Nucleosides, Nucleotides & Nucleic Acids, Volume 16, Issue 7-9 (1997)

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Nucleosides and Nucleotides, Volume 16, Issue 7-9 (1997)

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Miscellany

Contributors to This Issue
Pages: xxv-xxxv
Published online: 16 Aug 2006
First Page PreviewforContributors to This Issue | PDF (388.3 KB)
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Preface
P. Dan Cook
Pages: xxxvii-xliii
Published online: 16 Aug 2006
First Page PreviewforPreface | PDF (275.7 KB)
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I. PROGRESS IN SECOND GENERATION OLIGOMER THERAPEUTICS

Article
Antisense Properties of Morpholino Oligomers
James Summerton & Dwight Weller
Pages: 889-898
Published online: 16 Aug 2006
AbstractforAntisense Properties of Morpholino Oligomers | References | PDF (411.7 KB)
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Article
Synthesis and Properties of the Oligonucleotide N3′ →P5′ Phosphoramidates
Sergei M. Gryaznov
Pages: 899-905
Published online: 16 Aug 2006
AbstractforSynthesis and Properties of the Oligonucleotide N3′ →P5′ Phosphoramidates | References | PDF (420.8 KB)
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Article
Concept, Discovery and Development of MMI Linkage: Story of a Novel Linkage: for Antisense Constructs
Yogesh S. Sanghvi, Eric E. Swayze, Didier Peoc'h, Balkrishen Bhat & Stuart Dimock
Pages: 907-916
Published online: 16 Aug 2006
AbstractforConcept, Discovery and Development of MMI Linkage: Story of a Novel Linkage: for Antisense Constructs | References | PDF (414.3 KB)
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Article
Second Generation Antisense Oligonucleotides—Inhibition of PKC-α and c-raf Kinase Expression by Chimeric Oligonucleotides Incorporating 6″-Substituted Carbocyclic Nucleosides and 2″-O-Ethylene Glycol Substituted Ribonucleosides
Karl-Heinz Altmann, Pierre Martin, Nicholas M. Dean & Brett P. Mania
Pages: 917-926
Published online: 16 Aug 2006
AbstractforSecond Generation Antisense Oligonucleotides—Inhibition of PKC-α and c-raf Kinase Expression by Chimeric Oligonucleotides Incorporating 6″-Substituted Carbocyclic Nucleosides and 2″-O-Ethylene Glycol Substituted Ribonucleosides | References | PDF (480.5 KB)
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Article
Mixed-Backbone Oligonucleotides Containing Phosphorothioate and Methylphosphonate Linkages as Second Generation Antisense Oligonucleotide
Sudhir Agrawal, Zhiwei Jiang, Qiuyan Zhao, Denise Shaw, Daisy Sun & Carl Saxinger
Pages: 927-936
Published online: 16 Aug 2006
AbstractforMixed-Backbone Oligonucleotides Containing Phosphorothioate and Methylphosphonate Linkages as Second Generation Antisense Oligonucleotide | References | PDF (656.2 KB)
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Article
A Convenient Synthesis of Deoxynebularine Phosphoramidite
Douglas Picken & Vicki Gault
Pages: 937-939
Published online: 16 Aug 2006
AbstractforA Convenient Synthesis of Deoxynebularine Phosphoramidite | References | PDF (134 KB)
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Article
Positioning of Functionalities in a Heteroduplex Major Groove: Synthesis of 7-Deaza-2-Amino-2′-deoxyadenosines
Guity Balow, John Brugger, Elena Lesnik & Oscar L. Acevedo
Pages: 941-944
Published online: 16 Aug 2006
AbstractforPositioning of Functionalities in a Heteroduplex Major Groove: Synthesis of 7-Deaza-2-Amino-2′-deoxyadenosines | References | PDF (183 KB)
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Article
Oligonucleotide Phosphonates—Solid Phase Synthesis and Biochemical Characterization
D. Bankaitis-Davis, L. Huang, T. Koga & G. Beaton
Pages: 945-949
Published online: 16 Aug 2006
AbstractforOligonucleotide Phosphonates—Solid Phase Synthesis and Biochemical Characterization | References | PDF (160 KB)
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Article
Amino-Linked Ribozymes: Post-Synthetic Conjugation of Half-Ribozymes
Laurent Bellon, Christopher Workman, Carolyn Gonzalez & Francine Wincott
Pages: 951-954
Published online: 16 Aug 2006
AbstractforAmino-Linked Ribozymes: Post-Synthetic Conjugation of Half-Ribozymes | References | PDF (183.4 KB)
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Article
2′-O-Methyl Thiomethyl Modifications in Hammerhead Ribozymes
Alexander Karpeisky, Carolyn Gonzalez, Alex B. Burgin, Nassim Usman & Leonid Beigelman
Pages: 955-958
Published online: 16 Aug 2006
Abstractfor2′-O-Methyl Thiomethyl Modifications in Hammerhead Ribozymes | References | PDF (182.6 KB)
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Article
Synthesis and Evaluation Of 2″-Modified MMI Linked Dimers in Antisense Constructs
Didier Peoc'h, Eric E. Swayze, Balkrishen Bhat, Stuart Dimock, Richard Griffey & Yogesh S. Sanghvi
Pages: 959-962
Published online: 16 Aug 2006
AbstractforSynthesis and Evaluation Of 2″-Modified MMI Linked Dimers in Antisense Constructs | References | PDF (239.3 KB)
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Article
Duplex Stability of Oligonucleotides Containing 7-Substituted 7-Deaza- and 8-Aza-7-Deazapurine Nucleosides
F. Seela, N. Ramzaeva & M. Zulauf
Pages: 963-966
Published online: 16 Aug 2006
AbstractforDuplex Stability of Oligonucleotides Containing 7-Substituted 7-Deaza- and 8-Aza-7-Deazapurine Nucleosides | References | PDF (145.9 KB)
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Article
Synthesis and Properties of Oligoribonucleotide Analogues Having Amide (3″-CH2-CO-NH-5′) Internucleoside Linkages
Eriks Rozners & Roger Strömberg
Pages: 967-970
Published online: 16 Aug 2006
AbstractforSynthesis and Properties of Oligoribonucleotide Analogues Having Amide (3″-CH2-CO-NH-5′) Internucleoside Linkages | References | PDF (187.7 KB)
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Article
The Synthesis of the Sixteen Possible 2′-O-Methyl MMI Dimer Phosphoramidites: Building Blocks for the Synthesis of Novel Antisense Oligonucleotides
Eric E. Swayze, Balkrishen Bhat, Didier Peoc'h & Yogesh S. Sanghvi
Pages: 971-972
Published online: 16 Aug 2006
AbstractforThe Synthesis of the Sixteen Possible 2′-O-Methyl MMI Dimer Phosphoramidites: Building Blocks for the Synthesis of Novel Antisense Oligonucleotides | References | PDF (101 KB)
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Article
Hexitol Nucleic Acids (HNA): Synthesis and Properties
B. De Bouvere, L. Kerreinans, C. Hendrix, H. De Winter, G. Schepers, A. Van Aerschot & P. Herdewijn
Pages: 973-976
Published online: 16 Aug 2006
AbstractforHexitol Nucleic Acids (HNA): Synthesis and Properties | References | PDF (173.6 KB)
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Article
Synthesis and Hybridization Properties of Modified Oligonucleotides with PNA-DNA Dimer Blocks
D. Wenninger & H. Seliger
Pages: 977-980
Published online: 16 Aug 2006
AbstractforSynthesis and Hybridization Properties of Modified Oligonucleotides with PNA-DNA Dimer Blocks | References | PDF (169.7 KB)
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II. MEDICINAL CHEMISTRY OF NUCLEOSIDES/NUCLEOTIDES

Article
Therapeutic Potential of HPMPC (Cidofovir), PMEA (Adefovir) and Related Acyclic Nucleoside Phosphonate Analogues as Broad-Spectrum Anttviral Agents
Lieve Naesens & Erik de Clercq
Pages: 983-992
Published online: 16 Aug 2006
AbstractforTherapeutic Potential of HPMPC (Cidofovir), PMEA (Adefovir) and Related Acyclic Nucleoside Phosphonate Analogues as Broad-Spectrum Anttviral Agents | References | PDF (580.4 KB)
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Article
Structure-Activity Relationship of Pyrimidine Heterosubstituted Nucleoside Analogues
Tarek S. Mansour, Colleen A. Evans, M. Arshad Siddiqui, Marie Charron, Boulos Zacharie, Nghe Nguyen-Ba, Nola Lee & Brent Korba
Pages: 993-1001
Published online: 16 Aug 2006
AbstractforStructure-Activity Relationship of Pyrimidine Heterosubstituted Nucleoside Analogues | References | PDF (313.5 KB)
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Article
Antiviral Nucleoside Analogues with Axial Chirality
Jiri Zemlicka
Pages: 1003-1012
Published online: 16 Aug 2006
AbstractforAntiviral Nucleoside Analogues with Axial Chirality | References | PDF (483.4 KB)
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Article
Design, Synthesis and Anticonvulsant Activity of the Potent Adenosine Kinase Inhibitor GP3269
Mark D. Erion, Bheemarao G. Ugarkar, Jay DaRe, Angelo J. Castellino, James M. Fujitaki, Ross Dixon, James R. Appleman & James B. Wiesner
Pages: 1013-1021
Published online: 16 Aug 2006
AbstractforDesign, Synthesis and Anticonvulsant Activity of the Potent Adenosine Kinase Inhibitor GP3269 | References | PDF (417.6 KB)
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Article
Synthesis and Properties of Conformationally Rigid Cyclouridylic Acids Having Covalent Bonding Linkers Between the Uracil 5-Position and the 5′-Phosphate Group
Kohji Seio, Osamu Kurasawa, Takeshi Wada, Kensaku Sakamoto, Shigeyuki Yokoyama & M. Sekinea
Pages: 1023-1032
Published online: 16 Aug 2006
AbstractforSynthesis and Properties of Conformationally Rigid Cyclouridylic Acids Having Covalent Bonding Linkers Between the Uracil 5-Position and the 5′-Phosphate Group | References | PDF (745 KB)
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Article
Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety
Rosa Alvarez, María-Luisa Jimeno, Erik De Clercq, Jan Balzarini & María-José Camarasa
Pages: 1033-1036
Published online: 16 Aug 2006
AbstractforNovel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety | References | PDF (201.5 KB)
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Article
Intracellular Metabolism and Action of an Antitumor Nucleoside, 2′-C-Cyano-2′-Deoxy-1-β-d-arabinofuranosylcytosine (CNDAC)
Atsushi Azuma, Peng Huang, Akira Matsuda & William Plunkett
Pages: 1037-1039
Published online: 16 Aug 2006
AbstractforIntracellular Metabolism and Action of an Antitumor Nucleoside, 2′-C-Cyano-2′-Deoxy-1-β-d-arabinofuranosylcytosine (CNDAC) | References | PDF (123.4 KB)
  • 27 Views
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Article
Vibrational Study of a Nucleoside Analogue with Antitumoral and Antiviral Activity, 5-Fluoro-2′-deoxyuridine, FdU
L. Bailey, A. Hernanz & R. Navarro
Pages: 1041-1044
Published online: 16 Aug 2006
AbstractforVibrational Study of a Nucleoside Analogue with Antitumoral and Antiviral Activity, 5-Fluoro-2′-deoxyuridine, FdU | References | PDF (202.2 KB)
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Article
Synthesis and Cytotoxic Activity of Selenophenfurin, a New Inhibitor of IMP Dehydrogenase
L. Cappellacci, P. Franchetti, G. Abu Sheikha, H. N. Jayaram, V. V. Gurudutt, T. Sint, B. P. Schneider, B. M. Goldstein, G. Perra, S. Poma, P. La Colla & M. Grifantini
Pages: 1045-1048
Published online: 16 Aug 2006
AbstractforSynthesis and Cytotoxic Activity of Selenophenfurin, a New Inhibitor of IMP Dehydrogenase | References | PDF (216.4 KB)
  • 23 Views
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Article
Synthesis of Homo-C-D4T and Homo-C-Thymidine
Bogdan Doboszewski
Pages: 1049-1052
Published online: 16 Aug 2006
AbstractforSynthesis of Homo-C-D4T and Homo-C-Thymidine | References | PDF (146.1 KB)
  • 38 Views
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Article
Irreversible, Tight-Binding Inhibition of Adenosine Deaminase by Coformycins: Inhibitor Structural Features That Contribute to the Mode of Enzyme Inhibition
Mikyung Hong & Ramachandra S. Hosmane
Pages: 1053-1057
Published online: 16 Aug 2006
AbstractforIrreversible, Tight-Binding Inhibition of Adenosine Deaminase by Coformycins: Inhibitor Structural Features That Contribute to the Mode of Enzyme Inhibition | References | PDF (246.5 KB)
  • 78 Views
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Article
Synthesis and Anti-HIV Activity of Carbocyclic Ring-Enlarged 4′,1′a-Methano Oxetanocin Analogues
Lak S. Jeong, Min Bae, Moon W. Chun & Victor E. Marquez
Pages: 1059-1062
Published online: 16 Aug 2006
AbstractforSynthesis and Anti-HIV Activity of Carbocyclic Ring-Enlarged 4′,1′a-Methano Oxetanocin Analogues | References | PDF (182.1 KB)
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Article
Synthesis of Novel 3′-C-Hydroxymethyl Nucleosides by a Convergent Strategy
Pia N⊘rregaard J⊘rgensen & Jesper Wengel
Pages: 1063-1066
Published online: 16 Aug 2006
AbstractforSynthesis of Novel 3′-C-Hydroxymethyl Nucleosides by a Convergent Strategy | References | PDF (157.6 KB)
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Article
Synthesis of the Sulfonylpyrimidine Derivatives as a New Type of Sulfonylcycloureas
Biserka Kašnar, Irena Krizmanić & Mladen Žinić
Pages: 1067-1071
Published online: 16 Aug 2006
AbstractforSynthesis of the Sulfonylpyrimidine Derivatives as a New Type of Sulfonylcycloureas | References | PDF (170.3 KB)
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Article
Synthesis of 3′-Deoxy-3′ and 5′-Deoxy-5′-[4-(Purin-9-yl/Pyrimidin-1-yl) methyl-1,2,3-Triazol-1-yl]thymidine via 1,3-Dipolar Cycloaddition
H. B. Lazrek, M. Taourirte, T. Oulih, Y. Kabbaj, J. L. Barascut, J. L. Imbach, N. A. Almasoudi & W. Pfleiderer
Pages: 1073-1077
Published online: 16 Aug 2006
AbstractforSynthesis of 3′-Deoxy-3′ and 5′-Deoxy-5′-[4-(Purin-9-yl/Pyrimidin-1-yl) methyl-1,2,3-Triazol-1-yl]thymidine via 1,3-Dipolar Cycloaddition | References | PDF (189.9 KB)
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Article
Synthesis of N-Arylinosines
Tokumi Maruyama, Yoshiko Sato, Takeshi Goto & Mitsutoshi Fukuhara
Pages: 1079-1082
Published online: 16 Aug 2006
AbstractforSynthesis of N-Arylinosines | References | PDF (213.4 KB)
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Article
Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides
Nicolai E. Poopeiko, Natalia B. Khripach, Zygmunt Kazimierczuk, Jan Balzarini, Erik De Clercq & Igor A. Mikhailopulo
Pages: 1083-1086
Published online: 16 Aug 2006
AbstractforSynthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides | References | PDF (201.5 KB)
  • 29 Views
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Article
Dinucleotides Incorporating Isomeric Nucleosides: Synthesis, Structural and Stereochemical Characterization, and Enzymology
Tamera S. Jahnke, Qi Chao & Vasu Nair
Pages: 1087-1090
Published online: 16 Aug 2006
AbstractforDinucleotides Incorporating Isomeric Nucleosides: Synthesis, Structural and Stereochemical Characterization, and Enzymology | References | PDF (155.3 KB)
  • 19 Views
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Article
Synthesis of New Dideoxynucleosides Bearing Ring-Extended Nucleobases
Jianzhong Zhang & Vasu Nair
Pages: 1091-1094
Published online: 16 Aug 2006
AbstractforSynthesis of New Dideoxynucleosides Bearing Ring-Extended Nucleobases | References | PDF (158.6 KB)
  • 30 Views
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Article
Novel Intramolecular Introduction of Nucleophiles To 2,2′-Anhydrouridine
Danny P. C. McGee & Alecia Vaughn-Settle
Pages: 1095-1097
Published online: 16 Aug 2006
AbstractforNovel Intramolecular Introduction of Nucleophiles To 2,2′-Anhydrouridine | References | PDF (126.4 KB)
  • 43 Views
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Article
4-Substituted Uridine 5′-Triphosphates as Agonists of the P2Y2 Purinergic Receptor
Sammy R. Shaver, William Pendergast, Suhaib M. Siddiqi, Benjamin R. Yerxa, Dallas K. Croom, Robert W. Dougherty, Michael K. James, A. Neil Jones & Janet L. Rideout
Pages: 1099-1102
Published online: 16 Aug 2006
Abstractfor4-Substituted Uridine 5′-Triphosphates as Agonists of the P2Y2 Purinergic Receptor | References | PDF (211 KB)
  • 145 Views
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Article
Synthesis and Biological Activities of 2′-Modified 4′-Thionucleosides
Yuichi Yoshimura, Kenji Kitano, Mikari Watanabe, Hiroshi Satoh, Shinji Sakata, Shinji Miura, Noriyuki Ashida, Haruhiko Machida & Akira Matsuda
Pages: 1103-1106
Published online: 16 Aug 2006
AbstractforSynthesis and Biological Activities of 2′-Modified 4′-Thionucleosides | References | PDF (164 KB)
  • 82 Views
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Article
Addition of 2,3-Dihydrofuran to N2-Acetyl-8-bromoguanine
M. Madre, R. Zhuk & G.-J. Koomen
Pages: 1107-1110
Published online: 16 Aug 2006
AbstractforAddition of 2,3-Dihydrofuran to N2-Acetyl-8-bromoguanine | References | PDF (170.3 KB)
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Article
Synthesis and Properties of Oligonucleotides Containing 5-Aza-2′-deoxycytidine
Ramon Eritja, Victor E. Marquez & Ramon Güimil García
Pages: 1111-1114
Published online: 16 Aug 2006
AbstractforSynthesis and Properties of Oligonucleotides Containing 5-Aza-2′-deoxycytidine | References | PDF (220.3 KB)
  • 93 Views
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Article
Synthesis of New 1,2,3-Triazole Acyclonucleoside Analogues of ACV and HBG
H. B. Lazrek, M. Taourirte, T. Oulih, M. Lebtoumi, J. L. Barascut & J. L. Imbach
Pages: 1115-1118
Published online: 16 Aug 2006
AbstractforSynthesis of New 1,2,3-Triazole Acyclonucleoside Analogues of ACV and HBG | References | PDF (174.6 KB)
  • 75 Views
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III. PRECLINICAL STUDIES OF OLIGOMERS

Article
Delivery of Polynucleotides with Polyamine Lipids and Polymers
B. A. Demeneix, O. Boussif, M. A. Zanta, J. S. Remy & J. P. Behr
Pages: 1121-1127
Published online: 16 Aug 2006
AbstractforDelivery of Polynucleotides with Polyamine Lipids and Polymers | References | PDF (668.4 KB)
  • 23 Views
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Article
Conjugated Antisense Oligonucleotides
Muthiah Manoharan, Kathleen L. Tivel, Thomas P. Condon, Laura K. Andrade, Isabelle Barber-Peoch, Gopal Inamati, Shefali Shah, Venkatraman Mohan, Mark J. Graham, C. Frank Bennett, Stanley T. Crooke & P. Dan Cook
Pages: 1129-1138
Published online: 16 Aug 2006
AbstractforConjugated Antisense Oligonucleotides | References | PDF (366.8 KB)
  • 89 Views
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Article
Cholesterol Conjugated Uniform and Gapmer Phosphorothioate Oligonucleotides Targeted Against PKC-α and C-raf Gene Expression
Muthiah Manoharan, Kathleen L. Tivel, Gopal Inamati, Brett P. Monia, Nick Dean & P. Dan Cook
Pages: 1139-1140
Published online: 16 Aug 2006
AbstractforCholesterol Conjugated Uniform and Gapmer Phosphorothioate Oligonucleotides Targeted Against PKC-α and C-raf Gene Expression | References | PDF (117.1 KB)
  • 36 Views
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Article
2′- and 3′- Cholesterol-Conjugated Adenosine and Cytosine Nucleoside Building Blocks: Synthesis of Lipidic Nucleic Acids
Muthiah Manoharan, Gopal Inamati, Kathleen L. Tivel, Boyd Conklin, Bruce S. Ross & P. Dan Cook
Pages: 1141-1143
Published online: 16 Aug 2006
Abstractfor2′- and 3′- Cholesterol-Conjugated Adenosine and Cytosine Nucleoside Building Blocks: Synthesis of Lipidic Nucleic Acids | References | PDF (98.9 KB)
  • 96 Views
  • 9 CrossRef citations
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Article
Preclinical Profiling of Modified Oligonucleotides: Anticoagulation and Pharmacokinetic Properties
Paul L. Nicklin, John Ambler, Andrew Mitchelson, Deborah Bayley, Judy A. Phillips, Sarah J. Craig & Brett P. Mania
Pages: 1145-1153
Published online: 16 Aug 2006
AbstractforPreclinical Profiling of Modified Oligonucleotides: Anticoagulation and Pharmacokinetic Properties | References | PDF (381.2 KB)
  • 22 Views
  • 9 CrossRef citations
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Article
Enhanced Antisense Effects Resulting from an Improved Streptolysin-O Protocol for Oligodeoxynucleotide Delivery into Human Leukaemia Cells
R. V. Giles, J. Grzybowski, D. G. Spiller & D. M. Tidd
Pages: 1155-1163
Published online: 16 Aug 2006
AbstractforEnhanced Antisense Effects Resulting from an Improved Streptolysin-O Protocol for Oligodeoxynucleotide Delivery into Human Leukaemia Cells | References | PDF (473.4 KB)
  • 66 Views
  • 23 CrossRef citations
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Article
Modification of a Phosphorothioate Oligonucleotide with Cholesterol Induces Association of the Oligonucleotide to Serum Lipoproteins and Affects Its Biological Fate
Martin K. Bijsterbosch, Muthiah Manoharan, Kathleen L. Tivel, Erik T. Rump, Erik A.L. Biessen, Remco L.A. De Vrueh, P. Dan Cook & Theo J.C. van Berkel
Pages: 1165-1168
Published online: 16 Aug 2006
AbstractforModification of a Phosphorothioate Oligonucleotide with Cholesterol Induces Association of the Oligonucleotide to Serum Lipoproteins and Affects Its Biological Fate | References | PDF (201.1 KB)
  • 18 Views
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Article
Conjugated Antisense Oligonucleotides for Inhibition of Human Cytomegalovirus In Vitro
Zhaoda Zhang, Jean A. Smith, Adrienne P. Smyth, Warren Eisenberg, Alexandra Nichols, Gregory S. Pari & Jin Yan Tang
Pages: 1169-1172
Published online: 16 Aug 2006
AbstractforConjugated Antisense Oligonucleotides for Inhibition of Human Cytomegalovirus In Vitro | References | PDF (272.2 KB)
  • 19 Views
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Article
Restoration of ß-Globin Gene Expression in Mammalian Cells by Antisense Oligonucleotides That Modify the Aberrant Splicing Patierns of Thalassemic Pre-mRNAs
Halina Sierakowska, Michael Montague, Sudhir Agrawal & Ryszard Kole
Pages: 1173-1182
Published online: 16 Aug 2006
AbstractforRestoration of ß-Globin Gene Expression in Mammalian Cells by Antisense Oligonucleotides That Modify the Aberrant Splicing Patierns of Thalassemic Pre-mRNAs | References | PDF (768.4 KB)
  • 38 Views
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Article
Targeted Gene Correction: Synthesis and Characterization of Double-Hairpin 2′-O-Methyl RNA/DNA Chimera Oligonucleotides
Alex Andrus, Ravi Vinayak, Robert G. Kuimelis & Bashar Mullah
Pages: 1183-1194
Published online: 16 Aug 2006
AbstractforTargeted Gene Correction: Synthesis and Characterization of Double-Hairpin 2′-O-Methyl RNA/DNA Chimera Oligonucleotides | References | PDF (497.5 KB)
  • 23 Views
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Article
Inhibition of 5-α-Reductase (TYPE-II) Expression by Antisense 3′-Deoxy-(2′-5′) Oligonucleotide Chimeras
Purshotam Bhan, Anila Bhan, Mikung Hong, John G. Hartwell, June M. Saunders & Glenn D. Hoke
Pages: 1195-1199
Published online: 16 Aug 2006
AbstractforInhibition of 5-α-Reductase (TYPE-II) Expression by Antisense 3′-Deoxy-(2′-5′) Oligonucleotide Chimeras | References | PDF (243.7 KB)
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Article
Synthesis of (2′,5′)-Oligoadenylate Antisense Chimeras Targeting Steroid 5α-Reductase
Hagen Cramer & Paul F. Terrence
Pages: 1201-1204
Published online: 16 Aug 2006
AbstractforSynthesis of (2′,5′)-Oligoadenylate Antisense Chimeras Targeting Steroid 5α-Reductase | References | PDF (219.5 KB)
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Article
Biologically Active Oligodeoxyribonucleotides. VII. Anti-HIV-1 Activity of Hexadeoxyribonucleotides Bearing 3′- and 5′-End-Modifications
Makoto Koizumi, Rika Koga, Hitoshi Hotoda, Kenji Momota, Toshinori Ohmine, Hidehiko Furukawa, Takashi Nishigakit, Koji Abe, Toshiyuki Kosaka, Masakatsu Kaneko, Satoshi Kimura & Kaoru Shimada
Pages: 1205-1208
Published online: 16 Aug 2006
AbstractforBiologically Active Oligodeoxyribonucleotides. VII. Anti-HIV-1 Activity of Hexadeoxyribonucleotides Bearing 3′- and 5′-End-Modifications | References | PDF (195.2 KB)
  • 15 Views
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Article
Synthesis of 3′,5′-Dithymidylyl-α-hydroxyphosphonate Dimer Building Blocks for Oligonucleotide Synthesis—A New Pro-oliguncleotide
Ralf P. Mauritz, Chris Meier & Eugen Uhlmann
Pages: 1209-1212
Published online: 16 Aug 2006
AbstractforSynthesis of 3′,5′-Dithymidylyl-α-hydroxyphosphonate Dimer Building Blocks for Oligonucleotide Synthesis—A New Pro-oliguncleotide | References | PDF (272.5 KB)
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Article
The Pro-Oligonucleotide Approach: Chimeric Dodecamers Bearing Six Bioreversible Protecting Groups
F. Morvan, G. Tosquellas, N. Mignet, I. Barber, B. Rayner & J.-L. Imbach
Pages: 1213-1214
Published online: 16 Aug 2006
AbstractforThe Pro-Oligonucleotide Approach: Chimeric Dodecamers Bearing Six Bioreversible Protecting Groups | References | PDF (106.7 KB)
  • 19 Views
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Article
Enhanced Specificity of Minimally Modified Anti-c-myc Oligonucleotides
A. Peyman, H. Ragg, T. Ulshöfer, D. W. Will & E. Uhlmann
Pages: 1215-1219
Published online: 16 Aug 2006
AbstractforEnhanced Specificity of Minimally Modified Anti-c-myc Oligonucleotides | References | PDF (253.5 KB)
  • 14 Views
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Article
Targeting HIV mRNA for Degradation: 2,5-A Antisense Chimeras as Potential Chemotherapeutic Agents for AIDS
Mark R. Player, Ratan Maitra, Robert Silverman & Paul F. Torrence
Pages: 1221-1222
Published online: 16 Aug 2006
AbstractforTargeting HIV mRNA for Degradation: 2,5-A Antisense Chimeras as Potential Chemotherapeutic Agents for AIDS | PDF (80.2 KB)
  • 15 Views
  • 1 CrossRef citations
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Article
Conjugation of Oligonucleotides with Steroid Structures and Their Interaction with the Low-Density Lipoprotein
Erik T. Rump, Remco L.A. de Vrueh, Erik A.L. Biessen, Theo J.C. van Berkel & Martin K. Bijsterbosch
Pages: 1223-1226
Published online: 16 Aug 2006
AbstractforConjugation of Oligonucleotides with Steroid Structures and Their Interaction with the Low-Density Lipoprotein | References | PDF (168.3 KB)
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IV. PRECLINICAL STUDIES OF NUCLEOSIDES AND NUCLEOTIDES

Article
Beta-L-(-)-dioxolane Cytidine (β-L-(-)-OddC) as a Potent Compound for the Treatment of Cancer
K. L. Grove, X. Guo, S-H. Liu, M. Kukhanova, C-K. Chu & Y-C. Cheng
Pages: 1229-1233
Published online: 16 Aug 2006
AbstractforBeta-L-(-)-dioxolane Cytidine (β-L-(-)-OddC) as a Potent Compound for the Treatment of Cancer | References | PDF (252.1 KB)
  • 35 Views
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Article
Resistance Profile of a Novel 2′, 3′ - Dideoxynucleoside Analog with Activity Against HIV-1
Nathalie Richard, Antonietta R. Belmonte, Horacio Salomon, Kazushige Nagai, Tarek Mansour & Mark A. Wainberg
Pages: 1235-1240
Published online: 16 Aug 2006
AbstractforResistance Profile of a Novel 2′, 3′ - Dideoxynucleoside Analog with Activity Against HIV-1 | References | PDF (270 KB)
  • 18 Views
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Article
Characterization of GPI2A, a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication
Michael I. Anazodo, Elena Duta, Horacio Salomon, Albert D. Friesen, Mark A. Wainberg & Jim A. Wright
Pages: 1241-1249
Published online: 16 Aug 2006
AbstractforCharacterization of GPI2A, a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication | References | PDF (518.4 KB)
  • 17 Views
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Article
Suicide Gene Therapy for Intrinsically Drug Resistant Solid Tumors
J. Arly Nelson, Bih-Fang Pan, Frank C. Marini III, David Farquhar & Craig A. Mullen
Pages: 1251-1259
Published online: 16 Aug 2006
AbstractforSuicide Gene Therapy for Intrinsically Drug Resistant Solid Tumors | References | PDF (508.2 KB)
  • 15 Views
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Article
Gemcitabine: Actions and Interactions
William Plunkett, Peng Huang & Varsha Gandhi
Pages: 1261-1270
Published online: 16 Aug 2006
AbstractforGemcitabine: Actions and Interactions | References | PDF (416.9 KB)
  • 225 Views
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Article
Modulation of DNA Triplex Stability Through Nucleobase Modifications
Krishna N. Ganesh, Kallanthottathil G. Rajeev, Pradeep S. Pallan, Vipul S Rana, Dinesh A. Barawkar & Vaijayanti A. Kumar
Pages: 1271-1278
Published online: 16 Aug 2006
AbstractforModulation of DNA Triplex Stability Through Nucleobase Modifications | References | PDF (371.5 KB)
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Article
Lipophilic Derivatization of the Antiviral Drug 9-(2-Phosphonylmethoxyethyl)adenine and Its Incorporation into a Lactosylated Lipid Carrier to Improve Its Liver Uptake
Remco L.A. de Vrueh, Erik T. Rump, Erik A.L. Biessen, Jan Balzarini, Theo J.C. van Berkel & Martin K. Bijsterbosch
Pages: 1279-1282
Published online: 16 Aug 2006
AbstractforLipophilic Derivatization of the Antiviral Drug 9-(2-Phosphonylmethoxyethyl)adenine and Its Incorporation into a Lactosylated Lipid Carrier to Improve Its Liver Uptake | References | PDF (168.1 KB)
  • 23 Views
  • 1 CrossRef citations
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Article
Comparison of the Inhlbitory Effects of 2-Chloro-2′-deoxyadenosine and 9-β-D-Arabinosyl-2-fluoro-adenine on Metabolism of Deoxyadenosine in Human Lymphocytes and Erythrocytes
Krystyna Fabianowska-Majewska & Dorota Wyczechowska
Pages: 1283-1286
Published online: 16 Aug 2006
AbstractforComparison of the Inhlbitory Effects of 2-Chloro-2′-deoxyadenosine and 9-β-D-Arabinosyl-2-fluoro-adenine on Metabolism of Deoxyadenosine in Human Lymphocytes and Erythrocytes | References | PDF (244 KB)
  • 13 Views
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Article
Antiviral Activities of β-Enantiomers of 3′-Substituted-3′-deoxythymidine Analogs
Abdesslem Faraj, M. Abdelaziz El Alaoui, Geraldine Pavia, Gilles Gosselin, Jean-Louis Imbach, Raymond F. Schinazi & Jean Pierre Sommadossi
Pages: 1287-1290
Published online: 16 Aug 2006
AbstractforAntiviral Activities of β-Enantiomers of 3′-Substituted-3′-deoxythymidine Analogs | References | PDF (162.9 KB)
  • 34 Views
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Article
Anti-Inflammatory Activity of Purine Nucleoside Analogs
Stephanie A. Hartsel, Cecil Chen, John Kennedy, Allison Bendele, Cliff Wright & William S. Marshall
Pages: 1291-1294
Published online: 16 Aug 2006
AbstractforAnti-Inflammatory Activity of Purine Nucleoside Analogs | References | PDF (182.6 KB)
  • 26 Views
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Article
Thiated Pyrimidine Deoxynucleoside Analogues, Potential Chemotherapeutic Agents, and Substrates/Inhibitors in Various Enzyme Systems
M. Bretner, K. Felczak, J. M. Dzik, B. Golos, W. Rode, A. Drabikowska, J. Poznanski, K. Krawiec, A. Piasek, D. Shugar & T. Kulikowski
Pages: 1295-1299
Published online: 16 Aug 2006
AbstractforThiated Pyrimidine Deoxynucleoside Analogues, Potential Chemotherapeutic Agents, and Substrates/Inhibitors in Various Enzyme Systems | References | PDF (230.3 KB)
  • 41 Views
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Article
Derivatives of Imidazole-4-carboxamide as Substrates for Various DNA Polymerases
Christine Le Bec, Pascal Roux, Henri Buc & Sylvie Pochet
Pages: 1301-1302
Published online: 16 Aug 2006
AbstractforDerivatives of Imidazole-4-carboxamide as Substrates for Various DNA Polymerases | References | PDF (114.3 KB)
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Article
Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP) — A New Pro-Nucleotide Approach
Chris Meier, Martina Lorey, Eric De Clercq & Jan Balzarini
Pages: 1303-1306
Published online: 16 Aug 2006
AbstractforCyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP) — A New Pro-Nucleotide Approach | References | PDF (219.8 KB)
  • 86 Views
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Article
Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach for FdUMP
Martina Lorey, Chris Meier, Eric De Clercq & Jan Balzarini
Pages: 1307-1310
Published online: 16 Aug 2006
AbstractforCyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach for FdUMP | References | PDF (213.7 KB)
  • 70 Views
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Article
Di-ddU-α-Hydroxyphosphonate and α-Hydroxy- α- METHYLPHOSPHONATES as Potential Prodrugs of Antiviral Nucleoside Analogues
Lothar W. Habel & Chris Meier
Pages: 1311-1314
Published online: 16 Aug 2006
AbstractforDi-ddU-α-Hydroxyphosphonate and α-Hydroxy- α- METHYLPHOSPHONATES as Potential Prodrugs of Antiviral Nucleoside Analogues | References | PDF (206.1 KB)
  • 40 Views
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Article
Synergistic Combinations of Nucleoside Analog Drugs with Other Drugs Induce Greater Apoptosis in Human Leukemic T-Cells
Partha Nandy, Antonia P. Periclou & Vassilios I. Avramis
Pages: 1315-1319
Published online: 16 Aug 2006
AbstractforSynergistic Combinations of Nucleoside Analog Drugs with Other Drugs Induce Greater Apoptosis in Human Leukemic T-Cells | References | PDF (335.4 KB)
  • 13 Views
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Article
The Pronucleotide Approach. I. Synthesis, Anti-HIV Activity and Preliminary Stability Studies of Mononucleoside S,S′-Bis(O-acyl-2-oxyethyl) Phosphorodithiolates
N. Schlienger, C. Périgaud, G. Gosselin, I. Lefebvre, A. Pompon, A.-M. Aubertin, A. Kirn & J.-L. Imbach
Pages: 1321-1324
Published online: 16 Aug 2006
AbstractforThe Pronucleotide Approach. I. Synthesis, Anti-HIV Activity and Preliminary Stability Studies of Mononucleoside S,S′-Bis(O-acyl-2-oxyethyl) Phosphorodithiolates | References | PDF (165.4 KB)
  • 36 Views
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Article
The Pronucleotide Approach. II: Synthesis and Preliminary Stability Studies of Mononucleoside Glycosyl Phosphotriester Derivatives
N. Schlienger, C. Périgaud, G. Gosselin & J.-L. Imbach
Pages: 1325-1329
Published online: 16 Aug 2006
AbstractforThe Pronucleotide Approach. II: Synthesis and Preliminary Stability Studies of Mononucleoside Glycosyl Phosphotriester Derivatives | References | PDF (167 KB)
  • 29 Views
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Article
The Pronucleotide Approach. III. Synthesis, Anti-HBV Activity and Stability Studies of the Bis(S-pivaloyl-2-thioethyl) Phosphotriester Derivative of Acyclovir
Gilles Valette, Jean-Luc Girardet, Alain Pompon, Christian Périgaud, Gilles Gosselin, Brent Korba, Olivier Hantz & Jean-Louis Imbach
Pages: 1331-1335
Published online: 16 Aug 2006
AbstractforThe Pronucleotide Approach. III. Synthesis, Anti-HBV Activity and Stability Studies of the Bis(S-pivaloyl-2-thioethyl) Phosphotriester Derivative of Acyclovir | References | PDF (228.2 KB)
  • 20 Views
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Article
Synthesis and Biological Activity of Some 2-Aminopurine Carbonucleosides
L. Santana, M. Teijeira, E. Uriartea, C. Terán, G. Andrei, R. Snoeck & E. De Clercq
Pages: 1337-1339
Published online: 16 Aug 2006
AbstractforSynthesis and Biological Activity of Some 2-Aminopurine Carbonucleosides | References | PDF (119.9 KB)
  • 23 Views
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Article
Phosphodiester Amidates of Unsaturated Nucleoside Analogues as Anti-HIV Agents
Holger Winter, Yosuke Maeda, Hiroaki Mitsuya & Jiri Zemlicka
Pages: 1341-1345
Published online: 16 Aug 2006
AbstractforPhosphodiester Amidates of Unsaturated Nucleoside Analogues as Anti-HIV Agents | References | PDF (212.7 KB)
  • 27 Views
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Article
Antileukemic Activities and Mechanism of Action of 2′-Deoxy-4′-methylcytidine and Related Nucleosides
Toyofumi Yamaguchi, Aki Tomikawa, Toshiaki Hirai, Takeo Kawaguchi, Hiroshi Ohrui & Mineo Saneyoshi
Pages: 1347-1350
Published online: 16 Aug 2006
AbstractforAntileukemic Activities and Mechanism of Action of 2′-Deoxy-4′-methylcytidine and Related Nucleosides | References | PDF (196.5 KB)
  • 37 Views
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Article
Synthesis and Biological Activity of New 2′ 5′-Oligonucleotides
Evgeny I. Kvasyuk, Tamara I. Kulak, Igor A. Mikhailopulo, Robert J. Suhadolnik, Earl E. Henderson, Susan E. Horvath, Ming-Xu Guan & Wolfgang Pfleiderer
Pages: 1351-1354
Published online: 16 Aug 2006
AbstractforSynthesis and Biological Activity of New 2′ 5′-Oligonucleotides | References | PDF (164.6 KB)
  • 15 Views
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V. NOVEL NUCLEOSIDES AND OLIGOMERS

Article
Sequence-Specific Cleavage of RNA Using Macrocyclic Lanthanide Complexes Conjugated to Oligonucleotides: A Structure Activity Study
Jonathan Hall, Dieter Hüsken & Robert Häner
Pages: 1357-1368
Published online: 16 Aug 2006
AbstractforSequence-Specific Cleavage of RNA Using Macrocyclic Lanthanide Complexes Conjugated to Oligonucleotides: A Structure Activity Study | References | PDF (574.3 KB)
  • 118 Views
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Article
Pteridine Nucleosides—New Versatile Building Blocks in Oligonucleotide Synthesis
Ramamurthy Charubala, Juris Maurinsh, Angelika Rösler, Manuel Melguizo, Oliver Jungmann, Margarete Gottlieb, Jörg Lehbauer, Mary Hawkins & Wolfgang Pfleiderer
Pages: 1369-1378
Published online: 16 Aug 2006
AbstractforPteridine Nucleosides—New Versatile Building Blocks in Oligonucleotide Synthesis | References | PDF (393.3 KB)
  • 61 Views
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Article
Potent and Selective Ligands for Adenosine Binding Sites
G. Cristalli, E. Camaioni, E. Di Francesco, A. Eleuteri, S. Vittori & R. Volpini
Pages: 1379-1388
Published online: 16 Aug 2006
AbstractforPotent and Selective Ligands for Adenosine Binding Sites | References | PDF (475.3 KB)
  • 35 Views
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Article
New Unnatural L-Nucleoside Enantiomers:From Their Stereospecific Synthesis to Their Biological Activities
G. Gosselin, V. Boudou, J.-F. Griffon, G. Pavia, C. Pierra, J.-L. Imbach, A.-M. Aubertin, R. F. Schinazi, A. Faraj & J.-P. Sommadossi
Pages: 1389-1398
Published online: 16 Aug 2006
AbstractforNew Unnatural L-Nucleoside Enantiomers:From Their Stereospecific Synthesis to Their Biological Activities | References | PDF (379.7 KB)
  • 65 Views
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Article
Conformational Studies of 3′-Spironucleosides (TSAO-T and Analogues) by NMR Spectroscopy
Rosa Alvarez, María-Luisa Jimeno, Francisco J. Tomás-Gil, María-Jesús Pérez-Pérez & María-José Camarasa
Pages: 1399-1402
Published online: 16 Aug 2006
AbstractforConformational Studies of 3′-Spironucleosides (TSAO-T and Analogues) by NMR Spectroscopy | References | PDF (216.8 KB)
  • 19 Views
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Article
A Study Towards Total Synthesis of Antibiotic Agrocin 84
Dmitri Filippov, Cornelis M. Timmers, Gijs A. van der Marel & Jacques H. van Boom
Pages: 1403-1406
Published online: 16 Aug 2006
AbstractforA Study Towards Total Synthesis of Antibiotic Agrocin 84 | References | PDF (194 KB)
  • 78 Views
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Article
Solid Phase Conjugation Chemistry: Use of Alloc as a Protecting Group for 2′-Aminolinker Containing Oligonucleotides
Isabelle Barber-Peoc'h, Muthiah Manoharan & P. Dan Cook
Pages: 1407-1410
Published online: 16 Aug 2006
AbstractforSolid Phase Conjugation Chemistry: Use of Alloc as a Protecting Group for 2′-Aminolinker Containing Oligonucleotides | References | PDF (150.8 KB)
  • 45 Views
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Article
2′- and 3′- Biotin Conjugated Nucleoside Building Blocks: Synthesis of Biotinylated Oligonucleotides
Muthiah Manoharan, Gopal Inamati, Kathleen L. Tivel, Patrick Wheeler, Kim Stecker & P. Dan Cook
Pages: 1411-1413
Published online: 16 Aug 2006
Abstractfor2′- and 3′- Biotin Conjugated Nucleoside Building Blocks: Synthesis of Biotinylated Oligonucleotides | References | PDF (108 KB)
  • 29 Views
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Article
Synthesis and IMP Dehydrogenase (Type I and Type II) Inhibitory Activity of Isosteric NAD Analogs Derived from Thiophenfurin and Furanfurin
P. Franchetti, L. Cappellacci, G. Abu Sheikha, H. N. Jayaram, B. P. Schneider, T. Sint, V. V. Gurudutt, F. R. Collart, E. Hubeman & M. Grifantini
Pages: 1415-1418
Published online: 16 Aug 2006
AbstractforSynthesis and IMP Dehydrogenase (Type I and Type II) Inhibitory Activity of Isosteric NAD Analogs Derived from Thiophenfurin and Furanfurin | References | PDF (174.9 KB)
  • 25 Views
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Article
Development of Novel Bridged and Caged Nucleoside Analogs as Biochemical Tools
Michael P. Groziak & Ronghui Lin
Pages: 1419-1421
Published online: 16 Aug 2006
AbstractforDevelopment of Novel Bridged and Caged Nucleoside Analogs as Biochemical Tools | References | PDF (153.2 KB)
  • 12 Views
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Article
1,5-Translocation Strategy for Nucleoside Anomeric Radicals
Atsushi Kittaka, Hiromichi Tanaka, Naoki Yamada, Hajime Kato & Tadashi Miyasaka
Pages: 1423-1426
Published online: 16 Aug 2006
Abstractfor1,5-Translocation Strategy for Nucleoside Anomeric Radicals | References | PDF (241.2 KB)
  • 29 Views
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Article
The Synthesis of Enantiomerically Pure Pyrazolo[4,3-c]pyridine Carbarzbo C-Nucleoside
Barbara Mohar & Jože Kobe
Pages: 1427-1429
Published online: 16 Aug 2006
AbstractforThe Synthesis of Enantiomerically Pure Pyrazolo[4,3-c]pyridine Carbarzbo C-Nucleoside | References | PDF (114.2 KB)
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Article
Conformational Analysis of Nucleosides Constructed on a Bicyclo[3.1.0]hexane Template. Structure-Antiviral Activity Analysis for the Northern and Southern Hemispheres of the Pseudorotational Cycle
Victor E. Marquez, Abdallah Ezzitouni, Maqbool A. Siddiqui, Pamela Russ, Hisafumi Ikeda & Clifford George
Pages: 1431-1434
Published online: 16 Aug 2006
AbstractforConformational Analysis of Nucleosides Constructed on a Bicyclo[3.1.0]hexane Template. Structure-Antiviral Activity Analysis for the Northern and Southern Hemispheres of the Pseudorotational Cycle | References | PDF (196.2 KB)
  • 38 Views
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Article
Novel Bicyclic Nucleoside Analogues Related to Natural Griseolic Acids
Lea Pickering & Vasu Nair
Pages: 1435-1438
Published online: 16 Aug 2006
AbstractforNovel Bicyclic Nucleoside Analogues Related to Natural Griseolic Acids | References | PDF (153.8 KB)
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Article
Synthesis and Evaluation of Novel Oligodeoxynucleotides Containing 3′-C-(3-Benzoyloxypropyl)thymidine and Bicyclo Nucleoside Derivatives
Henrik M. Pfundheller, Poul Nielsen & Jesper Wengel
Pages: 1439-1442
Published online: 16 Aug 2006
AbstractforSynthesis and Evaluation of Novel Oligodeoxynucleotides Containing 3′-C-(3-Benzoyloxypropyl)thymidine and Bicyclo Nucleoside Derivatives | References | PDF (186.1 KB)
  • 18 Views
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Article
Properties of Some Diuridine Phosphate Analogues
Bhisma K. Patel, James B. Thomson, Victor Jiménez, Klaus Eckart & Fritz Fxkstein
Pages: 1443-1446
Published online: 16 Aug 2006
AbstractforProperties of Some Diuridine Phosphate Analogues | References | PDF (191.8 KB)
  • 34 Views
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Article
Steric and Stereoelectronic Effects of 7-Deazapurine Bases on the Sugar Conformation of 2′-Deoxynucleosides
Helmut Rosemeyer, Natalya Ramzaeva, Matthias Zulauf, Horst Thomas, Yaoming Chen, Cathrin Mittelbach & Frank Seela
Pages: 1447-1451
Published online: 16 Aug 2006
AbstractforSteric and Stereoelectronic Effects of 7-Deazapurine Bases on the Sugar Conformation of 2′-Deoxynucleosides | References | PDF (164.4 KB)
  • 27 Views
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Article
1,2-Disubstituted Carbocyclic Analogues of Thymine Nucleosides
V. Escuredo, B. Ferro, L. Santana, M. Teijeira & E. Uriarte
Pages: 1453-1456
Published online: 16 Aug 2006
Abstractfor1,2-Disubstituted Carbocyclic Analogues of Thymine Nucleosides | References | PDF (128.7 KB)
  • 21 Views
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Article
2′-C-Alkylribonucleosides: Design, Synthesis, and Conformation
Rogers E. Harry-O'kuru, Emily A. Kryjak & Michael S. Wolfe
Pages: 1457-1460
Published online: 16 Aug 2006
Abstractfor2′-C-Alkylribonucleosides: Design, Synthesis, and Conformation | References | PDF (215.1 KB)
  • 111 Views
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Article
New Pyrene Derivatives for Fluorescent Labeling of Oligonucleotides
V. A. Korshun, I. A. Prokhorenko, S. V. Gontarev, M. V. Skorobogatyi, K. V. Balakin, E. V. Manasova, A. D. Malakhov & Yu. A. Berlin
Pages: 1461-1464
Published online: 16 Aug 2006
AbstractforNew Pyrene Derivatives for Fluorescent Labeling of Oligonucleotides | References | PDF (220 KB)
  • 171 Views
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Article
Synthesis of Circular Oligonucleotide Conjugates
O. G. Chakhmakhcheva, A. A. Buryakova, M. V. Choob, A. L. Kalinkina, V. A. Efimov & R. F. Rando
Pages: 1465-1468
Published online: 16 Aug 2006
AbstractforSynthesis of Circular Oligonucleotide Conjugates | References | PDF (190 KB)
  • 22 Views
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Article
Structural Studies of 2-Thiouridine in RNA
Raju K. Kumar & Darrell R. Davis
Pages: 1469-1472
Published online: 16 Aug 2006
AbstractforStructural Studies of 2-Thiouridine in RNA | References | PDF (202.9 KB)
  • 37 Views
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Article
Unexpected High Hybridization Properties of α-Anomeric Oligodeoxynucleoside Methylphosphonates
F. Debart-Vasseur, J.-J. Vasseur, J.-L. Imbach & B. Rayner
Pages: 1473-1474
Published online: 16 Aug 2006
AbstractforUnexpected High Hybridization Properties of α-Anomeric Oligodeoxynucleoside Methylphosphonates | References | PDF (123.5 KB)
  • 20 Views
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Article
Synthesis of Novel DNA Analoues Containing Aminomethylphosphonate Internucleoside Linkages
V. A. Efimov, M. V. Choob, A. L. Kalinkina & O. G. Chakhmakkcheva
Pages: 1475-1480
Published online: 16 Aug 2006
AbstractforSynthesis of Novel DNA Analoues Containing Aminomethylphosphonate Internucleoside Linkages | References | PDF (199.3 KB)
  • 18 Views
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Article
DNA Duplexes Containing Alpha Anomeric Nucleotides and Polarity Reversals: Coexistence of Parallel and Antiparallel DNA
Markus W. Gerrnann, James M. Aramini, Bernd W. Kalisch, Richard T. Pon & Johan H. van de Sande
Pages: 1481-1485
Published online: 16 Aug 2006
AbstractforDNA Duplexes Containing Alpha Anomeric Nucleotides and Polarity Reversals: Coexistence of Parallel and Antiparallel DNA | References | PDF (226.1 KB)
  • 34 Views
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Article
Stepwise Solid-Phase Synthesis of Serine-, Tyrosine- and Homoserine-nucleopeptides
Maite Beltrán, Marta Maseda, Yolanda Pérez, Jordi Robles, Enrique Pedroso & Anna Grandas
Pages: 1487-1488
Published online: 16 Aug 2006
AbstractforStepwise Solid-Phase Synthesis of Serine-, Tyrosine- and Homoserine-nucleopeptides | References | PDF (133.8 KB)
  • 32 Views
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Article
Novel DNA Damage Mediated by Oxidation of Various Modified Nucleotide Residues
Hideo Inoue, Shiro Koizume, Takahiro Yamauchi, Kouichi Murata & Eiko Ohtsuka
Pages: 1489-1490
Published online: 16 Aug 2006
AbstractforNovel DNA Damage Mediated by Oxidation of Various Modified Nucleotide Residues | References | PDF (121.6 KB)
  • 17 Views
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Article
Synthesis, Biophysical Properties, and Stability Studies of Mixed Backbone Oligonucleotides Containing Novel Non-Ionic Linkages
Radhakrishnan P. Iyer, Dong Yu, Theresa Devlin, Nan-Hui Ho, Suzanne Johnson & Sudhir Agrawal
Pages: 1491-1495
Published online: 16 Aug 2006
AbstractforSynthesis, Biophysical Properties, and Stability Studies of Mixed Backbone Oligonucleotides Containing Novel Non-Ionic Linkages | References | PDF (215.5 KB)
  • 26 Views
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Article
The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA
Anthony J. Lawrence, John B. J. Pavey, Ian A. O'Neil & Richard Cosstick
Pages: 1497-1501
Published online: 16 Aug 2006
AbstractforThe Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA | References | PDF (203.2 KB)
  • 24 Views
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Article
Comparison of Physicochemical and Biological Properties of (o-Carboran-1-YL)methylphosphonate and Methylphosphonate Oligonucleotides
Zbipniew J. Lesnikowski, Robert M. Lloyd Jr. & Raymond F. Schinazi
Pages: 1503-1505
Published online: 16 Aug 2006
AbstractforComparison of Physicochemical and Biological Properties of (o-Carboran-1-YL)methylphosphonate and Methylphosphonate Oligonucleotides | References | PDF (181.7 KB)
  • 18 Views
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Article
Properties of Oligonucleotides Containing the Transition Bases P and K
F. Hill, D. Loakes & D. M. Brown
Pages: 1507-1511
Published online: 16 Aug 2006
AbstractforProperties of Oligonucleotides Containing the Transition Bases P and K | References | PDF (256.9 KB)
  • 32 Views
  • 3 CrossRef citations
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Article
A Solid-Phase Method for the Synthesis of Small to Medium-Sized Cyclic Oligonucleotides
ElMostafa Alazzouzi, Nuria Escaja, Marcus Straub, Blanca Martí, Anna Grandas & Enrique Pedroso
Pages: 1513-1514
Published online: 16 Aug 2006
AbstractforA Solid-Phase Method for the Synthesis of Small to Medium-Sized Cyclic Oligonucleotides | References | PDF (135.5 KB)
  • 48 Views
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Article
A Novel Class of 4′-Aza Analogues of 2′,3′-Dideoxynucleosides as Potential Anti-HIV Drugs
Antonella Leggio, Angelo Liguori, Antonio Procopio, Carlo Siciliano & Giovanni Sindona
Pages: 1515-1518
Published online: 16 Aug 2006
AbstractforA Novel Class of 4′-Aza Analogues of 2′,3′-Dideoxynucleosides as Potential Anti-HIV Drugs | References | PDF (192.7 KB)
  • 37 Views
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Article
Amino Acid Nucleic Acids: Synthesis and Hybridization Properties of a Novel Class of Antisense Oligonucleotides
Kanda S. Ramasamy & Wilfried Seifert
Pages: 1519-1522
Published online: 16 Aug 2006
AbstractforAmino Acid Nucleic Acids: Synthesis and Hybridization Properties of a Novel Class of Antisense Oligonucleotides | References | PDF (188.5 KB)
  • 35 Views
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Article
Oligonucleotides Containing Consecutive 2′-Deoxy-Isoguanosine Residues: Synthesis, Parallel Duplex Formation and Identification of a d(T4iG4T4) Tetraplex
Frank Seela, Changfu Wei & Alexander Melenewski
Pages: 1523-1527
Published online: 16 Aug 2006
AbstractforOligonucleotides Containing Consecutive 2′-Deoxy-Isoguanosine Residues: Synthesis, Parallel Duplex Formation and Identification of a d(T4iG4T4) Tetraplex | References | PDF (157.4 KB)
  • 27 Views
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Original Articles

Article
Synthesis and NMR Spectra of Some New Carbohydrate Modified Uridine Phosphoramidites
Pawel J. Serafinowski & Colin L. Barnes
Pages: 1529-1532
Published online: 16 Aug 2006
AbstractforSynthesis and NMR Spectra of Some New Carbohydrate Modified Uridine Phosphoramidites | References | PDF (168 KB)
  • 22 Views
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V. NOVEL NUCLEOSIDES AND OLIGOMERS

Article
Boranophosphate Oligonucleotides: New Synthetic Approaches
Dmitri Sergueev, Ahmad Hasan, Muthukumar Ramaswamy & Barbara Ramsay Shaw
Pages: 1533-1538
Published online: 16 Aug 2006
AbstractforBoranophosphate Oligonucleotides: New Synthetic Approaches | References | PDF (387.3 KB)
  • 94 Views
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Article
Oligonucleotides Containing N7-Cyanoborane-2′-deoxyguanosine
Ahmad Hasan & Barbara Ramsay Shaw
Pages: 1539-1542
Published online: 16 Aug 2006
AbstractforOligonucleotides Containing N7-Cyanoborane-2′-deoxyguanosine | References | PDF (197.4 KB)
  • 28 Views
  • 1 CrossRef citations
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Article
Synthesis of 3′-Thioribouridine, 3′-Thioribocytidine, and Their Phosphoramidites
Sengen Sun & Joseph A. Piccirilli
Pages: 1543-1545
Published online: 16 Aug 2006
AbstractforSynthesis of 3′-Thioribouridine, 3′-Thioribocytidine, and Their Phosphoramidites | References | PDF (122.7 KB)
  • 39 Views
  • 5 CrossRef citations
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Article
Synthesis and Incorporation of 2′-O-Methyl-Pseudouridine into Oligonucleotides
Bruce S. Ross, Guillermo Vasquez, Sheri Manalili, Elena Lesnik & Richard Griffey
Pages: 1547-1549
Published online: 16 Aug 2006
AbstractforSynthesis and Incorporation of 2′-O-Methyl-Pseudouridine into Oligonucleotides | References | PDF (152.6 KB)
  • 174 Views
  • 3 CrossRef citations
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Article
Replacement of the Phosphodiester Backbone of Oligodeoxynucleotide Analogues by Non-Ionic Phosphoramidate (P-NH2)
S. Peyrottes, J.-J. Vasseur, J.-L. Imbach & B. Rayner
Pages: 1551-1554
Published online: 16 Aug 2006
AbstractforReplacement of the Phosphodiester Backbone of Oligodeoxynucleotide Analogues by Non-Ionic Phosphoramidate (P-NH2) | References | PDF (158.5 KB)
  • 26 Views
  • 1 CrossRef citations
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Article
Dinucleoside Monophosphate Analogues Containing Disulfide Linkages
Emma M. Witch & Richard Cosstick
Pages: 1555-1558
Published online: 16 Aug 2006
AbstractforDinucleoside Monophosphate Analogues Containing Disulfide Linkages | References | PDF (158.2 KB)
  • 74 Views
  • 3 CrossRef citations
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Article
Site-Specific Introduction of Functional Groups onto Bases in Synthetic Oligonucleotides for Biological Applications
Yao-Zhong Xu, Qinguo Zheng, Gareth Urwin & Peter F. Swann
Pages: 1559-1562
Published online: 16 Aug 2006
AbstractforSite-Specific Introduction of Functional Groups onto Bases in Synthetic Oligonucleotides for Biological Applications | References | PDF (192 KB)
  • 27 Views
  • 1 CrossRef citations
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Article
The Derivatives of Phosphorothioate Oligonucleotides
N. V. Amirkhanov & V. F. Zarytova
Pages: 1563-1564
Published online: 16 Aug 2006
AbstractforThe Derivatives of Phosphorothioate Oligonucleotides | References | PDF (90.1 KB)
  • 22 Views
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Article
Mini-antisense Oligonucleotides
D. V. Pyshnyi, I. A. Pyshnaya, S. G. Lokhov, E. M. Ivanova & V. F. Zarytova
Pages: 1565-1569
Published online: 16 Aug 2006
AbstractforMini-antisense Oligonucleotides | References | PDF (284.1 KB)
  • 12 Views
  • 1 CrossRef citations
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Article
Oligonucleotide-Peptide Conjjugates for RNA Cleavage
D. Pyshnyi, M. Repkova, S. Lokhov, E. Ivanova, A. Venyaminova & V. Zarytova
Pages: 1571-1574
Published online: 16 Aug 2006
AbstractforOligonucleotide-Peptide Conjjugates for RNA Cleavage | References | PDF (299.6 KB)
  • 39 Views
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Article
Superactive Oligonucleotide Derivatives
D. S. Sergeyev, P. E. Vorobjev & V. F. Zarytova
Pages: 1575-1577
Published online: 16 Aug 2006
AbstractforSuperactive Oligonucleotide Derivatives | References | PDF (185.1 KB)
  • 12 Views
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Article
The Synthesis of 2–5A Antisense Chimeras with Various Non-nucleoside COMPONENTS
Weifeng Zhang & Paul Torrence
Pages: 1579-1582
Published online: 16 Aug 2006
AbstractforThe Synthesis of 2–5A Antisense Chimeras with Various Non-nucleoside COMPONENTS | References | PDF (145.4 KB)
  • 12 Views
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VI. CHEMICAL DEVELOPMENT AND ANALYTICAL CHEMISTRY

Article
Evaluation of Sulfur-Transfer Reagents for Large Scale Synthesis of Oligonucleotide Phosphorothioate Analogues
Zhaoda Zhang, Alexandra Nichols, Jimmy X. Tang, Mazen Alsbeti & Jin Yan Tang
Pages: 1585-1588
Published online: 16 Aug 2006
AbstractforEvaluation of Sulfur-Transfer Reagents for Large Scale Synthesis of Oligonucleotide Phosphorothioate Analogues | References | PDF (203.2 KB)
  • 60 Views
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Article
Ultrafast Cleavage and Deprotection of Oligonucleotides Synthesis and Use of CAc Derivatives
M. P. Reddy, Naeem B. Hanna & Firdous Farooqui
Pages: 1589-1598
Published online: 16 Aug 2006
AbstractforUltrafast Cleavage and Deprotection of Oligonucleotides Synthesis and Use of CAc Derivatives | References | PDF (491.4 KB)
  • 747 Views
  • 20 CrossRef citations
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Article
Structural Correlations of Backbone Modifications in Antisense Oligonucleotide Duplexes
Xiaolian Gao, Jeffrey S. Rice, Collin W. Cross & Xueyong Yang
Pages: 1599-1608
Published online: 16 Aug 2006
AbstractforStructural Correlations of Backbone Modifications in Antisense Oligonucleotide Duplexes | References | PDF (628.6 KB)
  • 17 Views
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Article
A Novel Approach for Gene Medicine: Synthetic Poly-L-lysine/serine Copolymer Enhances Bioactivity of Antisense Oligonucleotides
T. Goto, Y. Suzuki, A. Wada, I. Nozawa, S. Sato, S. Kawai & Y. Mizushima
Pages: 1609-1615
Published online: 16 Aug 2006
AbstractforA Novel Approach for Gene Medicine: Synthetic Poly-L-lysine/serine Copolymer Enhances Bioactivity of Antisense Oligonucleotides | References | PDF (391.5 KB)
  • 16 Views
  • 1 CrossRef citations
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Article
Efforts Toward Synthesis of Oligonucleotides for Commercialization
Mark Andrade, Anthony S. Scozzari, Douglas L. Cole & Vasulinga T. Ravikumar
Pages: 1617-1620
Published online: 16 Aug 2006
AbstractforEfforts Toward Synthesis of Oligonucleotides for Commercialization | References | PDF (170.1 KB)
  • 25 Views
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Article
Phthaloyl Strategy—A New Approach Towards Oligodeoxyribonucleotide Synthesis
Markus Beier & Wolfgang Pfleiderer
Pages: 1621-1624
Published online: 16 Aug 2006
AbstractforPhthaloyl Strategy—A New Approach Towards Oligodeoxyribonucleotide Synthesis | References | PDF (148.9 KB)
  • 129 Views
  • 2 CrossRef citations
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Article
Solution Phase Synthesis of an Oligodeoxyribonucleotide Phosphorothioate for Therapeutic Applications
Z. S. Cheruvallath, A. H. Krotz, D. L. Cole & V. T. Ravikumar
Pages: 1625-1628
Published online: 16 Aug 2006
AbstractforSolution Phase Synthesis of an Oligodeoxyribonucleotide Phosphorothioate for Therapeutic Applications | References | PDF (190.3 KB)
  • 18 Views
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Article
An Efficient Multigram Synthesis of Monomers for the Preparation of Novel Oligonucleotides Containing Isosteric Non-Phosphorous Backbones
Stuart Dimock, Balkrishen Bhat, Didier Peoc'h, Yogesh S. Sanghvi & Eric E. Swayze
Pages: 1629-1632
Published online: 16 Aug 2006
AbstractforAn Efficient Multigram Synthesis of Monomers for the Preparation of Novel Oligonucleotides Containing Isosteric Non-Phosphorous Backbones | References | PDF (253 KB)
  • 78 Views
  • 6 CrossRef citations
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Article
Synthesis of Oligodeoxynucleoside Phosphoro-Monothioates and Phosphorodithioates by a Phosphotriester Method
Jan Kehler, Ask Püschl & Otto Dahl
Pages: 1633-1636
Published online: 16 Aug 2006
AbstractforSynthesis of Oligodeoxynucleoside Phosphoro-Monothioates and Phosphorodithioates by a Phosphotriester Method | References | PDF (188.2 KB)
  • 54 Views
  • 1 CrossRef citations
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Article
Improved Impurity Profile of Phosphorothioate Oligonucleotides Through the Use of Dimeric Phosphoramidite Synthons
Achim H. Krotz, Patrick Klopchin, Douglas L. Cole & Vasulinga T. Ravikumar
Pages: 1637-1640
Published online: 16 Aug 2006
AbstractforImproved Impurity Profile of Phosphorothioate Oligonucleotides Through the Use of Dimeric Phosphoramidite Synthons | References | PDF (227.8 KB)
  • 66 Views
  • 9 CrossRef citations
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Article
A Novel and Economical Synthesis of 2″-O-Alkyl-Uridines
Bruce S. Ross, Robert H. Springer, Zeb Tortorici & Stuart Dimock
Pages: 1641-1643
Published online: 16 Aug 2006
AbstractforA Novel and Economical Synthesis of 2″-O-Alkyl-Uridines | References | PDF (226.6 KB)
  • 249 Views
  • 33 CrossRef citations
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Article
An Efficient and Scalable Synthesis of Arabinosylguanine and 2′-Deoxy-2′-Fluoro-guanosine
Bruce S. Ross, Robert H. Springer, Kelly G. Sprankle & Guillermo Vasquez
Pages: 1645-1647
Published online: 16 Aug 2006
AbstractforAn Efficient and Scalable Synthesis of Arabinosylguanine and 2′-Deoxy-2′-Fluoro-guanosine | References | PDF (197.2 KB)
  • 281 Views
  • 4 CrossRef citations
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Article
Protection of 2,6-Diaminopurine 2′-Deoxyriboside
I. Luyten, A. Van Aerschot, J. Rozenski, R. Busson & P. Herdewijn
Pages: 1649-1652
Published online: 16 Aug 2006
AbstractforProtection of 2,6-Diaminopurine 2′-Deoxyriboside | References | PDF (197.5 KB)
  • 70 Views
  • 9 CrossRef citations
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Article
Automated Chemical Synthesis of PNA and PNA-DNA Chimera on a Nucleic Acid Synthesizer
Ravi Vinayak, Alexander C. van der Laan, Rick Brill, Ken Otteson, Alex Andrus, Esther Kuyl-Yeheskiely & Jacques H. van Boom
Pages: 1653-1656
Published online: 16 Aug 2006
AbstractforAutomated Chemical Synthesis of PNA and PNA-DNA Chimera on a Nucleic Acid Synthesizer | References | PDF (165.9 KB)
  • 98 Views
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Article
An Inverse Approach in Oligodeoxyribonucleotide Synthesis
Thomas Wagner & Wolfgang Pfleiderer
Pages: 1657-1660
Published online: 16 Aug 2006
AbstractforAn Inverse Approach in Oligodeoxyribonucleotide Synthesis | References | PDF (179.2 KB)
  • 66 Views
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Article
Studies on Nucleoside H-Phosphonothioates as Synthons in the Synthesis of Oligonucleotide Analogues
Rula Zain, Martin Bollmark & Jacek Stawinski
Pages: 1661-1662
Published online: 16 Aug 2006
AbstractforStudies on Nucleoside H-Phosphonothioates as Synthons in the Synthesis of Oligonucleotide Analogues | References | PDF (102.9 KB)
  • 22 Views
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VII. BIOLOGICAL STUDIES OF OLIGOMERS

Article
Modulation of Splicing in the DMD Gene by Antisense Oligoribonucleotides
Matthew G. Dunckley, Ian C. Eperon & George Dickson
Pages: 1665-1668
Published online: 16 Aug 2006
AbstractforModulation of Splicing in the DMD Gene by Antisense Oligoribonucleotides | References | PDF (346.3 KB)
  • 29 Views
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Article
Backbone Modified Antisense Oligodeoxynucleotides Directed Against the Hepatitis-C-Virus (HCV)-RNA
S. Eisenhardt, W. Samstag, K. Jahn-Hofman, J. W. Engels, R. Renz, P. H. Hofschneider, W. H. Caselmann & M. Alt
Pages: 1669-1672
Published online: 16 Aug 2006
AbstractforBackbone Modified Antisense Oligodeoxynucleotides Directed Against the Hepatitis-C-Virus (HCV)-RNA | References | PDF (197.1 KB)
  • 12 Views
  • 1 CrossRef citations
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Article
Effects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics
Scott P. Henry, David Monteith, Doug J. Kornbrust & Arthur A. Levin
Pages: 1673-1676
Published online: 16 Aug 2006
AbstractforEffects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics | References | PDF (207.2 KB)
  • 45 Views
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Article
Stability of Stereoregular Oligo(Nucleoside Phosphorothioate)s in Human Cells. Diastereoselectivity of Cellular 3′-Exonuclease
Maria Koziokiewicz, Edyta Gendaszewska & Maria Maszewska
Pages: 1677-1682
Published online: 16 Aug 2006
AbstractforStability of Stereoregular Oligo(Nucleoside Phosphorothioate)s in Human Cells. Diastereoselectivity of Cellular 3′-Exonuclease | References | PDF (370.8 KB)
  • 26 Views
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Article
Anti-BCL2 Phosphorothioate G3139 Clinical Pharmacology: Plasma Levels During Contwous Subcutaneous Infusion by HPLC Assay
A. V. Lebedev, F. Raynaud, M. Dizik, T. Beck, J. A. Jaeger, B. D. Brown, D. Cunningham, A. Webb, E. McCampbell, T. Riley, I. Judson & M. C. Woodle
Pages: 1683-1687
Published online: 16 Aug 2006
AbstractforAnti-BCL2 Phosphorothioate G3139 Clinical Pharmacology: Plasma Levels During Contwous Subcutaneous Infusion by HPLC Assay | References | PDF (225.3 KB)
  • 14 Views
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Article
Pharmacokinetic Properties of Phosphorothioate Oligonucleotides
Janet M. Leeds, Richard S. Geary, Scott P. Henry, Jo Glover, William Shanahan, Jon Fitchett, Todd Burckin, LoAnne Tmong & Arthur A. Levin
Pages: 1689-1693
Published online: 16 Aug 2006
AbstractforPharmacokinetic Properties of Phosphorothioate Oligonucleotides | References | PDF (203.3 KB)
  • 36 Views
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Article
G-Rich Triplex-Forming Oligodeoxynucleotides as Transcription Repressors
Luigi E. Xodo, Marianna Alunni-Fabbroni & Gtorgio Manzini
Pages: 1695-1698
Published online: 16 Aug 2006
AbstractforG-Rich Triplex-Forming Oligodeoxynucleotides as Transcription Repressors | References | PDF (223.5 KB)
  • 18 Views
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Article
Pharmacologic Disposition of a Phosphorothioate Oligodeoxynucleotide in Mice
Rosanne M. Orr, Florence I. Raynaud, Phyllis M. Goddard, Ian R. Judson, Terry Beck, Bob Bryant & Finbarr E. Cotter
Pages: 1699-1702
Published online: 16 Aug 2006
AbstractforPharmacologic Disposition of a Phosphorothioate Oligodeoxynucleotide in Mice | References | PDF (180.1 KB)
  • 12 Views
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Article
Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides
Joshua O. Ojwang, T. Sudhakar Rao, Hélène B. Marshall, Shawn D. Mustain, Nilabh Chaudhary, David A. Walker, Anusch Peyman, Eugen Uhlmann, Ganapathi R. Revankar & Robert F. Rando
Pages: 1703-1707
Published online: 16 Aug 2006
AbstractforInhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides | References | PDF (219.1 KB)
  • 16 Views
  • 1 CrossRef citations
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Article
4-Cyano-2-butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis via Phosphoramidite Approach
Vasulinga T. Ravikumar, Zacharia S. Cheruvallath & Douglas L. Cole
Pages: 1709-1712
Published online: 16 Aug 2006
Abstractfor4-Cyano-2-butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis via Phosphoramidite Approach | References | PDF (195.6 KB)
  • 61 Views
  • 3 CrossRef citations
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Article
Anti-Influenza Virus Activities of Nicked and Circular Dumbbell RNA/DNA Chimeric Oligonucleotides
Hidefumi Yamakawa, Toshiaki Ishibashi, Takayuki Abe, Toshifumi Hatta, Kazuyuki Takai & Hiroshi Takaku
Pages: 1713-1716
Published online: 16 Aug 2006
AbstractforAnti-Influenza Virus Activities of Nicked and Circular Dumbbell RNA/DNA Chimeric Oligonucleotides | References | PDF (317.6 KB)
  • 28 Views
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Article
Enhanced Biological Activity of Antisense Oligonucleotides Containing 5-(1-Hexynyl)-substituted Pyrimidine Nucleotides
E. Uhlmann, L. Homung, S. Hein, S. Augustin, A. Peyman, D. W. Will, M. Helsberg, J. Sági, L. Ötvös, J. O. Ojwang, S. Mustain & R. F. Rando
Pages: 1717-1720
Published online: 16 Aug 2006
AbstractforEnhanced Biological Activity of Antisense Oligonucleotides Containing 5-(1-Hexynyl)-substituted Pyrimidine Nucleotides | References | PDF (224.6 KB)
  • 22 Views
  • 3 CrossRef citations
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Article
Cleavage of Leishmania Mini-exon Sequence by Oligonucleotides Conjugated to a Dimidazole Construction
Ludmila Yurchenko, Vladimir Silnikov, Tatyana Godovikova, Gennady Shishlan, Jean-Jacques Toulme & Valentin Vlassov
Pages: 1721-1725
Published online: 16 Aug 2006
AbstractforCleavage of Leishmania Mini-exon Sequence by Oligonucleotides Conjugated to a Dimidazole Construction | References | PDF (328.3 KB)
  • 24 Views
  • 8 CrossRef citations
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Article
Immune Cell Involvement in Anti-c-myc DNA Prevention of Tumor Formation in a Mouse Model of Burkitt'S Lymphoma
G. D. Gray, R. Townsend, H. Hayasaka, R. Korngold & E. Wickstrom
Pages: 1727-1730
Published online: 16 Aug 2006
AbstractforImmune Cell Involvement in Anti-c-myc DNA Prevention of Tumor Formation in a Mouse Model of Burkitt'S Lymphoma | References | PDF (199.6 KB)
  • 12 Views
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Article
Oligonucleotide Pharmacology and Formulation: G3139 Anti-BCL2 Phosphorothioate In Stealth® Liposomes and Gel Implants
M. C. Woodle, F. I. Raynaud, M. Dizik, O. Meyer, S. K. Huang, J. A. Jaeger, B. D. Brown, R. Orr, I. R. Judson & D. Papahadjopoulos
Pages: 1731-1734
Published online: 16 Aug 2006
AbstractforOligonucleotide Pharmacology and Formulation: G3139 Anti-BCL2 Phosphorothioate In Stealth® Liposomes and Gel Implants | References | PDF (174 KB)
  • 20 Views
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Article
Inhibition of Respiratory Syncytial Virus by Double Termini-Protected 2–5A Antisense Chimeras
Wei Xiao, Guiying Li, Paul F. Torrence, Nick M. Cirino & Robert H Silverman
Pages: 1735-1738
Published online: 16 Aug 2006
AbstractforInhibition of Respiratory Syncytial Virus by Double Termini-Protected 2–5A Antisense Chimeras | References | PDF (169.2 KB)
  • 12 Views
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VIII. SPECIAL TOPICS

Article
Oligonucleotide Conjugates Derived from an Electrophilic Site: Conjugation to Baseless Carbohydrate Residue. Synthesis, Hybridization and Modeling Studies
Muthiah Manoharan, Laura K. Andrade, Venkatraman Mohan, Susan M. Freier & P. Dan Cook
Pages: 1741-1744
Published online: 16 Aug 2006
AbstractforOligonucleotide Conjugates Derived from an Electrophilic Site: Conjugation to Baseless Carbohydrate Residue. Synthesis, Hybridization and Modeling Studies | References | PDF (164.5 KB)
  • 31 Views
  • 5 CrossRef citations
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Article
Sequencing Reactions Using 6-Thio-2′-Deoxyguanosine-5′-triphosphate
Mark G. McDougall, Bernie F. McArdle, Shiv Kumar, Carl W. Fuller, Lorraine M. Rellick & Alexei V. Govorine
Pages: 1745-1748
Published online: 16 Aug 2006
AbstractforSequencing Reactions Using 6-Thio-2′-Deoxyguanosine-5′-triphosphate | References | PDF (442.1 KB)
  • 37 Views
  • 1 CrossRef citations
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Article
Ambiguous Base Pairing of 1-(2-Deoxy-β-D-Ribofuranosyl)imidazole-4-carboxamide During PCR
Sylvie Pochet, Laurence Dugué, Monica Sala, Valérie Pézo & Simon Wain-Hobson
Pages: 1749-1752
Published online: 16 Aug 2006
AbstractforAmbiguous Base Pairing of 1-(2-Deoxy-β-D-Ribofuranosyl)imidazole-4-carboxamide During PCR | References | PDF (279.4 KB)
  • 22 Views
  • 1 CrossRef citations
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Article
Combinatorial Generation of Nucleobase Libraries by MCR
Alexander Dömling & Wolfgang Richter
Pages: 1753-1756
Published online: 16 Aug 2006
AbstractforCombinatorial Generation of Nucleobase Libraries by MCR | References | PDF (192.8 KB)
  • 35 Views
  • 8 CrossRef citations
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Article
3′-Modified Nucleotides for DNA Sequencing Without Gel Electrophoresis
Isabelle Rasolonjatovo, Catherine Guerreiro & Robert S. Sarfati
Pages: 1757-1760
Published online: 16 Aug 2006
Abstractfor3′-Modified Nucleotides for DNA Sequencing Without Gel Electrophoresis | References | PDF (198.8 KB)
  • 46 Views
  • 3 CrossRef citations
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Article
Histological Localization of Phosphorothioate Oligodeoxynucleotides in Normal Rodent Tissue
Madeline Butler, Kim Stecker & C. Frank Bennett
Pages: 1761-1764
Published online: 16 Aug 2006
AbstractforHistological Localization of Phosphorothioate Oligodeoxynucleotides in Normal Rodent Tissue | References | PDF (522.5 KB)
  • 50 Views
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Article
A Convenient Method for Labeling Oligonucleotide Analogs by a Fluorogenic Tag for Direct In Vitro and In Vivo Visualization of Carboxyesterase Activity
A. Laurent, F. Debart-Vasseur, J.-L. Imbach & B. Rayner
Pages: 1765-1766
Published online: 16 Aug 2006
AbstractforA Convenient Method for Labeling Oligonucleotide Analogs by a Fluorogenic Tag for Direct In Vitro and In Vivo Visualization of Carboxyesterase Activity | References | PDF (104.6 KB)
  • 19 Views
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Article
Study of the Enantioselectivity of Enzymes Involved in Nucleoside Analogue Metabolism: Deoxycytidine Kinase
M. Shafiee, V. Boudou, J.-F. Griffon, A. Pompon, G. Gosselin, S. Eriksson, J.-L. Imbach & G. Maury
Pages: 1767-1770
Published online: 16 Aug 2006
AbstractforStudy of the Enantioselectivity of Enzymes Involved in Nucleoside Analogue Metabolism: Deoxycytidine Kinase | References | PDF (182.4 KB)
  • 19 Views
  • 5 CrossRef citations
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Article
PNASynthesis and Diagnostic Application
Troels Koch, Martin B. Borre, Michael Naesby, Hans G. Batz & Henrik Ørum
Pages: 1771-1774
Published online: 16 Aug 2006
AbstractforPNASynthesis and Diagnostic Application | References | PDF (222.9 KB)
  • 22 Views
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Article
Triplex Formation Between DNA and Mixed Purine-Pyrimidine PNA Analog with Lysines in Backbone
E. Lesnik, F. Hassman, J. Barbeau, K. Teng, K. Weiler, R. Griffey & S. Freier
Pages: 1775-1779
Published online: 16 Aug 2006
AbstractforTriplex Formation Between DNA and Mixed Purine-Pyrimidine PNA Analog with Lysines in Backbone | References | PDF (189.7 KB)
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Synthesis of a 2-Hydroxy-oxolane Derivative as a New Potential Crosslinking Agent of DNA
L. Nzita, S. Ladame, L. Gomez & S. Moreau
Pages: 1781-784
Published online: 16 Aug 2006
AbstractforSynthesis of a 2-Hydroxy-oxolane Derivative as a New Potential Crosslinking Agent of DNA | References | PDF (214.9 KB)
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Molecular Engine for Transporting Drugs Across Cell Membranes
James Summerton & Dwight Weller
Pages: 1785-1788
Published online: 16 Aug 2006
AbstractforMolecular Engine for Transporting Drugs Across Cell Membranes | PDF (204.9 KB)
  • 11 Views
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Synthesis of Copper-64 and Technetium-99M Labeled Oligonucleotides with Macrocyclic Ligands
Sven Wagner, Michael Eisenhut, Ramon Eritja & Franz Oberdorfer
Pages: 1789-1792
Published online: 16 Aug 2006
AbstractforSynthesis of Copper-64 and Technetium-99M Labeled Oligonucleotides with Macrocyclic Ligands | References | PDF (167.8 KB)
  • 25 Views
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Picomole Syntheses of High Quality Oligonucleotide Primers in Combination with the Preparation of Oligonucleotide Arrays
Jan Weiler & Jörg D. Hoheisel
Pages: 1793-1796
Published online: 16 Aug 2006
AbstractforPicomole Syntheses of High Quality Oligonucleotide Primers in Combination with the Preparation of Oligonucleotide Arrays | References | PDF (220 KB)
  • 19 Views
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New Photoreactive RNA Analogues
M. N. Repkova, A. G. Venyaminova & V. F. Zarytova
Pages: 1797-1798
Published online: 16 Aug 2006
AbstractforNew Photoreactive RNA Analogues | References | PDF (91.2 KB)
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Photochemical Cross-Linking of λ-Cro Repressor to Operator DNA Containing 4-Thiothymine or 6-Thioguanine
Qinguo Zheng, Yao-Zhong Xu & Peter F Swann
Pages: 1799-1803
Published online: 16 Aug 2006
AbstractforPhotochemical Cross-Linking of λ-Cro Repressor to Operator DNA Containing 4-Thiothymine or 6-Thioguanine | References | PDF (357.6 KB)
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A New Model for the Comparison of the Efficiency and Selectivity of Photoreactive Groups Towards the Nucleic Acid and Protein Functional Groups
Dmitri G. Knorre, Tatyana S. Godovikova, Vera D. Knorre & Vladimir V. Koval
Pages: 1805-1806
Published online: 16 Aug 2006
AbstractforA New Model for the Comparison of the Efficiency and Selectivity of Photoreactive Groups Towards the Nucleic Acid and Protein Functional Groups | References | PDF (111.5 KB)
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Kinetic Approach for Determination of Affinity Properties of Reactive Oligonucleotide Derivatives to Complementary Regions in Nucleic Acids
Vladimir V. Koval, Dmitri G. Knorre & Olga S. Fedorova
Pages: 1807-1808
Published online: 16 Aug 2006
AbstractforKinetic Approach for Determination of Affinity Properties of Reactive Oligonucleotide Derivatives to Complementary Regions in Nucleic Acids | References | PDF (118 KB)
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