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COMMUNICATIONS

Polyfunctional O-Substituted Hydroxylamines: Modification of Nucleic Acids, Inhibition of Sam-Decarboxylase

, , &
Pages 359-362 | Published online: 05 Dec 2006
 

Abstract

Treo-1-aminooxy-2,3-dihydroxy-4-mercaptobu-tane is suggested for the introduction of reactive thiol groups via cytidine residues and/or 3′-end of nucleic acids. S-(5-desoxyadenosyl)-arainooxyethyl-thiomethyl hydroxy1-amine irreversibly inhibits SAM decarboxylase in 10−3 M.

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