Base Analogue Interactions in DNA Duplexes

D. M. Brown Laboratory of Molecular Biology, Cambridge England and University Chemical Laboratory, Hills Road, Cambridge, England

N. N. Anand Laboratory of Molecular Biology, Cambridge England and University Chemical Laboratory, Hills Road, Cambridge, England

S. A. Salisbury Laboratory of Molecular Biology, Cambridge England and University Chemical Laboratory, Hills Road, Cambridge, England

Abstract

Oligodeoxyribonucleotides containing N⁴ -methoxycytosine (mo⁴ C) and its 5-methyl derivative (mo⁴ m⁵ C) are synthesised and used to compare the stabilities of duplexes containing mo⁴ C.A and mo⁴C.G base-pairs with those containing normal and mismatch pairs.

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Base Analogue Interactions in DNA Duplexes

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Base Analogue Interactions in DNA Duplexes

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