25 Jun 1996, Published online: 09 Jul 2009
 

Summary

Information concerning the HLA-A and -B loci was considered in relation to 3796 Amerindians living in 39 places in South America, data related to HLA-C being based on a smaller subset of 2989 persons distributed among 33 localities. Synthetic gene frequency maps were then constructed using principal-components analysis. Clearly significant longitudinal (principal component 1) and latitudinal (principal components 1, 2, and 3) clines were observed, most probably indicating ancient migration routes.

Zusammenfassung

HLA-Daten der Loci HLA-A und HLA-B von insgesamt 3796 amerikanischen Indianern, die an 39 Orten in Südamerika leben, werden analysiert. Eine entsprechende Analyse für den HLA-C-Locus basiert auf einem kleineren Datenset: 2989 Personen, die sich auf 33 Orte verteilen. Mittels Principal Component Analyse wurden synthetische Genfrequenz-Karten konstruiert. Es ließen sich deutliche signifikante Clines entlang der Längen- (Principal Component 1) und Breitengrade (Principal Components 1, 2 und 3) beobachten, die wahrscheinlich ehemalige Wanderungsrouten anzeigen.

Resumé

On analyse des informations se rapportant aux loci HLA-A et HLA-B de 3796 amérindiens de 39 localisations différentes d'Amérique du Sud, ainsi que celles qui concernent le locus HLA-C mais qui ne sont rassemblées que pour un échantillon plus restreint de 2989 personnes distribuées en 33 localités. Des cartes synthétisant les fréquences géniques sont construites par analyse en composantes principales. On observe des gradients clairement significatifs de longitude (composante principale 1) et de latitude (composantes principales 1, 2 et 3), qui traduisent vraisembablement d'anciennes routes de migration.

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