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Nucleosides and Nucleotides Volume 6, 1987 - Issue 1-2
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The Use of Nucleoside H-Phosphonates in the Synthesis of Deoxyoligonucleotides

Brian C. Froehler Department of Molecular, Biology Genentech, Inc., South San Francisco, California, 94080
&
Mark D. Matteucci Department of Molecular, Biology Genentech, Inc., South San Francisco, California, 94080
Pages 287-291 | Published online: 05 Dec 2006
 
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Abstract

Nucleoside H-phosphonates are valuable intermediates in the synthesis of deoxyoligonucleotides. The DBU salt form is more stable in solution and is consequently an improvement in routine synthesis of DNA.

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