Synthesis Of Oligodeoxyribonucleotides Containing an Aliphatic Amino Linker Arm at Selected Adenine Bases and Derivatization with Biotin

Jean-Paul Roduit Biogen S.A., 3 route de Troinex, CH-1227 Carouge, Geneva, Switzerland

Jeffrey Shaw Biogen S.A., 3 route de Troinex, CH-1227 Carouge, Geneva, Switzerland

Angelika Chollet Biogen S.A., 3 route de Troinex, CH-1227 Carouge, Geneva, Switzerland

André Chollet Biogen S.A., 3 route de Troinex, CH-1227 Carouge, Geneva, Switzerland

Abstract

The chemical synthesis and characterization of oligodeoxyribonucleotides with a “linker arm” attached to the 8-position of some adenine bases are presented. Derivatizatlon with biotin is described and evaluation of these modified DNA fragments as nonradioactive hybridization probes is briefly discussed.

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Synthesis Of Oligodeoxyribonucleotides Containing an Aliphatic Amino Linker Arm at Selected Adenine Bases and Derivatization with Biotin

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Synthesis Of Oligodeoxyribonucleotides Containing an Aliphatic Amino Linker Arm at Selected Adenine Bases and Derivatization with Biotin

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