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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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I. PROGRESS IN SECOND GENERATION OLIGOMER THERAPEUTICS

Amino-Linked Ribozymes: Post-Synthetic Conjugation of Half-Ribozymes

Laurent Bellon Department of Oligonucleotide Chemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301
,
Christopher Workman Department of Oligonucleotide Chemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301
,
Carolyn Gonzalez Department of Enzymology, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301
&
Francine Wincott Department of Oligonucleotide Chemistry, Ribozyme Pharmaceuticals, Inc., 2950 Wilderness Place, Boulder, Colorado, 80301
Pages 951-954 | Published online: 16 Aug 2006
 
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Abstract

A convergent approach, based on the reductive amination of 3′-phospho-glycaldehyde-ribozyme 3 with 5′-aminohexyLribozyme 1 generated an amino-linked ribozyme 4 in good yields. Catalytic activity of the cross-linked ribozyme is discussed.

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