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Nucleosides and Nucleotides Volume 6, 1987 - Issue 1-2
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DNA Apurinic Sites: Synthesis of a Model Compound and Study of its Reactivity with 3-Aminocarbazole

J.-J. Vasseur Universite des Sciences et Techniques du Languedoc, Laboratoire de Chimie Bio-Organique, Place Eugene Bataillon, 34060, Montpellier Cédex, France
,
B. Rayner Universite des Sciences et Techniques du Languedoc, Laboratoire de Chimie Bio-Organique, Place Eugene Bataillon, 34060, Montpellier Cédex, France
,
J.-L. Imbach Universite des Sciences et Techniques du Languedoc, Laboratoire de Chimie Bio-Organique, Place Eugene Bataillon, 34060, Montpellier Cédex, France
,
S. Verla Departments of Medicinal Chemistry and Biochemistry, University of Utah, Salt Lake City, Utah, 84112, USA
,
J. A. McCloskey Departments of Medicinal Chemistry and Biochemistry, University of Utah, Salt Lake City, Utah, 84112, USA
,
J. W. Lown Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada
&
D. K. Chang Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada
 show all
Pages 467-468 | Published online: 05 Dec 2006
 
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Abstract

The mechanism of breakage of apurinic DNA with 3-aminocarbazole was determinated on a short oligonucleotide model. The results founded contrast with those reported in the literature.1

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