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Nucleosides and Nucleotides Volume 6, 1987 - Issue 1-2
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Biological Activities of Oligonucleotides Linked to Poly(L-Lysine)

M. Lemaltre Laboratoire de Biochimie des Proteines, (UA CNRS 1191) USTL, F-34060, Montpellier cedex
,
C. Bisbal Laboratoire de Biochimie des Proteines, (UA CNRS 1191) USTL, F-34060, Montpellier cedex
,
B. Bayard Laboratoire de Biochimie des Proteines, (UA CNRS 1191) USTL, F-34060, Montpellier cedex
&
B. Lebleu Laboratoire de Biochimie des Proteines, (UA CNRS 1191) USTL, F-34060, Montpellier cedex
Pages 311-315 | Published online: 05 Dec 2006
 
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Abstract

We have developped a method to couple oligonucleotides to poly(L-lysine). This tool has been tested with anti m-RNA synthetic oligodeoxyribonucleotides and 2′-5′(A)n and allows oligonucleotides to enter intact cells.

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