Positioning of Functionalities in a Heteroduplex Major Groove: Synthesis of 7-Deaza-2-Amino-2′-deoxyadenosines

Guity Balow Isis Pharmaceuticals, Carlsbad, CA, 92008

John Brugger Isis Pharmaceuticals, Carlsbad, CA, 92008

Elena Lesnik Isis Pharmaceuticals, Carlsbad, CA, 92008

Oscar L. Acevedo Isis Pharmaceuticals, Carlsbad, CA, 92008

Abstract

We have synthesized the 7-iodo-, 7-cyano-and 7-propynyl-7-deaza-2-ainino-2′-deoxyadenosines and incorporated each into several oligonucleotide (ODN) sequences. These oligonucleotides exhibit enhanced binding affinities to RNA complements relative to unmodified sequences.

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Positioning of Functionalities in a Heteroduplex Major Groove: Synthesis of 7-Deaza-2-Amino-2′-deoxyadenosines

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Positioning of Functionalities in a Heteroduplex Major Groove: Synthesis of 7-Deaza-2-Amino-2′-deoxyadenosines

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