Triciribine (TCN), A Novel Tricyclic Adenosine Analog with Anticancer Activity

Linda L. Wotring Department of Pharmaceutical Chemistry, College of Pharmacy, Ann Arbor, Michigan

Joseph L. Roti Division of Radiation Oncology, Department of Radiology, Washington University Medical School, St. Louis, Missouri, U.S.A.

Jerry L. Hudson Department of Pathology, University of Michigan, Ann Arbor, Michigan

Joan E. Passiatore Department of Pharmaceutical Chemistry, College of Pharmacy, Ann Arbor, Michigan

Katherine Z. Borysko Department of Pharmaceutical Chemistry, College of Pharmacy, Ann Arbor, Michigan

Richard D. Newcomb Department of Pharmaceutical Chemistry, College of Pharmacy, Ann Arbor, Michigan

Leroy B. Townsend Department of Medicinal Chemistry, College of Pharmacy, Ann Arbor, Michigan

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Abstract

Triciribine shows promise as an antitumor drug and is currently in clinical trials. In L1210 cells in vitro, triciribine lethality is associated with inhibition of DNA synthesis, a G₁(-S) cell progression block and slowing of progression of cells through s phase.

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Triciribine (TCN), A Novel Tricyclic Adenosine Analog with Anticancer Activity

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Triciribine (TCN), A Novel Tricyclic Adenosine Analog with Anticancer Activity

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