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Abstract
Mild formic acid hydrolysis at 90°C is a convenient method for releasing thymine modified residues which are formed upon gamma irradiation of DNA in oxygen-free solution from a polynucleotide chain backbone. The modified thymine residues are further isolated by chromatography and measured. The double helix prevents to some extent the attack of the thymine residue by the transient species OH, H and e provided by water radiolysis.