A New 5′-Protecting Group for Use in Solid-Phase Synthesis of Oligoribonucleotides

Chris Christodoulou MRC Laboratory of Molecular Biology, Hill Road, Cambridge, CB2 2QH, UK

Sudhir Agrawal MRC Laboratory of Molecular Biology, Hill Road, Cambridge, CB2 2QH, UK

Michael J. Gait MRC Laboratory of Molecular Biology, Hill Road, Cambridge, CB2 2QH, UK

Abstract

The 2-(2,4-dinitrobenzenesulphenyloxymethyl)benzoyl (DNBSB) group is proposed as a protecting group for the 5′-position of nucleosides. The DNBSB group may be removed under mild non-acidic conditions and may have potential in solid-phase synthesis of oligoribo- and oligodeoxyribonucleotides.

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A New 5′-Protecting Group for Use in Solid-Phase Synthesis of Oligoribonucleotides

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A New 5′-Protecting Group for Use in Solid-Phase Synthesis of Oligoribonucleotides

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