Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides

Nicolai E. Poopeiko Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

Natalia B. Khripach Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

Zygmunt Kazimierczuk Institute of Experimental Physics, University of Warsaw, 02-089, Warsaw, Poland

Jan Balzarini Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

Erik De Clercq Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

Igor A. Mikhailopulo Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, 220141, Minsk, Byelorussia

Abstract

Synthesis of 9-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2-chloroadenine (7b) and -2-chloro-6-methoxypurine (9b), as well as the α-D-anomer 7a of the former and its N isomer 10a is reported. Among the compounds synthesized, only the β-D-anomer 7b displays moderate cytotoxic activity.

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Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides

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Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides

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