Synthesis and Properties of Oligoribonucleotide Analogues Having Amide (3″-CH₂-CO-NH-5′) Internucleoside Linkages

Eriks Rozners Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-10691, Stockholm; Laboratory of Organic and Bioorganic Chemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

Roger Strömberg Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-10691, Stockholm; Laboratory of Organic and Bioorganic Chemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77, Stockholm, Sweden

Abstract

Amide linked ribonucleoside dimer 5 was prepared and converted into selectively protected H-phosphonate building block 9. Oligoribonucleotide duplexes having amide linkages at selected sites were synthesized and their stability was studied by UV melting experiments.

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Synthesis and Properties of Oligoribonucleotide Analogues Having Amide (3″-CH₂-CO-NH-5′) Internucleoside Linkages

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Synthesis and Properties of Oligoribonucleotide Analogues Having Amide (3″-CH2-CO-NH-5′) Internucleoside Linkages

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Synthesis and Properties of Oligoribonucleotide Analogues Having Amide (3″-CH₂-CO-NH-5′) Internucleoside Linkages